A GIS model-based assessment of the environmental distribution of g-hexachlorocyclohexane in European soils and waters

The MAPPE GIS based multimedia model is used to produce a quantitative description of the behaviour of γ-hexachlorocyclohexane (γ-HCH) in Europe, with emphasis on continental surface waters. The model is found to reasonably reproduce γ-HCH distributions and variations along the years in atmosphere and soil; for continental surface waters, concentrations were reasonably well predicted for year 1995, when lindane was still used in agriculture, while for 2005, assuming severe restrictions in use, yields to substantial underestimation. Much better results were yielded when same mode of release as in 1995 was considered, supporting the conjecture that for γ-HCH, emission data rather that model structure and parameterization can be responsible for wrong estimation of concentrations. Future research should be directed to improve the quality of emission data. Joint interpretation of monitoring and modelling results, highlights that lindane emissions in Europe, despite the marked decreasing trend, persist beyond the provisions of existing legislation. An spatially-explicit multimedia modelling strategy was applied to describe the historical distribution of γ-HCH in European soils and surface waters

Animal Models to Translate Phage Therapy to Human Medicine

Phagotherapy, the use of bacteriophages to fight bacterial infections as an alternative to antibiotic treatments, has become of increasing interest in the last years. This is mainly due to the diffusion of multi-drug resistant (MDR) bacterial infections that constitute a serious issue for public health. Phage therapy is gaining favor due to its success in agriculture and veterinary treatments and its extensive utilization for human therapeutic protocols in the Eastern world. In the last decades, some clinical trials and compassionate treatments have also been performed in the Western world, indicating that phage therapy is getting closer to its introduction in standard therapy protocols. However, several questions concerning the use of phages in human therapeutic treatments are still present and need to be addressed. In this review, we illustrate the state of art of phage therapy and examine the role of animal models to translate these treatments to humans

Towards a Pan-European Integrated Groundwater and Surface Water Model: Development and Applications

During the last years, we have developed a model, which is able to simulate hydrological processes at a Pan-European scale. The model has multiple possible uses, including flood forecasting, identification of groundwater recharge / discharge zones and large-scale water resources management. The integrated model is based on the LISFLOOD model, which simulates hydrological processes with a focus on snow and soil hydrology and streamflow routing. The area of interest is the full European continent, divided in 5 × 5 km cells. A conceptual 2D MODFLOW model was linked to improve groundwater simulation. With this coupling, it is now possible to simulate the water exchanges between adjacent cells, and between groundwater and river. Available meteorological data from 1-1-1990 to 31-10-2014 were used as input for the coupled model, together with values of aquifer properties derived from literature. We used observed data of recharge, discharge and hydraulic heads from the Danube river basin to check if the model results correspond to reality. The results show a reasonably high degree of agreement between observed and simulated data, taking into account the limitations of large scale modelling. This model is the first step to improve integrated groundwater and surface water modelling which includes the collection of data and the production of Pan-European groundwater parameter maps

Short-term exposure to fine particulate matter exposure impairs innate immune and inflammatory responses to a pathogen stimulus: A functional study in the zebrafish model

Short-term exposure to fine particulate matter (PM 2.5 ) is associated with the activation of adverse inflammatory responses, increasing the risk of developing acute respiratory diseases, such as those caused by pathogen infections. However, the functional mechanisms underlying this evidence remain unclear. In the present study, we generated a zebrafish model of short-term exposure to a specific PM 2.5 , collected in the northern metropolitan area of Milan, Italy. First, we assessed the immunomodulatory effects of short-term PM 2.5 exposure and observed that it elicited pro -inflammatory effects by inducing the expression of cytokines and triggering hyper -activation of both neutrophil and macrophage cell populations. Moreover, we examined the impact of a secondary infectious pro -inflammatory stimulus induced through the injection of Pseudomonas aeruginosa lipopolysaccharide ( Pa -LPS) molecules after exposure to short-term PM 2.5 . In this model, we demonstrated that the innate immune response was less responsive to a second pro -inflammatory infectious stimulus. Indeed, larvae exhibited dampened leukocyte activation and impaired production of reactive oxygen species. The obtained results indicate that short-term PM 2.5 exposure alters the immune microenvironment and affects the inflammatory processes, thus potentially weakening the resistance to pathogen infections

A hydrological model to estimate pollution from combined sewer overflows at the regional scale: Application to Europe

Study region Combined Sewer Overflows (CSO) of 671 Functional Urban Areas (FUAs) throughout the European Union + UK (EU28), representing almost half of the EU28 population. Study focus CSO loads can be quantified at the local scale through measurements, or with calibrated hydrological models. However, they are difficult to quantify at a large scale (e.g. regional or national), due to a lack of data, and the models used at local scale cannot be applied in the absence of knowledge of the combined sewer (CS) network. This paper presents a 6-parameter lumped hydrological model to simulate a CS network and its overflows, using population and rainfall data of 671 EU28 FUAs. New hydrological insights for the region When properly calibrated, the model can predict the CSO hydrographs as well as aggregated CSO descriptors of a catchment with known impervious surface area connected to a CS with a reasonable reliability. When model calibration is not possible, using default values of the parameters enables a first approximation estimate of CSOs, accurate within one order of magnitude, which can be used to support scenario analysis for regional and continental CSO management. At the EU28 scale, the estimated total CSO volume is 5.7·10$^3$ Mm$^3$/y, with a dry weather flow content in CSOs of 460 Mm$^3$/y (assuming a dry weather flow of 200 l/population equivalent (PE)/day including sanitary discharges, industrial discharge and infiltration). A collection of case studies on CSOs is also provided

Prediction of streamflow regimes over large geographical areas: interpolated flow–duration curves for the Danube region

ABSTRACTFlow–duration curves (FDCs) are essential to support decisions on water resources management, and their regionalization is fundamental for the assessment of ungauged basins. In comparison with calibrated rainfall–runoff models, statistical methods provide data-driven estimates representing a useful benchmark. The objective of this work is the interpolation of FDCs from ~500 discharge gauging stations in the Danube. To this aim we use total negative deviation top-kriging (TNDTK), as multi-regression models are shown to be unsuitable for representing FDCs across all durations and sites. TNDTK shows a high accuracy for the entire Danube region, with overall Nash-Sutcliffe efficiency values computed in a leave-p-out cross-validation scheme (p equal to one site, one-third and half of the sites), all above 0.88. A reliability measure based on kriging variance is attached to each interpolated FDC at ~4000 prediction nodes. The GIS layer of regionalized FDCs is made available for broader use in the region

Streamflow data availability in Europe: a detailed dataset of interpolated flow-duration curves

For about 24 000 river basins across Europe, we provide a continuous representation of the stream-flow regime in terms of empirical flow-duration curves (FDCs), which are key signatures of the hydrological behaviour of a catchment and are widely used for supporting decisions on water resource management as well as for assessing hydrologic change. In this study, FDCs are estimated by means of the geostatistical procedure termed total negative deviation top-kriging (TNDTK), starting from the empirical FDCs made available by the Joint Research Centre of the European Commission (DG-JRC) for about 3000 discharge measurement stations across Europe. Consistent with previous studies, TNDTK is shown to provide high accuracy for the entire study area, even with different degrees of reliability, which varies significantly over the study area. In order to provide this kind of information site by site, together with the estimated FDCs, for each catchment we provide indicators of the accuracy and reliability of the performed large-scale geostatistical prediction. The dataset is freely available at the PANGAEA open-access library (Data Publisher for Earth & Environmental Science) at https://doi.org/10.1594/PANGAEA.938975 (Persiano et al., 2021b)

An integrated assessment framework for the analysis of multiple pressures in aquatic ecosystems and the appraisal of management options

The contribution illustrates an integrated assessment framework aimed at evaluating the relationships between multiple pressures and water body status for the purposes of river basin management. The framework includes the following steps. (1) Understanding how the different pressures affect the status of water bodies. This entails the characterization of biophysical state variables and the definition of a causal relationship between pressures and status. Therefore this step involves interaction between experts bearing ecological understanding and experts providing models to represent the effect of pressures. (2) Identifying the relevant pressures to be addressed through appropriate measures to improve the status of water bodies. (3) Evaluating reduction targets for the relevant pressures identified in a river basin, by weighting the effort associated to reducing individual pressures and the potential benefits in terms of water body status. (4) Designing management measures through a creative process and political discussion of alternative options, balancing costs, benefits and effectiveness based on engineering and economic analysis. (5) Simulating scenarios of implementation of a programme of measures in order to check their effectiveness and robustness against climate and land use change. We discuss the five steps of the assessment framework, and particularly the interaction between science and policy at the different stages. We review the assessment tools required at each step and, for setting optimal pressure reduction targets (step 3), we propose and illustrate a simplified multicriteria approach based on semi-quantitative assessment, which produces frontiers of optimal trade-offs between effort spent on measures, and achievements