Implementación de un Sistema de Gestión Documental para la administración y gestión de documentos, a través de servicios y aplicaciones web, necesarias para la certificación de empresas en la Norma ISO 9001: 2008 proyectos técnicos

This project describes the implementation of a Document Management System (DMS) in order to meet the requirements of ISO 9001:2008; necessary for quality management certification of enterprises. This system is important, especially for consultants in the area of Quality and Processes, because of the need to meet customers with the requirements of the Standard; in addition to providing a system to manage business documentation, which is safe, easy to manage, friendly for non-technical users and to facilitate its integration with the software infrastructure that the customer has. For this implementation, the use of Java was considered as it´s cross-platform language, the standard JCR (Java Content Repository) that manages the content repository, JSF as a framework for web interfaces, JPA as the persistence API that allows data persistence, besides other tools related to the aforementioned technologies. In this context, several alternatives were considered: since developing an own system toward the implementation of open code systems, not as complex or restricted, to be customized later, giving LogicalDOC as the best solution to implement. The implementation of the system allowed the customer to optimize several of its processes, and facilitates communication and collaboration of its users, through an efficient control and document management.El presente proyecto describe la implementación de un Sistema de Gestión Documental (DMS, pos sus siglas en inglés) con el fin de satisfacer los requerimientos de la norma ISO 9001:2008; necesaria para la certificación de calidad de las empresas. Este sistema es importante, sobre todo para consultores del área de Calidad y Procesos, por la necesidad de hacer cumplir a los clientes con las exigencias de la Norma; además de ofrecer un sistema que gestione la documentación empresarial, que sea seguro, fácil de administrar, amigable para usuarios no técnicos y de facilitar su integración con la infraestructura de software con la que el cliente dispone. Para la implementación se consideró el uso del lenguaje Java por ser multiplataforma, el estándar JCR (Java Content Repository) que maneja el repositorio de contenidos, JSF como framework para interfaces web, JPA como el API que permite la persistencia de datos, entre otras herramientas que deriven de las tecnologías antes mencionadas. Dentro de este ámbito, se consideraron varias alternativas: desde el desarrollo de un sistema propio hasta la implementación de sistemas, no tan complejos o restringidos, de código abierto para personalizarlos posteriormente, dando como mejor solución a LogicalDOC. La implementación del sistema permitió al cliente optimizar varios de sus procesos; además de facilitar la comunicación y colaboración de sus usuarios, a través de un control y gestión documental eficientes

Relación espacio y estructura biblioteca de Quito.

Before the project was carried out there was an investigation of the relationship among the structure, space and enclosure, for which Ignacio Paricio in his book talks about three specific interactions that are the formal, the explicit and the radical. Through the study of these 3 interactions the project of the Library of Quito is performed n the current airport of Quito that in a few years will become a large park. This library takes into account these three interactions of space and structure, for decisionmaking designed and both formal space.Previo al proyecto se realizo una investigación de cómo interactúan la estructura, el espacio y el cerramiento, para lo cual Ignacio Paricio en su libro habla sobre tres interacciones especificas que son la formal, la explicita y la radical. Por medio del estudio de estas se realiza el proyecto de la Biblioteca de Quito que se encuentra en el actual aeropuerto que en unos años se convertirá en un gran parque. Esta biblioteca toma en cuenta estas tres interacciones de espacio, estructura y cerramiento para su diseñó y toma de decisiones tanto formales como espaciales

Problemas de fonética experimental

Esta publicación comprende los siguientes temas: - Interpretación fonética de los registros sonoros - La cuestión de los límites fonéticos - La altura o tono melódico - Medida de la intensidad - Algunas consideraciones relativas al timbre en fonética: delimitación de los distintos timbres de la voz hablada y cantada, crítica de los conceptos de ruido y de sonido, relación del timbre con los demás caracteres del sonido, teorías explicativas del timbre vocálico (modos de excitación de las cavidades supraglóticas) Apéndice: - Nuevos dispositivos de análisis fonético - Descripción del fotoliptófono (características fundamentales y de interés para los estudios de pronunciación)Material digitalizado en SEDICI gracias a la colaboración del Ateneo Popular "Alejandro Korn".Facultad de Humanidades y Ciencias de la Educació

Partículas codificadas

La presente invención se refiere a una partícula codificada. Específicamente, la partícula codificada según la presente invención, comprende: a) al menos un núcleo metálico; b) un agente de marcaje unido a la superficie de dicho núcleo metálico, proporcionando un núcleo metálico marcado; c) una capa externa de un material inerte que encapsula a dicho núcleo metálico marcado; y d) al menos una biomolécula directamente o indirectamente unida a dicha capa externa. Además, la presente invención se refiere a un método para la preparación de una partícula codificada. Además, la presente invención se refiere a un método para la preparación de una microesfera y a la microesfera obtenida por el método. Además, la presente invención se refiere a un método para detectar materiales biológicos. Adicionalmente, la presente invención se refiere al uso de una partícula codificadaPeer reviewedUniversidad de VigoB1 Patente sin examen previ

Partículas codificadas

La presente invención se refiere a una partícula codificada. Específicamente, la partícula codificada según la presente invención, comprende: a) al menos un núcleo metálico; b) un agente de marcaje unido a la superficie de dicho núcleo metálico, proporcionando un núcleo metálico marcado; c) una capa externa de un material inerte que encapsula a dicho núcleo metálico marcado; y d) al menos una biomolécula directamente o indirectamente unida a dicha capa externa. Además, la presente invención se refiere a un método para la preparación de una partícula codificada. Además, la presente invención se refiere a un método para la preparación de una microesfera y a la microesfera obtenida por el método. Además, la presente invención se refiere a un método para detectar materiales biológicos. Adicionalmente, la presente invención se refiere al uso de una partícula codificadaPeer reviewedUniversidad de VigoB1 Patente sin examen previ

Introducción : cultivando los aspectos culturales al hacer investigación

El objetivo de esta introducción es enmarcar dentro de la complejidad cultural de nuestro mundo contemporáneo, las 14 contribuciones incluidas en este volumen especial. No debe descuidarse la particularidad de hacer investigación cualitativa en específicos contextos locales, nacionales o de lenguaje. Se brinda una breve descripción de cada artículo para presentar este nuevo volumen sobre las prácticas cualitativas de investigación en algunas de las periferias de nuestro globalizado mundo académicoFraming the 14 contributions included in this special issue on "Advances in Qualitative Research in Ibero America" within the cultural complexity of our current world is the objective of this introduction. The particularity of doing qualitative research in specific local, national, and even language contexts should not be overlooked. A brief description of each article is provided to introduce this new issue on qualitative research practices in some of the peripheries of our globalized academic worl

Surface-Enhanced Raman Scattering Detection of Nucleic Acids Exhibiting Sterically Accessible Guanines Using Ruthenium-Polypyridyl Reagents

This is the peer reviewed version of the following article: Martínez-Calvo, M.; Guerrini, L.; Rodríguez, J.; Álvarez Puebla, R. A.; Mascareñas, J. L. (2020), Surface-enhanced Raman Scattering Detection of Nucleic Acids exhibiting Sterically Accessible Guanines using Ruthenium-polypyridyl Reagents. J. Phys. Chem. Lett., 11: 7218–7223, which has been published in final form at https://doi.org/10.1021/acs.jpclett.0c02148. This article may be used for non-commercial purposes in accordance with ACS Terms and Conditions for Use of Self-Archived VersionsHere, we report the application of surface-enhanced Raman scattering (SERS) spectroscopy as a rapid and practical tool for assessing the formation of coordinative adducts between nucleic acid guanines and ruthenium polypyridyl reagents. The technology provides a practical approach for the wash-free and quick identification of nucleic acid structures exhibiting sterically accessible guanines. This is demonstrated for the detection of a quadruplex-forming sequence present in the promoter region of the c-myc oncogene, which exhibits a nonpaired, reactive guanine at a flanking position of the G-quartetsWe are thankful for the financial support from the Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2019-2022, ED431G 2019/03) and the European Union (European Regional Development Fund – ERDF). We also acknowledge the support given by the Spanish Grant SAF2013-41943-R and SAF2016-76689-R, the Xunta de Galicia (Grants 2015-CP082, ED431C 2017/19,), the Spanish Ministry de Economia y Competitividad (CTQ2017-88648R and RYC-2016-20331), the Generalitat de Cataluña (2017SGR883), the Universitat Rovira i Virgili (2019PFR-URV-B2-02), the Universitat Rovira i Virgili and Banco Santander (2017EXIT-08), and the European Research Council (Advanced Grant No. 340055). M.M.-C. thanks the Ministerio de Economı́a y Competitividad for the Postdoctoral fellowship (IJCI-2014-19326) and the Ministerio de Ciencia e Innovación and Ministerio de Universidades for the Distinguished Researcher contract “Beatriz Galindo” (BEAGAL18/00144). J.R. thanks Xunta de Galicia for her predoctoral fellowshipS

Pyridine Based Antitumour Compounds Acting at the Colchicine Site

[EN]Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharmacokinetic and pharmacodynamics properties. CSL have been classified according to their chemical structures and the chemical structures of the pyridine and azine containing antimitotic compounds are described. The design principles behind the structural modifications and the achieved effect on the biological activity upon inclusion of these heterocycles are also discussed. Lessons from the achievements and failures have been extracted and future perspectives delineated

Substitution at the indole 3 position yields highly potent indolecombretastatins with reduced susceptibility to MDR resistance

[EN]Resistance to combretastatin A-4 is mediated by metabolic modification of the phenolic hydroxyl and ether groups of the 3-hydroxy-4-methoxyphenyl (B ring). Replacement of the B ring of combretastatin A-4 by a N-methyl-5-indolyl reduces tubulin polymerization inhibition (TPI) and cytotoxicity against human cancer cell lines but cyano, methoxycarbonyl, formyl, and hydroxyiminomethyl substitutions at the indole 3-position restores potent TPI and cytotoxicity against sensitive human cancer cell lines. These highly potent substituted derivatives displayed low nanomolar cytotoxicity against several human cancer cell lines due to tubulin inhibition, as shown by cell cycle analysis, confocal microscopy, and tubulin polymerization inhibitory activity studies and promoted cell killing mediated by caspase-3 activation. Binding at the colchicine site was suggested by molecular modeling studies. Substituted combretastatins displayed higher potencies than the isomeric isocombretastatins and the highest potencies were achieved for the hydroxyiminomethyl (21) and cyano (23) groups, with TPI values in the submicromolar range and cytotoxicities in the subnanomolar range. Dose-response and time-course studies showed that drug concentrations as low as 1 nM (23) or 10 nM (21) led to a complete G2/M cell cycle arrest after 15 h treatment followed by a high apoptosis-like cell § These authors contributed equally to this work. 3 response after 48-72 h treatment. The P-glycoprotein and calcium antagonist verapamil increased 21 and 23 cytotoxicity to IC50 values of 10-10 M, and highly potentiated the cytotoxic activity in 100-fold of the CHO derivative (17), in A549 human non-small cell lung cancer cells. The differences in cytotoxic potency observed between the highly potent cyano (23) and hydroxyiminomethyl (21) groups and other substituents with similar TPI values (17) were very much reduced upon co-treatment with verapamil. A 3,4,5-trimethoxyphenyl ring always afforded more potent derivatives than a 2,3,4-trimethoxyphenyl ring

Semantic recovery of traceability links between system artifacts

This paper introduces a mechanism to recover traceability links between the requirements and logical models in the context of critical systems development. Currently, lifecycle processes are covered by a good number of tools that are used to generate different types of artifacts. One of the cornerstone capabilities in the development of critical systems lies in the possibility of automatically recovery traceability links between system artifacts generated in different lifecycle stages. To do so, it is necessary to establish to what extent two or more of these work products are similar, dependent or should be explicitly linked together. However, the different types of artifacts and their internal representation depict a major challenge to unify how system artifacts are represented and, then, linked together. That is why, in this work, a concept-based representation is introduced to provide a semantic and unified description of any system artifact. Furthermore, a traceability function is defined and implemented to exploit this new semantic representation and to support the recovery of traceability links between different types of system artifacts. In order to evaluate the traceability function, a case study in the railway domain is conducted to compare the precision and recall of recovery traceability links between text-based requirements and logical model elements. As the main outcome of this work, the use of a concept-based paradigm to represent that system artifacts are demonstrated as a building block to automatically recover traceability links within the development lifecycle of critical systems.The research leading to these results has received funding from the H2020 ECSEL Joint Undertaking (JU) under Grant Agreement No. 826452 \Arrowhead Tools for Engineering of Digitalisation Solutions" and from speci¯c national programs and/or funding authorities