St. Augustine and Said Nursi on Introspection as a Vehicle for Change

St. Augustine, a fourth century philosopher and scholar (354-430), illustrates the significance of undergoing a process of introspection through his Confessions. Readers are taken by the hand and led through his childhood, adolescence, and adulthood all the while being immersed in his reflective thoughts. While Augustine does not make explicit mentions of how political affairs should be directed in Confessions in contrast to his later work, City of God, he sets up the model that one should follow if desiring social change; namely, focusing on inner change first. Particularly, Augustine makes mention of many instances of implicit and explicit violence in his youth which impact his later developed understandings of violence in the public sphere. While Augustine is a clear advocate of participating in the social life, he makes the process of individual introspection a prerequisite so as to ensure the efficacy of the former. Author information: Aysenur Guc is a senior at Rutgers University, New Brunswick studying philosophy and religion. In the near future, she hopes to pursue graduate studies

Towards trajectory anonymization: a generalization-based approach

Trajectory datasets are becoming popular due to the massive usage of GPS and locationbased services. In this paper, we address privacy issues regarding the identification of individuals in static trajectory datasets. We first adopt the notion of k-anonymity to trajectories and propose a novel generalization-based approach for anonymization of trajectories. We further show that releasing anonymized trajectories may still have some privacy leaks. Therefore we propose a randomization based reconstruction algorithm for releasing anonymized trajectory data and also present how the underlying techniques can be adapted to other anonymity standards. The experimental results on real and synthetic trajectory datasets show the effectiveness of the proposed techniques

The Molecularly Imprinted Polymers. Influence of Monomers on The Properties of Polymers - A Review

The synthesis of MIPs for two types of templates (herbicides, and flavonoids) and their application in analytical chemistry are discussed. Particular attention has been paid the issue of bonding the template and selection of appropriate monomer in different types of compounds. This short review aims at presenting the molecular imprinting technology (MIT) which is considered as an attractive method to produce impressive receptors for application in analytical chemistry. The challenge of designing and synthesizing a molecularly imprinted polymer (MIP) can be a daunting prospect to the uninitiated practitioner, simply because of the number of experimental variables involved, e.g. the nature and levels of template, functional monomers, cross-linkers, solvents, initiators and even the method of initiation and the duration of polymerization. Indubitably, the most important place of the polymer is its quotheartquot or the cavity corresponding to the template and the waynbs

Career Reentry Strategies for Highly Educated Stay-at-Home Mothers

Most stay-at-home mothers wish to return to the workplace; yet, the majority are not successful. There is a looming labor shortage and increasing organizational initiatives to increase female participation at most levels, providing opportunity for this talent pool. The purpose of this descriptive study was to examine the reentry strategies of networking, volunteerism, additional education, and additional training upon the reentry success for highly educated, stay-at-home mothers. In conjunction with the theoretical framework of the social cognitive career theory, self-efficacy, as measured by the New General Self-Efficacy Scale, was also examined as a reentry strategy. Survey research was used to gather data from previous stay-at-home mothers who had successfully reentered and stay-at-home mothers currently in the job search process (N=157). Logistic regressions and Pearson correlations were used to determine significant relationships between network size and self-efficacy upon reentry success; however, network size was negatively correlated with reentry success. The results of this study can be used by highly educated, stay-at-home mothers contemplating workplace reentry as well as vocational counselors who assist this group of job seekers. Highly educated, stay-at-home mothers can use the results of this study to improve their chances of effectively transitioning back into the workplace while also altering the perception of the traditional, stay-at-home mother

Regulation of Complement Activation at Sites of Chronic Inflammation

Biosynthesis of the complement regulatory proteins Cl-INH, C4-bp, factor H, factor I, S protein, SP-40,40, DAF, MCP, CD59 and CRl has been investigated in synovial membrane tissue cultures obtained from normal individuals, and patients with osteoarthritis (OA) and rheumatoid arthritis (RA) by a combination of immunological and molecular biological techniques. Normal, OA and RA synovial membranes were capable of s5mthesizing this battery of regulatory complement proteins. The abundances of the mRNAs encoding the classical and alternative pathway secreted proteins were elevated in RA synovium as was that of CD59 mRNA. However, tissue samples were small and they may not reflect the whole situation in RA joints. The cells present in synovial membrane, endothelial cells, monocytes, synovial fibroblasts and peripheral blood lymphocytes, were cultured and investigated in order to find which cell types provide which regulatory proteins detected in synovial membrane. Cell-specific differences were observed in the regulatory complement proteins synthesized. ELISA, immunohistochemical staining. Northern blot and doubling-dilution dot-blot analysis showed that both monocytes and fibroblasts expressed nine, endothelial cells expressed eight and lymphocytes expressed six of the eleven components under standard culture conditions. All of the cell types investigated synthesized factor H, DAF, MCP, CD59 and MIP. Endothelial cells and fibroblasts did not synthesize C4-bp and CRl. Also cell-specific differences were observed in the amounts of secretion for some proteins. Furthermore, cell specific differences were, observed for the expression of different mRNA species of DAF, MCP and CD59 between endothelial cells and fibroblasts. The effect of a cytokine, interferon-gamma (IFNgamma), on the synthesis of these complement regulatory proteins was also investigated. Treatment of endothelial cells with IFN? caused an increase of transcription rate of DAF, MCP and CD59 but this did not correlate with the protein levels on the cell surface detected by flow cytometry. This study indicated that complement regulatory protein s3mthesis is constitutive and varies between the different types of cells in synovial membrane. To some extent, the amounts of some complement regulatory proteins is regulated by IFN?

Influence of Zn excess on compositional, structural and vibrational properties of Cu2ZnSn0.5Ge0.5Se4 thin films and their effect on solar cell efficiency

This Accepted Manuscript will be available for reuse under a CC BY-NC-ND licence after 24 months of embargo periodThe effect of Zn content on compositional, structural and vibrational properties of Cu2ZnSn1-xGexSe4 (CZTGSe, x ~ 0.5) thin films is studied. Kesterite layer is deposited by co-evaporation onto 5 × 5 cm2 Mo/SLG substrate followed by a thermal treatment at maximum temperature of 480 °C, obtaining areas with different composition and morphology which are due to the sample position in the co-evaporation system and to the non-uniform temperature distribution across the substrate. Kesterite layers with higher Zn amounts are characterized by lower Cu and Ge contents; however, a uniform Ge distribution through the absorber layer is detected in all cases. The excess Zn concentration leads to the formation of ZnSe secondary phase on the surface and in the bulk of the absorber as determined by Raman spectroscopy. When higher Ge content and no ZnSe are present in the absorber layer, a compact structure is formed with larger grain size of kesterite. This effect could explain the higher Voc of the solar cell. The Zn content does not affect the bandgap energy significantly (Eg near 1.3 eV), although the observed effect of Zn excess in CZTGSe results in a decreased device performance from 6.4 to 4.2%. This investigation reveals the importance of the control of the off-stoichiometric CZTGSe composition during the deposition process to enhance solar cells propertiesThis work was supported by Spanish Ministry of Science, Innovation and Universities Project WINCOST (ENE2016-80788-C5-2-R) and European Project INFINITE CELL (H2020-MSCA-RISE-2017-777968). ARP also acknowledges financial support from Community of Madrid within Youth Employment Program (PEJD-2017-PRE/IND-4062). MG acknowledges the financial support from ACCIÓ-Generalitat de Catalunya within the TECNIOspring Plus fellowship (TECSPR18-1-0048

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients

© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.Background: Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized primary cells (lymphocytes and fibroblasts) derived from FA patients of the FA-D2 complementation group, which provides a more accurate physiological assessment than is possible with transformed cells or animal models. Results: We analyzed telomere length, telomere dysfunction-induced foci (TIFs), sister chromatid exchanges (SCE), telomere sister chromatid exchanges (T-SCE), apoptosis and expression of shelterin components TRF1 and TRF2. FANCD2 lymphocytes exhibited multiple types of telomeric abnormalities, including premature telomere shortening, increase in telomeric recombination and aberrant telomeric structures ranging from fragile to long-string extended telomeres. The baseline incidence of SCE in FANCD2 lymphocytes was reduced when compared to control, but in response to diepoxybutane (DEB) the 2-fold higher rate of SCE was observed. In contrast, control lymphocytes showed decreased SCE incidence in response to DEB treatment. FANCD2 fibroblasts revealed a high percentage of TIFs, decreased expression of TRF1 and invariable expression of TRF2. The percentage of TIFs inversely correlated with telomere length, emphasizing that telomere shortening is the major reason for the loss of telomere capping function. Upon irradiation, a significant decrease of TIFs was observed at all recovery times. Surprisingly, a considerable percentage of TIF positive cells disappeared at the same time when incidence of γ-H2AX foci was maximal. Both FANCD2 leucocytes and fibroblasts appeared to die spontaneously at higher rate than control. This trend was more evident upon irradiation; the percentage of leucocytes underwent apoptosis was 2.59- fold higher than that in control, while fibroblasts exhibited a 2- h delay before entering apoptosis. Conclusion: The results of our study showed that primary cells originating from FA-D2 patients display shorten telomeres, elevated incidence of T-SCEs and high frequency of TIFs. Disappearance of TIFs in early response to irradiation represent distinctive feature of FANCD2 cells that should be examined further.This article is made available through the Brunel Open Access Publishing Fund. This work was supported by the Ministry of Education and Science of the Republic of Serbia (Project No.173046)

HFE H63D mutation frequency shows an increase in Turkish women with breast cancer

BACKGROUND: The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls. METHODS: Archived DNA samples of Hacettepe University Oncology Institute were used in this study. The HFE gene was investigated by PCR-RFLP. RESULTS: All subjects studied were free from C282Y mutation. Thirty-nine patients had H63D mutation and were all heterozygous. H63D allele frequency was 22.2% (39/176) in the breast cancer patients, and 14% (28/200) in the healthy volunteers. Statistical analysis of cases with HFE H63D phenotype showed significant difference between breast cancer and healthy volunteers (P = 0.02). CONCLUSION: Our results suggest that HFE H63D mutation frequencies were increased in the breast cancer patients in comparison to those in the general population. Also, odds ratios (odds ratio = 2.05) computed in this study suggest that H63D has a positive association with breast cancer

Revealing the beneficial effects of Ge doping on Cu2ZnSnSe4 thin film solar cells

Kesterite (CZTSe) is a promising thin film photovoltaic absorber material due to its composition of more earth abundant materials compared to mature thin film photovoltaic technologies. Up to now, power conversion efficiencies are still lower and its main problem is the low open circuit voltage (Voc). Recently, a novel sintering approach using a nanometric Ge layer showed a large increase in device performance and especially in Voc. In this work, in-depth solar cell characterization as well as Raman and Photoluminescence studies of devices employing different Ge doped CZTSe absorber layers is presented. The main focus is to reveal the beneficial effects of Ge doping and furthermore investigate the interaction of Ge and Na. For low Ge doping an increase in charge carrier concentration is observed, resulting in devices with Voc of 460 mV, which corresponds to Voc deficits (Eg/q–Voc) of 596 mV a value comparable to current record devices. For high Ge amounts admittance spectroscopy measurements identified the appearance of a deep defect which can explain the observed deterioration of solar cell performance. Additional Na provided during crystallization of high Ge doped devices can reduce the density of this deep defect and recover device performance. These results indicate that Na plays an important role in defect passivation and we propose a defect model based in the interaction of group IV elements and Na with Cu vacancies