Sharp Metal-Insulator Transition in a Random Solid

We have measured zero temperature metallic conductivities above and below Mott's minimum value σ_(MIN) in bulk crystals of P doped Si. Studies of lattice heating, electronic heating and macroscopic inhomogeneities support the finding that conductivities below σ_(MIN) increase by over 10 as the P density is increased by 1%, and that over a wider density range the data can be fit t o a scaling form with a characteristic length that tends to diverge with the same exponent (ν = 0.55±0.10) in the metal and insulator

Giant dielectric constants at the approach to the insulator-metal transition

We have measured the real and imaginary parts of the dielectric susceptibility of insulating samples of P-doped Si at millikelvin temperatures at 400 MHz using a resonant transmission cavity. We find that the real part is enhanced by more than two orders of magnitude over the isolated donor polarizability, and we determine the exponent which describes the critical divergence of the real part at the insulator-metal transition by fitting the temperature dependence of the corresponding imaginary part. The form of the observed divergence remains unexplained theoretically

Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms.

BackgroundRapid spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of coronavirus disease 2019 (COVID-19) infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell/taste loss in COVID-19 may help facilitate screening and early isolation of cases.MethodsA single-institution, cross-sectional study evaluating patient-reported symptoms with a focus on smell and taste was conducted using an internet-based platform on adult subjects who underwent testing for COVID-19. Logistic regression was employed to identify symptoms associated with COVID-19 positivity.ResultsA total of 1480 patients with influenza-like symptoms underwent COVID-19 testing between March 3, 2020, and March 29, 2020. Our study captured 59 of 102 (58%) COVID-19-positive patients and 203 of 1378 (15%) COVID-19-negative patients. Smell and taste loss were reported in 68% (40/59) and 71% (42/59) of COVID-19-positive subjects, respectively, compared to 16% (33/203) and 17% (35/203) of COVID-19-negative patients (p < 0.001). Smell and taste impairment were independently and strongly associated with COVID-19 positivity (anosmia: adjusted odds ratio [aOR] 10.9; 95% CI, 5.08-23.5; ageusia: aOR 10.2; 95% CI, 4.74-22.1), whereas sore throat was associated with COVID-19 negativity (aOR 0.23; 95% CI, 0.11-0.50). Of patients who reported COVID-19-associated loss of smell, 74% (28/38) reported resolution of anosmia with clinical resolution of illness.ConclusionIn ambulatory individuals with influenza-like symptoms, chemosensory dysfunction was strongly associated with COVID-19 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks, paralleling resolution of other disease-related symptoms

Parent and Provider Perspectives on Early Intervention in Ohio: A Community Collaborative Approach

The network of early intervention (EI) for families with children who are deaf or hard of hearing (D/HH) consists of multiple professionals that partner with parents. As part of a community collaborative initiative, diverse perspectives were gathered via online surveys as part of a state-wide needs assessment to evaluate the landscape of EI in Ohio. The qualitative and quantitative feedback were analyzed in light of the Joint Committee on Infant Hearing’s (2007) goals and the 2013 early intervention supplement to those goals. Care coordination and equitable access emerged as top priorities across all three stakeholder groups queried (audiologists, EI providers, and parents). Through a theory of change framework, these results offer a pathway to strengthening EI in order to promote the well-being of families and children who are D/HH

Low-Temperature Magnetoresistance of a Disordered Metal

A contribution to the magnetoresistance is observed at temperatures below 100 mK in bulk metallic Si: P that is unanticipated within theoretical analyses of localization. This contribution is positive, approximately independent of sample orientation, and varying roughly as the square root of the applied field. An analysis of Coulomb interactions including spin splitting is presented which, when combined with localization, describes the magnetoresistance

Outcomes in endoscopic sinus surgery: olfaction, nose scale and quality of life in a prospective cohort study

OBJECTIVES: To determine the efficacy of endoscopic sinus surgery (ESS) on olfactory function in chronic rhinosinusitis patients with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) and to compare the nasal obstruction and symptom evaluation (NOSE) scale before and after surgery. DESIGN: A prospective cohort study. SETTING: Royal National Throat and Nose and Ear Hospital, London UK. PARTICIPANTS: One hundred and thirteen patients with CRS; 60 CRSwNP and 53 CRSsNP. OUTCOME ASSESSMENTS: Olfaction was measured using both the University of Pennsylvania Smell Investigation Test (UPSIT) and the ‘sense of smell’ visual analogue scale (VAS). The NOSE scale, the sinonasal outcome test (SNOT 22) and the Lund–Kennedy (LK) surgeon reported scores were also measured pre- and postoperatively at 6 months. RESULTS: The UPSIT psychophysical measurement significantly improved following ESS in the CRSwNP subgroup as did the patients perceived VAS sense of smell. However, in the CRSsNP subgroup, the improved VAS and UPSIT measurements were not significant. The NOSE, SNOT 22 and LK scores all improved significantly. The olfactory improvement as measured by the UPSIT correlated to the SNOT-22, but a correlation between the NOSE score and UPSIT was not found. CONCLUSIONS: Endoscopic sinus surgery significantly improved the patient's perceived and measured sense of smell in the CRSwNP subgroup which is the most surgically responsive CRS subgroup. Additionally, improved olfaction in the CRSwNP subgroup is most likely to improve the patient's quality of life. Endoscopic sinus surgery significantly improved the NOSE scale in both CRS subgroups at 6 months following surgery

Robust rank aggregation for gene list integration and meta-analysis

Motivation: The continued progress in developing technological platforms, availability of many published experimental datasets, as well as different statistical methods to analyze those data have allowed approaching the same research question using various methods simultaneously. To get the best out of all these alternatives, we need to integrate their results in an unbiased manner. Prioritized gene lists are a common result presentation method in genomic data analysis applications. Thus, the rank aggregation methods can become a useful and general solution for the integration task