Turkish Air Mobility Modeling

The aim of this research is to provide a tactical mobility model which is user friendly and flexible so the user is able to change the inputs, and evaluate the situation with the projected data for an operational plan. Thus, the users can analyze their system by using the model to see whether or not mobility requirements can be met within a definite time frame, and how long it takes to satisfy the requirements. Generalized Air Mobility Model (GAMM) was chosen to model TAMC\u27s airlift system and has been found suitable for application to TUAF mobility problems. The software enables the user to model future or existing airlift system requirements in an existing theater environment or against projected theater airlift requirements

HYDROGEN STRESS AND SYNTROPHY OF HYPERTHERMOPHILIC HETEROTROPHS AND METHANOGENS

Approximately 1 giga ton (Gt, 1015 g) of CH4 is formed globally per year from H2, CO2, and acetate through methanogenesis, largely by methanogens growing in syntrophic association with anaerobic microbes that hydrolyze and ferment biopolymers. However, our understanding of methanogenesis in hydrothermal regions of the subseafloor and potential syntrophic methanogenesis at thermophilic temperatures is nascent. This dissertation shows that thermophilic H2 syntrophy can support methanogenesis within natural microbial assemblages at hydrothermal vents and that it can be an important alternative energy source for thermophilic autotrophs in marine geothermal environments. This dissertation also elucidates H2 stress survival strategies of the H2 producing heterotrophs and the H2 consuming methanogens as well as their cooperation with one another for survival. The growth of natural assemblages of thermophilic methanogens from Axial Seamount was primarily limited by H2 availability. Heterotrophs supported thermophilic methanogenesis by H2 syntrophy in microcosm incubations of hydrothermal fluids at 80°C supplemented with tryptone only. Based on 16S rRNA gene sequencing, H2 producing heterotrophs, Thermococcus, and H2-consuming methanogens, Methanocaldococcus were abundant in 80°C tryptone microcosms from an Axial Seamount hydrothermal vent. In order to model the impact of H2 syntrophy at hyperthemophilic temperatures, a coculture was established consisting of a H2-producing hyperthermophilic heterotroph and a H2-consuming hyperthermophilic methanogen. The model organisms, hyperthermophilic heterotroph Thermococcus paralvinellae and the hydrogenotrophic methanogen Methanocaldococcus jannaschii, were examined in monocultures and cocultures for their H2 stress and syntrophy strategies. In monocultures, H2 inhibition changed the growth kinetics and the transcriptome of T. paralvinellae. A significant decrease in batch phase growth rates and steady state cell concentrations was observed with high H2 background. Metabolite production measurements, RNA-seq analyses of differentially expressed genes, and in silico experiments performed with a constraint-based metabolic network model showed that T. paralvinellae produces formate by a formate hydrogenlyase to survive H2 inhibition. H2 limitation on M. jannaschii caused a significant decrease in batch phase growth rates and CH4 production rates but also caused a significant increase in cell yields. In cocultures, H2 syntrophy relieved H2 stress for T. paralvinellae but not for M. jannaschii. T. paralvinellae only produced formate when grown in monoculture while no formate was detected during growth in coculture. While M. jannaschii was capable of growth and methanogenesis solely on the H2 produced by T. paralvinellae, the growth and CH4 production rates of M. jannaschii decreased in coculture compared to when M. jannaschii was grown in monoculture

Unchain Your Traditions in Teaching with the Power of Technology

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Use of Monoclonal Antibodies in Conditioning Regimen in Transplantation

Monoclonal antibodies (MoAbs) alone or in the combination of conventional therapies have been used in the treatment of many benign or malign diseases. In the transplantation setting, Moabs have been generally applied as a part of conditioning regimen in the aims of the prevention of graft versus host disease and/or graft failure or treatment of underlying hematologic disease. The most frequent used moAbs for this purpose are rituximab, alemtuzumab, Gemtuzumab Ozogamicin or radioimmunoconjugates. In this chapter, we discussed the role of moAbs use in the conditioning regimens of allogeneic or autologous stem cell transplantation

Experience Report on the Challenges and Opportunities in Securing Smartphones Against Zero-Click Attacks

Zero-click attacks require no user interaction and typically exploit zero-day (i.e., unpatched) vulnerabilities in instant chat applications (such as WhatsApp and iMessage) to gain root access to the victim's smartphone and exfiltrate sensitive data. In this paper, we report our experiences in attempting to secure smartphones against zero-click attacks. We approached the problem by first enumerating several properties we believed were necessary to prevent zero-click attacks against smartphones. Then, we created a security design that satisfies all the identified properties, and attempted to build it using off-the-shelf components. Our key idea was to shift the attack surface from the user's smartphone to a sandboxed virtual smartphone ecosystem where each chat application runs in isolation. Our performance and usability evaluations of the system we built highlighted several shortcomings and the fundamental challenges in securing modern smartphones against zero-click attacks. In this experience report, we discuss the lessons we learned, and share insights on the missing components necessary to achieve foolproof security against zero-click attacks for modern mobile devices

Fracture resistance of roots filled with three different obturation techniques

Objectives: The aim of this study was to compare in vitro root fracture resistance following root canal filling with AH 26 using lateral condensation, BeeFill, and Thermafil techniques. Study Design: Eighty extracted human mandibular premolars with similar dimensions were selected. In order to standardize the roots, measurements were taken in two separate regions of the teeth?at the cemento-enamel junction and 8 mm apically from the junction?buccolingual as well as mesiodistal for every tooth. Teeth were then randomly divided into five groups (n=16). With the exception of the non-prepared group (Group 1), instrumentation was done in all groups. In group 2, instrumentation but no filling was performed; in group 3, the obturation was done with AH 26 + gutta-percha; in group 4, with AH 26 + BeeFill and in group 5, AH 26 + a Thermafil obturator was used. All the roots were mounted vertically in copper rings and filled with acrylic resin, exposing 8 mm of the coronal part. A universal testing machine was used for the strength test. Results: The results were analyzed using the one-way ANOVA test. The significance between the groups was tested with Temhane?s T2 test. The results indicate that instrumentation of root canals had a significant effect on fracture resistance (p0.05). Conclusions: The results suggest that instrumentation of root canals significantly weakens the tooth structure to fracture and the root canal obturation techniques that are used are not able to form reinforcement

The Short and Long-Term Effectiveness of Online Sales Promotion Type and Fit in Hotels

Sales promotion is an important component of the marketing mix and is used by marketers to communicate the company brand and products with their target consumers. Hospitality marketers adopt different sales promotion techniques for satisfying different organizational and customer needs including managing room inventory, boosting sales, differentiating the company brands, and making the consumer decision making process easier. The main focus of this research is to understand the effectiveness of different online hotel sales promotions. The specific purpose of this study is to investigate the short and long-term effects of online hotel sales promotion type (SP type) and sales promotion fit (SP fit) with the hotel room on travelers and explore the magnitude of these effects based on consumers’ need for cognition (NFC), deal proneness (DP), intention to travel (TI), and promotional attractiveness (PA). So, this dissertation study tends to explore the effectiveness of different hotel sales promotion strategies on consumer behavior within the foundations of resource matching theory (RMT). The outcome variables are intent to purchase (PI) and intent to spread word-of-mouth (WOM) indicating the short-term effects and brand image perceptions (BI), attitude toward the brand (Ab), and attitude toward the hotel (Ahot) of travelers as long-term effects of sales promotions. In Study 1, one-factor (SP type: monetary vs. non-monetary) experimental design was utilized to test the differences in the effects of different sales promotion types on traveler behaviors. Also, these effects were investigated across the levels of travelers’ NFC, DP, TI, and PA. To provide more insights into the promotional framing effects, the differences in the effects within each promotion type were examined (Monetary: Dollar vs. Percentage discount and Non-monetary: Free room night vs. Free room upgrade). In Study 2, one factor (SP: Fit presence for monetary and non-monetary vs. Fit absence for monetary and non-monetary) experimental design was employed. In both studies, the participants’ PI, WOM, BI, Ab, Ahot, NFC, DP, TI, and PA were measured. Data were collected through an online consumer marketing panel. The total sample size was 609. The findings of this study have both high theoretical and practical value. Theoretical implications are the deeper insights into consumer behavior in terms of responses to different marketing stimuli and the extension of resource matching theory (RMT). Specifically, this research attempts to extend resource matching theory by testing the matching effects of sales promotion type and fit with consumer motivations and traits of information processing. Practical implications are useful suggestions to marketers in terms of the effectiveness of different marketing communication designs and their usage to develop favorable brand-related attitudes

Investigation of the presence of pregnancy rhinitis in the third trimester with rhinomanometry

Aim: Pregnancy rhinitis (PR) is characterized with nasal symptoms during pregnancy without any signs of respiratory infection and it usually disappears within 2 weeks after delivery. We aimed to investigate the relationship between pregnancy rhinitis and findings derived from anterior rhinoscopy (AnR), anterior rhinomanometry (ARM) and subjective nasal obstruction score (SNOS). Methods: This prospective, controlled study was performed in otorhinolaryngology and obstetrics and gynecology departments of our tertiary care center. A total of 30 pregnant women in the third trimester and 30 non-pregnant women were involved. All participants underwent otorhinolaryngology examination, as well as clinical evaluation for AnR, ARM and SNOS. Results: Pregnancy rhinitis was detected in 66.7% of the pregnant women. The mean AnR was 3.60 ± 1.35 in pregnant women and 0.77 ± 0.73 in the control group. Total nasal inspiratory resistance (TNID) was 0.46±0.23 in pregnant women and 0.27±0.06 in the control group. The mean SNOS was 1.37±0.72 in pregnant women and 0.57±0.63 in the control group. AnR, ARM and SNOS findings were significantly higher in pregnant women (p<0.05). There is a low positive and significant correlation between AnR, ARM, and SNOS values in pregnant women (p<0.05). Conclusion: Our data yielded that nasal obstruction and pregnancy rhinitis were common in pregnant women.  Nasal symptoms and complaints must be carefully examined during pregnancy. Further prospective, controlled, randomized trials on larger series are warranted to elucidate the clinical and pathophysiological features of pregnancy rhinitis

Scheduling data flow program in xkaapi: A new affinity based Algorithm for Heterogeneous Architectures

Efficient implementations of parallel applications on heterogeneous hybrid architectures require a careful balance between computations and communications with accelerator devices. Even if most of the communication time can be overlapped by computations, it is essential to reduce the total volume of communicated data. The literature therefore abounds with ad-hoc methods to reach that balance, but that are architecture and application dependent. We propose here a generic mechanism to automatically optimize the scheduling between CPUs and GPUs, and compare two strategies within this mechanism: the classical Heterogeneous Earliest Finish Time (HEFT) algorithm and our new, parametrized, Distributed Affinity Dual Approximation algorithm (DADA), which consists in grouping the tasks by affinity before running a fast dual approximation. We ran experiments on a heterogeneous parallel machine with six CPU cores and eight NVIDIA Fermi GPUs. Three standard dense linear algebra kernels from the PLASMA library have been ported on top of the Xkaapi runtime. We report their performances. It results that HEFT and DADA perform well for various experimental conditions, but that DADA performs better for larger systems and number of GPUs, and, in most cases, generates much lower data transfers than HEFT to achieve the same performance