Is Serum TGF-β1 and TGF-β2 levels Correlated to Children with Autism Intensity?

Objective Transforming growth factor-beta (TGF-β), a group of multifunctional growth factors, plays an important role in the neuron survival and neurodevelopmental functions. Some studies have evaluated the correlation between TGF-β1 and TGF-β2 abnormalities and autism spectrum disorders. In this study, we compared the TGF-β1 andTGF-β2 levels between autistic and intellectually normal individuals. Materials & Methods The study population consisted of 39 autistic and 30 age-matched intellectually normal individuals (control group). Blood samples were taken from all individuals, and all patients were divided into 2 groups (mild-to-moderate and severe) according to the childhood autism rating scale. The cytokines levels were measured by Enzyme Linked Immunosorbent Assay (ELISA). Results The mean concentration of TGF-β1 was significantly lower (P < 0.0001) in children with autism compared to the control group (25.3 ± 6.5 versus 35.1 ± 9.4 ng/mL, respectively). Also, the mean concentration of TGF-β2 in children with autism (32.35± 7.75 ng/mL) was higher compared to those in the control group (30.47± 4.36 ng/mL); however, this difference did not reach statistical significance (P = 0.21). A positive correlation was observed between TGF-β1 concentration and autism severity (r = 0.41; P = 0.02), whereas a negative correlation was found between TGF-β2 concentration andautism severity (r = -0.41; P = 0.02). Conclusion The results of the present investigation suggest that there is a decrease in the levels of TGF-β1 in the serum of patients with autism and this cytokine may be effective in the treatment of the pathophysiological aspects of autism

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Evaluation of Relationship between Academic Motivation and Achievement in Students of Zanjan University of Medical Sciences

Background & Objective: Considering the significant importance of academic achievement of medical students in the improvement of society health, this study aimed to evaluate academic motivation and its relationship with academic achievement. Materials and Methods: This cross-sectional research was conducted on junior students in fields of medicine, dentistry and pharmacy of Zanjan University of Medical Sciences, Zanjan, Iran in 2016. Subjects were selected through convenience sampling and filled Herman’s motivation questionnaire. Data analysis was performed in SPSS using Pearson’s correlation coefficient and t-test (P<0.05). Results: In this research, 85% of the students were within the age range of 24-26. In total, 53.1% of students were male and 46.9% of them were female. In terms of marital status, 85% and 15% of the participants were single and married, respectively. Moreover, 74.1% of the students had a quota and 25.9% had no quota. Furthermore, 52.4% were living in dormitories and 47.6% were residing in other places. After the evaluation of the medicine, pharmacy, and dentistry students, their academic motivation score was 2.83, 2.87, and 2.86, respectively. According to the results, students residing in places other than dormitories had a higher motivation level, compared to those living in dormitories. Moreover, a significant relationship was observed between motivation and score of basic science GPA. Conclusion: Given the fact that only living in dormitories reduced motivation in students, it is recommended that counseling meetings be held to familiarize students with this type of life and facilities in dormitories be improved to increase the motivation of students residing in dormitories

In Silico study of adsorption of penicillin antibiotic on the surface of single walled nitride boron nanotubes(SBNNT)

Objectives: The present study aimed to assess the adsorption of single-walled nitride boron nanotubes (SBNNT) with penicillin Antibiotic agent at the B3LYP/6–31 G (d) theoretical level. Materials and Methods: Initially, the structures of penicillin antibiotic and SBNNT were optimized. Afterward, with the molecular docking method and its ranking algorithm, the configuration of ten complexes with more negative binding energy and steady-state was calculated. Then, for the most stable configuration with SBNNT, IR calculations and molecular orbitals were performed on them. Adsorption energy and thermodynamic parameters were calculated, molecular orbitals, and related parameters showed that the adsorption of penicillin antibiotic on SBNNT is a thermogenic and spontaneous process. This process was performed at 298 K and 1 atm. The Calculations of thermodynamic parameters and molecular orbitals analysis were performed. In addition, some important parameters were assessed, including the adsorption energy, Gibbs free energy changes (ΔGad), enthalpy (ΔHad) variations, chemical hardness, energy gap, and electrophilicity. Results: According to the results, Gibbs free energy changes (ΔGad), enthalpy (ΔHad) variations, of These Interactions were negatives at 298 K and 1 atm. Conclusions: Since according to the obtained results for adsorption of Penicillin on the SBNNT in every 10 complexes obtained were spontaneous at 298 K and 1 atm, also Findings of molecular orbital analysis, indicated that SBNNT could be utilized as a sensing material in the construction of thermal and electrochemical sensors for Penicillin determination

Lip Commissure Reconstruction with the Facial Artery Muscular-Mucosal (FAMM) Flap: A Case Report of a Child with Electrical Commissural Injury: A Case Report of a Child with Electrical Commissural Injury

Electrical burn damages constitutes of 4% of all burn trauma. Approximately 20% of total electrical burn injuries occur in children. Most electrical injuries in children occur at home. When the child bites or chews an electrical cord, it results in oral and commissural injury. It is also noted that male children are predominantly affected with electric current injuries than female children. We introduce an immigrant 3-year-old boy admitted in the hospital one week after an electrical injury of the oral cavity due to biting a television cord. He had a necrotic lesion on his right oral commissure. There is controversy about the time and relevant management of mouth commissure injury. In this case, because of lack of parents’ consent, we did the reconstruction of his oral commissure very late without any molding intervention. There is more than 200 techniques in the management of lip and oral commissural injury; we used a Facial Artery Mucosal-Muscular (FAMM) flap for the repair with good result. Although with the improvement of burn care and its management outcomes, prevention is still the best way of minimizing the prevalence and severity of electric current burn injuries

Application of AzollaFiliculoides Biomass in Acid Black 1 Dye Adsorption from Aqueous Solution

Background and purpose: The textile dyes are considered as important pollutants due to the toxicity on human and environment. Therefore, the dye removal from industrial effluents is necessary. This study evaluates the ability of Azolla for the adsorption of acid black 1 (AB1) dye from aqueous solution. Materials and Methods: This was an experimental-laboratory study. The Azolla biomass was sun dried, crushed and sieved to particle sizes in the range of 1-2 mm. Then, it treated with 0.1 M HCl for 5 h, followed by washing with distilled water, and it used as an adsorbent. The effect of study parameter was investigated, and the residues AB1 concentration was measured by DR2800 spectrophotometer at in &lambda;max = 622 nm. Results: The results indicated that the efficiency of AB1 adsorption decreased with increased initial dye concentration. It increased with increased contact time and adsorbent. The highest adsorption efficiency was occurred at pH = 2. The equilibrium data were the best fitted on Langmuir isotherm and pseudo-second-order kinetic model. Conclusion: The Azolla could present high ability in dye removal. Therefore, it can be used as inexpensive and effective adsorbent in textile effluent treatment

Correction to: Cadmium Removal from Aqueous Solutions using L-cysteine Functionalized Single-Walled Carbon Nanotubes

Mohammad Ali Zazouli1, Zabihollah Yousefi1, Mahmoud Taghavi1,  Behrouz Akbari-adergani2,  Jamshid Yazdani-Charati3,4 1 Department of Environmental Health Engineering, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 2 Food & Drug Laboratory Research Center, Food & Drug Organization, Ministry of Health and Medical Education, Tehran, Iran 3 Department of Biostatistics, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 4 Psychiatry & Behavioral Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran In the article published in volume 23, issue 98, 2013, the second author’s first name is Zabihollah Yousefi, and fourth author’s last name is Jamshid Yazdani-Charati, were incorrect which is now corrected

Teachers’ and Students’ Satisfaction with DOPS Examination in Islamic Azad University of Mashhad, a Study in Year 2012

Introduction: Assessment is an essential and integral part of medicine. In addition to validity and reliability, a desirable method for student evaluation should leave a positive effect on student’s learning and be feasible and acceptable by students and teachers. Hence, this study aimed to survey students’ and teachers’ satisfaction with DOPS examination. Methods: This experimental study used a single group post test study design in which a total of 60 medical internship students of emergency ward of 22 Bahman and Arya educational hospitals participated. After obtaining testimonial from students, in an emergency course, they were trained for one month on how the DOPS evaluation is run. The assessors (n=23) included clinical teachers and other professionals such as nurses. Expert panel selected seven basic medical skills and provided assessment checklists. Students selected two skills out of seven and performed through DOPS. A researcher-made questionnaire in Likert scale (0-3 points) was developed to investigate students’ and assessors’ viewpoints in areas of feasability, educational effects, and satisfaction that and its validity and reliability was confirmed prior to utilization. Data was analyzed using students’ one-sample and paired samples t test. Results: From students’ viewpoint, feasibility, educational effects, and satisfaction rates were significantly higher than 50 (average expected grade). Meanwhile, educational and learning effects showed the highest points (78±14.8) among them. From the assessors’ viewpoint also, satisfaction in the mentioned areas was significantly higher than fifty. Satisfaction with examination showed highest score (76.7±11.6) among all domains. Conclusion: According to the compliance of DOPS method with the performance objectives of medical curriculum and students’ and assessors’ viewpoints regarding its acceptability, feasibility, and educational impact in the existing clinical centers, as well as their satisfaction with this method, it is recommended to assess senior medical students’ clinical performance using this method

Correction to: Evaluation of L-Cysteine Functionalized Single-Walled Carbon Nanotubes On Mercury Removal from Aqueous Solutions

Mohammad Ali Zazouli1,  Zabihollah Yousefi1,  Jamshid Yazdani-Charati2,  Hajar Tabarinia3, Farzaneh Tabarinia4, Behrouz Akbari Adergani5 1 Associate Professor, Department of Environmental Health Engineering, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 2 Associate Professor, Department of Biostatics, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 3 MSc in Environment Health Engineering, Student Research Committee, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran 4 MSc in Chemistry, Mazandaran Standard Office, Sari, Iran 5 Food & Drug Laboratory Research Center, Food & Drug Organization, Ministry of Health and Medical Education, Tehran, Iran In the article published in volume 24, issue 111, 2014, the second author’s first name is Zabihollah Yousefi, and third author’s last name is Jamshid Yazdani-Charati, were incorrect which is now corrected