BENEFÍCIOS DA RADIOFREQUÊNCIA FRACIONADA NO ENVELHECIMENTO CUTÂNEO FACIAL – REVISÃO INTEGRATIVA

It will be discussed in the present study about RF (Radio Frequency) which is a technique that uses electromagnetic radiation with the frequency range of 3-300 GHz, its main energy effects on the tissues are thermal, this new device aims to act on the basis of the frequency ranges that heat specific layers of the skin and with this makes the new collagen to be stimulated and modifies the epidermis, It stimulates lymphatics and lipolysis, that is, its effect is beneficial and helps to rejuvenate the skin. Well, aging is something that cannot be controlled and skin aging occurs chronologically or intrinsicly, where people are currently increasingly concerned with self-care and facial skin is no different, for this reason fractional radiofrequency in aging is a low-cost alternative, it is not invasive, its effects are immediate, It can be done in any season of the year, among others.  The study was carried out through an integrative review, reinforced with a qualitative approach, with the purpose of collaborating with the learning associated with the investigated theme, related to the perspective of the benefits of fractional radiofrequency in facial skin aging.Se discutirá en el presente estudio sobre la RF (Radio Frecuencia) la cual es una técnica que utiliza radiación electromagnética con el rango de frecuencia de 3-300 GHz, sus principales efectos energéticos sobre los tejidos son térmicos, este nuevo dispositivo pretende actuar en base a los rangos de frecuencia que calientan capas específicas de la piel y con esto hace que el nuevo colágeno sea estimulado y modifique la epidermis, Estimula la linfática y la lipólisis, es decir, su efecto es beneficioso y ayuda a rejuvenecer la piel. Pues bien, el envejecimiento es algo que no se puede controlar y el envejecimiento de la piel se da de forma cronológica o intrínseca, donde actualmente las personas se preocupan cada vez más por el cuidado personal y la piel del rostro no es diferente, por esta razón la radiofrecuencia fraccionada en el envejecimiento es una alternativa de bajo costo, no es invasiva, sus efectos son inmediatos, Se puede realizar en cualquier estación del año, entre otras.  El estudio se realizó a través de una revisión integradora, reforzada con un enfoque cualitativo, con el propósito de colaborar con el aprendizaje asociado al tema investigado, relacionado con la perspectiva de los beneficios de la radiofrecuencia fraccionada en el envejecimiento cutáneo facial.Será discorrido no presente estudo sobre a RF (Radiofrequência), que se trata de uma técnica utilizando radiação eletromagnética na faixa de frequência de 3 a 300 GHz. Seus principais efeitos de energia sobre os tecidos são térmicos. Esse dispositivo novo tem como objetivo atuar na base das gamas de frequência que aquecem camadas específicas da pele, estimulando assim a produção de novo colágeno e modificando a epiderme. Ele também estimula a linfática e a lipólise; ou seja, seu efeito é benéfico e auxilia a rejuvenescer a pele. O envelhecimento, que é um processo incontrolável, ocorre de forma cronológica ou intrínseca. Atualmente, as pessoas se preocupam cada vez mais com autocuidados, e com a pele facial não é diferente. Por essa razão, a radiofrequência fracionada no envelhecimento é uma alternativa de baixo custo, não invasiva, com efeitos imediatos, podendo ser realizada em qualquer estação do ano, entre outros benefícios. O estudo desenvolvido, baseado em uma revisão integrativa reforçada com abordagem qualitativa, tem o propósito de colaborar com o aprendizado associado ao tema investigado, relacionado à ótica dos benefícios da radiofrequência fracionada no envelhecimento cutâneo facial.Será discorrido no presente estudo sobre a RF (Radiofrequência), que se trata de uma técnica utilizando radiação eletromagnética na faixa de frequência de 3 a 300 GHz. Seus principais efeitos de energia sobre os tecidos são térmicos. Esse dispositivo novo tem como objetivo atuar na base das gamas de frequência que aquecem camadas específicas da pele, estimulando assim a produção de novo colágeno e modificando a epiderme. Ele também estimula a linfática e a lipólise; ou seja, seu efeito é benéfico e auxilia a rejuvenescer a pele. O envelhecimento, que é um processo incontrolável, ocorre de forma cronológica ou intrínseca. Atualmente, as pessoas se preocupam cada vez mais com autocuidados, e com a pele facial não é diferente. Por essa razão, a radiofrequência fracionada no envelhecimento é uma alternativa de baixo custo, não invasiva, com efeitos imediatos, podendo ser realizada em qualquer estação do ano, entre outros benefícios. O estudo desenvolvido, baseado em uma revisão integrativa reforçada com abordagem qualitativa, tem o propósito de colaborar com o aprendizado associado ao tema investigado, relacionado à ótica dos benefícios da radiofrequência fracionada no envelhecimento cutâneo facial

A percepção de futuros administradores sobre o trabalho de pessoas com deficiência (PcDs): inclusão ou benevolência?

The objective of the present study was to analyze the perception of undergraduates in administration about the work potential of people with disabilities (PcDs). A descriptive survey, with a quantitative approach, and data collection was done through the Carvalho-Freitas and Marques (2010) Inventory of Conceptions of Disability in Work Situations (ICD-ST) applied to 217 undergraduate students in Management. The data were treated through descriptive analysis and correlation (Pearson’s coefficient). The results show a perception that PCDs can perform well in the workplace, provided they have the necessary conditions, besides contributing positively to the image of the organization and being more involved. On the other hand, the greater the perception of performance, the more a concept based on normality assumptions is evidenced. Thus, it can be concluded that the respondents’ perception meets the assumptions of inclusion, however, the moderate and positive correlation between performance and normality factors indicates that the “deviation” from normality, caused by disability, is still seen as low productivity generator.O objetivo do presente estudo foi analisar qual a percepção de graduandos em administração sobre as potencialidades de trabalho de pessoas com deficiência (PcDs). Realizou-se uma pesquisa descritiva, do tipo survey, com abordagem quantitativa, e coleta de dados por meio do Inventário de Concepções de Deficiência em Situações de Trabalho (ICD-ST) de Carvalho-Freitas e Marques (2010) aplicado a 217 graduandos em Administração. Os dados foram tratados por meio de análises descritivas e correlação (Coeficiente de Pearson). Os resultados obtidos mostram uma percepção de que PcDs podem ter bom desempenho no trabalho, desde que possuam as condições necessárias, além de contribuir positivamente para a imagem da organização e serem mais comprometidos. Por outro lado, quanto maior a percepção de desempenho mais se evidencia uma concepção baseada em pressupostos de normalidade. Assim, pode-se concluir que a percepção dos respondentes vem ao encontro de pressupostos de inclusão, contudo, a correlação moderada e positiva entre os fatores de desempenho e normalidade sinaliza que o “desvio” da normalidade, causado pela deficiência, ainda é visto como gerador de baixa produtividade

Factors Associated With Red Blood Cell Transfusions In Very-low-birth-weight Preterm Infants In Brazilian Neonatal Units

Background: Preterm infants in neonatal intensive care units frequently receive red blood cells (RBC) transfusions due to the anemia of prematurity. A number of variables related to gestational age, severity of illness and transfusion practices adopted in the neonatal unit where the neonate was born may contribute to the prescription of RBC transfusions. This study aimed to analyse the frequency and factors associated with RBC transfusions in very-low-birth-weight preterm infants. Methods: A prospective cohort of 4283 preterm infants (gestational age: 29.9 +/- 2.9 weeks; birth weight: 1084 +/- 275 g) carried out at 16 university hospitals in Brazil between January 2009 and December 2011 was analysed. Factors associated with RBC transfusions were evaluated using univariate and multiple logistic regression analysis. Results: A total of 2208 (51.6 %) infants received RBC transfusions (variation per neonatal unit: 34.1 % to 66.4 %). RBC transfusions were significantly associated with gestational age (OR: -1.098; 95% CI: -1.12 to -1.04), SNAPPE II score (1.01; 1.00-1.02), apnea (1.69; 1.34-2.14), pulmonary hemorrhage (2.65; 1.74-4.031), need for oxygen at 28 days of life (1.56; 1.17-2.08), clinical sepsis (3.22; 2.55-4.05), necrotising enterocolitis (3.80; 2.26-6.41), grades III/IV intraventricular hemorrhage (1.64; 1.05-2.58), mechanical ventilation (2.27; 1.74-2.97), use of umbilical catheter (1.86; 1.35-2.57), parenteral nutrition (2.06; 1.27-3.33), > 60 days of hospitalization (5.29; 4.02-6.95) and the neonatal unit where the neonate was born. Conclusions: The frequency of RBC transfusions varied among neonatal intensive care units. Even after adjusting for adverse health conditions and therapeutic interventions, the neonatal unit continued to influence transfusion practices in very-low birth-weight infants.1

PESQUISAS DESENVOLVIDAS NO PROGRAMA DE PÓS-GRADUAÇÃO EM GERONTOLOGIA DA UNIVERSIDADE FEDERAL DE SÃO CARLOS E SUA IMPORTÂNCIA NO CONTEXTO DO ENVELHECIMENTO

Esta revisão narrativa tem como objetivo apresentar e discutir a relevância dos estudos desenvolvidos no Programa de Pós-Graduação em Gerontologia da Universidade Federal de São Carlos (PPGGero/UFSCar). Os dados foram coletados na disciplina “Seminários Avançados em Gerontologia”, em que os docentes autores apresentaram suas linhas de pesquisa, as quais foram compiladas pelos discentes autores. Os resultados desta revisão apresentam os estudos realizados em um programa interdisciplinar de mestrado acadêmico que possui duas linhas de pesquisa denominadas: 1) Saúde, Biologia e Envelhecimento; e 2) Gestão, Tecnologia e Inovação em Gerontologia. Os estudos se inserem em diversas temáticas da área do envelhecimento, que se articulam entre ambas as linhas de pesquisa do programa. Na linha 1 destacam-se estudos relacionados à cognição, à demência e suas consequências aos pacientes e cuidadores, bem como a pesquisas relacionadas ao seu diagnóstico e cuidado. Destacam-se também pesquisas epidemiológicas e aquelas relacionadas a condições ou doenças comuns no envelhecimento, como dor crônica, osteoartrite e, mais recentemente, a infecções em idosos, incluindo a COVID-19. Na linha 2 destacam-se pesquisas relacionadas a tecnologias assistivas voltadas aos idosos, bem como estratégias de marketing e políticas de atenção para esse público. É notório que a multidimensionalidade de abordagens das questões do envelhecimento exige enfoque multidisciplinar sobre um contexto de excelência acadêmica. Assim, conclui-se que as pesquisas do PPGGero/UFSCar, ao abrangerem várias áreas do conhecimento – as quais permeiam as ciências humanas, biológicas, sociais e exatas no contexto de tecnologia e inovação –, promovem a formação de mestres e pesquisadores que contribuem para a produção de conhecimento em Gerontologia no país

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

english

Brazilian pharmacists’ education and training aims to prepare them for the various activities they will undertake during professional practice, especially in the national health system (SUS). By using an exploratory transversal study based on a validated questionnaire, we have characterized the educational and training background of pharmacists working in SUS municipal units in Ribeirão Preto, State of São Paulo (SP), Brazil, and the frequency with which these professionals carry out several activities. Pharmacists working in these municipal outpatient units (N=44) graduated between 1981 and 2014 (56.8% of them graduated from public state or federal institutions), are predominantly female (84%), and are aged 25-57 years; 34% of these pharmacists have a “Generalist” degree, and 90.9% attended postgraduate programs, mostly specialization (75%). All the pharmacists pointed out the need for continuing education. The frequency with which they carry out activities varies, but those involving direct contact with patients predominate. Consultations, therapeutic follow-up, case discussions, and health promotion activities take place only occasionally. We concluded that pharmacists who work in the municipality of Ribeirão Preto, SP, are very much involved with dispensing, but not with health education or pharmacotherapeutic follow-up, so investing in education and training in these areas is necessary

Resistência de mamoeiros transgênicos à mancha anelar no Brasil

The objective of this work was to evaluate the resistance of transgenic papaya populations (PTPs) to Papaya ringspot virus-P (PRSV-P). 'Sunrise Solo' transgenic papaya plants were produced with the gene of the PRSV-P protein coat, and PRSV was mechanically inoculated in plants in greenhouse conditions. The presence of the CP/PRSV gene and homozygosis were evaluated by polymerase chain reaction (PCR). Selected plants and the 'Sunrise Solo' control were transplanted to the field for agronomic evaluations. The plants evaluated in greenhouse conditions showed resistance between 96.3 and 5.8%, without variation of symptoms. The PTPs 1/6, 1/7, 1/9, 1/10, 1/15, 2/38, 2/41, 2/56, 2/65, 3/27, 3/46, 3/48, 4/9, 4/27, 8/4, 8/23, 8/33, 18/3, 18/4, 18/8, 18/22, 18/27, 28/97, 28/104, and 28/110 showed no symptoms, they were ELISA negative, and most of them contained the CP and NPT II genes. PTPs 1/6 and 3/46 had the CP gene in homozygosis and in double insertion. PTPs 1/6/20, 1/6/59, 1/6/64, 1/6/90, 3/46/44, 3/46/52, and 18/27/97 had a well-formed fruit cluster, piriform fruit weighing approximately 500 grams, orange pulp, and less than 10% carpelloidy. PTPs 1/6/59 and 3/46/52 show resistance to PRSV, good agronomic characteristics, and the CP gene in homozygosis.O objetivo deste trabalho foi avaliar a resistência de populações transgênicas de mamoeiro (PTPs) ao vírus da mancha anelar do mamoeiro [Papaya ringspot virus-P (PRSV-P)]. Plantas transgênicas 'Sunrise Solo' foram produzidas com o gene da proteína da capa viral PRSV-P, e o PRSV foi inoculado mecanicamente nas plantas em casa de vegetação. A presença do gene CP/PRSV e a homozigose foram avaliadas por reação em cadeia da polimerase. As plantas selecionadas e o controle 'Sunrise Solo' foram transplantados para o campo, para avaliações agronômicas. As plantas avaliadas em casa de vegetação apresentaram resistência entre 96,3 e 5,8%, sem variação nos sintomas. As PTPs 1/6, 1/7, 1/9, 1/10, 1/15, 2/38, 2/41, 2/56, 2/65, 3/27, 3/46, 3/48, 4/9, 4/27, 8/4, 23/8, 33/33, 18/3, 18/4, 18/8, 18/22, 18/27, 28/97, 28/104 e 28/110 não apresentaram sintomas, tiveram resultado negativo ao teste ELISA, e a maioria delas continha os genes CP e NPT II. As PTPs 1/6 e 3/46 apresentaram gene CP em homozigose e em dupla inserção. As PTPS 1/6/20, 1/6/59, 1/6/64, 1/6/90, 3/46/44, 3/46/52 e 18/27/97 apresentaram cacho de frutos bem formado, frutos piriformes com 500 g, polpa laranja e menos de 10% de carpeloidia. As PTPS 1/6/59 e 3/46/52 apresentam resistência ao PRSV, boas características agronômicas e o gene CP em homozigose

Effectiveness of Medical Treatment of Cushing's Disease: A Systematic Review and Meta-Analysis

Objective:& nbsp;The objective of this systematic review was to evaluate the effectiveness and safety of pasireotide, cabergoline, ketoconazole, levoketoconazole, metyrapone, osilodrostat, and temozolomide for the treatment of Cushing's disease (CD). Methods:& nbsp;The primary outcomes were the proportion of CD control, adverse events (AE), and reduction of urinary free cortisol. Search strategies were applied to Embase, Medline, and CENTRAL. Independent reviewers assessed the study eligibility, extracted data, and evaluated risk of bias. Standardized mean difference was calculated with 95% confidence interval (CI) for continuous data (i.e., pre- and post-intervention). Random meta-analyses for the proportion of CD control and AE were conducted. Results:& nbsp;Twenty-nine controlled and non-controlled studies were included. No study with temozolomide and levoketoconazole and one study with osilodrostat fulfilled the inclusion criteria. The meta-analyses of proportion of CD control was 35% for cabergoline (95% CI: 27-43%, six studies, 141 participants), 44% for pasireotide (95% CI: 25-35%, eight studies, 522 participants), 41% for ketoconazole (95% CI: 36-46%, six studies, 450 participants), 66% for metyrapone (95% CI: 46-87%, four studies, 66 participants), and of 66.4% for osilodrostat (95% CI: 57.9, 74.3, 97 participants, one study). One study compared two different treatments (cabergoline vs. ketoconazole), and no statistical difference was observed in CD control (RR: 0.53, 95% CI: 0.15 to 1.87, 14 participants, very low certainty of evidence). The most frequent AE associated with pasireotide was hyperglycemia, dizziness and nausea with cabergoline and metyrapone, and elevated transaminases with ketoconazole. Conclusion:& nbsp;The superiority of one drug over another could not be determined due to lack of controlled studies, but the proportion of disease control identified in our meta-analysis may support clinical decision. New therapeutic options should be investigated due to the limited efficacy and tolerability of the currently available medical treatment for patients with Cushing's disease.</p