Characterization of the lifestyle in adult patients with diabetes mellitus type II. Yara, 2017

Introducción: el estilo de vida de los pacientes diabéticos puede cambiar la historia natural de la enfermedad o en su defecto agravar las condiciones de la misma.Objetivo: caracterizar el estilo de vida en pacientes adultos con diabetes mellitus tipo II pertenecientes al CMF 14 del municipio Yara.Método: se realizó un estudio descriptivo observacional de tipo retrospectivo entre   diciembre 2016 – enero 2017. El universo de estudio estuvo constituido por todos los adultos diagnosticados como diabéticos, 78 pacientes, en esta área de salud. La muestra quedó constituida por 41 pacientes que representan el 53%, se utilizó el probabilístico por el método aleatorio simple. Se estudiaron las variables edad, sexo, nivel de escolaridad, y las áreas del estilo de vida a través   de instrumentos tales como la guía para el estudio del estilo de vida.   Resultados: los pacientes diabéticos presentaron un estilo de vida con riesgo, lo que tiene respaldo en el seguimiento de una adecuada dieta, por otro lado, el mantenimiento aún de algunos hábitos tóxicos, como el tabaquismo, y la pobre práctica de ejercicio físico sistemático, ventaja esta que se aprecia en el uso de su tiempo libre en actividades placenteras y el autocuidado y cuidado médico que mantienen.Conclusiones: en el grupo de estudio seleccionado predominó el sexo femenino, así como el grupo de edades mayores de 70 años, a su vez el nivel de escolaridad predominante fue la de primaria terminada.Introduction: the lifestyle of diabetic patients can change the natural history of the disease or failing to aggravate the conditions of it.Objective: to characterize the lifestyle in adult patients with type II diabetes mellitus belonging to CMF 14, Yara municipality.Methods: a retrospective observational descriptive study was conducted between December 2016 and January 2017. The universe of study was constituted by all adults diagnosed as diabetic, 78 patients, in this health area. The sample consisted of 41 patients representing 53%, the probabilistic was used by the simple random method. The variables age, sex, level of education, and lifestyle areas were studied through instruments such as the guide for the study of lifestyle.Results: diabetic patients presented a lifestyle with risk, which has support in the follow-up of an adequate diet, on the other hand, the maintenance of some toxic habits, such as smoking, and the poor practice of systematic physical exercise, This advantage is appreciated in the use of their free time in pleasant activities and the self-care and medical care they maintain.Conclusions: in the selected study group the female sex prevailed, as well as the group of older than 70 years old, in turn, the predominant level of schooling was that of primary school completed

Caracterización del estilo de vida en pacientes adultos con diabetes mellitus tipo II. Yara, 2017

RESUMEN Introducción: el estilo de vida de los pacientes diabéticos puede cambiar la historia natural de la enfermedad o en su defecto agravar las condiciones de la misma. Objetivo: caracterizar el estilo de vida en pacientes adultos con diabetes mellitus tipo II pertenecientes al CMF 14 del municipio Yara. Método: se realizó un estudio descriptivo observacional de tipo retrospectivo entre diciembre 2016 – enero 2017. El universo de estudio estuvo constituido por todos los adultos diagnosticados como diabéticos, 78 pacientes, en esta área de salud. La muestra quedó constituida por 41 pacientes que representan el 53%, se utilizó el probabilístico por el método aleatorio simple. Se estudiaron las variables edad, sexo, nivel de escolaridad, y las áreas del estilo de vida a través de instrumentos tales como la guía para el estudio del estilo de vida. Resultados: los pacientes diabéticos presentaron un estilo de vida con riesgo, lo que tiene respaldo en el seguimiento de una adecuada dieta, por otro lado, el mantenimiento aún de algunos hábitos tóxicos, como el tabaquismo, y la pobre práctica de ejercicio físico sistemático, ventaja esta que se aprecia en el uso de su tiempo libre en actividades placenteras y el autocuidado y cuidado médico que mantienen. Conclusiones: en el grupo de estudio seleccionado predominó el sexo femenino, así como el grupo de edades mayores de 70 años, a su vez el nivel de escolaridad predominante fue la de primaria terminada. ABSTRACT Introduction: the lifestyle of diabetic patients can change the natural history of the disease or failing to aggravate the conditions of it. Objective: to characterize the lifestyle in adult patients with type II diabetes mellitus belonging to CMF 14, Yara municipality. Methods: a retrospective observational descriptive study was conducted between December 2016 and January 2017. The universe of study was constituted by all adults diagnosed as diabetic, 78 patients, in this health area. The sample consisted of 41 patients representing 53%, the probabilistic was used by the simple random method. The variables age, sex, level of education, and lifestyle areas were studied through instruments such as the guide for the study of lifestyle. Results: diabetic patients presented a lifestyle with risk, which has support in the follow-up of an adequate diet, on the other hand, the maintenance of some toxic habits, such as smoking, and the poor practice of systematic physical exercise, This advantage is appreciated in the use of their free time in pleasant activities and the self-care and medical care they maintain. Conclusions: in the selected study group the female sex prevailed, as well as the group of older than 70 years old, in turn, the predominant level of schooling was that of primary school completed

Mutual recovery in people with psychological disorders or functional diversity through the creative practice

En el presente artículo introducimos el concepto de “recuperación mutua” y proponemos las prácticas creativas como herramientas eficientes de recuperación de personas tanto con problemas de salud mental como con algún tipo de diversidad funcional. Frente al concepto clásico de “arte-terapia” nosotros proponemos el concepto de “práctica creativa” como más compatible con el modelo de “recuperación mutua”. Para ello, en primer lugar realizamos un breve repaso crítico a la relación del arte con la locura. Seguidamente, presentamos los conceptos hermanos de “recuperación” y “recuperación mutua” en el marco de lo que se ha venido a denominar las “health humanities”. Para finalizar, describimos dos prácticas creativas que en la actualidad están siendo evaluadas en España en el contexto de un proyecto de investigación internacional en recuperación mutua: Los seminarios creativos con personas con trastorno mental grave en el Museo de Arte Contemporáneo de Sevilla y el grupo de teatro con personas con diversidad funcional de la Asociación Síndrome de Down.In this paper we introduce the concept of “mutual recovery” and we propose creative practices as efficient recovery tools people with both mental health problems as some sort of functional diversity. Compared with the traditional concept of “art therapy” we propose the concept of “creative practice” as more consistent with the model of “mutual recovery.” To do this, we first make a brief critical review of the relationship between art and madness. Next, we present the related concepts of “recovery” and “mutual recovery” in the context of what has become known as the “health humanities”. Finally, we describe two creative practices currently being tested in Spain in the context of the a international research project about mutual recovery:Creative workshops with people with serious mental illness at the Museum of Contemporary Art of Seville and the theater group of people with diverse functionality with the Down Syndrome Association of Seville

An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair

The aim of this study was to evaluate injectable, in situ cross-linkable elastin-like recombinamers (ELRs) for osteochondral repair. Both the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells (rMSCs) were tested for the regeneration of critical subchondral defects in 10 New Zealand rabbits. Thus, cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4 months for histological and gross evaluation of features of biomaterial performance, including integration, cellular infiltration, surrounding matrix quality and the new matrix in the defects. Although both approaches helped cartilage regeneration, the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration, whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline cartilage. In conclusion, the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesisThis project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 642687. The authors are grateful for the funding from the European Commission (NMP-2014-646075), the Spanish Government (PCIN-2015-010, MAT2015-68901-R, MAT2016-78903-R, MAT2016-79435-R), Junta de Castilla y León (VA015U16) and Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León. The authors also wish to thank Maria Victoria Saez Velasco for her important contribution to cell culture experimentsS

Prevalence of Rotavirus Genogroup A and Norovirus Genogroup II in Bassaseachic Falls National Park Surface Waters in Chihuahua, Mexico

Abstract: In areas lacking potable water treatment, drinking contaminated water may represent a public health threat. In addition to enteropathogenic bacteria and parasites, fecal contamination in water environments is associated with the transmission of enteric viruses and other causal agents of infectious disease. Rotavirus and norovirus are the main enteric viral agents responsible for diarrheic outbreaks. The aim of the present study was to detect seasonal variation of rotavirus and norovirus in the surface water at Bassaseachic Falls National Park during 2013. Rivers and streams within and nearby this park were sampled once in each season during 2013. Viral concentration was carried out by a handmade filtration equipment, using a commercial electropositive membrane coupled with the virus absortion elution technique (VIRADEL©). Detection of rotavirus and norovirus was performed by SYBR Green reverse transcription-real time polymerase chain reaction (SYBR GREEN© RT-qPCR) analyses. Norovirus genogroup II was detected in samples collected in June and October 2013. Inthecaseofrotavirus,genogroupAwasdetectedinMarchandJune. Thepresenceofrotavirus and norovirus was related to viral acute diarrhea in children less than five years of age, who were inhabiting the sampled areas. This may indicates that the contaminated water was potentially a risk factor for regional diarrheic outbreaks. Keywords: norovirus; rotavirus; surface water; VIRADEL; virus detection; environmen

Tailoring of magnetocaloric effect in Ni45.5Mn43.0In11.5 metamagnetic shape memory alloy

We investigate the direct and inverse magnetocaloric effect in Ni45.5Mn43.0In11.5 Heusler alloy ribbons comparing the results obtained for the as-quenched sample with the ones after different annealing procedures. An enhancement and shift of the entropy maximum to near room temperature is observed in all annealed samples. A remarkable magnetocaloric effect is observed in samples with short-time treatment (10 minutes) and at the lowest annealing temperature. We show that the suppressing of uncompensated martensitic transition and thermal hysteresis are both influenced by the heat treatment. Also, an improvement on Curie’s temperature is observed and, at low magnetic field, it has been risen up to 310 K. Our results demonstrate that the martensitic transformation is highly sensitive to the applied magnetic field and also to the annealing treatment, which means that the magnetocaloric effect can be tuned showing different behaviors for each sample.Authors are thankful to Spanish MICINN for financial support: MAT2009-13108-C02-01-02 and MAT2010-20798-C05-04. L. Gonzalez also thanks MICINN for a FPI Grant and J. García FICYT for a “Severo Ochoa” Grant

Immediate effects of dasatinib on the migration and redistribution of naïve and memory lymphocytes associated with lymphocytosis in chronic myeloid leukemia patients

Introduction: Dasatinib is a dual SRC/ABL tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) that is known to have unique immunomodulatory effects. In particular, dasatinib intake typically causes lymphocytosis, which has been linked to better clinical response. Since the underlying mechanisms are unknown and SRC family kinases are involved in many cell motility processes, we hypothesized that the movement and migration of lymphocytes is modulated by dasatinib. Patients, Materials and Methods: Peripheral blood samples from CML patients treated with second-line dasatinib were collected before and 2 h after the first dasatinib intake, and follow-up samples from the same patients 3 and 6 months after the start of therapy. The migratory capacity and phenotype of lymphocytes and differential blood counts before and after drug intake were compared for all study time-points. Results: We report here for the first time that dasatinib intake is associated with inhibition of peripheral blood T-cell migration toward the homeostatic chemokines CCL19 and CCL21, which control the trafficking toward secondary lymphoid organs, mainly the lymph nodes. Accordingly, the proportion of lymphocytes in blood expressing CCR7, the chemokine receptor for both CCL19 and CCL21, decreased after the intake including both naïve CD45RA+ and central memory CD45RO+ T-cells. Similarly, naïve B-cells diminished with dasatinib. Finally, such changes in the migratory patterns did not occur in those patients whose lymphocyte counts remained unchanged after taking the drug. Discussion: We, therefore, conclude that lymphocytosis induced by dasatinib reflects a pronounced redistribution of naïve and memory populations of all lymphocyte subsets including CD4+ and CD8+ T-cells and B-cells

Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation

The present study was partially granted by Gerencia Regional de Salud de Castilla y León under grant number GRS COVID 111/A/20 and a grant from the Spanish Society of Cardiology SEC/FEC-INVCLI 2.Introduction: Coronavirus disease 2019 (COVID-19) is a systemic disease characterized by a disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted a prospective single-center study (NCT04689490) of previously hospitalized COVID-19 patients with and without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing with a cardiopulmonary exercise test (CPET), transthoracic echocardiogram, pulmonary lung test, six-minute walking test, serum biomarker analysis, and quality of life questionaries. Results: Patients with dyspnea (n = 41, 58.6%), compared with asymptomatic patients (n = 29, 41.4%), had a higher proportion of females (73.2 vs. 51.7%; p = 0.065) with comparable age and prevalence of cardiovascular risk factors. There were no significant differences in the transthoracic echocardiogram and pulmonary function test. Patients who complained of persistent dyspnea had a significant decline in predicted peak VO2 consumption (77.8 (64–92.5) vs. 99 (88–105); p 50% of COVID-19 survivors present a symptomatic functional impairment irrespective of age or prior hospitalization. Our findings suggest a potential ventilation/perfusion mismatch or hyperventilation syndrome.Fac. de MedicinaTRUEJunta de Castilla y León. Gerencia Regional de Salud de Castilla y LeónSociedad Española de Cardiologíapu

Ciencia, Tecnología y Salud en la Atención de los Adolescentes

El Centro de Investigación en Ciencias Médicas (CICMED) de la Universidad Autónoma del Estado de México, institución que se distingue por su preocupación en el desarrollo de proyectos de investigación, actividades académicas y de vinculación encaminadas a la detección y tratamiento de aquellos problemas que aquejan a los adolescentes, se ha distinguido por la promoción de la salud del adolescente, además de un trabajo intenso a través de redes de investigación con otras instituciones con lo cual se han enriquecido nuestros proyectos de investigación, permitiendo establecer convenios con instituciones tanto nacionales como internacionales. Los temas que se tratan en este libro, han dado lugar a una gran cantidad de reflexiones, mitos, estrategias y propuestas para la cuidado del adolescente, motivo por el cual se invitó tanto a docentes como a investigadores a participar en este libro y poder mostrar lo que se está haciendo actualmente en relación con la atención de la salud del adolescente desde diferentes perspectivas temáticas, con el propósito de difundir ampliamente los hallazgos que como investigadores se han encontrado a través del trabajo clínico y de campo, aportar información relevante para la prevención y tratamiento de la problemática más frecuente en el adolescente y abrir un espacio de intercambio y actualización, basado en el trabajo interdisciplinario para entender mejor y ampliar la visión de los diferentes factores que inciden en la salud integral del adolescente. El adolescente concebido como la persona que está en la transición de la niñez a la vida adulta, ha existido siempre. Sin embargo, la adolescencia entendida como un proceso bio-psico-social con entidad propia y, en consecuencia, con características necesidades y problemas específicos, es una realidad que apenas ha comenzado a tenerse en cuenta recientemente. La adolescencia es el período de tiempo en el que se producen los cambios desde la inmadurez propia del niño a la madurez propia del adulto. Entendiendo al individuo maduro como: aquel que es capaz de orientar su propia vida según el sentido de la existencia, con criterios propios. Desde el punto de vista intelectual o mental, el individuo maduro es aquel que es capaz de juzgar con independencia y objetividad, con sentido crítico. Desde la vertiente afectiva, posee autocontrol de las emociones y es capaz de aceptar los fracasos sin grandes conmociones interiores. Desde el aspecto social, está dispuesto a colaborar en las tareas colectivas, es tolerante con los demás y es capaz de asumir su propia responsabilidad. Esta etapa de la vida de los seres humanos es importante ya que depende del desarrollo armónico de ésta, obliga al futuro adulto en su mundo globalizado lleno de exigencias y riesgos, que los profesionales de la salud reconsideren su actuar con estas personas, dado que hoy en día no hay especialistas o posgraduados que atiendan de manera específica a los adolescentes. En este sentido la Universidad Autónoma del Estado de México, a través del Centro de Investigación en Ciencias Médica adquiere la responsabilidad y el compromiso de motivar a padres, educadores, profesionales de la salud y a los mismos adolescentes para que se conviertan en promotores de la salud física y mental que bajo la misma meta en la escuela y el hogar promuevan una conducta saludable. Por lo que brindamos nuestro agradecimiento a los autores por su valiosa participación y confianza al dejar en nuestras manos su trabajo profesional, comprometido y entusiasta, con el propósito de aportar a la sociedad una perspectiva general sobre el adolescente y sus trastornos para ubicarnos después en un contexto de salud integral