Photohadronic scenario in interpreting the February-March 2014 flare of 1ES 1011+496

The extraordinary multi-TeV flare from 1ES 1011 +496 during February-March 2014 was observed by MAGIC telescopes for 17 nights and the average spectrum of the whole period has a non-trivial shape. We have used the photohadronic model and a template EBL model to explain the average spectrum which fits well to the flare data. The spectral index $\alpha$ is the only free parameter in our model. We have also shown that the non-trivial nature of the spectrum is due to the change in the behavior of the optical depth above $\sim 600$ GeV $\gamma$-ray energy accompanied with the high SSC flux.Comment: 11 pages, 3 figures, LaTe

Blazar origin of some IceCube events

Recently ANTARES collaboration presented a time dependent analysis to a selected number of flaring blazars to look for upward going muon events produced from the charge current interaction of the muon neutrinos. We use the same list of flaring blazars to look for possible positional correlation with the IceCube neutrino events. In the context of photohadronic model we propose that the neutrinos are produced within the nuclear region of the blazar where Fermi accelerated high energy protons interact with the background synchrotron/SSC photons. Although we found that some objects from the ANTARES list are within the error circles of few IceCube events, the statistical analysis shows that none of these sources have a significant correlation.Comment: Latex file, 6 pages, two columns, 1 Figur

The origin of multi-TeV flares from the nearest blazar Markarian 421

Markarian 421 is a high-peaked BL Lac object and it has undergone many strong outbursts since its discovery as a TeV source in 1992. Markarian 421 has been stud- ied intensively and was observed by various Cherenkov tele- scope arrays ever since. The outbursts of April 2004 observed by the Whipple telescope and of February 2010 by the HESS telescopes are explained well in this work by using the photohadronic model. To account for the attenuation of these high- energy gamma-rays by the extragalactic background light (EBL), we use template EBL models. The intrinsic spectrum of each epoch is different even though the high-energy protons have almost the same spectral index. We observe that this difference in intrinsic spectra is due to the change in the spectral index of the low-energy tail of the synchrotron self Compton (SSC) photons during different epochs of flaring. Our results show that the contemporaneous multiwavelength observations, particularly in the low-energy tail region of the SSC emission of the source, are important in explaining the flaring phenomenon.Comment: Title changed, Single column, 19 pages, 6 figure

The nature of the intrinsic spectra from the VHE emission of H 2356-309 and 1ES 1101-232

The VHE emission from the HBLs H 2356-309 and 1ES 1101-232 were observed by HESS telescopes during 2004--2007. Particularly the observation in 2004 from H 2356-309 and during 2004--2005 from 1ES 1101-232 were analyzed to derive strong upper limits on the EBL which was found to be consistent with the lower limits from the integrated light of resolved galaxies. Here we have used the photohadronic model corroborated by two template EBL models to fit the observed VHE gamma-ray data from these two HBLs and to predict their intrinsic spectra. We obtain very good fit to the VHE spectra of these two HBLs. However, the predicted intrinsic spectra are different for each EBL model. For the HBL H 2356-309, we obtain a flat intrinsic spectrum and for 1ES 1101-232 the spectrum is mildly harder than 2 but much softer than 1.5.Comment: 25 pages, 14 figure

Photohadronic modelling of the 2010 gamma-ray flare from Mrk 421

Blazars are a subclass of active galactic nuclei (AGNs) that have a relativistic jet with a small viewing angle towards the observer. Recent results based on hadronic scenarios have motivated an ongoing discussion of how a blazar can produce high energy neutrinos during a flaring state and which scenario can successfully describe the observed gamma-ray behaviour. Markarian 421 is one of the closest and brightest objects in the extragalactic gamma-ray sky and showed flaring activity over a 14-days period in 2010 March. In this work, we describe the performed analysis of Fermi-LAT data from the source focused on the MeV range (100 MeV–1 GeV), and study the possibility of a contribution coming from the pγ interactions between protons and MeV SSC target photons to fit the very high energy (VHE) gamma-ray emission. The fit results were compared with two leptonic models (one-zone and two-zone) using the Akaike Information Criteria (AIC) test, which evaluates goodness-of-fit alongside the simplicity of the model. In all cases, the photohadronic model was favoured as a better fit description in comparison to the one-zone leptonic model, and with respect to the two-zone model in the majority of cases. Our results show the potential of a photohadronic contribution to a lepto-hadronic origin of gamma-ray flux of blazars. Future gamma-ray observations above tens of TeV and below 100 MeV in energy will be crucial to test and discriminate between models

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Actualidad y prospectiva de la investigación científica en el Centro Universitario Amecameca de la Universidad Autónoma del Estado de México

Con responsabilidad, se organizó un programa cuya finalidad fuera publicitar con transparencia dichos avances, a través de un esfuerzo de rendición de cuentas a la comunidad inmediata, la universitaria, y a la comunidad abierta, la sociedad que la principal referencia para tal efecto. El programa se concretiza a través del presente libro, conformado con una inspiración de investigación multidisciplinaria; sin embargo, para llegar a tal fin, el reto es realizar el proceso de búsqueda y generación de conocimiento transitando hacia la colaboración de los cuerpos académicos, que puedan construir nuevos conocimientos fortalecidos por la convergencia de diferentes campos del saber. En consecuencia, la primera etapa de esta estrategia es la publicidad de los trabajos investigativos ejercidos, para hacer un balance al día, pero también proyectar el futuro de cada campo y área del conocimiento. La organización explicativa está organizada por tres bloques representativos del quehacer en la generación de conocimiento del Centro Universitario, un primer bloque centra el interés en las humanidades, educación y sustentabilidad; el segundo bloque lo integra la reflexión científica sobre la construcción democrática, derechos humanos y equidad de género; en el tercer segmento se destina a la seguridad alimentaria, salud pública y sistemas agropecuarios. La actualidad de la investigación eleva la producción lograda y lo que en el momento se encuentra en construcción y los alcances que produce para la docencia, la investigación misma, y para la sociedad en general. La prospectiva es un área que todos los capítulos desarrollan con el propósito de delinear los alcances innovadores por andar en teoría, metodología e incluso en los saberes mismo

Diverse functional interactions between nitric oxide and abscisic acid in plant development and responses to stress

[EN] The extensive support for abscisic acid (ABA) involvement in the complex regulatory networks controlling stress responses and development in plants contrasts with the relatively recent role assigned to nitric oxide (NO). Because treatment with exogenous ABA leads to enhanced production of NO, it has been widely considered that NO participates downstream of ABA in controlling processes such as stomata movement, seed dormancy, and germination. However, data on leaf senescence and responses to stress suggest that the functional interaction between ABA and NO is more complex than previously thought, including not only cooperation but also antagonism. The functional relationship is probably determined by several factors including the time- and place-dependent pattern of accumulation of both molecules, the threshold levels, and the regulatory factors important for perception. These factors will determine the actions exerted by each regulator. Here, several examples of well-documented functional interactions between NO and ABA are analysed in light of the most recent reported data on seed dormancy and germination, stomata movements, leaf senescence, and responses to abiotic and biotic stressesThis work was supported by MICINN (Spain) grants BIO2011-27526 and CONSOLIDER CSD2007-00057 to JL and postdoctoral contracts to MCC and AC. RM was funded by a pre-doctoral fellowship of the FPU Program from MEC (Spain). We thank Michael Holdsworth (University of Nottingham, UK) for critical reading of this manuscript and for his helpful comments and corrections. We would also like to express our appreciation for all the contributions reported in this research area, and particularly to those researchers who have not been cited in this review because of the limitations of manuscript length.Leon Ramos, J.; Castillo López Del Toro, MC.; Coego González, A.; Lozano Juste, J.; Mir Moreno, R. (2014). 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El Estado tiene como obligación asegurar la salud pública de los pobladores y ha instaurado para ello diversos sistemas que garanticen la cobertura del servicio, sean estos públicos o privados. Entre estos destaca el Sistema Integral de Salud (SIS). La investigación se centró en establecer si el SIS como sistema de salud ha permitido la reducción de las altas tasas de enfermedades entre una población de 508 256 habitantes de un distrito limeño, evaluando las variables salud de la población beneficiaria, cobertura de seguro y gobernanza del sistema, a noviembre del 2019. La metodología que se empleó fue cualitativa-evaluativa. Desde el 2017 (fecha de inicio del SIS) hasta noviembre del 2019 los resultados de metas/objetivos del SIS no han sido satisfactorios, y se han incrementado fuertemente los índices de enfermedades, a pesar de la ampliación de la cobertura; además la gobernanza del sistema sigue en duda cuando el órgano rector presenta diversos modelos de gestión sanitaria sin ninguna efectividad