How to Characterize Cylindrical Magnetic Nanowires

Cylindrical magnetic nanowires made through the help of nanoporous alumina templates are being fabricated and characterized since the beginning of 2000. They are still actively investigated nowadays, mainly due to their various promising applications, ranging from high-density magnetic recording to high-frequency devices, passing by sensors, and biomedical applications. They also represent suitable systems in order to study the dimensionality effects on a given material. With time, the development in fabrication techniques allowed to increase the obtained nanowire complexity (controlled crystallinity, modulated composition and/or geometry, range of materials, etc.), while the improvements in nanomanipulation permitted to fabricate system based either on arrays or on single nanowires. On the other side, their increased complexity requires specific physical characterization methods, due to their particular features such as high anisotropy, small magnetic volume, dipolar interaction field between them, and interesting electronic properties. The aim of this chapter was to offer an ample overview of the magnetic, electric, and physical characterization techniques that are suitable for cylindrical magnetic nanowire investigation, of what is the specific care that one needs to take into account and which information will be extracted, with typical and varied examples

Direct Measurement of the Top Quark Mass at D0

We determine the top quark mass m_t using t-tbar pairs produced in the D0 detector by \sqrt{s} = 1.8 TeV p-pbar collisions in a 125 pb^-1 exposure at the Fermilab Tevatron. We make a two constraint fit to m_t in t-tbar -> b W^+bbar W^- final states with one W boson decaying to q-qbar and the other to e-nu or mu-nu. Likelihood fits to the data yield m_t(l+jets) = 173.3 +- 5.6 (stat) +- 5.5 (syst) GeV/c^2. When this result is combined with an analysis of events in which both W bosons decay into leptons, we obtain m_t = 172.1 +- 5.2 (stat) +- 4.9 (syst) GeV/c^2. An alternate analysis, using three constraint fits to fixed top quark masses, gives m_t(l+jets) = 176.0 +- 7.9 (stat) +- 4.8 (syst) GeV/C^2, consistent with the above result. Studies of kinematic distributions of the top quark candidates are also presented.Comment: 43 pages, 53 figures, 33 tables. RevTeX. Submitted to Phys. Rev.

Search for First Generation Scalar Leptoquark Pairs in ppbar Collisions at sqrt(s)=1.8 TeV

We have searched for first generation scalar leptoquark (LQ) pairs in the enu+jets channel using ppbar collider data (integrated luminosity= 115 pb^-1) collected by the DZero experiment at the Fermilab Tevatron during 1992-96. The analysis yields no candidate events. We combine the results with those from the ee+jets and nunu+jets channels to obtain 95% confidence level (CL) upper limits on the LQ pair production cross section as a function of mass and of beta, the branching fraction to a charged lepton. Comparing with the next-to-leading order theory, we set 95% CL lower limits on the LQ mass of 225, 204, and 79 GeV/c^2 for beta=1, 1/2, and 0, respectively.Comment: 14 pages, 4 figures, submitted to Physical Review Letters Replaced to correct visitor addresse

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Measurement of the Isolated Photon Cross Section in p-pbar Collisions at sqrt{s}=1.96 TeV

The cross section for the inclusive production of isolated photons has been measured in p anti-p collisions at sqrt{s}=1.96 TeV with the D0 detector at the Fermilab Tevatron Collider. The photons span transverse momenta 23 to 300 GeV and have pseudorapidity |eta|<0.9. The cross section is compared with the results from two next-to-leading order perturbative QCD calculations. The theoretical predictions agree with the measurement within uncertainties.Comment: 7 pages, 5 figures, submitted to Phys.Lett.

Dwarf Galaxies in the Coma Cluster: II. Spectroscopic and Photometric Fundamental Planes

We present a study of the fundamental plane, FP, for a sample of 71 dwarf galaxies in the core of Coma cluster in magnitude range $-21 < M_I <-15$. Taking advantage of high resolution DEIMOS spectrograph on Keck II for measuring the internal velocity dispersion of galaxies and high resolution imaging of HST/ACS, which allows an accurate surface brightness modeling, we extend the fundamental plane (FP) of galaxies to $\sim$1 magnitude fainter luminosities than all the previous studies of the FP in Coma cluster. We find that, the scatter about the FP depends on the faint-end luminosity cutoff, such that the scatter increases for fainter galaxies. The residual from the FP correlates with the galaxy colour, with bluer galaxies showing larger residuals from FP. We find $M/L \propto M^{-0.15\pm0.22}$ in F814W-band indicating that in faint dwarf ellipticals, the $M/L$ ratio is insensitive to the mass. We find that less massive dwarf ellipticals are bluer than their brighter counterparts, possibly indicating ongoing star formation activity. Although tidal encounters and harassment can play a part in removing stars and dark matter from the galaxy, we believe that the dominant effect will be the stellar wind associated with the star formation, which will remove material from the galaxy resulting in larger $M/L$ ratios. We attribute the deviation of a number of faint blue dwarfs from the FP of brighter ellipticals to this effect. We also study other scaling relations involving galaxy photometric properties including the photometric plane. We show that, compared to the FP, the scatter about the photometric plane is smaller at the faint end.Comment: 19 pages, 12 figures and 4 tables. Accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journal. (ref. MN-11-0266-MJ.R1) Accepted 2011 October 10. Received 2011 September 13; in original form 2011 February

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin