Condon Domain Phase Diagram for Silver

We present the Condon domain phase diagram for a silver single crystal measured in magnetic fields up to 28 T and temperatures down to 1.3 K. A standard ac method with a pickup coil system is used at low frequency for the measurements of the de Haas-van Alphen effect (dHvA). The transition point from the state of homogeneous magnetization to the inhomogeneous Condon domain state (CDS) is found as the point where a small irreversibility in the dHvA magnetization arises, as manifested by an extremely nonlinear response in the pickup voltage showing threshold character. The third harmonic content in the ac response is used to determine with high precision the CDS phase boundary. The experimentally determined Condon domain phase diagram is in good agreement with the theoretical prediction calculated by the standard Lifshitz-Kosevich (LK) formula

The efficiency of using the substrate technological module in the technology of growing potato mini-tubers

Known technologies and methods for obtaining virus-free potato mini-tubers of a required size fraction do not fully provide the highest multiplication factor, which occurs due to the insufficient productivity of an individual potato plant. On the basis of long-term experimental data (2012…2022), an assessment of the effectiveness of methods for growing potato mini-tubers in open and protected ground conditions is given. According to the number of tubers harvested from one plant, all growing methods can be divided into two large groups:  traditional (3-12 potatoes per plant) and modified (more than 40 potatoes per plant). A highly efficient method has been developed for obtaining mini-tubers of potatoes harvested as they grow on soil substrates with an average annual productivity of at least 50 mini-tubers from one micro-tuber and 40 mini-tubers from one virus-free plant (with traditional substrate methods – from 3 to 10 mini-tubers). Based on this method, there has been created a substrate technological module of a new generation harvesting tubers as they grow which makes it possible to obtain an average of 40 to 55 mini-tubers from one virus-free plant over the years, that is almost 10 times more in comparison with traditional methods of growing with a single harvest at the end of vegetation. Harvesting mini-tubers as they grow up to a required size creates the possibility of obtaining tubers of one size fraction (10-25 g), which allows later, when laying the nursery of the first field reproduction, to apply mechanized planting in the field and obtain uniform seedlings

Higher Partial Waves in p+p->p+p+eta near Threshold

Exclusive measurements of the production of eta mesons in the p+p->p+p+eta reaction have been carried out at excess energies of 16 and 37 MeV above threshold. The deviations from phase space are dominated by the proton-proton final state interaction and this influences particularly the energy distribution of the eta meson. However, evidence is also presented at the higher energy for the existence of an anisotropy in the angular distributions of the eta meson and also of the final proton-proton pair, probably to be associated with D-waves in this system interfering with the dominant S-wave term. The sign of the eta angular anisotropy suggests that rho-exchange is important for this reaction.Comment: 16 pages, LaTeX2e, 3 EPS Figures, Updated version, Accepted for publication in Phys. Lett.

Observation of strong final-state effects in pi+ production in pp collisions at 400 MeV

Differential cross sections of the reactions $pp \to d\pi^+$ and $pp \to pn\pi^+$ have been measured at $T_p = 400$ MeV by detecting the charged ejectiles in the angular range $4^0 \leq \Theta_{Lab} \leq 21^\circ$. The deduced total cross sections agree well with those published previously for neighbouring energies. The invariant mass spectra are observed to be strongly affected by $\Delta$ production and $NN$ final-state interaction. The data are well described by Monte Carlo simulations including both these effects. The ratio of $pp \to pn\pi^+$ and $pp \to d\pi^+$ cross sections also compares favourably to a recent theoretical prediction which suggests a dominance of $np$-production in the relative $^3S_1$-state.Comment: 17 pages, 5 figure

Обоснование конструктивных требований к автоматизированному посадочному агрегату мини-клубней картофеля

The authors showed that the transition to the technology of virus-free minitubers mass production changed the machines requirements for planting original seed potatoes.(Research purpose) To develop a technological scheme and substantiate the design parameters of the planting apparatus of an automatic planter of potato minitubers.(Materials and methods) The development was based on an elevator-type planting apparatus. The authors decided to create a spoon design with the ability to grip and move into the guide casing one minituber in each spoon, eliminating the minitubers jumping from one spoon to another or pinching them when moving along the guiding casing to the furrow bottom. The diameters of the lower guide and upper drive rollers were theoretically substantiated in order to exclude the influence of the planting tubers sizes difference on the uniformity of their submitting into the furrow.(Results and discussion) The authors determined the minimum permissible elevator belt speed, which depended on the distance between the spoons on the elevator belt and the planting unit speed. The size of the upper driving reel diameter was justified from the condition that the spoon unfolded 180 degrees in at least 1.5 seconds, which ensured a tuber smooth transition to the back side of the spoon.(Conclusions) The authors developed a technological scheme of an automatic planting elevator type device for planting potato minitubers with a working speed of 6-9 kilometers per hour. It was found that the upper driving reel diameter was not less than 44 centimeters, and the lower guide roller diameter was not more than 12 centimeters. They showed that the double-sided design of scooping spoons with the possibility of installing replaceable bowls in them would ensure a high-quality planting of not only minitubers, but also subsequent reproductions of seed and ware potatoes with a tuber mass of 5-80 grams.Показали, что переход на технологии массового получения безвирусных мини-клубней меняет требования к машинам для посадки оригинального семенного картофеля.(Цель исследования) Разработать технологическую схему и обосновать конструктивные параметры высаживающего аппарата автоматической сажалки мини-клубней картофеля.(Материалы и методы) За основу разработки взяли высаживающий аппарат элеваторного типа. Решили создать конструкцию ложечки с возможностью захвата и перемещения в направляющий кожух по одному мини-клубню в каждой ложечке, исключив перескакивание мини-клубней с одной ложечки на другую или защемление их при перемещении по направляющему кожуху на дно борозды. Теоретически обосновали диаметры нижнего направляющего и верхнего ведущего роликов, чтобы исключить влияние разницы в размерах посадочных клубней на равномерность подачи их в борозду.(Результаты и обсуждение) Определили минимально допустимую скорость ленты элеватора, которая зависит от расстояния между ложечками на ленте элеватора и скорости посадочного агрегата. Размер диаметра верхнего ведущего барабана обосновали из условия разворачивания ложечки на 180 градусов не менее чем за 1,5 секунды, что обеспечивает плавный переход клубня на обратную сторону ложечки.Выводы. Разработали технологическую схему автоматического высаживающего аппарата элеваторного типа для сажалки мини-клубней картофеля с рабочей скоростью 6-9 километров в час. Выявили, что диаметр верхнего ведущего барабана не меньше 44 сантиметров, нижнего направляющего ролика – не более 12 сантиметров. Показали, что двусторонняя конструкция вычерпывающих ложечек с возможностью установки в них сменных чаш обеспечит качественную посадку не только мини-клубней, но и последующих репродукций семенного, а также продовольственного картофеля при массе клубней 5-80 граммов

Role of targeted therapy in the treatment of HER-2-positive breast cancer brain metastases

Brain metastases are detectable in 25–35 % of patients with progressive HER-2-positve breast cancer. Even after spreading metastases into the brain, chemotherapy in combination with anti-HER- 2 therapy improves survival due to better control of the systemic disease. The paper presents the results of investigations substantiating the use of anti-HER-2 targeting agents, as well as the innovative agent T-DM1 to treat brain metastases

Ionospheric scintillation monitoring and modelling

This paper presents a review of the ionospheric scintillation monitoring and modelling by the European groups involved in COST 296. Several of these groups have organized scintillation measurement campaigns at low and high latitudes. Some characteristic results obtained from the measured data are presented. The paper also addresses the modeling activities: four models, based on phase screen techniques, with different options and application domains are detailed. Finally some new trends for research topics are given. This includes the wavelet analysis, the high latitudes analysis, the construction of scintillation maps and the mitigation techniques

In silico approach to screen compounds active against parasitic nematodes of major socio-economic importance

Infections due to parasitic nematodes are common causes of morbidity and fatality around the world especially in developing nations. At present however, there are only three major classes of drugs for treating human nematode infections. Additionally the scientific knowledge on the mechanism of action and the reason for the resistance to these drugs is poorly understood. Commercial incentives to design drugs that are endemic to developing countries are limited therefore, virtual screening in academic settings can play a vital role is discovering novel drugs useful against neglected diseases. In this study we propose to build robust machine learning model to classify and screen compounds active against parasitic nematodes.A set of compounds active against parasitic nematodes were collated from various literature sources including PubChem while the inactive set was derived from DrugBank database. The support vector machine (SVM) algorithm was used for model development, and stratified ten-fold cross validation was used to evaluate the performance of each classifier. The best results were obtained using the radial basis function kernel. The SVM method achieved an accuracy of 81.79% on an independent test set. Using the model developed above, we were able to indentify novel compounds with potential anthelmintic activity.In this study, we successfully present the SVM approach for predicting compounds active against parasitic nematodes which suggests the effectiveness of computational approaches for antiparasitic drug discovery. Although, the accuracy obtained is lower than the previously reported in a similar study but we believe that our model is more robust because we intentionally employed stringent criteria to select inactive dataset thus making it difficult for the model to classify compounds. The method presents an alternative approach to the existing traditional methods and may be useful for predicting hitherto novel anthelmintic compounds.12 page(s

ТЕХНОЛОГИЯ УБОРКИ И ТРАНСПОРТИРОВКИ СЕМЕННОГО КАРТОФЕЛЯ

When engineering potatoes harvesting procedure for its optimization it is important to calculate precisely the quantity of machines, containers and workers who will be involved in harvesting process. This depends on the acreage and productivity. An output yield should be harvested in predetermined terms. Harvesting and transportation of potatoes in bags is obsolete technology which complicates and slows down process of harvest and transport operations. Agrarian introduce mechanization to reduce the level of manual work use or to exclude it completely. The authors offered container technology of harvesting, transportation and sorting of seed potatoes. The containers having identical amount and load-carrying capacity were made of different materials for check of this technology. Branded structure of the machines which can be used at harvesting was established. The main specifications were indicated. The authors determined shortcomings of the soft bags for potatoes harvesting and brought into focus benefits of containers use. The exact quantity of containers and machines for potatoes harvesting in the OOO Redkinskoye APC (Tver region) was calculated. The seed potatoes are grown there on 2.43 hectares. The time frames of harvesting were determined.При разработке технологического процесса уборки картофеля для его оптимизации важно точно рассчитать количество техники, тары и рабочих, которые будут задействованы в процессе уборки, в зависимости от площади посева и урожайности, так как урожай должен быть убран в заранее установленные сроки. Сбор и транспортировка картофеля в мешках - устаревшая технология, которая затрудняет и замедляет процесс уборочно-транспортных работ. Механизация призвана снизить уровень использования ручного труда или полностью исключить его. Предложена контейнерная технология уборки, транспортировки и сортировки семенного картофеля. Для проверки данной технологии разработали контейнеры, выполненные из разных материалов, но имеющие одинаковые объем и грузоподъемность. Установили марочный состав техники, которая может быть использована в процессе уборки, с указанием главных технических характеристик. Определили недостатки мягкой тары (мешков) для уборки картофеля и подчеркнули преимущества использования контейнеров. Рассчитали точное количество контейнеров и техники для осуществления процесса уборки картофеля на примере предприятия ООО «Редкинское АПК» (Тверской области), где на 2,43 га пашни выращивают семенной картофель. Определили временные интервалы процесса уборки

Ionospheric scintillation monitoring and modelling

This paper presents a review of the ionospheric scintillation monitoring and modelling by the European groups involved in COST 296. Several of these groups have organized scintillation measurement campaigns at low and high latitudes. Some characteristic results obtained from the measured data are presented. The paper also addresses the modeling activities: four models, based on phase screen techniques, with different options and application domains are detailed. Finally some new trends for research topics are given. This includes the wavelet analysis, the high latitudes analysis, the construction of scintillation maps and the mitigation techniques