Predicting Female Managers\' Feelings of Loneliness based on Couples\' Communication Patterns and Interpersonal Dependence: The Mediating Role of Spiritual Health

The purpose of this research is to predict the feeling of loneliness of female managers based on couples' communication patterns and interpersonal dependence with the mediator role of spiritual health. The participants were 300 female managers working in the program and budget organization of Tehran (Iran), who were selected by accessible sampling. Research tools included couple communication patterns questionnaire, interpersonal dependence questionnaire, spiritual health questionnaire and feeling of loneliness questionnaire. To examine the hypotheses of the study, structural equation modeling was used in AMOS 24 software. The results showed that there is a significant relationship between communication patterns and feelings of loneliness, between spiritual health and feelings of loneliness and between interpersonal dependence and feeling of loneliness (p<0.001). Accordingly, couples' communication patterns and interpersonal dependence significantly predict the loneliness of female managers. Also, the findings showed that communication patterns and interdependence are indirectly related to feelings of loneliness through spiritual health. Based on the findings, it is suggested that in the treatment of managers' feelings of loneliness, sufficient attention should be paid to couples' communication patterns, interpersonal dependence, and their spiritual health

Novel high step up DC/DC converters with reduced switch voltage stress

In this paper, a novel step up DC/DC converter with reduced switch voltage stress is introduced firstly. The proposed converter is analyzed in steady state and is compared with other DC/DC converters with equal number of components. The voltage stress on all switches is lower than the output voltage. Then, it is shown that the voltage transfer gain can be increased considerable by replacing one of its inductor with two types of switched inductor voltage multiplier cell. Therefore, high step up switched inductor DC/DC converters are realized. The operations of the proposed converters are verified using the simulation result

Effect of magnetic field on thermo-physical and hydrodynamic properties of different metals-decorated multi-walled carbon nanotubes-based water coolants in a closed conduit

In this paper, the thermo-physical and hydrodynamic properties of heat transfer nanofluids containing metal nanoparticles-decorated multi-wall carbon nanotube (MWCNT) are reported. To this end, Cu-decorated MWCNT, Fe-decorated MWCNT, and Ni-decorated MWCNT (covalently functionalized samples) were synthesized with pre-functionalization with the aspartic acid as the hydrophilic chain. To have a comprehensive comparison, water-based non-covalently functionalized MWCNT nanofluids were also synthesized. A significant increase in the thermal and electrical conductivities of heat transfer nanofluids containing metal nanoparticles-based MWCNT as compared to the non-covalently functionalized sample as well as water has been determined at the same operational conditions. All the prepared nanofluids are stable and the viscosity and density remained approximately the same after loading additives. The present paper also focused on the study of the role of weight concentrations of additives, flow rate and thermo-physical properties of the prepared nanofluids on the convective heat transfer rate and hydrodynamic performances in the laminar flow. Further, the convective heat transfer coefficient, pressure drop, friction factor, performance index and pumping power variation were also investigated under applied magnetic field, which improves the overall thermal performance of the closed conduit insignificantly

Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer

Colorectal cancer (CRC) is distinguished by epigenetic elements like DNA methylation, histone modification, histone acetylation and RNA remodeling which is related with genomic instability and tumor initiation. Correspondingly, as a main epigenetic regulation, DNA methylation has an impressive ability in order to be used in CRC targeted therapy. Meaningly, DNA methylation is identified as one of most important epigenetic regulators in gene expression and is considered as a notable potential driver in tumorigenesis and carcinogenesis through gene-silencing of tumor suppressors genes. Abnormal methylation situation, even in the level of promoter regions, does not essentially change the gene expression levels, particularly if the gene was become silenced, leaving the mechanisms of methylation without any response. According to the methylation situation which has a strong eagerness to be highly altered on CpG islands in carcinogenesis and tumorigenesis, considering its epigenetic fluctuations in finding new biomarkers is of great importance. Modifications in DNA methylation pattern and also enrichment of methylated histone signs in the promoter regions of some certain genes like MUTYH, KLF4/6 and WNT1 in different signaling pathways could be a notable key contributors to the upregulation of tumor initiation in CRC. These epigenetic alterations could be employed as a practical diagnostic biomarkers for colorectal cancer. In this review, we will be discuss these fluctuations of MUTYH, KLF4/6 and WNT1 genes in CRC