A vision of elementary school leadership : a reflective essay

The smell of coffee and crayons has always warmed my heart. Coming home from kindergarten, I couldn\u27t wait to join my mother and her perennial cup of coffee at our dining room table for a ritual of coloring and catching up. While I labored away with my Crayolas, my mother would ask me about my day at school, and we would talk together about the sound that a cardinal makes, or the color of our oak tree in the front yard. Through these conversations my mother fostered a joy of learning and sharing that would grow with me into adulthood, and set me on the path toward educational leadership that I am pursuing today

Theodor Mommsen (1817-1903) auf Medaillen und Plaketten. Sammlung des Instituts für Klassische Archäologie der Universität Tübingen.

Zusammenstellung mehrer Beiträge zu den Medaillen und Plaketten auf Theodor Mommsen aus der Sammlung des Instituts für Klassische Archäologie der Universität Tübingen

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19

A zooarchaeological perspective on late pleistocene/early holocene human behaviour in the Maloti-Drakensberg region, southern Africa: The view from Ha Makotoko and Ntloana Tšoana rock-shelters, Lesotho

Re-excavation of Ha Makotoko and Ntloana Tšoana rock-shelters in western Lesotho, produced abundant faunal remains (both macro and micro) from people using the Robberg technocomplex during the late Pleistocene (Ha Makotoko and Ntloana Tšoana (15.4–13.4 kcal. BP) and early Holocene (Ntloana Tšoana 11.1–10.2 kcal. BP). This faunal material allows us to identify the subsistence strategies they employed, using the unbiased Simpson's evenness index (1-D′), and Shannon's evenness index to track diet breadth. Detailed analyses of the sites' microfauna indicates that eagle owls and/or small carnivores — not humans — were responsible for introducing them into the deposits. A chi-squared test comparing diet breadth across the sites identifies hunting strategy, focused on size 2 and 3 migratory ungulates (equids, suids, and bovids), supplemented with size 1 and 4 bovids. Comparing the evenness values from Ha Makotoko and Ntloana Tšoana to published data from other Robberg-associated sites in the wider Maloti-Drakensberg region (Sehonghong, Rose Cottage Cave and Tloutle) allows variability in subsistence strategies to be addressed. A chi-squared test comparing ungulate size classes, small mammals and fish with the evenness index reveals two important statistical differences: the warm period occupation (16.5–14.3 kcal. BP) at Rose Cottage Cave presents a narrow diet heavily focused on size 3 ungulates (with a lack of fish). At the other end of the climate spectrum, cold conditions at Sehonghong immediately before the Last Glacial Maximum were associated with a narrow diet focused on intensive fishing, with lower-than-expected numbers of size 3 ungulates. The deposits at Ntloana Tšoana, Ha Makotoko, and Tloutle, along with the Younger Dryas-associated assemblage from Sehonghong, on the other hand, present broad diets. Fish and small mammals make more of a contribution to the expanding diet in the highlands. Our approach demonstrates the flexibility that makers of Robberg tools displayed in adapting to the changing climatic and ecological conditions of this high-elevation region in the interior of southern Africa during Marine Isotope Stage 2 and across the Pleistocene/Holocene transition

Caves and their fauna in Highlands and Escarpments of Angola and Namibia

Several landscapes in the highlands and escarpments of Angola and Namibia (HEAN) have karstic regions with caves. Within the Northern Escarpment in Angola there are two main karstic regions. The first one includes the northern caves associated with a tropical climate and mostly concentrated in Ambuíla, Uíge Province. The second region comprises caves near the Atlantic coast, which are linked to underground flows of the Cambongo-Negunza River. An additional cluster of caves is on the Humpata Plateau and its edges within Angola’s Marginal Mountain Chain landscape. Most caves in Namibia are in the Karstveld and Khomas Hochland Plateau landscapes in karstic areas of relatively high rainfall. In this paper, we provide a brief overview of the history of cave exploration, sites and fauna documented in them. We report on the fauna recorded during surveys in 2010 and 2018–2021 in the southern karst around Humpata, Huíla Province; and summarise information available on fauna from Namibia. Most species recorded in Angolan caves are trogloxene taxa observed or collected in cave sediments. Namibian caves house a diversity of invertebrates, many of which are endemic or likely to be endemic to Namibia and the HEAN. Two endemic fish in underground lakes in Namibia are critically endangered. This study emphasises the need for further field research and for strategies to conserve caves and their faunas in both countries.BA13-DFD0-F761 | Daniela Filipa Mirote de Matosinfo:eu-repo/semantics/publishedVersio

Middle Bronze Age land use practices in the northwestern Alpine foreland – A multi-proxy study of colluvial deposits, archaeological features and peat bogs

This paper aims to reconstruct Middle Bronze Age (MBA; 1600–1250 BCE) land use practices in the northwestern Alpine foreland (SW Germany, Hegau). We used a multi-proxy approach including the analysis of biogeochemical proxies from colluvial deposits and buried topsoils in the surroundings of the well-documented settlement site of Anselfingen and off-site pollen data from two peat bogs. This approach allowed for in-depth insights into the MBA subsistence economy and shows that the MBA in the northwestern Alpine foreland was a period of establishing settlements with sophisticated land management and land use practices. The reconstruction of phases of colluvial deposition was based on ages from optically stimulated luminescence (OSL) and radiocarbon (AMS14C) dating from multi-layered colluvial deposits and supports the local archaeological record with the first phase of major colluvial deposition occurring during the MBA followed by phases of colluvial deposition during the Iron Age, the Medieval period and modern times. The on-site deposition of charred archaeobotanical remains and animal bones from archaeological features, as well as polycyclic aromatic hydrocarbons (PAHs), charcoal spectra, phytoliths, soil microstructure, urease enzymatic activity, microbial biomass carbon (Cmic) and heavy metal contents from colluvial deposits, were used as proxies for on-site and near-site land use practices. The charcoal spectra indicate MBA forest management which favored the dominance of Quercus in the woodland vegetation in the surrounding area north of the settlement site. Increased levels of 5β stanols (up to 40 %) and the occurrence of pig bones (up to 14 %) support the presence of a forest pasture mainly used for pig farming. In the surrounding area south of the settlement, an arable field with a buried MBA plow horizon (2Apb) could be verified by soil micromorphological investigations and high concentrations of grass phytoliths from leaves and stems. Agricultural practices (e.g., plowing) focussed on five staple crops (Hordeum distichon/vulgare, Triticum dicoccum, Triticum monococcum, Triticum spelta, Triticum aestivum/turgidum), while the presence of stilted pantries as storage facilities and of heat stones indicate post-harvest processing of cereal crops and other agrarian products within the settlement. In the area surrounding the settlement, increased levels of urease activity, compared to microbial biomass carbon (up to 2.1 µg N µg C−1mic), and input of herbivorous and omnivorous animal faeces indicate livestock husbandry on fallow land. The PAH suites and their spatial distribution support the use of fire for various purposes, e.g., for opening and maintaining the landscape, for domestic burning and for technical applications. The off-site palynological data support the observed change in on-site and near-site vegetation as well as the occurrence of related land use practices. During the Early and Middle Bronze Age, fire played a major role in shaping the landscape (peak of micro-charcoal during the MBA), and anthropogenic activities promoted Quercus-dominated forest ecosystems at the expense of natural beech forests. This indicates a broader regional human influence in the northwestern Alpine foreland at low- and mid-altitude inland sites during the Middle Bronze Age