Информационные потребности учёных и проблемы поиска информации (по материалам анкетирования сотрудников Новосибирского научного центра СО РАН)

Researchers’ information needs and information search issues are examined based on polling the researchers ofNovosibirskResearchCenterof theRussianAcademyof Sciences Siberian Branch. The polling was organized by the State Public Library for Science and Technology RAS SB. The answers related to information retrieval and difficulties the researchers are facing, were analyzed. It was found that the researchers regularly search information within their studies subject scope and, as a rule, made advanced users of different level information systems, and used independently the databases like Web of Science, Scopus, Russian Science Citation Index. However, some researchers experience difficulties in choosing resources for information sources or formulating queries. Based on the study findings, the authors propose several services to be demanded by researcher users, among them: analyzing dynamics of the document flow within specific topics and the most productive authors, retrospective subject search and assistance provided by bibliographic managers. Besides, the Library could provide information services for using archives and dealing with intellectual property issues.Освещены информационные потребности научных сотрудников и проблемы поиска информации по результатам анкетирования сотрудников Новосибирского научного центра СО РАН, проведённого сотрудниками ГПНТБ СО РАН. Проанализированы ответы на вопросы, которые возникают у учёных при поиске информации; отмечены сложности, с которыми сталкиваются исследователи. Анализ результатов анкетирования позволил установить, что научные сотрудники регулярно занимаются поиском информации для проведения научно-исследовательской работы и в основном являются уверенными пользователями информационных систем различного уровня, самостоятельно работают с такими базами данных, как Web of Science, Scopus, РИНЦ. Однако отдельные учёные испытывают затруднения как в выборе информационных ресурсов для поиска необходимой информации, так и при формулировании запроса.По результатам исследования предложен ряд услуг, которые могут быть востребованы читателями – научными сотрудниками. Среди них: анализ динамики развития документопотока по определённой теме; выявление организаций, работающих в том или ином направлении, и наиболее продуктивных авторов; ретроспективный тематический поиск, а также помощь в работе с современными библиографическими менеджерами. Кроме того, библиотека могла бы оказывать информационные услуги по работе в архивах и в решении вопросов, связанных с интеллектуальной собственностью

Ligand-Induced Tyrosine Phosphorylation of Cysteinyl Leukotriene Receptor 1 Triggers Internalization and Signaling in Intestinal Epithelial Cells

Leukotriene D(4) (LTD(4)) belongs to the bioactive lipid group known as eicosanoids and has implications in pathological processes such as inflammation and cancer. Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2). The high affinity LTD(4) receptor CysLT(1)R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells. In addition, increased expression and nuclear localization of CysLT(1)R correlates with a poorer prognosis for patients with colon cancer

ИНВАЗИВНЫЙ МОНИТОРИНГ СЕРДЕЧНОГО ВЫБРОСА ПО ВРЕМЕНИ ТРАНЗИТА ПУЛЬСОВОЙ ВОЛНЫ ПОСЛЕ АОРТОКОРОНАРНОГО ШУНТИРОВАНИЯ НА РАБОТАЮЩЕМ СЕРДЦЕ

Goal of the study: to evaluate the accuracy of invasive measurement of cardiac output (CO) by pulse wave transit time (PWTT) (esCCO, Japan) compared to transpulmonary thermodilution (TPTD) (PiCCO2 , Germany) after aortocoronary bypass (ACB) without cardiopulmonary bypass (ACB without CPB). Methods. 21 patients with ACB without CPB were enrolled into the study. During early post-operative period CO was simultaneously registered at eight stages basing on PWTT (COPWTT) and TPTD (COTPTD). Statistic analysis included evaluation of congruence of CO absolute values and capability to follow-up changes in CO. Results. In accordance with Bland-Altman analysis the average difference between two methods made 0.3 l/min. with consistency limits of ± 2.1 l/min. and percent error of 40%. Polar chart analysis showed the angular difference of 2.6°, radial consistency limits ± 53.3° and polar concordance of 69%. Conclusion: Lower repeatability of CO measurement by PWTT and insufficient capability to follow the changes in CO after ACB without CPB don not allow recommending this method in its invasive variant for routine practice as an alternative to thermodilution methods.  Цель исследования: оценка точности инвазивного измерения сердечного выброса (СВ) по времени транзита пульсовой волны (ВТПВ) (esCCO, Япония) в сравнении с методом транспульмональной термодилюции (ТПТД) (PiCCO2 , Германия) после аортокоронарного шунтирования (АКШ) без искусственного кровообращения (АКШ без ИК). Методы. В исследование включен 21 пациент после АКШ без ИК. В раннем послеоперационном периоде на восьми этапах выполняли параллельную регистрацию СВ, определенного на основе оценки ВТПВ (СВВТПВ) и ТПТД (СВТПТД). Статистический анализ включал оценку согласованности абсолютных значений СВ и способности отслеживать динамику СВ. Результаты. Согласно анализу Бланда – Альтмана, средняя разница между методами составила 0,3 л/мин с границами согласованности ± 2,1 л/мин и процентной ошибкой 40%. Анализ полярной диаграммы показал угловую разницу 2,6°, радиальные границы согласованности ± 53,3° и полярную конкордантность 69%. Вывод. Низкая воспроизводимость измерения СВ на основе оценки ВТПВ и недостаточная способность отслеживать динамику СВ после АКШ без ИК не позволяют рекомендовать рутинное использование данного метода в его инвазивном варианте в качестве альтернативы термодилюционным методикам.

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1

Ubiquitin chains linked through lysine63 (K63) play a critical role in inflammatory signalling. Following ligand engagement of immune receptors, the RING E3 ligase TRAF6 builds K63-linked chains together with the heterodimeric E2 enzyme Ubc13-Uev1A. Dimerisation of the TRAF6 RING domain is essential for the assembly of K63-linked ubiquitin chains. Here, we show that TRAF6 RING dimers form a catalytic complex where one RING interacts with a Ubc13~Ubiquitin conjugate, while the zinc finger 1 (ZF1) domain and linker-helix of the opposing monomer contact ubiquitin. The RING dimer interface is conserved across TRAFs and we also show that TRAF5–TRAF6 heterodimers form. Importantly, TRAF5 can provide ZF1, enabling ubiquitin transfer from a TRAF6-bound Ubc13 conjugate. Our study explains the dependence of activity on TRAF RING dimers, and suggests that both homo- and heterodimers mediated by TRAF RING domains have the capacity to synthesise ubiquitin chains

Эффективность и безопасность эрибулина при различных подтипах рака молочной железы: данные из реальной клинической практики в России

The article presents a pooled experience of the use of eribulin in the real clinical practice of treatment of metastatic breast cancer in Russian oncological institutions. The effectiveness of the drug in monotherapy with HER2‑negative breast cancer was analyzed, groups of patients with most effective use of eribulin were identified depending on the localization of metastases, the most effective lines of therapy. The effectiveness of the drug in combination with trastuzumab in HER2‑positive breast cancer is described, as well as toxic reactions. В статье представлен обобщенный опыт применения эрибулина в реальной клинической практике онкологических учреждений РФ при метастатическом раке молочной железы. Проанализирована эффективность препарата в монотерапии при HER2-отрицательном раке молочных желез, выделены группы больных в зависимости от локализации метастазов, линии терапии, в которых препарат оказался максимально эффективным. Описана эффективность препарата в комбинации с трастузумабом при HER2-положительном раке молочной железы, а также токсические реакции. 

Session 17 Ecophysiology

n/

The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second independent patient cohort, we analysed the ATG7 V471A polymorphism in additional 1,464 European HD patients of the “REGISTRY” cohort from the European Huntington Disease Network (EHDN). In the entire REGISTRY cohort we could not confirm a modifying effect of the ATG7 V471A polymorphism. However, analysing a modifying effect of ATG7 in these REGISTRY patients and in patients of our previous HD cohort according to their ethnic origin, we identified a significant effect of the ATG7 V471A polymorphism on the HD age at onset only in the Italian population (327 patients). In these Italian patients, the polymorphism is associated with a 6-years earlier disease onset and thus seems to have an aggravating effect. We could specify the role of ATG7 as a genetic modifier for HD particularly in the Italian population. This result affirms the modifying influence of the autophagic pathway on the course of HD, but also suggests population-specific modifying mechanisms in HD pathogenesis

15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Prostaglandin (PG) E(2) (PGE(2)) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE(2) is accomplished by conversion of the cyclooxygenase (COX) product PGH(2) by several terminal prostaglandin E synthases (PGES). Among the known PGES isoforms, microsomal PGES type 1 (mPGES-1) and type 2 (mPGES-2) were found to be overexpressed in colorectal cancer (CRC); however, the role and regulation of these enzymes in this malignancy are not yet fully understood. Here, we report that the cyclopentenone prostaglandins (CyPGs) 15-deoxy-Delta(12,14)-PGJ(2) and PGA(2) downregulate mPGES-2 expression in the colorectal carcinoma cell lines Caco-2 and HCT 116 without affecting the expression of any other PGES or COX. Inhibition of mPGES-2 was subsequently followed by decreased microsomal PGES activity. These effects were mediated via modulation of the cellular thiol-disulfide redox status but did not involve activation of the peroxisome proliferator-activated receptor gamma or PGD(2) receptors. CyPGs had antiproliferative properties in vitro; however, this biological activity could not be directly attributed to decreased PGES activity because it could not be reversed by adding PGE(2). Our data suggest that there is a feedback mechanism between PGE(2) and CyPGs that implicates mPGES-2 as a new potential target for pharmacological intervention in CRC

Application of information technologies in competitive intelligence

Данная работа посвящена практическому применению информационных технологий и инструментов в конкурентной разведки. Понятие конкурентной разведки, цикл разведки и алгоритм процесса конкурентной разведки изучаются. Программное обеспечение для сбора, хранения, обработки и распространения информации рассматривается. Особое внимание уделяется конкурентной разведке в Интернете.This article is dedicated to the practical application of information technologies and tools in competitive intelligence. The concept of competitive intelligence, the intelligence cycle and the algorithm of the process of competitive intelligence are studied. Software for collection, storage, processing and dissemination of information is reviewed. Special attention is given to the competitive intelligence tools on the Internet

Effect of the Solvate Environment of Lithium Cations on the Resistance of the Polymer Electrolyte/Electrode Interface in a Solid-State Lithium Battery

The effect of the composition of liquid electrolytes in the bulk and at the interface with the LiFePO4 cathode on the operation of a solid-state lithium battery with a nanocomposite polymer gel electrolyte based on polyethylene glycol diacrylate and SiO2 was studied. The self-diffusion coefficients on the 7Li, 1H, and 19F nuclei in electrolytes based on LiBF4 and LiTFSI salts in solvents (gamma-butyrolactone, dioxolane, dimethoxyethane) were measured by nuclear magnetic resonance (NMR) with a magnetic field gradient. Four compositions of the complex electrolyte system were studied by high-resolution NMR. The experimentally obtained 1H chemical shifts are compared with those theoretically calculated by quantum chemical modeling. This made it possible to suggest the solvate shell compositions that facilitate the rapid transfer of the Li+ cation at the nanocomposite electrolyte/LiFePO4 interface and ensure the stable operation of a solid-state lithium battery