An eye-tracking study examining information search in transit maps. Using China’s high-speed railway map as a case study

This study investigates the legibility of China’s high-speed railway map through eye-tracking measurement. The information searching process was identified by conducting: (1) Scoping stage – a user performance test and interview to inform the design of the eye-tracking study; (2) In-depth stage – an eye-tracking study. A number of visual design problems with the map have been identified. This research explores user-centered design map solutions and provides detailed design guidance for transit maps. It also demonstrates that eye-tracking is an effective method of evaluating the design quality of a transit map as it can identify design limitations and user needs

Conformational effects on the pro-S hydrogen abstraction reaction in cyclooxygenase-1: an integrated QM/MM and MD study

A key step in the cyclooxygenase reaction cycle of cyclooxygenase 1 (COX-1) is abstraction of the pro-S hydrogen atom of the arachidonic acid by a radical that is formed at the protein residue Tyr-385. Here we investigate this reaction step by a quantum-mechanics/molecular-mechanics approach in combination with molecular-dynamics simulations. The simulations identify the hydrogen abstraction angle as a crucial geometric determinant of the reaction, thus revealing the importance of the cyclooxygenase active site for calculating the potential energy surface of the reaction

Stellar populations of ultraluminous infrared galaxies

Ultraluminous infrared galaxies (ULIRGs) have several types according to dominance of starburst or AGN component. We made stellar population analysis for a sample of 160 ULIRGs to study the evolution of ULIRGs. We found that the dominance of intermediate-age and old stellar populations increases along the sequence of HII-like ULIRGs, Seyfert-HII composite ULIRGs, and Seyfert 2 ULIRGs. Consequently the typical mean stellar age and the stellar mass increase along the sequence. Comparing the gas mass estimated from the CO measurements with the stellar mass estimated from the optical spectra, we found that gas fraction is anti-correlated with the stellar mass. HII-like ULIRGs with small stellar masses do not possess enough gas and the total mass, and therefore have no evolution connections with massive Seyfert 2 ULIRGs. Only massive ULIRGs may follow the evolution sequence toward AGNs, and massive HII-like ULIRGs are probably in an earlier stage of the sequence.Comment: 8 pages, 10 figures, 1 table. Accepted by Ap

A Catalog of Luminous Infrared Galaxies in the IRAS Survey and the Second Data Release of the SDSS

We select the Luminous Infrared Galaxies by cross-correlating the Faint Source Catalogue (FSC) and Point Source Catalogue (PSC) of the IRAS Survey with the Second Data Release of the SDSS for studying their infrared and optical properties. The total number of our sample is 1267 for FSC and 427 for PSC by using 2$\sigma$ significance level cross-section. The "likelihood ratio" method is used to estimate the sample's reliability and for a more reliable subsample (908 for FSC and 356 for PSC) selection. Then a Catalog with both the infrared, optical and radio informations is presented and will be used in further works. Some statistical results show that the Luminous Infrared Galaxies are quite different from the Ultra-Luminous Infrared Galaxies. The AGN fractions of galaxies with different infrared luminosities and the radio to infrared correlations are consist with previous studies.Comment: 15 pages, 11 figures. Accepted by ChJAA. Reference adde

Spitzer 70 and 160-micron Observations of the COSMOS Field

We present Spitzer 70 and 160 micron observations of the COSMOS Spitzer survey (S-COSMOS). The data processing techniques are discussed for the publicly released products consisting of images and source catalogs. We present accurate 70 and 160 micron source counts of the COSMOS field and find reasonable agreement with measurements in other fields and with model predictions. The previously reported counts for GOODS-North and the extragalactic First Look Survey are updated with the latest calibration, and counts are measured based on the large area SWIRE survey to constrain the bright source counts. We measure an extragalactic confusion noise level of sigma_c = 9.4+/-3.3 mJy (q=5) for the MIPS 160-micron band based on the deep S-COSMOS data and report an updated confusion noise level of sigma_c = 0.35+/-0.15 mJy (q=5) for the MIPS 70-micron band.Comment: Accepted AJ, 15 Aug. 2009. Data available at http://spider.ipac.caltech.edu/staff/frayer/mycosmos/ until released by IRS

Communication style and exercise compliance in physiotherapy (CONNECT). A cluster randomized controlled trial to test a theory-based intervention to increase chronic low back pain patients’ adherence to physiotherapists’ recommendations: study rationale, design, and methods

Physical activity and exercise therapy are among the accepted clinical rehabilitation guidelines and are recommended self-management strategies for chronic low back pain. However, many back pain sufferers do not adhere to their physiotherapist’s recommendations. Poor patient adherence may decrease the effectiveness of advice and home-based rehabilitation exercises. According to self-determination theory, support from health care practitioners can promote patients’ autonomous motivation and greater long-term behavioral persistence (e.g., adherence to physiotherapists’ recommendations). The aim of this trial is to assess the effect of an intervention designed to increase physiotherapists’ autonomy-supportive communication on low back pain patients’ adherence to physical activity and exercise therapy recommendations. \ud \ud This study will be a single-blinded cluster randomized controlled trial. Outpatient physiotherapy centers (N =12) in Dublin, Ireland (population = 1.25 million) will be randomly assigned using a computer-generated algorithm to either the experimental or control arm. Physiotherapists in the experimental arm (two hospitals and four primary care clinics) will attend eight hours of communication skills training. Training will include handouts, workbooks, video examples, role-play, and discussion designed to teach physiotherapists how to communicate in a manner that promotes autonomous patient motivation. Physiotherapists in the waitlist control arm (two hospitals and four primary care clinics) will not receive this training. Participants (N = 292) with chronic low back pain will complete assessments at baseline, as well as 1 week, 4 weeks, 12 weeks, and 24 weeks after their first physiotherapy appointment. Primary outcomes will include adherence to physiotherapy recommendations, as well as low back pain, function, and well-being. Participants will be blinded to treatment allocation, as they will not be told if their physiotherapist has received the communication skills training. Outcome assessors will also be blinded. \ud \ud We will use linear mixed modeling to test between arm differences both in the mean levels and the rates of change of the outcome variables. We will employ structural equation modeling to examine the process of change, including hypothesized mediation effects. \ud \ud This trial will be the first to test the effect of a self-determination theory-based communication skills training program for physiotherapists on their low back pain patients’ adherence to rehabilitation recommendations. Current Controlled Trials ISRCTN63723433\u

Mid-Infrared Spectroscopic Properties of Ultra-Luminous Infrared Quasars

We analyse mid-infrared (MIR) spectroscopic properties for 19 ultra-luminous infrared quasars (IR QSOs) in the local universe based on the spectra from the Infrared Spectrograph on board the Spitzer Space Telescope. The MIR properties of IR QSOs are compared with those of optically-selected Palomar-Green QSOs (PG QSOs) and ultra-luminous infrared galaxies (ULIRGs). The average MIR spectral features from ~ 5 to 30um, including the spectral slopes, 6.2um PAH emission strengths and [NeII] 12.81um luminosities of IR QSOs, differ from those of PG QSOs. In contrast, IR QSOs and ULIRGs have comparable PAH and [NeII] luminosities. These results are consistent with IR QSOs being at a transitional stage from ULIRGs to classical QSOs. We also find that the colour index alpha(30, 15) is a good indicator of the relative contribution of starbursts to AGNs for all QSOs. Correlations between the [NeII] 12.81um and PAH 6.2um luminosities and those between the [NeII], PAH with 60um luminosities for ULIRGs and IR QSOs indicate that both [NeII] and PAH luminosities are approximate star formation rate indicators for IR QSOs and starburst-dominated galaxies; the scatters are, however, quite large (~ 0.7 to 0.8 dex). Finally the correlation between the EW(PAH 6.2um) and outflow velocities suggests that star formation activities are suppressed by feedback from AGNs and/or supernovae.Comment: 19 pages, 8 figures, 6 tables, accepted for publication in MNRA

An XMM-Newton Observation of the Massive Edge-on Sb Galaxy NGC 2613

We present an XMM-Newton observation of the massive edge-on Sb galaxy NGC 2613. We discover that this galaxy contains a deeply embedded active nucleus with a 0.3-10 keV luminosity of 3.3x10^40 erg/s and a line-of-sight absorption column of 1.2x10^23 cm^-2. Within the 25 mag/arcsec^2 optical B-band isophote of the galaxy, we detect an additional 4 sources with an accumulated luminosity of 4.3x10^39 erg/s. The bulk of the unresolved X-ray emission spatially follows the near-infrared (NIR) K-band surface brightness distribution; the luminosity ratio L_X/L_K ~ 8x10^-4 is consistent with that inferred from galactic discrete sources. This X-ray-NIR association and the compatibility of the X-ray spectral fit with the expected spectrum of a population of discrete sources suggest that low-mass X-ray binaries (LMXBs) are the most likely emitters of the unresolved emission in the disk region. The remaining unresolved emission is primarily due to extraplanar hot gas. The luminosity of this gas is at least a factor of 10 less than that predicted by recent simulations of intergalactic gas accretion by such a massive galaxy with a circular rotation speed V_c ~ 304 km/s^2 (Toft et al. 2002). Instead, we find that the extraplanar hot gas most likely represents discrete extensions away from the disk, including two ``bubble-like'' features on either side of the nucleus. These extensions appear to correlate with radio continuum emission and, energetically, can be easily explained by outflows from the galactic disk.Comment: 17 pages, accepted by MNRA

Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk

Most breast cancer (BC) risk-associated single-nucleotide polymorphisms (raSNPs) identified in genome-wide association studies (GWAS) are believed to cis-regulate the expression of genes. We hypothesise that cis-regulatory variants contributing to disease risk may be affecting microRNA (miRNA) genes and/or miRNA binding. To test this, we adapted two miRNA-binding prediction algorithms-TargetScan and miRanda-to perform allele-specific queries, and integrated differential allelic expression (DAE) and expression quantitative trait loci (eQTL) data, to query 150 genome-wide significant ( P≤5×10-8 ) raSNPs, plus proxies. We found that no raSNP mapped to a miRNA gene, suggesting that altered miRNA targeting is an unlikely mechanism involved in BC risk. Also, 11.5% (6 out of 52) raSNPs located in 3'-untranslated regions of putative miRNA target genes were predicted to alter miRNA::mRNA (messenger RNA) pair binding stability in five candidate target genes. Of these, we propose RNF115, at locus 1q21.1, as a strong novel target gene associated with BC risk, and reinforce the role of miRNA-mediated cis-regulation at locus 19p13.11. We believe that integrating allele-specific querying in miRNA-binding prediction, and data supporting cis-regulation of expression, improves the identification of candidate target genes in BC risk, as well as in other common cancers and complex diseases.Funding Agency Portuguese Foundation for Science and Technology CRESC ALGARVE 2020 European Union (EU) 303745 Maratona da Saude Award DL 57/2016/CP1361/CT0042 SFRH/BPD/99502/2014 CBMR-UID/BIM/04773/2013 POCI-01-0145-FEDER-022184info:eu-repo/semantics/publishedVersio

Tomato: a crop species amenable to improvement by cellular and molecular methods

Tomato is a crop plant with a relatively small DNA content per haploid genome and a well developed genetics. Plant regeneration from explants and protoplasts is feasable which led to the development of efficient transformation procedures. In view of the current data, the isolation of useful mutants at the cellular level probably will be of limited value in the genetic improvement of tomato. Protoplast fusion may lead to novel combinations of organelle and nuclear DNA (cybrids), whereas this technique also provides a means of introducing genetic information from alien species into tomato. Important developments have come from molecular approaches. Following the construction of an RFLP map, these RFLP markers can be used in tomato to tag quantitative traits bred in from related species. Both RFLP's and transposons are in the process of being used to clone desired genes for which no gene products are known. Cloned genes can be introduced and potentially improve specific properties of tomato especially those controlled by single genes. Recent results suggest that, in principle, phenotypic mutants can be created for cloned and characterized genes and will prove their value in further improving the cultivated tomato.