7,808 research outputs found
Information theory in high energy physics (extensive and nonextensive approach)
The application of information theory approach (both in its extensive and
nonextensive versions) to high energy multiparticle processes is discussed and
confronted with experimental data on e+e- annihilation processes, pp and
\bar{p}p scatterings and heavy ion collisions.Comment: 6 pages - contribution to International Workshop on: Trends and
Perspectives in Extensive and Non-Extensive Statistical Mechanics (in Honour
to the q-60th Birthday of Constantino Tsallis) November 19-21, 2003, Angra
dos Reis, Brazil Small corrections added. To be published in Physica A (2004
Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature. Elevated levels of homocysteine may lead to increased generation of superoxide by a biochemical mechanism involving nitric oxide synthase, and, to a lesser extent, by an increase in the chemical oxidation of homocysteine and other aminothiols in the circulation. The resultant increase in superoxide levels is further amplified by homocysteinedependent alterations in the function of cellular antioxidant enzymes such as cellular glutathione peroxidase or extracellular superoxide dismutase. One direct clinical consequence of elevated vascular superoxide levels is the inactivation of the vasorelaxant messenger nitric oxide, leading to endothelial dysfunction. Scavenging of superoxide anion by either superoxide dismutase or 4,5-dihydroxybenzene 1,3-disulfonate (Tiron) reverses endothelial dysfunction in hyperhomocysteinemic animal models and in isolated aortic rings incubated with homocysteine. Similarly, homocysteineinduced endothelial dysfunction is also reversed by increasing the concentration of the endogenous antioxidant glutathione or overexpressing cellular glutathione peroxidase in animal models of mild hyperhomocysteinemia. Taken together, these findings strongly suggest that the adverse vascular effects of homocysteine are at least partly mediated by oxidative inactivation of nitric oxide
Pressure balance at the magnetopause: Experimental studies
The pressure balance at the magnetopause is formed by magnetic field and
plasma in the magnetosheath, on one side, and inside the magnetosphere, on the
other side. In the approach of dipole earth's magnetic field configuration and
gas-dynamics solar wind flowing around the magnetosphere, the pressure balance
predicts that the magnetopause distance R depends on solar wind dynamic
pressure Pd as a power low R ~ Pd^alpha, where the exponent alpha=-1/6. In the
real magnetosphere the magnetic filed is contributed by additional sources:
Chapman-Ferraro current system, field-aligned currents, tail current, and
storm-time ring current. Net contribution of those sources depends on
particular magnetospheric region and varies with solar wind conditions and
geomagnetic activity. As a result, the parameters of pressure balance,
including power index alpha, depend on both the local position at the
magnetopause and geomagnetic activity. In addition, the pressure balance can be
affected by a non-linear transfer of the solar wind energy to the
magnetosheath, especially for quasi-radial regime of the subsolar bow shock
formation proper for the interplanetary magnetic field vector aligned with the
solar wind plasma flow.Comment: 8 pages, 2 figure
Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis : analysis of pooled data from the randomized trials SOLO 1 and SOLO 2
Background: Atopic dermatitis (AD) profoundly affects quality of life (QoL). Dupilumab significantly improves clinical outcomes, is well tolerated, and approved to treat inadequately controlled moderate-to-severe AD in adults; however, its effect on patient-reported outcomes (PROs) is not fully characterized. Objective: To evaluate the impact of dupilumab on patient-reported AD symptoms and QoL. Methods: Pooled data were analyzed from two identically designed phase 3 studies, LIBERTY AD SOLO 1 (NCT02277743) and SOLO 2 (NCT02277769), assessing the following PROs: Peak Pruritus Numerical Rating Scale (NRS), Pruritus Categorical Scale, SCORing AD (SCORAD), Dermatology Life Quality Index (DLQI), Patient-Oriented Eczema Measure (POEM), Hospital Anxiety and Depression Scale (HADS), five-dimension EuroQoL questionnaire (EQ-5D), and patient-assessed disease status and treatment effectiveness. Results: Dupilumab rapidly improved (vs. placebo) Peak Pruritus NRS scores by day 2 (p <.05), anxiety and depression (HADS), and QoL (DLQI) by week 2, and maintained through week 16 (p <.0001). At week 16, more dupilumab-treated than placebo-treated patients reported improvement in SCORAD itch and sleep, and no pain/discomfort (EQ-5D) (p <.0001). Limitations: Cultural differences of translated PROs. Conclusion: Dupilumab had a significant, positive impact on AD symptoms, including itch, sleep, pain, anxiety and depression, and QoL in adults with moderate-to-severe AD.Peer reviewe
A Color Mutation Model of Soft Interaction in High Energy Hadronic Collisions
A comprehensive model, called ECOMB, is proposed to describe multiparticle
production by soft interaction. It incorporates the eikonal formalism, parton
model, color mutation, branching and recombination. The physics is conceptually
opposite to the dynamics that underlies the fragmentation of a string. The
partons are present initially in a hadronic collision; they form a single,
large, color-neutral cluster until color mutation of the quarks leads to a
fission of the cluster into two color-neutral subclusters. The mutation and
branching processes continue until only pairs are left in each small
cluster. The model contains self-similar dynamics and exhibits scaling behavior
in the factorial moments. It can satisfactorily reproduce the intermittency
data that no other model has been able to fit.Comment: 24 pages including 11 figures in revtex epsf styl
Estimating the inelasticity with the information theory approach
Using the information theory approach, in both its extensive and nonextensive
versions, we estimate the inelasticity parameter of hadronic reactions
together with its distribution and energy dependence from and
data. We find that the inelasticity remains essentially constant in energy
except for a variation around , as was originally expected.Comment: 14 pages, 8 figures. Misprints correcte
Extreme Food-Plant Specialisation in Megabombus Bumblebees as a Product of Long Tongues Combined with Short Nesting Seasons
© 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/ The attached file is the published version of the article
Information theory approach (extensive and nonextensive) to high energy multiple production processes
We present an overview of information theory approach (both in its extensive
and nonextensive versions) applied to high energy multiparticle production
processes. It will be illustrated by analysis of single particle distributions
measured in proton-proton, proton-antiproton and nuclear collisions. We shall
demonstrate the particular role played by the nonextensivity parameter q in
such analysis as summarizing our knowledge on the fluctuations existed in
hadronizing system.Comment: Presented at NEXT2003 (Second Sardinian Conference on News and
Expectations in Thermostatistics), Villasimius (Cagliari) Italy, 21-28
September 200
Comparison of direct machine parameter optimization versus fluence optimization with sequential sequencing in IMRT of hypopharyngeal carcinoma
Higher order WKB corrections to black hole entropy in brick wall formalism
We calculate the statistical entropy of a quantum field with an arbitrary
spin propagating on the spherical symmetric black hole background by using the
brick wall formalism at higher orders in the WKB approximation. For general
spins, we find that the correction to the standard Bekenstein-Hawking entropy
depends logarithmically on the area of the horizon. Furthermore, we apply this
analysis to the Schwarzschild and Schwarzschild-AdS black holes and discuss our
results.Comment: 21 pages, published versio
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