The epidemiology of irritable bowel syndrome in North America: a systematic review 1

The aim of this study was to systematically review published literature about the prevalence, incidence, and natural history of irritable bowel syndrome (IBS) in North America. Methods : A computer-assisted search of MEDLINE, EMBASE, and Current Contents/Science Edition databases was performed independently by two investigators. Study selection criteria included: 1) North American population-based sample of adults; 2) objective diagnostic criteria for IBS ( i.e. , Rome or Manning criteria); and 3) publication in full manuscript form in English. Eligible articles were reviewed in a duplicate and independent manner. Data extracted were converted into individual tables and presented in descriptive form. Results : The prevalence of IBS in North America ranges from 3% to 20%, with most prevalence estimates ranging from 10% to 15%. The prevalences of diarrhea-predominant and constipation-predominant IBS are both approximately 5%. Published prevalence estimates by gender range from 2:1 female predominance to a ratio of 1:1. Constipation-predominant IBS is more common in female individuals. The prevalence of IBS varies minimally with age. No true population-based incidence studies or natural history studies were found. In one cohort surveyed on two occasions 1 yr apart, 9% of subjects who were free of IBS at baseline reported IBS at follow-up producing an onset rate of 67 per 1000 person-years. In all, 38% of patients meeting criteria for IBS did not meet IBS criteria at 1-yr follow-up. Conclusion : Approximately 30 million people in North America meet the diagnostic criteria for IBS. However, data about the natural history of IBS is quite sparse and renewed efforts should be focused at developing appropriately designed trials of the epidemiology of IBS.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72339/1/j.1572-0241.2002.05913.x.pd

Central concentration of warm and dense molecular gas in a strongly lensed submillimeter galaxy at z=6

We report the detection of the CO(12-11) line emission toward G09-83808 (or H-ATLAS J090045.4+004125), a strongly-lensed submillimeter galaxy at $z = 6.02$, with Atacama Large Millimeter/submillimeter Array observations. Combining previously detected [O III]$\,88\:\mathrm{\mu m}$, [N II]$\,205\:\mathrm{\mu m}$, and dust continuum at 0.6$\:$mm and 1.5$\:$mm, we investigate the physical properties of the multi-phase interstellar medium in G09-83808. A source-plane reconstruction reveals that the region of the CO(12-11) emission is compact ($R_\mathrm{{e, CO}}=0.49^{+0.29}_{-0.19}\,\mathrm{kpc}$) and roughly coincides with that of the dust continuum. Non-local thermodynamic equilibrium radiative transfer modeling of CO spectral-line energy distribution reveals that most of the CO(12-11) emission comes from a warm (kinetic temperature of $T_{\mathrm{kin}}=320\pm170\:$K) and dense ($\log(n_{\mathrm{H2}}/\mathrm{cm^{-3}})=5.4\pm0.6$) gas, indicating that the warm and dense molecular gas is concentrated in the central 0.5-kpc region. The luminosity ratio in G09-83808 is estimated to be $L_\mathrm{{CO(12-11)}} / L_\mathrm{{CO(6-5)}}=1.1\pm0.2$. The high ratio is consistent with those in local active galactic nuclei (AGNs) and $6<z<7$ quasars, the fact of which implies that G09-83808 would be a good target to explore dust-obscured AGNs in the epoch of reionization. In the reconstructed [O III]$\,88\:\mathrm{\mu m}$ and [N II]$\,205\:\mathrm{\mu m}$ cubes, we also find that a monotonic velocity gradient is extending over the central starburst region by a factor of two and that star-forming sub-components exist. High-resolution observations of bright [C II]$\,158\:\mathrm{\mu m}$ line emissions will enable us to characterize the kinematics of a possible rotating disk and the nature of the sub-components.Comment: 13 pages, 11 figures, accepted for publication in PAS

Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1

Sequencing of the complete genome of Anoxybacillus flavithermus reveals enzymes that are required for silica adaptation and biofilm formation

Octahedral molybdenum cluster complexes with aromatic sulfonate ligands

This article describes the synthesis, structures and systematic study of the spectroscopic and redox properties of a series of octahedral molybdenum metal cluster complexes with aromatic sulfonate ligands (nBu4N)2[{Mo6X8}(OTs)6] and (nBu4N)2[{Mo6X8}(PhSO3)6] (where X- is Cl-, Br- or I-; OTs- is p-toluenesulfonate and PhSO3 - is benzenesulfonate). All the complexes demonstrated photoluminescence in the red region and an ability to generate singlet oxygen. Notably, the highest quantum yields (>0.6) and narrowest emission bands were found for complexes with a {Mo6I8}4+ cluster core. Moreover, cyclic voltammetric studies revealed that (nBu4N)2[{Mo6X8}(OTs)6] and (nBu4N)2[{Mo6X8}(PhSO3)6] confer enhanced stability towards electrochemical oxidation relative to corresponding starting complexes (nBu4N)2[{Mo6X8}X6]

What are the fundamental modes of energy transfer and partitioning in the coupled Magnetosphere-Ionosphere system?

The fundamental processes responsible for energy exchange between large-scale electromagnetic fields and plasma are well understood theoretically, but in practice these theories have not been tested. These processes are ubiquitous in all plasmas, especially at the interface between high and low beta plasmas in planetary magnetospheres and other magnetic environments. Although such boundaries pervade the plasma Universe, the processes responsible for the release of the stored magnetic and thermal plasma energy have not been fully identified and the importance of the relative impact of each process is unknown. Despite advances in understanding energy release through the conversion of magnetic to kinetic energy in magnetic reconnection, how the extreme pressures in the regions between stretched and more relaxed field lines in the transition region are balanced and released through adiabatic convection of plasma and fields is still a mystery. Recent theoretical advances and the predictions of large-scale instabilities must be tested. In essence, the processes responsible remain poorly understood and the problem unresolved. The aim of the White Paper submitted to ESA's Voyage 2050 call, and the contents of this paper, is to highlight three outstanding open science questions that are of clear international interest: (i) the interplay of local and global plasma physics processes: (ii) the partitioning during energy conversion between electromagnetic and plasma energy: and (iii) what processes drive the coupling between low and high beta plasmas. We present a discussion of the new measurements and technological advances required from current state-of-the-art, and several candidate mission profiles with which these international high-priority science goals could be significantly advanced.Peer reviewe

Fano resonances in nanoscale structures

Nowadays nanotechnology allows to scale-down various important devices (sensors, chips, fibres, etc), and, thus, opens up new horizon for their applications. Nevertheless, the efficiency most of them is still based on the fundamental physical phenomena, such as resonances. Thus, the understanding of the resonance phenomena will be beneficial. One of the well-known examples is the resonant enhancement of the transmission known as Breit-Wigner resonances, which can be described by a Lorentzian function. But, in many physical systems the scattering of waves involves propagation along different paths, and, as a consequence, results in interference phenomena, where constructive interference corresponds to resonant enhancement and destructive interference to resonant suppression of the transmission. Recently, a variety of experimental and theoretical work has revealed such patterns in different branches of physics. The purpose of this Review is to demonstrate that this kind of resonant scattering is related to the Fano resonances, known from atomic physics. One of the main features of the Fano resonances is the asymmetric profile. The asymmetry comes from the close coexistence of resonant transmission and resonant reflection. Fano successfully explained such a phenomenon in his seminal paper in 1961 in terms of interaction of a discrete (localized) state with a continuum of propagation modes. It allows to describe both resonant enhancement and resonant suppression in a unified manner. All of these properties can be demonstrated in the frame of a very simple model, which will be used throughout the Review to show that resonant reflections observed in different complex systems are indeed closely related to the Fano resonances.Comment: This review paper was submitted to Review of Modern Physics. But all comments are still welcome

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

オミクロンBA.2.86株のウイルス学的特性の解明. 京都大学プレスリリース. 2024-01-30.A comprehensive systematic characterization of the SARS-CoV-2 strain BA.2.86. 京都大学プレスリリース. 2024-01-31.In late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct SARS-CoV-2 lineage, the BA.2.86 variant, also emerged. BA.2.86 is phylogenetically distinct from other Omicron sublineages, accumulating over 30 amino acid mutations in its spike protein. Here, we examined the virological characteristics of the BA.2.86 variant. Our epidemic dynamics modeling suggested that the relative reproduction number of BA.2.86 is significantly higher than that of EG.5.1. Additionally, four clinically available antivirals were effective against BA.2.86. Although the fusogenicity of BA.2.86 spike is similar to that of the parental BA.2 spike, the intrinsic pathogenicity of BA.2.86 in hamsters was significantly lower than that of BA.2. Since the growth kinetics of BA.2.86 are significantly lower than those of BA.2 both in vitro and in vivo, the attenuated pathogenicity of BA.2.86 is likely due to its decreased replication capacity. These findings uncover the features of BA.2.86, providing insights for control and treatment

One-Step Detection of the 2009 Pandemic Influenza A(H1N1) Virus by the RT-SmartAmp Assay and Its Clinical Validation

<div><h3>Background</h3><p>In 2009, a pandemic (pdm) influenza A(H1N1) virus infection quickly circulated globally resulting in about 18,000 deaths around the world. In Japan, infected patients accounted for 16% of the total population. The possibility of human-to-human transmission of highly pathogenic novel influenza viruses is becoming a fear for human health and society.</p> <h3>Methodology</h3><p>To address the clinical need for rapid diagnosis, we have developed a new method, the “RT-SmartAmp assay”, to rapidly detect the 2009 pandemic influenza A(H1N1) virus from patient swab samples. The RT-SmartAmp assay comprises both reverse transcriptase (RT) and isothermal DNA amplification reactions in one step, where RNA extraction and PCR reaction are not required. We used an exciton-controlled hybridization-sensitive fluorescent primer to specifically detect the HA segment of the 2009 pdm influenza A(H1N1) virus within 40 minutes without cross-reacting with the seasonal A(H1N1), A(H3N2), or B-type (Victoria) viruses.</p> <h3>Results and Conclusions</h3><p>We evaluated the RT-SmartAmp method in clinical research carried out in Japan during a pandemic period of October 2009 to January 2010. A total of 255 swab samples were collected from outpatients with influenza-like illness at three hospitals and eleven clinics located in the Tokyo and Chiba areas in Japan. The 2009 pdm influenza A(H1N1) virus was detected by the RT-SmartAmp assay, and the detection results were subsequently compared with data of current influenza diagnostic tests (lateral flow immuno-chromatographic tests) and viral genome sequence analysis. In conclusion, by the RT-SmartAmp assay we could detect the 2009 pdm influenza A(H1N1) virus in patients' swab samples even in early stages after the initial onset of influenza symptoms. Thus, the RT-SmartAmp assay is considered to provide a simple and practical tool to rapidly detect the 2009 pdm influenza A(H1N1) virus.</p> </div