3,257 research outputs found
Multi-objective optimization of semi-submersible platforms using particle swam optimization algorithm based on surrogate model
An Innovative Semi-submersible platform Optimization Program (ISOP) has been developed to solve the multi-objective optimization problem for semi-submersible platforms (SEMI). Three types of SEMIs, including semi-submersible floating production unit (SEMI FPU), heave and vortex induced motion (VIM) suppressed semi-submersible (HVS) and semi-submersible floating drilling unit (SEMI FDU) are selected for case studies. The hydrodynamic performances of three types of semi-submersible platforms are analyzed by using panel method and Morison's equation. In order to improve the computing efficiency, the hydrodynamic performances for different hull forms during optimization process are estimated by the surrogate models, which are built by artificial neural network prediction method and Inverse Multi-Quadric (IMQ) radial basis function (RBF). The accuracy of surrogate models is ensured by performing leave-one-out cross validation (LOOCV). The most probable maximum (MPM) heave motion and total weight, representing the safety and economy, respectively, are chosen as the two objectives for optimization. The transverse metacentric height, the MPM surge motion, and the most probable minimum (MPMin) airgap are selected as constraints. Based on surrogate models, multi-objective particle swarm optimization (MOPSO) is employed to search for the Pareto-optimal solutions. A Computational Fluid Dynamics (CFD) tool is adopted to validate the proposed model for the prediction of the motion responses. By comparing the obtained Pareto-optimal solutions with the initial design using simple panel method plus Morison's equation, it is confirmed that the MPM heave motions for SEMI FPU, HVS and SEMI FDU can be suppressed by up to 12.68%, 11.92%, and 14.96%, respectively, and the total weights can be reduced by up to 12.16%, 13.00%, and 24.91%, respectively. Through the detailed analyses of optimization results, the most efficient design strategies for semi-submersible platforms are discussed and proposed
Multi-objective optimization of Tension Leg Platform using evolutionary algorithm based on surrogate model
An Innovative Tension Leg Platform (TLP) Optimization Program, called ITOP, has been developed to solve the multi-objective optimization problem for TLP. We first examine the hydrodynamic behavior of a base TLP for wave headings between 0∘ and 45∘. The numerical results show that the maximum heave and surge motion responses occur in 0∘ wave heading in long-crest waves. It is found that the dynamic tension of No. 8 tendon is larger than the other tendons and reaches its maximum in 45∘ wave heading. It can be attributed to the fact that heave and pitch motions are almost out of phase for wave periods between 10 and 15 s. Because the maximum wave elevation occurs near the northeast column and the vertical motion is very small, the minimum airgap occurs there. Moreover, a surrogate model based on radial basis function (RBF) has been built and adopted to estimate the hydrodynamic performance of TLP. A multi-objective evolutionary algorithm, Non-dominated Sorting Genetic Algorithm II (NSGAII), is employed to find the Pareto-optimal solutions. By comprehensive and systematic computations and analyses, it is revealed that the maximum dynamic tension shows positive correlation with pontoon height and width, but negative correlation with hull draft, column spacing, and column diameter. The most efficient modification strategy for design is proposed to reduce the maximum dynamic tendon tension. According to the strategy, the column spacing, draft, and column diameter should be increased in sequence. By applying this strategy, the maximum dynamic tendon tensions can be reduced while the total weight of the platform is minimized as much as possible
The association between serum phosphorus and common carotid artery intima–media thickness in ischemic stroke patients
PurposeAn elevated concentration of phosphorus is associated with an increased risk of atherosclerosis and cardiovascular diseases. Common carotid artery intima–media thickness (cIMT) is an imaging marker of atherosclerosis. However, data on the relationship between phosphorus and cIMT in ischemic stroke are scarce. We aimed to evaluate the association between serum phosphorus levels and cIMT in patients who had experienced ischemic stroke.Patients and methodsA total of 1,450 ischemic stroke patients were enrolled. Participants were divided into four groups (quartiles) according to baseline serum phosphorus level. Carotid atherosclerosis was identified by measurement of cIMT; abnormal cIMT was defined as a maximum cIMT or mean cIMT ≥ 1 mm. Multivariable logistic regression models were used to assess the association between serum phosphorus level and the presence of abnormal cIMT.ResultsIn the multivariable adjusted analysis, falling into the highest quartile for serum phosphorus (Q4) was associated with a 2.00-fold increased risk of having abnormal maximum cIMT [adjusted odds ratio (OR) 2.00; 95% confidence interval (CI) 1.44–2.79] and a 1.76-fold increased risk of having abnormal mean cIMT (adjusted OR 1.76; 95% CI 1.22–2.53) in comparison to Q1. Furthermore, the association between serum phosphorus and abnormal cIMT was confirmed in analyses treating serum phosphorus as a continuous variable and in subgroup analyses.ConclusionIn acute ischemic stroke patients, baseline elevated serum phosphorus level was found to be independently associated with carotid atherosclerosis, as measured by cIMT
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RpoN (σ54) Is Required for Floc Formation but Not for Extracellular Polysaccharide Biosynthesis in a Floc-Forming Aquincola tertiaricarbonis Strain.
Some bacteria are capable of forming flocs, in which bacterial cells become self-flocculated by secreted extracellular polysaccharides and other biopolymers. The floc-forming bacteria play a central role in activated sludge, which has been widely utilized for the treatment of municipal sewage and industrial wastewater. Here, we use a floc-forming bacterium, Aquincolatertiaricarbonis RN12, as a model to explore the biosynthesis of extracellular polysaccharides and the regulation of floc formation. A large gene cluster for exopolysaccharide biosynthesis and a gene encoding the alternative sigma factor RpoN1, one of the four paralogues, have been identified in floc formation-deficient mutants generated by transposon mutagenesis, and the gene functions have been further confirmed by genetic complementation analyses. Interestingly, the biosynthesis of exopolysaccharides remained in the rpoN1-disrupted flocculation-defective mutants, but most of the exopolysaccharides were secreted and released rather than bound to the cells. Furthermore, the expression of exopolysaccharide biosynthesis genes seemed not to be regulated by RpoN1. Taken together, our results indicate that RpoN1 may play a role in regulating the expression of a certain gene(s) involved in the self-flocculation of bacterial cells but not in the biosynthesis and secretion of exopolysaccharides required for floc formation.IMPORTANCE Floc formation confers bacterial resistance to predation of protozoa and plays a central role in the widely used activated sludge process. In this study, we not only identified a large gene cluster for biosynthesis of extracellular polysaccharides but also identified four rpoN paralogues, one of which (rpoN1) is required for floc formation in A. tertiaricarbonis RN12. In addition, this RpoN sigma factor regulates the transcription of genes involved in biofilm formation and swarming motility, as previously shown in other bacteria. However, this RpoN paralogue is not required for the biosynthesis of exopolysaccharides, which are released and dissolved into culture broth by the rpoN1 mutant rather than remaining tightly bound to cells, as observed during the flocculation of the wild-type strain. These results indicate that floc formation is a regulated complex process, and other yet-to-be identified RpoN1-dependent factors are involved in self-flocculation of bacterial cells via exopolysaccharides and/or other biopolymers
Measurement of Trace I-129 Concentrations in CsI Powder and Organic Liquid Scintillator with Accelerator Mass Spectrometry
Levels of trace radiopurity in active detector materials is a subject of
major concern in low-background experiments. Procedures were devised to measure
trace concentrations of I-129 in the inorganic salt CsI as well as in organic
liquid scintillator with Accelerator Mass Spectrometry (AMS) which leads to
improvement in sensitivities by several orders of magnitude over other methods.
No evidence of their existence in these materials were observed. Limits of < 6
X 10^{-13} g/g and < 2.6 X 10^{-17} g/g on the contaminations of I-129 in CsI
and liquid scintillator, respectively, were derived.These are the first results
in a research program whose goals are to develop techniques to measure trace
radioactivity in detector materials by AMS.Comment: Proceedings of 10th International Conference on Accelerator Mass
Spectrometr
A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III
We established a method on measuring the \dzdzb mixing parameter for
BESIII experiment at the BEPCII collider. In this method, the doubly
tagged events, with one decays to
CP-eigenstates and the other decays semileptonically, are used to
reconstruct the signals. Since this analysis requires good separation,
a likelihood approach, which combines the , time of flight and the
electromagnetic shower detectors information, is used for particle
identification. We estimate the sensitivity of the measurement of to be
0.007 based on a fully simulated MC sample.Comment: 6 pages, 7 figure
The LAMOST Survey of Background Quasars in the Vicinity of the Andromeda and Triangulum Galaxies -- II. Results from the Commissioning Observations and the Pilot Surveys
We present new quasars discovered in the vicinity of the Andromeda and
Triangulum galaxies with the LAMOST during the 2010 and 2011 observational
seasons. Quasar candidates are selected based on the available SDSS, KPNO 4 m
telescope, XSTPS optical, and WISE near infrared photometric data. We present
509 new quasars discovered in a stripe of ~135 sq. deg from M31 to M33 along
the Giant Stellar Stream in the 2011 pilot survey datasets, and also 17 new
quasars discovered in an area of ~100 sq. deg that covers the central region
and the southeastern halo of M31 in the 2010 commissioning datasets. These 526
new quasars have i magnitudes ranging from 15.5 to 20.0, redshifts from 0.1 to
3.2. They represent a significant increase of the number of identified quasars
in the vicinity of M31 and M33. There are now 26, 62 and 139 known quasars in
this region of the sky with i magnitudes brighter than 17.0, 17.5 and 18.0
respectively, of which 5, 20 and 75 are newly-discovered. These bright quasars
provide an invaluable collection with which to probe the kinematics and
chemistry of the ISM/IGM in the Local Group of galaxies. A total of 93 quasars
are now known with locations within 2.5 deg of M31, of which 73 are newly
discovered. Tens of quasars are now known to be located behind the Giant
Stellar Stream, and hundreds behind the extended halo and its associated
substructures of M31. The much enlarged sample of known quasars in the vicinity
of M31 and M33 can potentially be utilized to construct a perfect astrometric
reference frame to measure the minute PMs of M31 and M33, along with the PMs of
substructures associated with the Local Group of galaxies. Those PMs are some
of the most fundamental properties of the Local Group.Comment: 26 pages, 6 figures, AJ accepte
Computing Optical Properties of Ultra-thin Crystals
An overview is given of recent advances in experimental and theoretical
understanding of optical properties of ultra-thin crystal structures (graphene,
phosphorene, silicene, MoS2, MoSe2 , WS2 , WSe2 , h-AlN, h-BN, fluorographene,
graphane). Ultra-thin crystals are atomically-thick layered crystals that have
unique properties which differ from their 3D counterpart. Because of the
difficulties in the synthesis of few-atom-thick crystal structures, which are
thought to be the main building blocks of future nanotechnology, reliable
theoretical predictions of their electronic, vibrational and optical properties
are of great importance. Recent studies revealed the reliable predictive power
of existing theoretical approaches based on density functional theory (DFT)
Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys
Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment
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