Scalings of Inverse Energy Transfer and Energy Decay in 3-D Decaying Isotropic Turbulence with Non-rotating or Rotating Frame of Reference

Energy development of decaying isotropic turbulence in a 3-D periodic cube with non-rotating or rotating frames of reference is studied through direct numerical simulation using GPU accelerated lattice Boltzmann method. The initial turbulence is isotropic, generated in spectral space with prescribed energy spectrum E(κ)~κm in a range between κmin and κmax. The Taylor microscale Reynolds number Reλ and Rossby number Ro are introduced to characterize the inertial, viscous, and rotational attributes of the system. The focus of this study is on the scalings of early inverse energy transfer and late energy decay in the development of turbulent energy under various conditions through combinations of m, κmin, κmax, Reλ and Ro. First, we demonstrate the validity of the simulation by confirming the quantitative dependence of the decay exponent n on the initial energy spectrum exponent m, at Reλ =255 and Ro=∞, varying the values of m, κmin and κmax. Second, at relatively low Reλ, the decay exponent for different initial spectra statistically fall in respective ranges, all of which agree well with the corresponding analytical predictions. Third, we quantitatively investigate the 3-D inverse energy transfer. Our findings include (i) the exponent of inverse energy transfer spectrum E(κ)~κσ depends on the initial spectrum exponent E(κ) ~ κm: if m<4, σ=m while if m≥4, σ=4; (ii) rotation alters the inverse energy transfer rate when Reλ≤255 and Ro≥0.8; (iii) the energy increase in large scale during inverse energy transfer exhibits a bell shape, the peak of which varies with Reλ and Ro

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solved. METHODS: The level of cytosolic Ca RESULTS: Here, we demonstrated that TNFα induced extracellular Ca CONCLUSIONS: Our study provides the evidence supporting a novel mechanism by which TNFα induces extracellular C

Scalings of Inverse Energy Transfer and Energy Decay in 3-D Decaying Isotropic Turbulence with Non-rotating or Rotating Frame of Reference

Energy development of decaying isotropic turbulence in a 3-D periodic cube with non-rotating or rotating frames of reference is studied through direct numerical simulation using GPU accelerated lattice Boltzmann method. The initial turbulence is isotropic, generated in spectral space with prescribed energy spectrum E(κ)~κm in a range between κmin and κmax. The Taylor microscale Reynolds number Reλ and Rossby number Ro are introduced to characterize the inertial, viscous, and rotational attributes of the system. The focus of this study is on the scalings of early inverse energy transfer and late energy decay in the development of turbulent energy under various conditions through combinations of m, κmin, κmax, Reλ and Ro. First, we demonstrate the validity of the simulation by confirming the quantitative dependence of the decay exponent n on the initial energy spectrum exponent m, at Reλ =255 and Ro=∞, varying the values of m, κmin and κmax. Second, at relatively low Reλ, the decay exponent for different initial spectra statistically fall in respective ranges, all of which agree well with the corresponding analytical predictions. Third, we quantitatively investigate the 3-D inverse energy transfer. Our findings include (i) the exponent of inverse energy transfer spectrum E(κ)~κσ depends on the initial spectrum exponent E(κ) ~ κm: if

Bedform evolution along a submarine canyon in the South China Sea: New insights from an autonomous underwater vehicle survey

Traditional mapping of bedforms in submarine canyons relied on vessel-mounted and towed sensors, but their fine-scale geomorphology and shallow structure requires higher resolution datasets. This study utilizes a high-resolution dataset obtained from an autonomous underwater vehicle, combined with seismic reflection profiles and sediment cores, to analyze bedform sets within a 25.6 km long submarine canyon (canyon C14) in the northern South China Sea. A train of crescent-shaped axial steps, indicative of cyclic steps formed by supercritical turbidity currents, is imaged along the canyon. Axial steps in the upper course show erosional truncations and sub-horizontal reflectors on the lee and stoss sides, respectively, pointing to erosional–depositional cyclic steps formed by confined flows with high erosional capacity. This is facilitated by canyon narrowness and steeper axial gradient. After a transition segment, the lower course widens, with a gentler axial gradient, resulting in increased asymmetry and wavelength of axial steps. Backset bed deposits on the stoss sides of these steps indicate depositional cyclic steps with higher aggradation. Sediment filling, almost padding each cyclic step associated scour suggests the reworking of previously formed bedforms by gravity flows fed by destabilization processes on the canyon sidewalls and upstream lee faces and, possibly, by shelf-edge and uppermost slope spillover into the canyon. At the lowermost course, cyclic steps transition to a furrow field, likely associated to flow velocity reduction facilitated by canyon floor widening and a further decrease in slope gradient. Flow braiding and re-convergence, related to the erosion of fine-grained deposits within the canyon floor, should have played a role to produce furrows under supercritical conditions. This work enhances our understanding of the detailed morphology and shallow relief configuration of bedforms in deep-water submarine canyons, providing insights into their causative processes and evolution

Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex

Dynamic balance of excitation and inhibition is crucial for network stability and cortical processing, but it is unclear how this balance is achieved at different membrane potentials (Vm) of cortical neurons, as found during persistent activity or slow Vm oscillation. Here we report that a Vm-dependent modulation of recurrent inhibition between pyramidal cells (PCs) contributes to the excitation-inhibition balance. Whole-cell recording from paired layer-5 PCs in rat somatosensory cortical slices revealed that both the slow and the fast disynaptic IPSPs, presumably mediated by low-threshold spiking and fast spiking interneurons, respectively, were modulated by changes in presynaptic Vm. Somatic depolarization (>5 mV) of the presynaptic PC substantially increased the amplitude and shortened the onset latency of the slow disynaptic IPSPs in neighboring PCs, leading to a narrowed time window for EPSP integration. A similar increase in the amplitude of the fast disynaptic IPSPs in response to presynaptic depolarization was also observed. Further paired recording from PCs and interneurons revealed that PC depolarization increases EPSP amplitude and thus elevates interneuronal firing and inhibition of neighboring PCs, a reflection of the analog mode of excitatory synaptic transmission between PCs and interneurons. Together, these results revealed an immediate Vm-dependent modulation of cortical inhibition, a key strategy through which the cortex dynamically maintains the balance of excitation and inhibition at different states of cortical activity

An Overview of Recent Development in Composite Catalysts from Porous Materials for Various Reactions and Processes

Catalysts are important to the chemical industry and environmental remediation due to their effective conversion of one chemical into another. Among them, composite catalysts have attracted continuous attention during the past decades. Nowadays, composite catalysts are being used more and more to meet the practical catalytic performance requirements in the chemical industry of high activity, high selectivity and good stability. In this paper, we reviewed our recent work on development of composite catalysts, mainly focusing on the composite catalysts obtained from porous materials such as zeolites, mesoporous materials, carbon nanotubes (CNT), etc. Six types of porous composite catalysts are discussed, including amorphous oxide modified zeolite composite catalysts, zeolite composites prepared by co-crystallization or overgrowth, hierarchical porous catalysts, host-guest porous composites, inorganic and organic mesoporous composite catalysts, and polymer/CNT composite catalysts

Plasmodium falciparum populations from northeastern Myanmar display high levels of genetic diversity at multiple antigenic loci

Levels of genetic diversity of the malaria parasites and multiclonal infections are correlated with transmission intensity. In order to monitor the effect of strengthened malaria control efforts in recent years at the China-Myanmar border area, we followed the temporal dynamics of genetic diversity of three polymorphic antigenic markers msp1, msp2, and glurp in the Plasmodium falciparum populations. Despite reduced malaria prevalence in the region, parasite populations exhibited high levels of genetic diversity. Genotyping 258 clinical samples collected in four years detected a total of 22 PCR size alleles. Multiclonal infections were detected in 45.7% of the patient samples, giving a minimum multiplicity of infection of 1.41. The majority of alleles experienced significant temporal fluctuations through the years. Haplotype diversity based on the three-locus genotypes ranged from the lowest in 2009 at 0.33 to the highest in 2010 at 0.80. Sequencing of msp1 fragments from 36 random samples of five allele size groups detected 13 different sequences, revealing an additional layer of genetic complexity. This study suggests that despite reduced prevalence of malaria infections in this region, the parasite population size and transmission intensity remained high enough to allow effective genetic recombination of the parasites and continued maintenance of genetic diversity

Liver X Receptors as potential therapeutic targets in atherosclerosis

Purpose: Atherosclerosis is the primary independent risk factor of cardiovascular disease, and Liver X Receptors (LXR? and LXR?) activation may play an anti-atherosclerosis effect. In this article, we summarize the current state of knowledge of roles of LXRs in physiology and homeostasis as well as the links between LXR action and atherosclerosis, and discuss the potential therapeutic effects of LXR agonists. Source: A MEDLINE database search was performed to identify relevant articles using the keywords “liver X receptors”, “LXRs”, and “atherosclerosis”. Additional papers were identified by a manual research of the references from the key articles. Principle findings: Both LXR isoforms promote reverse cholesterol transport (RCT) and have anti-inflammatory activity. LXR? is the predominant receptor in the liver regulating triglyceride synthesis. The antiatherosclerotic ability of LXRs makes them attractive targets for drugs for the treatment of cardiovascular disease. However, LXR activation induces lipogenesis and hypertriglyceridemia. The first-generation synthetic ligands of LXR increase hepatic lipogenesis and plasma triglyceride levels. New LXR ligands need to be designed without undesirable side effects. Conclusion: LXR ?-selective agonists and LXR modulators, which act as agonists in macrophages and induce cholesterol efflux while as antagonists of lipogenesis in the liver, are two critical and attractive approaches to treat atherosclerosis and cardiovascular diseases

FK506 treatment in a Long-term chronic rejection rat model of small bowel transplantation

Background: Although acute rejection (AR) can be significantly improved by effective immunosuppressants, such as FK506, chronic rejection (CR) remains a major hurdle to long-term allograft survival after small bowel transplantation, in part because the pathogenic mechanisms of CR are, as yet, unknown. The rat orthotopic small bowel transplantation (OSBT) model has been used by a few researchers, but without long-term survival. Methods: Rats were randomly divided into five groups: Group 1 (n=20), sham-operation rats; Group 2 (n=20), Lewis to Lewis; Group 3 (n=20), F344 to Lewis treated with FK506 (0.3 mg/kg/day); Group 4 (n=20), F344 to Lewis with FK506 (0.5 mg/kg/day); Group 5 (n=20), F344 to Lewis with FK506 (1.0 mg/kg/day). FK506 was administrated intramuscularly to recipients on postoperative days (POD) 0-13, 20 and 27. Body weight, survival rate and histology were measured. Results: Histopathological analysis revealed distinctive abnormalities of the allograft for all animals, including changes in villous architecture, interstitial fibrosis and intimal thickening; however, survival times were significantly increased with higher doses of FK506. Rats in Group 3 and Group 4 (low and moderate FK506 doses) survived 16-18 weeks, while recipients in Group 5 (high dose) survived 24-27 weeks. Conclusion: FK506 treatment (1.0 mg/kg/day, intramuscularly administrated to recipients on POD0-13, 20 and 27) can be used effectively to establish a rat OBST model of CR that will be useful for the study of the pathogenesis of CR and the effectiveness of various drugs