Excision boundary conditions for black hole initial data

We define and extensively test a set of boundary conditions that can be applied at black hole excision surfaces when the Hamiltonian and momentum constraints of general relativity are solved within the conformal thin-sandwich formalism. These boundary conditions have been designed to result in black holes that are in quasiequilibrium and are completely general in the sense that they can be applied with any conformal three-geometry and slicing condition. Furthermore, we show that they retain precisely the freedom to specify an arbitrary spin on each black hole. Interestingly, we have been unable to find a boundary condition on the lapse that can be derived from a quasiequilibrium condition. Rather, we find evidence that the lapse boundary condition is part of the initial temporal gauge choice. To test these boundary conditions, we have extensively explored the case of a single black hole and the case of a binary system of equal-mass black holes, including the computation of quasi-circular orbits and the determination of the inner-most stable circular orbit. Our tests show that the boundary conditions work well.Comment: 23 pages, 23 figures, revtex4, corrected typos, added reference, minor content changes including additional post-Newtonian comparison. Version accepted by PR

Manipulating gene expression for the metabolic engineering of plants

Introducing and expressing foreign genes in plants present many technical challenges that are not encountered with microbial systems. This review addresses the variety of issues that must be considered and the variety of options that are available, in terms of choosing transformation systems and designing recombinant transgenes to ensure appropriate expression in plant cells. Tissue specificity and proper developmental regulation, as well as proper subcellular localization of products, must be dealt with for successful metabolic engineering in plants

Collisions of boosted black holes: perturbation theory prediction of gravitational radiation

We consider general relativistic Cauchy data representing two nonspinning, equal-mass black holes boosted toward each other. When the black holes are close enough to each other and their momentum is sufficiently high, an encompassing apparent horizon is present so the system can be viewed as a single, perturbed black hole. We employ gauge-invariant perturbation theory, and integrate the Zerilli equation to analyze these time-asymmetric data sets and compute gravitational wave forms and emitted energies. When coupled with a simple Newtonian analysis of the infall trajectory, we find striking agreement between the perturbation calculation of emitted energies and the results of fully general relativistic numerical simulations of time-symmetric initial data.Comment: 5 pages (RevTex 3.0 with 3 uuencoded figures), CRSR-107

Ca2+/Calmodulin-Dependent Kinase Kinase α Is Expressed by Monocytic Cells and Regulates the Activation Profile

Macrophages are capable of assuming numerous phenotypes in order to adapt to endogenous and exogenous challenges but many of the factors that regulate this process are still unknown. We report that Ca2+/calmodulin-dependent kinase kinase α (CaMKKα) is expressed in human monocytic cells and demonstrate that its inhibition blocks type-II monocytic cell activation and promotes classical activation. Affinity chromatography with paramagnetic beads isolated an approximately 50 kDa protein from nuclear lysates of U937 human monocytic cells activated with phorbol-12-myristate-13-acetate (PMA). This protein was identified as CaMKKα by mass spectrometry and Western analysis. The function of CaMKKα in monocyte activation was examined using the CaMKKα inhibitors (STO-609 and forskolin) and siRNA knockdown. Inhibition of CaMKKα, enhanced PMA-dependent CD86 expression and reduced CD11b expression. In addition, inhibition was associated with decreased translocation of CaMKKα to the nucleus. Finally, to further examine monocyte activation profiles, TNFα and IL-10 secretion were studied. CaMKKα inhibition attenuated PMA-dependent IL-10 production and enhanced TNFα production indicating a shift from type-II to classical monocyte activation. Taken together, these findings indicate an important new role for CaMKKα in the differentiation of monocytic cells

Can a combination of the conformal thin-sandwich and puncture methods yield binary black hole solutions in quasi-equilibrium?

We consider combining two important methods for constructing quasi-equilibrium initial data for binary black holes: the conformal thin-sandwich formalism and the puncture method. The former seeks to enforce stationarity in the conformal three-metric and the latter attempts to avoid internal boundaries, like minimal surfaces or apparent horizons. We show that these two methods make partially conflicting requirements on the boundary conditions that determine the time slices. In particular, it does not seem possible to construct slices that are quasi-stationary and avoid physical singularities and simultaneously are connected by an everywhere positive lapse function, a condition which must obtain if internal boundaries are to be avoided. Some relaxation of these conflicting requirements may yield a soluble system, but some of the advantages that were sought in combining these approaches will be lost.Comment: 8 pages, LaTeX2e, 2 postscript figure

Cervical, Thoracic, and Spinopelvic Compensation After Proximal Junctional Kyphosis (PJK): Does Location of PJK Matter?

Study Design:Retrospective case series. Objective:Compensatory changes above a proximal junctional kyphosis (PJK) have not been defined. Understanding these mechanisms may help determine optimal level selection when performing revision for PJK. This study investigates how varying PJK location changes proximal spinal alignment. Methods:Patients were grouped by upper instrumented vertebrae (UIV): lower thoracic (LT; T8-L1) or upper thoracic (UT; T1-7). Alignment parameters were compared. Correlation analysis was performed between PJK magnitude and global/cervical alignment. Results:A total of 369 patients were included; mean age of 63 years, body mass index 28, and 81% female, LT (n = 193) versus UT (n = 176). The rate of radiographic PJK was 49%, higher in the LT group (55% vs 42%, P = .01). The UT group displayed significant differences in all cervical radiographic parameters (P < .05) between PJK versus non-PJK patients, while the LT group displayed significant differences in T1S and C2-T3 sagittal vertical axis (SVA) (CTS). In comparing UT versus LT patients, UT had more posterior global alignment (smaller TPA [T1 pelvic angle], SVA, and larger PT [pelvic tilt]) and larger anterior cervical alignment (greater cSVA [cervical SVA], T1S-CL [T1 slope-cervical lordosis] mismatch, CTS) compared to LT. Correlation analysis of PJK magnitude and location demonstrated a correlation with increases in CL, T1S, and CTS in the UT group. In the LT group, PT increased with PJK angle (r = 0.17) and no significant correlations were noted to SVA, cSVA, or T1S-CL. Conclusions:PJK location influences compensation mechanisms of the cervical and thoracic spine. LT PJK results in increased PT and CL with decreased CTS. UT PJK increases CL to counter increases in T1S with continued T1S-CL mismatch and elevated cSVA

The Lopsidedness of Present-Day Galaxies: Connections to the Formation of Stars, the Chemical Evolution of Galaxies, and the Growth of Black Holes

We have used the Sloan Digital Sky Survey (SDSS) to undertake an investigation of lopsidedness in a sample of ~25,000 nearby galaxies (z < 0.06). We use the m=1 azimuthal Fourier mode between the 50% and 90% light radii as our measure of lopsidedness. The SDSS spectra are used to measure the properties of the stars, gas, and black hole in the central-most few-kpc-scale region. We show that there is a strong link between lopsidedness in the outer parts of the galactic disk and the youth of the stellar population in the central region. This link is independent of the other structural properties of the galaxy. These results provide a robust statistical characterization of the connections between accretion/interactions/mergers and the resulting star formation. We also show that residuals in the galaxy mass-metallicity relation correlate with lopsidedness (at fixed mass, the more metal-poor galaxies are more lopsided). This suggests that the events causing lopsidedness and enhanced star formation deliver lower metallicity gas into the galaxy's central region. Finally, we find that there is a trend for the more powerful active galactic nuclei to be hosted by more lopsided galaxies (at fixed galaxy mass, density, or concentration). However if we compare samples matched to have both the same structures and central stellar populations, we then find no difference in lopsidedness between active and non-active galaxies. This leads to the following picture. The presence of cold gas in the central region of a galaxy (irrespective of its origin) is essential for both star-formation and black hole growth. The delivery of cold gas is aided by the processes that produce lopsidedness. Other processes on scales smaller than we can probe with our data are required to transport the gas to the black hole.Comment: 39 pages, 16 figures, 3 tables, accepted to ApJ. Updated author affiliation

A Large, Uniform Sample of X-ray Emitting AGN from the ROSAT All-Sky and Sloan Digital Sky Surveys: the Data Release 5 Sample

We describe further results of a program aimed to yield ~10^4 fully characterized optical identifications of ROSAT X-ray sources. Our program employs X-ray data from the ROSAT All-Sky Survey (RASS), and both optical imaging and spectroscopic data from the Sloan Digital Sky Survey (SDSS). RASS/SDSS data from 5740 deg^2 of sky spectroscopically covered in SDSS Data Release 5 (DR5) provide an expanded catalog of 7000 confirmed quasars and other AGN that are probable RASS identifications. Again in our expanded catalog, the identifications as X-ray sources are statistically secure, with only a few percent of the SDSS AGN likely to be randomly superposed on unrelated RASS X-ray sources. Most identifications continue to be quasars and Seyfert 1s with 15<m<21 and 0.01<z<4; but the total sample size has grown to include very substantial numbers of even quite rare AGN, e.g., now including several hundreds of candidate X-ray emitting BL Lacs and narrow-line Seyfert 1 galaxies. In addition to exploring rare subpopulations, such a large total sample may be useful when considering correlations between the X-ray and the optical, and may also serve as a resource list from which to select the "best" object (e.g., X-ray brightest AGN of a certain subclass, at a preferred redshift or luminosity) for follow-on X-ray spectral or alternate detailed studies.Comment: Accepted for publication in AJ; 32 pages, including 11 figures, and 6 example table

Comparing initial-data sets for binary black holes

We compare the results of constructing binary black hole initial data with three different decompositions of the constraint equations of general relativity. For each decomposition we compute the initial data using a superposition of two Kerr-Schild black holes to fix the freely specifiable data. We find that these initial-data sets differ significantly, with the ADM energy varying by as much as 5% of the total mass. We find that all initial-data sets currently used for evolutions might contain unphysical gravitational radiation of the order of several percent of the total mass. This is comparable to the amount of gravitational-wave energy observed during the evolved collision. More astrophysically realistic initial data will require more careful choices of the freely specifiable data and boundary conditions for both the metric and extrinsic curvature. However, we find that the choice of extrinsic curvature affects the resulting data sets more strongly than the choice of conformal metric.Comment: 18 pages, 12 figures, accepted for publication in Phys. Rev.

CGCG 292-057 - a radio galaxy with merger-modulated radio activity

We announce the discovery of a unique combination of features in a radio source identified with the merger galaxy CGCG 292-057. The radio galaxy both exhibits a highly complex, X-like structure and shows signs of recurrent activity in the form of double-double morphology. The outer lobes of CGCG 292-057 are characterized by low radio power, P_{1400MHz} \simeq 2 * 10^{24} W\Hz^{-1}, placing this source below the FRII/FRI luminosity threshold, and are highly polarized (almost 20 per cent at 1400 MHz) as is typical of X-shaped radio sources. The host is a LINER-type galaxy with a relatively low black hole mass and double-peaked narrow emission lines. These features make this galaxy a primary target for studies of merger-triggered radio activity.Comment: 7 pages, 5 figures, submitted to MNRA