LA INTEGRACIÓN DE LAS TIC EN LA PRÁCTICA PEDAGÓGICA DE UN GRUPO DE DOCENTES DE LA CORPORACIÓN TECNOLÓGICA EMPRESARIAL.

El objetivo principal de este trabajo es comprender la integración de las TIC en las prácticas pedagógicas de un grupo de docentes de la Corporación Tecnológica Empresarial como apoyo a la docencia.Universidad de San Buenaventura Sede Bogot

La comunicación integrada de marketing, pilar fundamental en la creación de relaciones de valor con el cliente

El presente estudio de investigación se realizó en la empresa ALVESA, dedicada a la producción y comercialización de productos médico-veterinarios, el objetivo de la investigación es analizar la gestión comunicacional llevada a cabo por la organización. Se aplicó un enfoque cualicuantitativo, los tipos de investigación utilizadas fueron bibliográfica y descriptiva, apoyada en los métodos inductivo-deductivo y analítico-sintético y deductivo; las técnicas utilizadas para recopilar información primaria corresponden a la encuesta aplicada a los clientes detallistas y la entrevista dirigida al nivel directivo. Los hallazgos de la investigación evidenciaron áreas de oportunidad que inciden en el cumplimiento de los objetivos organizacionales, es así que no existe un proceso comunicacional adecuado que posibilite el fortalecimiento de las relaciones entre la empresa y sus clientes, así como la deficiente atención otorgada a los mismos en el proceso de postventa, debilidades con el uso de las redes sociales y la página web de la empresa. Para superar dichas falencias, es imperiosa la necesidad de diseñar una mezcla de estrategias comunicacionales, diseñada sobre el conocimiento de la situación actual de la empresa y el mercado, con la finalidad de generar identidad y proyectar una imagen favorable hacia su público objetivo y actores de interés en aras de obtener mejores resultados en la relación de la empresa-clientes para alcanzar así los objetivos estratégicos establecidos por la organización

Estrategias de comunicación para mejorar el posicionamiento de la cooperativa de ahorro y crédito “San Jorge” Ltda.

La presente investigación tiene como objetivo fundamental mejorar el nivel de posicionamiento de la Cooperativa de Ahorro y Crédito “San Jorge” Ltda., en la ciudad de Riobamba, a partir del diagnóstico en el que se han contemplado aspectos de decisión valorados por los clientes actuales y potenciales de la cooperativa.  Para el logro de dicho objetivo, la investigación recoge las principales teorías, enfoques teóricos relacionados al posicionamiento y comunicación que permiten sustentar la propuesta; respecto al marco metodológico se empleó un enfoque cuali- cuantitativo, se aplicó una investigación de tipo descriptivo apoyada en los métodos analítico sintético, inductivo y deductivo. Los resultados obtenidos en la investigación determinan las preferencias de la población objeto de estudio en torno a los criterios considerados al elegir una institución financiera en los que se destacan la solvencia, seguridad y confianza, el bajo nivel de conocimiento de la institución, probabilidad de interesarse en los productos y servicios ofertados por la cooperativa, principales medios de comunicación utilizados; hallazgos que constituyen el insumo para el diseño de las estrategias de comunicación, su ejecución aportaron resultados positivos, evidenciados en el incremento de las captaciones de socios y clientes, colocaciones de crédito de consumo y microcrédito, conocimiento y recordación de marca

Relación entre el estreñimiento y la calidad de vida de las personas en tratamiento renal sustitutivo con hemodiálisis

Introducción: El estreñimiento es un problema frecuente en pacientes en hemodiálisis, asociado, entre otros aspectos a comorbilidad, polimedicación y restricciones hídricas y dietéticas, pudiendo llegar a afectar la calidad de vida. Objetivos: Analizar la relación del estreñimiento en la calidad de vida de pacientes en hemodiálisis, determinar la prevalencia del estreñimiento objetivo y subjetivo, y analizar las variables más influyentes. Material y Método: Estudio observacional descriptivo transversal en una unidad de hemodiálisis hospitalaria. Se emplearon los Criterios Diagnósticos Roma IV (2016) y escala visual Bristol para evaluar el estreñimiento. Para evaluar la calidad de vida, el cuestionario CVE-20. Resultados: Se estudiaron 38 pacientes (58% hombres) con una edad media de 68,69±12,76 años, tiempo en hemodiálisis de 44±37,19 meses y el 31,57% eran sedentarios. La ingesta hídrica diaria fue de 1004,05±460,13 ml y diuresis 658,11±696,47 ml. El índice de Charlson fue 8,15±2,29 puntos. El 45% presentaron estreñimiento subjetivo y 42% objetivo. Los pacientes con estreñimiento fueron: 56% mujeres, con edad media de 67,81±14,88 años y tiempo en hemodiálisis de 40,06±32,97 meses; 12% tenían pautados opioides, 44% quelantes del fósforo, 56% hierro intravenoso y 25% laxantes. La calidad de vida fue inferior en los pacientes estreñidos (53,06 vs 69,62 puntos); existiendo diferencias significativas en todas las dimensiones del cuestionario. Conclusiones: En los pacientes en hemodiálisis existe una importante prevalencia de estreñimiento, siendo más prevalente en mujeres. Este estreñimiento está asociado a peor percepción de la calidad de vida

Prokaryotic and viral community of the sulfate‐rich crust from Peñahueca ephemeral lake, an astrobiology analogue

Peñahueca is an athalassohaline hypersaline inland ephemeral lake originated under semiarid conditions in the central Iberian Peninsula (Spain). Its chemical composition makes it extreme for microbial life as well as a terrestrial analogue of other planetary environments. To investigate the persistence of microbial life associated with sulfate‐rich crusts, we applied cultivation‐independent methods (optical and electron microscopy, 16S rRNA gene profiling and metagenomics) to describe the prokaryotic community and its associated viruses. The diversity for Bacteria was very low and was vastly dominated by endospore formers related to Pontibacillus marinus of the Firmicutes phylum. The archaeal assemblage was more diverse and included taxa related to those normally found in hypersaline environments. Several ‘metagenome assembled genomes’ were recovered, corresponding to new species of Pontibacillus, several species from the Halobacteria and one new member of the Nanohaloarchaeota. The viral assemblage, although composed of the morphotypes typical of high salt systems, showed little similarity to previously isolated/reconstructed halophages. Several putative prophages of Pontibacillus and haloarchaeal hosts were identified. Remarkably, the Peñahueca sulfate‐rich metagenome contained CRISPR‐associated proteins and repetitions which were over 10‐fold higher than in most hypersaline systems analysed so far.This research was supported by the Spanish Ministry of Economy projects CLG2015_66686-C3-1 (to RRM) CLG2015_66686-C3-3 (to JA), CGL2015-66455-R (to MAGC, MESM, JPRA), AYA2011-24803 and ESP2015-69540-R (to VP) which were also supported by the European Regional Development Fund and the MDM-2017-0737 Unidad de Excelencia “María de Maeztu”- Centro de Astrobiología (INTA-CSIC)

The spatiotemporal dynamics of exposure of wild ungulates to Flavivirus shapes the patterns of West Nile virus outbreaks in Spain

Resumen del póster presentado a la Joint Virtual Conference of the WDA and EWDA, celebrada del 31 de agosto al 2 de septiembre de 2021.West Nile virus (WNV) is a neuropathic virus for humans, horses and birds transmitted by mosquitoes. The recent increase of clinical cases in Spain shows the need to better understand the ecology of this Flavivirus, not only in urban areas, but also where birds, WNV and mosquitoes interact with wild ungulates, to better predict/prevent WNV outbreaks. We analysed the dynamics of exposure of wild ungulates to Flavivirus along 15 years (2005-2019) in a south-to-north gradient in 5 areas where WNV cases occur since 2007. Sera of 2,418 wild ungulates (Cervus elaphus &Sus scrofa) from Doñana National Park (A1), Western Sierra Morena (A2), Central Sierra Morena (A3), Guadiana river Valley (A4) and Toledo Mounts (A5) were analysed with a blocking ELISA highly specific for WNV. Weather conditions were gathered from two climatically and environmentally contrasting areas: i) A1, a thermo-Mediterranean wetland; and ii) A4, a Mediterranean continental forest/shrubland. The risk of Flavivirus exposure of ungulates was modelled with weather covariates (average winter/spring/summer temperatures and annual/winter-spring/spring/summer rainfall) by logistic binary regression. The proportion of exposed ungulates was higher in A1 (33.5%) and A2 (35.3%) than in A3 (18.7%), A4 (20.3%) and A5 (18.7%), shaping the contrasting reported incidence of WNV outbreaks in southern (n=189) and south-central (n=2) Spain. The annual patterns of exposure of ungulates also shaped the temporal emergence of WNV outbreaks. Higher winter temperature associated positively to the risk of exposure in A1 whereas in A4 the risk increased with annual rainfall whereas it decreased with increasing spring precipitation. These preliminary results point out that whereas in wetlands, where water is abundant, smoother winter temperatures better predict WNV circulation, annual rainfall seems to be a better predictor for WNV infection risk in dry continental Mediterranean areas. Wild ungulates additionally prove to be efficient predictors for Flavivirus spatiotemporal dynamics.Peer reviewe

Red deer reveal spatial risks of Crimean-Congo haemorrhagic fever virus infection

In press.Crimean-Congo haemorrhagic fever virus (CCHFV) continues to cause new human cases in Iberia while its spatial distribution and ecological determinants remain unknown. The virus remains active in a silent tick-animal cycle to which animals contribute maintaining the tick populations and the virus itself. Wild ungulates, in particular red deer, are essential hosts for Hyalomma ticks in Iberia, which are the principal competent vector of CCHFV. Red deer could be an excellent model to understand the ecological determinants of CCHFV as well as to predict infection risks for humans because it is large, gregarious, abundant and the principal host for Hyalomma lusitanicum. We designed a cross-sectional study, analysed the presence of CCHFV antibodies in 1444 deer from 82 populations, and statistically modelled exposure risk with host and environmental predictors. The best-fitted statistical model was projected for peninsular Spain to map infection risks. Fifty out of 82 deer populations were seropositive, with individual population prevalence as high as 88%. The highest prevalence of exposure to CCHFV occurred in the southwest of the Iberian Peninsula. Climate and ungulate abundance were the most influential predictors of the risk of exposure to the virus. The highest risk regions were those where H. lusitanicum is most abundant. Eight of the nine primary human cases occurred in or bordering these regions, demonstrating that the model predicts human infection risk accurately. A recent human case of CCHF occurred in northwestern Spain, a region that the model predicted as low risk, pointing out that it needs improvement to capture all determinants of the CCHFV infection risk. In this study, we have been able to identify the main ecological determinants of CCHFV, and we have also managed to create an accurate model to assess the risk of CCHFV infection.This study has been funded by the Spanish Ministry for the Science and Innovation (MCI) through projects CGL2017-89866-R & E-RTA2015-0002-C02-02, and by the Regional Government of Castilla-La Mancha and the European Social Fund (ESF) through project SBPLY/19/180501/000321. RC-M, LC-M, SJ-R and JM-G would like to thank the MCI, ESF and the University of Castilla-La Mancha for their support through contracts PRE2018-083801, PEJ2018-003155-A, 2018/12504 and BES-2015-072206, respectively. BC was supported by FCT-Fundação para a Ciência e Tecnologia (2020.04872.BD). DG-B would like to thank MCI and Instituto de Salud Carlos III (CD19CIII/00011) for funding him.Peer reviewe

Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care

<p>Abstract</p> <p>Background</p> <p>Vaginitis is a common complaint in primary care. In uncomplicated candidal vaginitis, there are no differences in effectiveness between oral or vaginal treatment. Some studies describe that the preferred treatment is the oral one, but a Cochrane's review points out inconsistencies associated with the report of the preferred way that limit the use of such data. Risk factors associated with recurrent vulvovaginal candidiasis still remain controversial.</p> <p>Methods/Design</p> <p>This work describes a protocol of a multicentric prospective observational study with one year follow up, to describe the women's reasons and preferences to choose the way of administration (oral vs topical) in the treatment of not complicated candidal vaginitis. The number of women required is 765, they are chosen by consecutive sampling. All of whom are aged 16 and over with vaginal discharge and/or vaginal pruritus, diagnosed with not complicated vulvovaginitis in Primary Care in Madrid.</p> <p>The main outcome variable is the preferences of the patients in treatment choice; secondary outcome variables are time to symptoms relief and adverse reactions and the frequency of recurrent vulvovaginitis and the risk factors. In the statistical analysis, for the main objective will be descriptive for each of the variables, bivariant analysis and multivariate analysis (logistic regression).. The dependent variable being the type of treatment chosen (oral or topical) and the independent, the variables that after bivariant analysis, have been associated to the treatment preference.</p> <p>Discussion</p> <p>Clinical decisions, recommendations, and practice guidelines must not only attend to the best available evidence, but also to the values and preferences of the informed patient.</p

Ofrendas para una entrada: el depósito ritual de la Puerta Oeste de la Bastida de les Alcusses (Moixent, Valencia).

En este trabajo se dan a conocer los resultados de las excavaciones llevadas a cabo en la Puerta Oeste de la Bastida de les Alcusses entre los años 2010 y 2011. Asociado a una renovación de las estructuras de la entrada y la muralla, se documentó un depósito de varios centenares de objetos incluyendo herrajes, maderas, armas, cerámica, semillas, frutos, fauna y restos constructivos. Presentamos el estudio multidisciplinar de todos los materiales y las varias líneas de interpretación que nos sugiere este extraordinario contexto

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

The Wild-type p53-induced phosphatase 1, Wip1 (or PPM1D), is unusual in that it is a serine/threonine phosphatase with oncogenic activity. A member of the type 2C phosphatases (PP2Cδ), Wip1 has been shown to be amplified and overexpressed in multiple human cancer types, including breast and ovarian carcinomas. In rodent primary fibroblast transformation assays, Wip1 cooperates with known oncogenes to induce transformed foci. The recent identification of target proteins that are dephosphorylated by Wip1 has provided mechanistic insights into its oncogenic functions. Wip1 acts as a homeostatic regulator of the DNA damage response by dephosphorylating proteins that are substrates of both ATM and ATR, important DNA damage sensor kinases. Wip1 also suppresses the activity of multiple tumor suppressors, including p53, ATM, p16INK4a and ARF. We present evidence that the suppression of p53, p38 MAP kinase, and ATM/ATR signaling pathways by Wip1 are important components of its oncogenicity when it is amplified and overexpressed in human cancers