СЕРВІС ДЛЯ ВІДДАЛЕНИХ ТЕЛЕМЕДИЧНИХ КОНСУЛЬТАЦІЙ ІЗ ВИКОРИСТАННЯМ ВІРТУАЛЬНИХ МАШИН У ГРІД

Для вирішення сучасних ресурсоємних завдань у різних галузях науки та техніки академічний ГРІД-сегмент було розвинуто до національного рівня (УНГ). Він увійшов до світових ГРІД-інфраструктур, наприклад EGI, та широко застосовується в прикладних проектах у різних галузях. Так, для завдань медичних популяційних досліджень неінфекційних захворювань з вико ристанням ГРІД-інфраструктури в Україні було створено проект MedGrid. У рамках даного проекту вже проведено роботи щодо накопичення електрокардіограм у форматі SCP на сховищах даних УНГ з реплікацією та проведення масових досліджень накопичених даних. У результаті співпраці з лікарями провідних закладів охорони здоров'я виявилося, що актуальними є завдання проведення аналізу та візуалізації окремих медичних досліджень із можливістю надання віддалених телемедичних консультацій

КЛИНИЧЕСКИЕ И СОЦИАЛЬНЫЕ ФАКТОРЫ РИСКА ТАРДИВНОЙ ДИСКИНЕЗИИ У ПАЦИЕНТОВ С ШИЗОФРЕНИЕЙ В ПРОЦЕССЕ ЛЕЧЕНИЯ АНТИПСИХОТИКАМИ

The purpose of the present work was to study the clinical features and risk factors of tardive dyskinesia among     the     schizophrenia     patients     who     durably     receive     the     antipsychotic     therapy. 180 of the 18 to 65 age bracket schizophrenia patients, who were treated in a residential psychiatric treatment facility, were examined with the use of the Positive and Negative Syndrome Scale (PANSS), Abnormal Involuntary Movement Scale (AIMS), and the basic chart of formalized sociodemographic and clinico-dynamic features developed at the Tomsk Mental Health Research Institute. The acquired data were processed by the Mann–Whitney U-Test and χ2. The average age of the tardive dyskinesia patients  turned out to be conclusively older than that of the patients without this derangement. People who have tardive dyskinesia statistically often happen to be single in comparison with other variants of marital status. It was found out that women happen to have tardive dyskinesia more often, which allows us to see the female gender as a risk factor. The tardive dyskinesia patients had certain negative symptoms. The patients were arranged into groups according to the prepotency of symptom-complexes over the subgroups: with orofacial, thoracolumbar and combined tardive dyskinesia. The average age of the orofacial dyskinesia patients turned out to be conclusively older than that of the patients without tardive dyskinesia. The negative symptoms level in the subgroup was conclusively higher than among those without tardive dyskinesia. The average age of the thoracolumbar dyskinesia patients was conclusively older than that of the patients without tardive dyskinesia. The average age of the combined dyskinesia patients was conclusively older than the patients without the tardive dyskinesia. The patients having schizophrenia for longer than 10 years prevailed in the combined dyskinesia group. Such characteristics as education level and social status, age of when the medical problem started, dominance of the positive symptoms, duration of antipsychotic agents administration, somatic condition, use of psychoactive substances, suicidal and hetero-aggressive behaviors make no contribution to the risk of tardive dyskinesia development in the presence of schizophrenia, and they are not protective factors either.Целью данной работы являлось исследование клинических особенностей и факторов риска возникновения тардивной дискинезии (ТД) у пациентов, страдающих шизофренией и длительно принимающих антипсихотическую терапию.Было обследовано 180 больных шизофренией в возрасте от 18 до 65 лет, проходивших лечение в психиатрических стационарах, с применением Шкалы позитивного и негативного синдромов (Positive and Negative Syndrome Scale – PANSS), Шкалы патологических непроизвольных движений (Abnormal Involuntary Movement Scale – AIMS), а также с использованием базисной карты формализованных социодемографических и клинико-динамических признаков, разработанной в НИИ психического здоровья (г. Томск). Достоверность статистических различий оценивалась с помощью U-критерия Манна–Уитни и χ2.Средний возраст больных с ТД оказался достоверно выше, чем у пациентов без данного нарушения. Лица с ТД статистически значимо чаще являются холостыми в сравнении с остальными вариантами семейного положения. Тардивная дискинезия достоверно чаще встречалась у женщин, что позволяет рассматривать женский пол как фактор риска ее развития. У больных с ТД достоверно преобладала негативная симптоматика. Пациенты были сгруппированы по преобладанию симптомокомплексов на подгруппы: с орофациальной, тораколюмбальной и сочетанной тардивной дискинезией. Средний возраст пациентов с орофациальной дискинезией был достоверно выше, чем у больных без ТД. Уровень негативной симптоматики в подгруппе с орофациальной дискинезией оказался достоверно выше, чем у лиц без ТД. Средний возраст больных с тораколюмбальной дискинезией был достоверно выше, чем у пациентов без ТД. Средний возраст группы с сочетанной дискинезией был статистически значимо выше, чем у больных без ТД. Достоверно преобладали пациенты с продолжительностью шизофрении свыше 10 лет в группе сочетанной дискинезии. Такие характеристики, как уровень образования и социальный статус, возраст начала заболевания, преобладание позитивной симптоматики, длительность приема антипсихотиков, соматическое состояние, употребление психоактивных веществ, суицидальное и гетероагрессивное поведение, не вносят вклад в риск развития ТД при шизофрении и не являются протективными факторами

Extensive Copy-Number Variation of Young Genes across Stickleback Populations

MM received funding from the Max Planck innovation funds for this project. PGDF was supported by a Marie Curie European Reintegration Grant (proposal nr 270891). CE was supported by German Science Foundation grants (DFG, EI 841/4-1 and EI 841/6-1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Observation of a ppb mass threshoud enhancement in \psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p}) decay

The decay channel $\psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p})$ is studied using a sample of $1.06\times 10^8$ $\psi^\prime$ events collected by the BESIII experiment at BEPCII. A strong enhancement at threshold is observed in the $p\bar{p}$ invariant mass spectrum. The enhancement can be fit with an $S$-wave Breit-Wigner resonance function with a resulting peak mass of $M=1861^{+6}_{-13} {\rm (stat)}^{+7}_{-26} {\rm (syst)} {\rm MeV/}c^2$ and a narrow width that is $\Gamma<38 {\rm MeV/}c^2$ at the 90% confidence level. These results are consistent with published BESII results. These mass and width values do not match with those of any known meson resonance.Comment: 5 pages, 3 figures, submitted to Chinese Physics

Cut-points for waist circumference in Europids and South Asians

There is little strong evidence that currently recommended higher waist circumference cut-points for Europids compared with South Asians are associated with similar risk for type 2 diabetes. This study was designed to provide such evidence. Longitudinal studies over 5 years were conducted among 5,515 Europid and 2,214 ethnically South Asian participants. Age-standardized diabetes incidence at different levels of waist circumference and incidence difference relative to a reference value were calculated. The Youden Index was used to determine waist circumference cut-points. At currently recommended cut-points, estimated annual diabetes incidence for a 50-year-old Europid was &lt;0.6% for both sexes, and for a 50-year-old South Asian, 5.8% for men and 2.1% for women. Annual diabetes incidence of 1% was observed for a 50 year old at a waist circumference 35&ndash;40 cm greater in Europid compared to South Asian men and women. Incidence difference between recommended cut-points and a reference value (80 cm in men, 70 cm in women) was 0.3 and 4.4% per year for Europid and South Asian men, and 0.2 and 0.8% per year for Europid and South Asian women, respectively. Waist circumference cut-points chosen using the Youden Index were shown to be dependent on obesity levels in the population. The much higher observed risk of diabetes in South Asians compared to Europids at the respective recommended waist circumference cut-points suggests that differences between them should be greater. Approaches that use the Youden Index to select waist circumference cut-points are inappropriate and should not be used for this purpose.<br /

Observation of a charged charmoniumlike structure in e+e−→(D∗Dˉ∗)±π∓e^+e^- \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp at s=4.26\sqrt{s}=4.26GeV

We study the process $e^+e^- \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp$ at a center-of-mass energy of 4.26GeV using a 827pb$^{-1}$ data sample obtained with the BESIII detector at the Beijing Electron Positron Collider. Based on a partial reconstruction technique, the Born cross section is measured to be $(137\pm9\pm15)$pb. We observe a structure near the $(D^{*} \bar{D}^{*})^{\pm}$ threshold in the $\pi^\mp$ recoil mass spectrum, which we denote as the $Z^{\pm}_c(4025)$. The measured mass and width of the structure are $(4026.3\pm2.6\pm3.7)$MeV/c$^2$ and $(24.8\pm5.6\pm7.7)$MeV, respectively. Its production ratio $\frac{\sigma(e^+e^-\to Z^{\pm}_c(4025)\pi^\mp \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp)}{\sigma(e^+e^-\to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp)}$ is determined to be $0.65\pm0.09\pm0.06$. The first uncertainties are statistical and the second are systematic.Comment: 7 pages, 4 figures, 1 table; version accepted to be published in PR

Precision measurement of the branching fractions of J/psi -> pi+pi-pi0 and psi' -> pi+pi-pi0

We study the decays of the J/psi and psi' mesons to pi+pi-pi0 using data samples at both resonances collected with the BES III detector in 2009. We measure the corresponding branching fractions with unprecedented precision and provide mass spectra and Dalitz plots. The branching fraction for J/psi -> pi+pi-pi0 is determined to be (2.137 +- 0.004 (stat.) +0.058-0.056 (syst.) +0.027-0.026 (norm.))*10-2, and the branching fraction for psi' -> pi+pi-pi0 is measured as (2.14 +- 0.03 (stat.) +0.08-0.07 (syst.) +0.09-0.08 (norm.))*10-4. The J/psi decay is found to be dominated by an intermediate rho(770) state, whereas the psi' decay is dominated by di-pion masses around 2.2 GeV/c2, leading to strikingly different Dalitz distributions.Comment: 15 pages, 2 figure