Latinos\u27 Knowledge and Perceptions Towards Child Protective Services

This study examined the knowledge and perceptions of the Latino population in Southern California towards Children Protective Services (CPS). Modern representation of social workers from the Department of Children and Family Services (DCFS), or Child Protective Services (CPS) often do not complement, support, or value the profession. This is a quantitative study with a sample of 103 Hispanic/Latino individuals ranging from the ages of 18 to over 60. An online Qualtrics survey was disseminated through social media and in person. It included a total of 26 questions measuring knowledge and perceptions. The purpose of this study was to better understand the Latino population as it relates to CPS, and create positive changes in the Latino communities CPS serves, with the hope to bring awareness and better service delivery

Spatial heterogeneity of land cover response to climatic change in the Nilgiri highlands (southern India) since the Last Glacial Maximum

25 pagesFourteen hillslope soil profiles were sampled under natural vegetation (i.e., grassland or forest) and plantations in the Nilgiri highlands, southern India. Delta 13C ratios were measured at different depths and 14C ages determined for six profiles. In these highland soils where the turnover rate of organic matter is extremely low, the Δ13C ratios of entire soil profiles have recorded signatures of past land cover. By correlating the data with results previously obtained from peat bogs and with knowledge concerning the history of human settlement, we distinguish three contrasting trajectories of palaeoenvironmental history and landscape change since the Last Glacial Maximum. In the central Nilgiris, between 18 and 10 ka BP, forest expansion occurred due to the conjunction of a wetter climate (the maximum of southwest monsoon-related humidity occurring at ca. 11 ka BP) and higher temperatures; since 10 ka BP, the reversal towards grassland vegetation is attributed to drier conditions. In the western Nilgiris, where strong southwest monsoon winds permanently restrict forest patches to sheltered valley sites, steady but limited expansion of forest from 18 ka BP to the present is recorded and attributed to rising temperatures. The southern and eastern Nilgiris, where the northeast monsoon contributes 20% of the annual rainfall, are the less sensitive to fluctuations in the southwest monsoon. In these areas, rapid and extensive expansion of forest occurred mainly as a consequence of higher temperatures from 18 ka BP to the present. Massive deforestation by Badaga cultivators and Europeans planters followed after the 16th century AD. As a result, and in contrast with the western Nilgiris where the land cover mosaic has remained remarkably stable in the last 18 ka BP, the current landscape differs sharply from the land cover pattern detected by the soil record

Predictive Model Evaluation for PHM

In the past decades, machine learning techniques or algorithms, particularly, classifiers have been widely applied to various real-world applications such as PHM. In developing high-performance classifiers, or machine learning-based models, i.e. predictive model for PHM, the predictive model evaluation remains a challenge. Generic methods such as accuracy may not fully meet the needs of models evaluation for prognostic applications. This paper addresses this issue from the point of view of PHM systems. Generic methods are first reviewed while outlining their limitations or deficiencies with respect to PHM. Then, two approaches developed for evaluating predictive models are presented with emphasis on specificities and requirements of PHM. A case of real prognostic application is studies to demonstrate the usefulness of two proposed methods for predictive model evaluation. We argue that predictive models for PHM must be evaluated not only using generic methods, but also domain-oriented approaches in order to deploy the models in real-world applications

Arrhythmogenic gene remodelling in elderly patients with type 2 diabetes with aortic stenosis and normal left ventricular ejection fraction

New Findings What is the central question of this study? Type 2 diabetes is associated with a higher rate of ventricular arrhythmias compared with the non‐diabetic population, but the associated myocardial gene expression changes are unknown; furthermore, it is also unknown whether any changes are attributable to chronic hyperglycaemia or are a consequence of structural changes. What is the main finding and its importance? We found downregulation of left ventricular ERG gene expression and increased NCX1 gene expression in humans with type 2 diabetes compared with control patients with comparable left ventricular hypertrophy and possible myocardial fibrosis. This was associated with QT interval prolongation. Diabetes and associated chronic hyperglycaemia may therefore promote ventricular arrhythmogenesis independently of structural changes. Type 2 diabetes is associated with a higher rate of ventricular arrhythmias, and this is hypothesized to be independent of coronary artery disease or hypertension. To investigate further, we compared changes in left ventricular myocardial gene expression in type 2 diabetes patients with patients in a control group with left ventricular hypertrophy. Nine control patients and seven patients with type 2 diabetes with aortic stenosis undergoing aortic valve replacement had standard ECGs, signal‐averaged ECGs and echocardiograms before surgery. During surgery, a left ventricular biopsy was taken, and mRNA expressions for genes relevant to the cardiac action potential were estimated by RT‐PCR. Mathematical modelling of the action potential and calcium transient was undertaken using the O'Hara–Rudy model using scaled changes in gene expression. Echocardiography revealed similar values for left ventricular size, filling pressures and ejection fraction between groups. No difference was seen in positive signal‐averaged ECGs between groups, but the standard ECG demonstrated a prolonged QT interval in the diabetes group. Gene expression of KCNH2 and KCNJ3 were lower in the diabetes group, whereas KCNJ2 , KCNJ5 and SLC8A1 expression were higher. Modelling suggested that these changes would lead to prolongation of the action potential duration with generation of early after‐depolarizations secondary to a reduction in density of the rapid delayed rectifier K+ current and increased Na+–Ca2+ exchange current. These data suggest that diabetes leads to pro‐arrythmogenic changes in myocardial gene expression independently of left ventricular hypertrophy or fibrosis in an elderly population

Chronic medication does not affect hyperactive error responses in obsessive-compulsive disorder

Patients with obsessive-compulsive disorder (OCD) show an increased error-related negativity (ERN), yet previous studies have not controlled for medication use, which may be important given evidence linking performance monitoring to neurotransmitter systems targeted by treatment, such as serotonin. In an examination of 19 unmedicated OCD patients, 19 medicated OCD patients, 19 medicated patient controls without OCD, and 21 unmedicated healthy controls, we found greater ERNs in OCD patients than in controls, irrespective of medication use. Severity of generalized anxiety and depression was associated with ERN amplitude in controls but not patients. These data confirm previous findings of an exaggerated error response in OCD, further showing that it cannot be attributed to medication. The absence in patients of a relationship between ERN amplitude and anxiety/depression, as was found in controls, suggests that elevated error signals in OCD may be disorder-specific.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79361/1/j.1469-8986.2010.00988.x.pd

Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit.

Heart failure is a major killer worldwide. Atrioventricular conduction block is common in heart failure; it is associated with worse outcomes and can lead to syncope and bradycardic death. We examine the effect of heart failure on anatomical and ion channel remodelling in the rabbit atrioventricular junction (AVJ). Heart failure was induced in New Zealand rabbits by disruption of the aortic valve and banding of the abdominal aorta resulting in volume and pressure overload. Laser micro-dissection and real-time polymerase chain reaction (RT-PCR) were employed to investigate the effects of heart failure on ion channel remodelling in four regions of the rabbit AVJ and in septal tissues. Investigation of the AVJ anatomy was performed using micro-computed tomography (micro-CT). Heart failure animals developed first degree heart block. Heart failure caused ventricular myocardial volume increase with a 35% elongation of the AVJ. There was downregulation of HCN1 and Cx43 mRNA transcripts across all regions and downregulation of Cav1.3 in the transitional tissue. Cx40 mRNA was significantly downregulated in the atrial septum and AVJ tissues but not in the ventricular septum. mRNA abundance for ANP, CLCN2 and Navβ1 was increased with heart failure; Nav1.1 was increased in the inferior nodal extension/compact node area. Heart failure in the rabbit leads to prolongation of the PR interval and this is accompanied by downregulation of HCN1, Cav1.3, Cx40 and Cx43 mRNAs and anatomical enlargement of the entire heart and AVJ

Reporting of ethical considerations in clinical trials in Chinese nursing journals

Background: It is acknowledged that publishers now require all primary research papers to demonstrate that they have obtained ethical approval for their research. Objectives: To assess the rate of reporting of ethical approval in clinical trials in core nursing journals in mainland China. Research design: A retrospective observational study. Participants: All clinical trials published in all of the 12 core nursing periodicals from 2016 edition China Science and Technology Journal Citation Report (core version) between 2013 and 2016 were retrieved by hand to explicate rate of reporting ethical approval and informed consent. Ethical considerations: The study did not require approval from the research ethics committee as it did not involve human subjects or records. Results: In total, 40,278 papers were published in 12 nursing periodicals between 2013 and 2016. Out of these, 9488 (23.6%) focused on clinical trials. Informed consent obtained from patients or the legally authorized representative was reported in 51.8% of clinical trials. Notably, only 27.4% of clinical trials reported that they had obtained written consent. Furthermore, 25.9% of clinical trials described ethical approval; however, the rate of reporting informed consent and ethical approval in these 12 nursing journals in China during 4 years from 2013 to 2016 improved markedly, with 38.1%, 44.0%, 59.0% and 66.6%, respectively (p<0.001), and 17.6%, 21.9%, 28.6% and 35.8%, respectively (p<0.001). In addition, both reporting informed consent and reporting written informed consent had a positive significant correlation with the reporting ethical approval (p<0.05 or p<0.01). Conclusion: Chinese scientific nursing journals have improved the rate of reporting informed consent and ethical approval in clinical trials during the last 4 years. However, it should be noted that nearly half of clinical trials still did not report either ethical approval or whether informed consent was obtained. Efforts from editors, researchers, sponsors and authors are needed to ensure the transparency of ethical scrutiny and adherence to ethical guidelines in publishing clinical trials in Chinese nursing journals