Feature recommendation strategy for graph convolutional network

Graph Convolutional Network (GCN) is a new method for extracting, learning, and inferencing graph data that builds an embedded representation of the target node by aggregating information from neighbouring nodes. GCN is decisive for node classification and link prediction tasks in recent research. Although the existing GCN performs well, we argue that the current design ignores the potential features of the node. In addition, the presence of features with low correlation to nodes can likewise limit the learning ability of the model. Due to the above two problems, we propose Feature Recommendation Strategy (FRS) for Graph Convolutional Network in this paper. The core of FRS is to employ a principled approach to capture both node-to-node and node-to-feature relationships for encoding, then recommending the maximum possible features of nodes and replacing low-correlation features, and finally using GCN for learning of features. We perform a node clustering task on three citation network datasets and experimentally demonstrate that FRS can improve learning on challenging tasks relative to state-of-the-art (SOTA) baselines

Context-sensitive graph representation learning

Graph Convolutional Network (GCN) is a powerful emerging deep learning technique for learning graph data. However, there are still some challenges for GCN. For example, the model is shallow; the performance is poor when labelled nodes are severely scarce. In this paper, we propose a Multi-Semantic Aligned Graph Convolutional Network (MSAGCN), which contains two fundamental operations: multi-angle aggregation and semantic alignment, to resolve two challenges simultaneously. The core of MSAGCN is the aggregation of nodes that belong to the same class from three perspectives: nodes, features, and graph structure, and expects the obtained node features to be mapped nearby. Specifically, multi-angle aggregation is applied to extract features from three angles of the labelled nodes, and semantic alignment is utilised to align the semantics in the extracted features to enhance the similar content from different angles. In this way, the problem of over-smoothing and over-fitting for GCN can be alleviated. We perform the node clustering task on three citation datasets, and the experimental results demonstrate that our method outperforms the state-of-the-art (SOTA) baselines

Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

Failed root canal treatment is best addressed primarily with the provision of repeat endodontic treatment with thorough irrigation under isolation. If a post is present in the root of the tooth it needs to be removed first. This paper is the second in a series of two which provide an overview of techniques for post removal. Specifically designed post removal devices and the removal of fibre posts are described. Post removal device techniques are illustrated with a series of clinical case figures

Mesoscale Eddies in the Northwestern Pacific Ocean: Three-Dimensional Eddy Structures and Heat/Salt Transports

The region encompassing the Kuroshio Extension (KE) in the Northwestern Pacific Ocean (25°N–45°N and 130°E–180°E) is one of the most eddy-energetic regions of the global ocean. The three-dimensional structures and transports of mesoscale eddies in this region are comprehensively investigated by combined use of satellite data and Argo profiles. With the allocation of Argo profiles inside detected eddies, the spatial variations of structures of eddy temperature and salinity anomalies are analyzed. The results show that eddies predominantly have subsurface (near-surface) intensified temperature and salinity anomalies south (north) of the KE jet, which is related to different background stratifications between these regions. A new method based on eddy trajectories and the inferred three-dimensional eddy structures is proposed to estimate heat and salt transports by eddy movements in a Lagrangian framework. Spatial distributions of eddy transports are presented over the vicinity of the KE for the first time. The magnitude of eddy-induced meridional heat (freshwater volume) transport is on the order of 0.01 PW (103 m3/s). The eddy heat transport divergence results in an oceanic heat loss south and heat gain north of the KE, thereby reinforcing and counteracting the oceanic heat loss from air-sea fluxes south and north of the KE jet, respectively. It also suggests a poleward heat transport across the KE jet due to eddy propagation

A ROP GTPase-Dependent Auxin Signaling Pathway Regulates the Subcellular Distribution of PIN2 in Arabidopsis Roots

SummaryPIN-FORMED (PIN) protein-mediated auxin polar transport is critically important for development, pattern formation, and morphogenesis in plants. Auxin has been implicated in the regulation of polar auxin transport by inhibiting PIN endocytosis [1, 2], but how auxin regulates this process is poorly understood. Our genetic screen identified the Arabidopsis SPIKE1 (SPK1) gene whose loss-of-function mutations increased lateral root density and retarded gravitropic responses, as do pin2 knockout mutations [3]. SPK1 belongs to the conserved DHR2-Dock family of Rho guanine nucleotide exchange factors [4–6]. The spk1 mutations induced PIN2 internalization that was not suppressed by auxin, as did the loss-of-function mutations for Rho-like GTPase from Plants 6 (ROP6)-GTPase or its effector RIC1. Furthermore, SPK1 was required for auxin induction of ROP6 activation. Our results have established a Rho GTPase-based auxin signaling pathway that maintains PIN2 polar distribution to the plasma membrane via inhibition of its internalization in Arabidopsis roots. Our findings provide new insights into signaling mechanisms that underlie the regulation of the dynamic trafficking of PINs required for long-distance auxin transport and that link auxin signaling to PIN-mediated pattern formation and morphogenesis

Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage

The lung is a specialized barrier organ that must tightly regulate interstitial fluid clearance and prevent infection in order to maintain effective gas exchange. Lymphatic vessels are important for these functions in other organs, but their roles in the lung have not been fully defined. In the present study, we addressed how the lymphatic vasculature participates in lung homeostasis. Studies using mice carrying a lymphatic reporter allele revealeded that, in contrast to other organs, lung lymphatic collecting vessels lack smooth muscle cells entirely, suggesting that forward lymph flow is highly dependent on movement and changes in pressure associated with respiration. Functional studies using CLEC2-deficient mice in which lymph flow is impaired due to loss of lympho-venous hemostasis or using inducible lung-specific ablation of lymphatic endothelial cells in a lung transplant model revealeded that loss of lymphatic function leads to an inflammatory state characterized by the formation of tertiary lymphoid organs (TLOs). In addition, impaired lymphatic flow in mice resulteds in hypoxia and features of lung injury that resemble emphysema. These findings reveal both a lung-specific mechanism of lymphatic physiology and a lung-specific consequence of lymphatic dysfunction that may contribute to chronic lung diseases that arise in association with TLO formation

Education in inpatient children and young people’s mental health services

<p>As a chronic disease, osteoarthritis (OA) leads to the degradation of both cartilage and subchondral bone, its development being mediated by proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of specnuezhenide (SPN) in OA and its underlying mechanism were studied in vitro and in vivo. The results showed that SPN decreases the expression of cartilage matrix-degrading enzymes and the activation of NF-κB and wnt/β-catenin signaling, and increases chondrocyte-specific gene expression in IL-1β-induced inflammation in chondrocytes. Furthermore, SPN treatment prevents the degeneration of both cartilage and subchondral bone in a rat model of OA. To the best of our knowledge, this study is the first to report that SPN decreases interleukin-1β-induced inflammation in rat chondrocytes by inhibiting the activation of the NF-κB and wnt/β-catenin pathways, and, thus, has therapeutic potential in the treatment of OA.</p

Scour protection of submarine pipelines using rubber plates underneath the pipes

YesThis paper presents the results from laboratory experiments to investigate the protection of scour around submarine pipelines under unidirectional flow using a rubber plate placed underneath the pipes. The pressure difference on the two sides of the pipeline is the driving force to initiate the movement of sediment particles and can be obtained by force balance analysis. Experiments covering a wide range of incoming flow velocity, pipe diameter and plate length show that there exists a critical pressure difference over which the movement of sediment and, thus, scour takes place. Analysis of the experimental results demonstrates that this critical pressure difference is related to the pressure difference of the axial points between upstream and downstream of the pipe, which can be easily determined. This critical pressure difference is used to develop an empirical formula for estimating the critical length of the rubber plate, over which the sediment movement and scour will not take place. Good agreement between the experiments and calculated critical plate length using the proposed formula is obtained.National High-Tech Research and Development program of China (863 Program, Grant No.2008AA09Z309), National Nature Science Fund of China (Grant No.50879084, 51279071 and 51279189), the Open Funding from the State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University (SKLH-OF-1306