Quantifying the levitation picture of extended states in lattice models

The behavior of extended states is quantitatively analyzed for two dimensional lattice models. A levitation picture is established for both white-noise and correlated disorder potentials. In a continuum limit window of the lattice models we find simple quantitative expressions for the extended states levitation, suggesting an underlying universal behavior. On the other hand, these results point out that the Quantum Hall phase diagrams may be disorder dependent.Comment: 5 pages, submitted to PR

Splitting of critical energies in the nn=0 Landau level of graphene

The lifting of the degeneracy of the states from the graphene $n$=0 Landau level (LL) is investigated through a non-interacting tight-binding model with random hoppings. A disorder-driven splitting of two bands and of two critical energies is observed by means of density of states and participation ratio calculations. The analysis of the probability densities of the states within the $n$=0 LL provides some insights into the interplay of lattice and disorder effects on the splitting process. An uneven spatial distribution of the wave function amplitudes between the two graphene sublattices is found for the states in between the two split peaks. It is shown that as the splitting is increased (linear increasing with disorder and square root increasing with magnetic field), the two split levels also get increasingly broadened, in such a way that the proportion of the overlapped states keeps approximately constant for a wide range of disorder or magnetic field variation.Comment: 6 figure

Cosmic rays in the surroundings of SNR G35.6-0.4

HESS J1858+020 is a TeV gamma-ray source that was reported not to have any clear cataloged counterpart at any wavelength. However, it has been recently proposed that this source is indirectly associated with the radio source, re-identified as a supernova remnant (SNR), G35.6-0.4. The latter is found to be middle-aged ($\sim 30$ kyr) and to have nearby molecular clouds (MCs). HESS J1858+020 was proposed to be the result of the interaction of protons accelerated in the SNR shell with target ions residing in the clouds. The Fermi Large Area Telescope (LAT) First Source Catalog does not list any source coincident with the position of HESS J1858+020, but some lie close. Here, we analyse more than 2 years of data obtained with the Fermi-LAT for the region of interest, and consider whether it is indeed possible that the closest LAT source, 1FGL J1857.1+0212c, is related to HESS J1858+020. We conclude it is not, and we impose upper limits on the GeV emission originating from HESS J1858+020. Using a simplified 3D model for the cosmic-ray propagation out from the shell of the SNR, we consider whether the interaction between SNR G35.6-0.4 and the MCs nearby could give rise to the TeV emission of HESS J1858+020 without producing a GeV counterpart. If so, the pair of SNR/TeV source with no GeV detection would be reminiscent of other similarly-aged SNRs, such as some of the TeV hotspots near W28, for which cosmic-ray diffusion may be used to explain their multi-frequency phenomenology. However, for HESS J1858+020, we found that although the phase space in principle allows for such GeV--TeV non-correlation to appear, usual and/or observationally constrained values of the parameters (e.g., diffusion coefficients and cloud-SNR likely distances) would disfavor it.Comment: In press in MNRA

Huesca ¿un destino turístico gastronómico?

RESUMEN :El turismo gastronómico es una nueva forma de turismo que ha aumentado rápidamente en los últimos años y España es una potencia gastronómica internacional y uno de los líderes indiscutibles del mercado gastronómico mundial. De momento el Ayuntamiento de Huesca está intentando que Huesca sea una ciudad gastronómica. Por ello, en este contexto, el objetivo de este trabajo de fin de máster es analizar si Huesca es un destino turístico gastronómico a través de los recursos gastronómicos disponibles, las características del turismo gastronómico y el número de potenciales turistas gastronómicos en la provincia, Huesca. También realizó un cuestionario a algunas personas para tratar de conocer la imagen de Huesca en sus opiniones, el perfil de los turistas y la fidelidad del turismo gastronómico. Además, he diseñado un nuevo itinerario para el Ayuntamiento de Huesca, combina los recursos gastronómicos de la provincia de Huesca con la ciudad de Huesca, con el objetivo de desarrollar el turismo gastronómico en la ciudad de Huesca.<br /

Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis.

Epidermal growth factor receptor (EGFR)-mutation-positive non-smallcell lung cancer (NSCLC) is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors (TKIs). We investigated receptor tyrosine kinases (RTKs), Src family kinases and focal adhesion kinase (FAK) as genetic modifiers of innate resistance in EGFR-mutation-positive NSCLC. We performed gene expression analysis in two cohorts (Cohort 1 and Cohort 2) of EGFR-mutation-positive NSCLC patients treated with EGFR TKI. We evaluated the efficacy of gefitinib or osimertinib with the Src/FAK/Janus kinase 2 (JAK2) inhibitor, TPX0005 in vitro and in vivo. In Cohort 1, CUB domain-containing protein-1 (CDCP1) was an independent negative prognostic factor for progression-free survival (hazard ratio of 1.79, p=0.0407) and overall survival (hazard ratio of 2.23, p=0.0192). A two-gene model based on AXL and CDCP1 expression was strongly associated with the clinical outcome to EGFR TKIs, in both cohorts of patients. Our preclinical experiments revealed that several RTKs and non-RTKs, were up-regulated at baseline or after treatment with gefitinib or osimertinib. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing

Novel pulsatile-release microparticles for single-injection vaccination

Many controlled release devices are designed to achieve near zero-order release kinetics, however for some applications, such as vaccination, non-continuous or pulsatile release is desired. Such pulsatile release systems may enable the creation of single-injection vaccines that eliminate the need for subsequent booster immunizations by spontaneously releasing antigen at time points that correspond to normal vaccination regimens. This would be especially important in the developing world where a lack of consistent access to healthcare contributes to approximately 1.5 million vaccine-preventable deaths each year.1 Here we present the fabrication and characterization of biodegradable core-shell microparticles that exhibit pulsatile release kinetics due to their unique structure. These particles are produced using a novel fabrication process that combines soft lithography, picoliter dispensing, optical alignment, and a gentle heat-based sintering step to generate microparticles with a biodegradable polymeric shell surrounding an antigen-filled core. By altering the composition (e.g. copolymer ratio or molecular weight) of the poly(lactic-co-glycolic acid) shell, particles can be tuned to release discrete pulses of a model antigen at times ranging from four days to two months. This fabrication method is also compatible with sensitive biologics, such as the inactivated polio virus, which retains \u3e80% of its antigenicity after encapsulation. Further, because the shell of the particle is physically separated from the core, these particles can be filled with any aqueous vaccine solution without affecting release kinetics and be easily scaled via massively parallel fabrication. As a result, these particles have exciting potential as single-injection vaccines that fully mimic the antigen presentation profile of traditional bolus injections administered over the course of months or years. Please click Additional Files below to see the full abstract

In vivo study of the bioavailability and metabolic profile of (poly)phenols after sous-vide artichoke consumption

Artichokes are a rich source of (poly)phenols, mainly caffeoylquinic acids, but little is known about their bioavailability from this source. This study investigated the absorption, metabolism and excretion of (poly)phenols after sous-vide artichoke consumption (5776 µmol of (poly)phenols) by healthy volunteers. Seventy-six (poly)phenol metabolites were identified by UHPLC-MS/MS using authentic standards, including acyl-quinic acids plus C6–C3, C6–C1, C6–C2, C6–C1–N, C6–C0 metabolites, and their phase-II conjugates. The major metabolites were 3ʹ-methoxy-4ʹ-hydroxycinnamic acid, 3ʹ-methoxycinnamic acid-4ʹ-sulfate, and 4ʹ-hydroxycinnamic acid-3ʹ-sulfate, which appeared early in plasma (Tmax 6 h). The 24 h urinary recovery averaged 8.9% (molar basis) of the (poly)phenols consumed. Hepatic beta-oxidation of 3ʹ,4ʹ-dihydroxycinnamic acid and methylated conjugates occurred, but was limited (<0.04%). 3ʹ-Methylation exceeded 4ʹ-methylation and interindividual variability was high, especially for gut microbial metabolites (up to 168-fold)

Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine

Microglia, the immune competent cells of the central nervous system (CNS), normally exist in a resting state characterized by a ramified morphology with many processes, and become activated to amoeboid morphology in response to brain injury, infection, and a variety of neuroinflammatory stimuli. Many studies focused on how neurotransmitters affect microglia activation in pathophysiological circumstances. In this study, we tried to gain mechanistic insights on how dopamine (DA) released from neurons modulates cellular functions of resting and activated microglia. DA induced the reduction of the number of cellular processes, the increase of cell adhesion/spreading, and the increase of vimentin filaments in resting primary and BV2 microglia. In contrast to resting cells, DA downregulated the cell spreading and phagocytosis of microglia activated by LPS. DA also significantly downregulated ERK1/2 phosphorylation in activated microglia, but not in resting microglia. Downregulation of ERK1/2 by DA in activated microglia required receptor signaling. In contrast, we found a significant increase of p38MAPK activity by DA treatment in resting, but not in activated microglia. These latter effects required the uptake of DA through the high-affinity transporter but did not require receptor signaling. Activation of p38MAPK resulted in the increase of focal adhesion number via phosphorylation of paxillin at Ser83. These results indicate that DA might have a differential, depending upon the activation stage of microglia, impact on cellular functions such as adhesion and phagocytosis

A genetic approach for long term virtual organization distribution

Electronic versíon of an article published as International Journal on Artificial Intelligent Tools, Volume 20, issue 2, 2011. 10.1142/S0218213011000152. © World Scientific Publishing Company[EN] An agent-based Virtual Organization is a complex entity where dynamic collections of agents agree to share resources in order to accomplish a global goal or offer a complex service. An important problem for the performance of the Virtual Organization is the distribution of the agents across the computational resources. The final distribution should provide a good load balancing for the organization. In this article, a genetic algorithm is applied to calculate a proper distribution across hosts in an agent-based Virtual Organization. Additionally, an abstract multi-agent system architecture which provides infrastructure for Virtual Organization distribution is introduced. The developed genetic solution employs an elitist crossover operator where one of the children inherits the most promising genetic material from the parents with higher probability. In order to validate the genetic proposal, the designed genetic algorithm has been successfully compared to several heuristics in different scenarios. © 2011 World Scientific Publishing Company.This work is supported by TIN2008-04446, TIN2009-13839-C03-01, CSD2007-00022 and FPU grant AP2008-00600 of the Spanish government, and PROMETEO 2008/051 of the Generalitat Valenciana.Sánchez Anguix, V.; Valero Cubas, S.; García Fornes, AM. (2011). A genetic approach for long term virtual organization distribution. International Journal on Artificial Intelligence Tools. 20(2):271-295. https://doi.org/10.1142/S0218213011000152S27129520

Spontaneous Interlayer Coherence in Double-Layer Quantum Hall Systems: Symmetry Breaking Interactions, In-Plane Fields and Phase Solitons

At strong magnetic fields double-layer two-dimensional-electron-gas systems can form an unusual broken symmetry state with spontaneous inter-layer phase coherence. The system can be mapped to an equivalent system of pseudospin $1/2$ particles with pseudospin-dependent interactions and easy-plane magnetic order. In this paper we discuss how the presence of a weak interlayer tunneling term alters the properties of double-layer systems when the broken symmetry is present. We use the energy functional and equations of motion derived earlier to evaluate the zero-temperature response functions of the double-layer system and use our results to discuss analogies between this system and Josephson-coupled superconducting films. We also present a qualitative picture of the low-energy charged excitations of this system. We show that parallel fields induce a highly collective phase transition to an incommensurate state with broken translational symmetry.Comment: 26 pages, RevTex, 8 postscript figures (submitted to Phys. Rev. B