Synthesis and Characterization of 1-(1-chlorocyclopropyl)-2-(1,2,4-triazol-1-yl)ethan-1-one

A simple and efficient method to prepare 1-(1-chlorocyclopropyl)-2-(1,2,4-triazol-1-yl)ethan-1-one via nucleophilic substitution of 2-chloro-1-(1-chlorocyclopropyl)ethanone and 1,2,4-triazole is described. The title compound is the key intermediate required for the synthesis of prothioconazole, a promising agricultural fungicide. By exploring changes in the reaction time, temperature, ratio of starting reagents, acid binding agent, and the nature of phase transfer catalyst, the reaction conditions could be optimized to afford the desired N-alkylated material in near-quantitative yield. The ultimate yield of the product after recrystallization was 93%, with a purity of 99% based on its characterization by Gas Chromatography-Mass Spectrometer (GC-MS), Fourier Transform infrared spectroscopy (IR), Proton Magnetic Resonance (1H NMR), and Carbon-13 Nuclear Magnetic Resonance (13C NMR). The synthetic process is suitable for industrial application, with the advantages of high yield and facile preparation under mild operating conditions

Bis(3,5-lutidine)alkyl Dications and Their Use in the Fabrication of Organic–Inorganic 2D Polypseudorotaxane by Templated Self-Assembly

A series of organic–inorganic polypseudorotaxanes based on Cu_<i>x</i>(SCN)_<i>y</i> polyanionic ring and bis­(3,5-lutidine)­alkyl dication threads are reported. This kind of interesting bis­(pyridinium)­alkyl template may facilitate the formation of 2D polypseudorotaxane. All these complexes exhibit excellent photochemical properties