N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer reviewe

DESARROLLO DE UN SOFTWARE DESDE TERAPIA OCUPACIONAL PARA VALORACIÓN DE HABILIDADES PERCEPTIVO-COGNITIVAS, OBTENIENDO UN CONCEPTO OCUPACIONAL Y PLAN DE ACCIÓN INMEDIATO, EN NIÑOS DE 6 A 10 AÑOS EN EDAD ESCOLAR DEL INSTITUTO SALESIANO SAN JUAN BOSCO.

Este proyecto de investigación buscó desarrollar un software desde Terapia Ocupacional para valorar las habilidades perceptivo cognitivas, en niños de 6 a 10 años en edad escolar, que son las destrezas necesarias para el desempeño ocupacional en la escuela, para esto se recopilaron 14 pruebas de 2 baterías estandarizadas; 8 subpruebas del DTVP-2 “Método de la evaluación de la percepción visual de Marianne Frostig”; y 6 subpruebas de la ENI “Evaluación Neuropsicológica Infantil”, con las cuales se elabora un protocolo de valoración el cual lleva por nombre SVH-E “software de valoración de habilidades escolares”, una herramienta interactiva que se implementa a través de una tablet electrónica, donde el niño interactúa directamente con una aplicación lúdica, que paralelamente evalúa al menor sin que él lo detecte; esta aplicación nos arrojara una tabla de calificación de las áreas ya mencionadas, un concepto ocupacional y el plan de acción para la prevención de futuros problemas de aprendizaje. Siendo el fin último disminuir el tiempo requerido en el proceso de valoración; haciéndolo más rápido, ágil, verás y atractivo; evitando tener un proceso extenuante, abrumador, agotador y repetitivo. Para la validación de este proceso se realizo la aplicación de pruebas piloto en el Instituto Salesiano san Juan Bosco, con una muestras base de 89 escolares, identificación los beneficios y falencias del proceso realizado, e identificando las habilidades y/o falencias, según edad cronológica, escolaridad y genero

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Field performance of various Pinus radiata breeding families established on a drought-prone site in central Chile

Background: Pinus radiata D. Don is in its third generation of selective breeding on contrasting site types in central Chile, creating interest in its responses to selection and any differential adaptation to site types. We studied the phenotypic variability of growth traits, survival and six ecophysiological traits in 30 open- and control-pollinated families, representing two breeding regions and three breeding generations, in a 2-year-old P. radiata field trial on a sandy soil in the Mediterranean drylands of Central Chile. Findings: Growth, survival and the ecophysiological traits did not differ between the regional origin of the breeding populations. However, breeding-generation effects were significant for height and diameter. As expected, growth traits showed progressive improvement with successive generations. Individual-family effects were evident for all traits except one ecophysiological trait. Conclusions: Breeding has evidently improved early growth performance in the field, despite no clear effect of regional breeding population, but no such effects were observed for the ecophysiological traits. Despite the current study demonstrating considerable family variation at age 2 years, it is unclear how these results relate to performance of mature trees in the field.CONICYT, 11121484, 7915001

Efficient, mild synthesis of N-unsubstituted 1,2,3-triazoles from methanolysis of 1-sulfonyl-1,2,3-triazoles

<p>A small library of diverse N-unsubstituted 1,2,3-triazoles was prepared from the corresponding 1-sulfonyl-1,2,3-triazoles, which were treated only with MeOH at reflux temperature. This process was carried out in good yields showing high efficiency and good functional group tolerance.</p

Combinations of antimicrobial polymers with nanomaterials and bioactives to improve biocidal therapies

The rise of antibiotic-resistant microorganisms has become a critical issue in recent years and has promoted substantial research efforts directed to the development of more effective antimicrobial therapies utilizing different bactericidal mechanisms to neutralize infectious diseases. Modern approaches employ at least two mixed bioactive agents to enhance bactericidal effects. However, the combinations of drugs may not always show a synergistic effect, and further, could also produce adverse effects or stimulate negative outcomes. Therefore, investigations providing insights into the effective utilization of combinations of biocidal agents are of great interest. Sometimes, combination therapy is needed to avoid resistance development in difficult-to-treat infections or biofilm-associated infections treated with common biocides. Thus, this contribution reviews the literature reports discussing the usage of antimicrobial polymers along with nanomaterials or other inhibitors for the development of more potent biocidal therapies.RYM and CGS also thank CONACyT (Consejo Nacional de Ciencia y Tecnología, México) and DAAD (Deutscher Akademischer Austauschdienst, Germany) for financial support within the framework of the funding program for international mobility PROALMEX 2015 (CONACyT project: 267752 and DAAD project: 57271725). USS and CGS gratefully acknowledge the support of the DFG (Deutsche Forschungsgemeinschaft, Germany) -funded Collaborative Research Center PolyTarget (SFB 1278, projects Z01 and B02). MAJT acknowledges the support of the CONACYT through project CB-2015/253303. The support of the CONACYT through Grant 299092 (LANIAUTO) is greatly appreciated.Peer reviewe

Effect of the Soil Matric Potential on the Germination Capacity of <i>Prosopis chilensis</i>, <i>Quillaja saponaria</i> and <i>Cryptocarya alba</i> from Contrasting Geographical Origins

As a consequence of the megadrought in Central Chile, it is expected that most of the distribution of woody species will be narrowed in the northern limits because of restrictions imposed by soil matric potential on seed germination. In this study, we analyzed the effect of the soil matric potential on seed germination and initial recruitment of the sclerophyllous species Prosopis chilensis, Quillaja saponaria and Cryptocarya alba from contrasting geographic origins (i.e., seed sources). We evaluated the germination capacity (%) under different matric potentials (i.e., 0, −6, −33, −750 and −1250 kPa) for 100 days. Soil matric potential of −1250 kPa negatively affected the germination capacity of the three species. P. chilensis seeds stopped germinating under soil matric potential close to −1200 kPa, whereas in Q. saponaria and C. alba the complete inhibition of germination was under −1000 kPa. Seed sources also differed in their germination capacity by soil matric potential: northern seed sources of P. chilensis germinated with the lowest soil matric potential. There was no clear trend in Q. saponaria and C. alba, but in general, southern seed sources performed better than the northern ones. The results showed that Ѱm in the soil played an important role in the germinative capacity against different seed source origins, but not in soils with a north–south gradient