The Wilson renormalization group for low x physics: towards the high density regime

We continue the study of the effective action for low $x$ physics based on a Wilson renormalization group approach. We express the full nonlinear renormalization group equation in terms of the average value and the average fluctuation of extra color charge density generated by integrating out gluons with intermediate values of $x$. This form clearly exhibits the nature of the phenomena driving the evolution and should serve as the basis of the analysis of saturation effects at high gluon density at small $x$.Comment: 14 pages, late

Influence of the Magnetic Field on the Fermion Scattering off Bubble and Kink Walls

We investigate the scattering of fermions off domain walls at the electroweak phase transition in presence of a magnetic field. We consider both the bubble wall and the kink domain wall. We derive and solve the Dirac equation for fermions with momentum perpendicular to the walls, and compute the transmission and reflection coefficients. In the case of kink domain wall, we briefly discuss the zero mode solutions localized on the wall. The possibile role of the magnetic field for the electroweak baryogenesis is also discussed.Comment: 11 pages and 3 eps figure

The Intrinsic Glue Distribution at Very Small x

We compute the distribution functions for gluons at very small x and not too large values of transverse momenta. We extend the McLerran-Venugopalan model by using renormalization group methods to integrate out effects due to those gluons which generate an effective classical charge density for Weizs\"acker-Williams fields. We argue that this model can be extended from the description of nuclei at small x to the description of hadrons at yet smaller values of x. This generates a Lipatov like enhancement for the intrinsic gluon distribution function and a non-trivial transverse momentum dependence as well. We estimate the transverse momentum dependence for the distribution functions, and show how the issue of unitarity is resolved in lepton-nucleus interactions.Comment: 31 pages, Latex2e, 5 postecript figure included, using epsf, latexsym, amssymb and fancyheading

Vector potential versus colour charge density in low-x evolution

We reconsider the evolution equations for multigluon correlators derived in hep-ph/9709432. We show how to derive these equations directly in terms of vector potentials (or colour field strength) avoiding the introduction of the concept of colour charge density in the intermediate steps. The two step procedure of deriving the evolution of the charge density correlators followed by the solution of classical equations for the vector potentials is shown to be consistent with direct derivation of evolution for vector potentials. In the process we correct some computational errors of hep-ph/9709432 and present the corrected evolution equations which have a somewhat simpler appearance.Comment: 15 pages, 1 figure, changes made referee report, to be published in Phys. Rev

Unitarization of the BFKL Pomeron on a Nucleus

We analyze the evolution equation describing all multiple hard pomeron exchanges in a hadronic or nuclear structure functions that was proposed earlier. We construct a perturbation series providing us with an exact solution to the equation outside of the saturation region. The series demonstrates how at moderately high energies the corrections to the single BFKL pomeron exchange contribution which are due to the multiple pomeron exchanges start unitarizing total deep inelastic scattering cross section. We show that as energy increases the scattering cross section of the quark-antiquark pair of a fixed transverse separation on a hadron or nucleus given by the solution of our equation inside of the saturation region unitarizes and becomes independent of energy. The corresponding F_2 structure function also unitarizes and becomes linearly proportional to ln s. We also discuss possible applications of the developed technique to diffraction.Comment: REVTeX, 20 pages, 6 figure

Polarization of Lambda^0 hyperons in nucleus-nucleus collisions at high energies

The measurement of Lambda^0 hyperons polarization in nucleus-nucleus collisions is considered as one of possible tools to study the phase transition. Fixed target and collider experiments are discussed for the case of Lambda^0's production from Au-Au central collisions at \sqrt{s_{NN}} of several GeV.Comment: 15 pages, 6 figure

Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii

Mesenchymal stromal cells (MSCs) have recently been shown to play important roles in mammalian host defenses against intracellular pathogens, but the molecular mechanism still needs to be clarified. We confirmed that human MSCs (hMSCs) pre-stimulated with IFN-γ showed a significant and dose-dependent ability to inhibit the growth of two types of Toxoplasma gondii (type I strain RH/GFP or type II strain PLK/RED). However, in contrast to previous reports, the anti-T. gondii activity of hMSCs was not mediated by indoleamine 2,3-dioxygenase (IDO). Genome-wide RNA-seq analysis revealed that IFN-γ increased the expression of the p65 family of guanylate-binding proteins (hGBPs) in hMSCs, especially hGBP1. To analyze the functional role of hGBPs, stable knockdowns of hGBP1, -2, -5 in hMSCs were established using a lentiviral transfection system. hGBP1 knockdown in hMSCs resulted in a significant loss of the anti-T. gondii host defense property, compared with hMSCs infected with non-targetted control sequences. hGBP2 and -5 knockdowns had no effect. Moreover, the hGBP1 accumulation on the parasitophorous vacuole (PV) membranes of IFN-γ-stimulated hMSCs might protect against T. gondii infection. Taken together, our results suggest that hGBP1 plays a pivotal role in anti-T. gondii protection of hMSCs and may shed new light on clarifying the mechanism of host defense properties of hMSCs

A spectroscopic and proper motion search of Sloan Digital Sky Survey : red subdwarfs in binary systems

Red subdwarfs in binary systems are crucial for both model calibration and spectral classification. We search for red subdwarfs in binary systems from a sample of high proper motion objects with Sloan Digital Sky Survey spectroscopy. We present here discoveries from this search, as well as highlight several additional objects of interest. We find 30 red subdwarfs in wide binary systems including: two with spectral type of esdM5.5, 6 companions to white dwarfs and 3 carbon-enhanced red subdwarfs with normal red subdwarf companions. 15 red subdwarfs in our sample are partially resolved close binary systems. With this binary sample, we estimate the low limit of the red subdwarf binary fraction of similar to 10 per cent. We find that the binary fraction goes down with decreasing masses and metallicities of red subdwarfs. A spectroscopic esdK7 subdwarf + white dwarf binary candidate is also reported. 30 new M subdwarfs have spectral type of >= M6 in our sample. We also derive relationships between spectral types and absolute magnitudes in the optical and near-infrared for M and L subdwarfs, and we present an M subdwarf sample with measured U, V, W space velocities.Peer reviewe

Eicosanoid Release Is Increased by Membrane Destabilization and CFTR Inhibition in Calu-3 Cells

The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2α) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at membrane phospholipids, all three proteins modulate eicosanoid production. We have previously shown the association of ANXA1 expression with that of CFTR, the multifactorial protein mutated in cystic fibrosis. This could in part account for the abnormal inflammatory status characteristic of this disease. We postulated that CFTR participates in the regulation of eicosanoid release by direct interaction with a complex containing ANXA1, p11 and cPLA2α. We first analyzed by plasmon surface resonance the in vitro binding of CFTR to the three proteins. A significant interaction between p11 and the NBD1 domain of CFTR was found. We observed in Calu-3 cells a rapid and partial redistribution of all four proteins in detergent resistant membranes (DRM) induced by TNF-α. This was concomitant with increased IL-8 synthesis and cPLA2α activation, ultimately resulting in eicosanoid (PGE2 and LTB4) overproduction. DRM destabilizing agent methyl-β-cyclodextrin induced further cPLA2α activation and eicosanoid release, but inhibited IL-8 synthesis. We tested in parallel the effect of short exposure of cells to CFTR inhibitors Inh172 and Gly-101. Both inhibitors induced a rapid increase in eicosanoid production. Longer exposure to Inh172 did not increase further eicosanoid release, but inhibited TNF-α-induced relocalization to DRM. These results show that (i) CFTR may form a complex with cPLA2α and ANXA1 via interaction with p11, (ii) CFTR inhibition and DRM disruption induce eicosanoid synthesis, and (iii) suggest that the putative cPLA2/ANXA1/p11/CFTR complex may participate in the modulation of the TNF-α-induced production of eicosanoids, pointing to the importance of membrane composition and CFTR function in the regulation of inflammation mediator synthesis

Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes

<p>Abstract</p> <p>Background</p> <p>The prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. The tumor-associated stroma is marked by increased expression of CD90/THY1. Isolation and characterization of these stromal cells could provide valuable insight into the biology of the tumor microenvironment.</p> <p>Methods</p> <p>Prostate CD90⁺stromal fibromuscular cells from tumor specimens were isolated by cell-sorting and analyzed by DNA microarray. Dataset analysis was used to compare gene expression between histologically normal and tumor-associated stromal cells. For comparison, stromal cells were also isolated and analyzed from the urinary bladder.</p> <p>Results</p> <p>The tumor-associated stromal cells were found to have decreased expression of genes involved in smooth muscle differentiation, and those detected in prostate but not bladder. Other differential expression between the stromal cell types included that of the CXC-chemokine genes.</p> <p>Conclusion</p> <p>CD90⁺prostate tumor-associated stromal cells differed from their normal counterpart in expression of multiple genes, some of which are potentially involved in organ development.</p