Spatial distribution of photoelectrons participating in formation of x-ray absorption spectra

Interpretation of x-ray absorption near-edge structure (XANES) experiments is often done via analyzing the role of particular atoms in the formation of specific peaks in the calculated spectrum. Typically, this is achieved by calculating the spectrum for a series of trial structures where various atoms are moved and/or removed. A more quantitative approach is presented here, based on comparing the probabilities that a XANES photoelectron of a given energy can be found near particular atoms. Such a photoelectron probability density can be consistently defined as a sum over squares of wave functions which describe participating photoelectron diffraction processes, weighted by their normalized cross sections. A fine structure in the energy dependence of these probabilities can be extracted and compared to XANES spectrum. As an illustration of this novel technique, we analyze the photoelectron probability density at the Ti K pre-edge of TiS2 and at the Ti K-edge of rutile TiO2.Comment: Journal abstract available on-line at http://link.aps.org/abstract/PRB/v65/e20511

OGLE-2017-BLG-0329L: A Microlensing Binary Characterized with Dramatically Enhanced Precision Using Data from Space-based Observations

Mass measurements of gravitational microlenses require one to determine the microlens parallax π E, but precise π E measurement, in many cases, is hampered due to the subtlety of the microlens-parallax signal combined with the difficulty of distinguishing the signal from those induced by other higher-order effects. In this work, we present the analysis of the binary-lens event OGLE-2017-BLG-0329, for which π E is measured with a dramatically improved precision using additional data from space-based Spitzer observations. We find that while the parallax model based on the ground-based data cannot be distinguished from a zero-π E model at the 2σ level, the addition of the Spitzer data enables us to identify two classes of solutions, each composed of a pair of solutions according to the well-known ecliptic degeneracy. It is found that the space-based data reduce the measurement uncertainties of the north and east components of the microlens-parallax vector π E by factors ~18 and ~4, respectively. With the measured microlens parallax combined with the angular Einstein radius measured from the resolved caustic crossings, we find that the lens is composed of a binary with component masses of either (M1, M2) ~ (1.1, 0.8) M⊙ or ~(0.4, 0.3) M⊙ according to the two solution classes. The first solution is significantly favored but the second cannot be securely ruled out based on the microlensing data alone. However, the degeneracy can be resolved from adaptive optics observations taken ~10 years after the event

A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice

Tissue plasminogen activator (t-PA) has a short therapeutic time window for administration (3 h) and carries a risk of promoting intracerebral hemorrhage. The aim of the present study was to investigate a therapeutic time window and frequency of hemorrhagic region by treatment with Stachybotrys microspora triprenyl phenol-7 (SMTP-7). Thrombotic occlusion was induced by transfer of acetic acid-induced thrombus at the right common carotid artery into the brain of mice. Infarction area, neurological score, edema percentage, and regional cerebral blood flow (CBF) were determined as the index of the efficacy of SMTP-7. In order to evaluate the mechanism of SMTP-7, plasmin activities and the expressions of interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-6 mRNA were examined. SMTP-7 (0.1, 1, 10 mg/kg) dose dependently reduced infarction area, neurological score, and edema percentage. Additionally, its therapeutic time window was longer than that of t-PA, a high-molecular-weight compound. In addition, little hemorrhagic region was induced by treatment with SMTP-7. SMTP-7 showed plasmin activity in vivo and caused a decreased CBF to recover. Furthermore, the expressions of inflammatory cytokine mRNA (IL-1β, TNF-α, IL-6) were increased by t-PA treatment 3 h after ischemia but were not induced by SMTP-7 treatment. These results indicate that SMTP-7 shows potential thrombolytic and anti-inflammatory effects as well as a wide therapeutic time window and little hemorrhagic region compared with that of t-PA. Therefore, this novel low-molecular-weight compound may represent a novel approach for the treatment of cerebral infarction

Gaia21blx: complete resolution of a binary microlensing event in the Galactic disk

Context. Gravitational microlensing is a method that is used to discover planet-hosting systems at distances of several kiloparsec in the Galactic disk and bulge. We present the analysis of a microlensing event reported by the Gaia photometric alert team that might have a bright lens. Aims. In order to infer the mass and distance to the lensing system, the parallax measurement at the position of Gaia21blx was used. In this particular case, the source and the lens have comparable magnitudes and we cannot attribute the parallax measured by Gaia to the lens or source alone. Methods. Since the blending flux is important, we assumed that the Gaia parallax is the flux-weighted average of the parallaxes of the lens and source. Combining this assumption with the information from the microlensing models and the finite source effects we were able to resolve all degeneracies and thus obtained the mass, distance, luminosities and projected kinematics of the binary lens and the source. Results. According to the best model, the lens is a binary system at 2.18 ± 0.07 kpc from Earth. It is composed of a G star with 0.95 ± 0.17 M ⊙ and a K star with 0.53 ± 0.07 M ⊙. The source is likely to be an F subgiant star at 2.38 ± 1.71 kpc with a mass of 1.10 ± 0.18 M ⊙. Both lenses and the source follow the kinematics of the thin-disk population. We also discuss alternative models, that are disfavored by the data or by prior expectations, however.</p

Gaia21blx : Complete resolution of a binary microlensing event in the Galactic disk

This work has made use of the IAC-STAR Synthetic CMD computation code. IAC-STAR is supported and maintained by the IT department of the Instituto de Astrofísica de Canarias. EB gratefully acknowledges support from NASA grant 80NSSC19K0291. This research has made use of the NASA Exoplanet Archive, which is operated by the California Institute of Technology, under contract with the National Aeronautics and Space Administration under the Exoplanet Exploration Program. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium) and the Photometric Science Alerts Team (http://gsaweb.ast.cam.ac.uk/alerts). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This work makes use of observations from the Las Cumbres Observatory global telescope network. YT acknowledges the support of DFG priority program SPP 1992 “Exploring the Diversity of Extrasolar Planets” (TS 356/3-1). RFJ acknowledges support for this project provided by ANID’s Millennium Science Initiative through grant ICN12_009, awarded to the Millennium Institute of Astrophysics (MAS), and by ANID’s Basal project FB210003. This work is supported by Polish MNiSW grant DIR/WK/2018/12 and European Union’s Horizon 2020 research and innovation program under grant agreement no. 101004719 (OPTICON-RadioNet Pilot, ORP). We also acknowledge support by the italian PRIN 2022J4H55R – Detection of Earth-like ExoPlanets, CUP D53D23002590006. N.P.’s work was supported by Fundação para a Ciência e a Tecnologia (FCT) through the research grants UIDB/04434/2020 and UIDP/04434/2020. We acknowledge support from the Novo Nordisk Foundation Interdisciplinary Synergy Program grant no. NNF19OC0057374.Context. Gravitational microlensing is a method that is used to discover planet-hosting systems at distances of several kiloparsec in the Galactic disk and bulge. We present the analysis of a microlensing event reported by the Gaia photometric alert team that might have a bright lens. Aims. In order to infer the mass and distance to the lensing system, the parallax measurement at the position of Gaia21blx was used. In this particular case, the source and the lens have comparable magnitudes and we cannot attribute the parallax measured by Gaia to the lens or source alone. Methods. Since the blending flux is important, we assumed that the Gaia parallax is the flux-weighted average of the parallaxes of the lens and source. Combining this assumption with the information from the microlensing models and the finite source effects we were able to resolve all degeneracies and thus obtained the mass, distance, luminosities and projected kinematics of the binary lens and the source. Results. According to the best model, the lens is a binary system at $2.18 \pm 0.07$ kpc from Earth. It is composed of a G star with $0.95\pm 0.17\,M_{\odot}$ and a K star with $0.53 \pm 0.07 \, M_{\odot}$. The source is likely to be an F subgiant star at $2.38 \pm 1.71$ kpc with a mass of $1.10 \pm 0.18 \, M_{\odot}$. Both lenses and the source follow the kinematics of the thin-disk population. We also discuss alternative models, that are disfavored by the data or by prior expectations, however.Peer reviewe

The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia.

Brain preconditioning (PC) refers to a state of transient tolerance against a lethal insult that can be evoked by a prior mild event. It is thought that PC may induce different pathways responsible for neuroprotection, which may involve the attenuation of cell damage pathways, including the apoptotic cell death. In this context, p53 is a stress sensor that accumulates during brain ischemia leading to neuronal death. The murine double minute 2 gene (MDM2), a p53-specific E3 ubiquitin ligase, is the main cellular antagonist of p53, mediating its degradation by the proteasome. Here, we study the role of MDM2-p53 pathway on PC-induced neuroprotection both in cultured neurons (in vitro) and rat brain (in vivo). Our results show that PC increased neuronal MDM2 protein levels, which prevented ischemiainduced p53 stabilization and neuronal death. Indeed, PC attenuated ischemia-induced activation of the p53/PUMA/caspase-3 signaling pathway. Pharmacological inhibition of MDM2-p53 interaction in neurons abrogated PC-induced neuroprotection against ischemia. Finally, the relevance of the MDM2-p53 pathway was confirmed in rat brain using a PC model in vivo. These findings demonstrate the key role of the MDM2-p53 pathway in PC-induced neuroprotection against a subsequent ischemic insult and poses MDM2 as an essential target in ischemic tolerance

An Improved RNS Variant of the BFV Homomorphic Encryption Scheme

We present an optimized implementation of the Fan-Vercauteren variant of Brakerski\u27s scale-invariant homomorphic encryption scheme. Our algorithmic improvements focus on optimizing decryption and homomorphic multiplication in the Residue Number System (RNS), using the Chinese Remainder Theorem (CRT) to represent and manipulate the large coefficients in the ciphertext polynomials. In particular, we propose efficient procedures for scaling and CRT basis extension that do not require translating the numbers to standard (positional) representation. Compared to the previously proposed RNS design due to Bajard et al., our procedures are simpler and faster, and introduce a lower amount of noise. We implement our optimizations in the PALISADE library and evaluate the runtime performance for the range of multiplicative depths from 1 to 100. For example, homomorphic multiplication for a depth-20 setting can be executed in 62 ms on a modern server system, which is already practical for some outsourced-computing applications. Our algorithmic improvements can also be applied to other scale-invariant homomorphic encryption schemes, such as YASHE

Neuroprotection of Tanshinone IIA against Cerebral Ischemia/Reperfusion Injury through Inhibition of Macrophage Migration Inhibitory Factor in Rats

. Recent studies have demonstrated that TSA has protective effects against focal cerebral I/R injury. However, little is known about the underlying mechanisms. Here we put forward the hypothesis that TSA acts through inhibition of MIF expression during focal cerebral I/R injury in rats.Rats were subjected to middle cerebral artery occlusion (MCAO) for 2 hours. This was followed by reperfusion. We measured neurological deficits, brain water content, and infarct volume, and found that neurological dysfunction, brain edema, and brain infarction were significantly attenuated by TSA 6 hours after reperfusion. We also measured myeloperoxidase (MPO) activity at 6 and 24 hours, and found that neutrophil infiltration was significantly higher in the vehicle+I/R group than in the TSA+I/R group. ELISA demonstrated that TSA could inhibit MIF expression and the release of TNF-α and IL-6 induced by I/R injury. Western blot analysis and immunofluorescence staining showed that MIF expression was significantly lower in the TSA+I/R group than in the vehicle+I/R group. MIF was found almost all located in neurons and hardly any located in astrocytes in the cerebral cortex. Western blot analysis and EMSA demonstrated that NF-κB expression and activity were significantly increased in the vehicle+I/R group. However, these changes were attenuated by TSA.Our results suggest that TSA helps alleviate the proinflammatory responses associated with I/R-induced injury and that this neuroprotective effect may occur through down-regulation of MIF expression in neurons

Large-scale changes of the cloud coverage in the ε Indi Ba,Bb system

We present the results of 14 nights of I-band photometric monitoring of the nearby brown dwarf binary, ε Indi Ba,Bb. Observations were acquired over 2 months, and total close to 42 hours of coverage at a typically high cadence of 1.4 minutes. At a separation of just 0.7″, we do not resolve the individual components, and so effectively treat the binary as if it were a single object. However, ε Indi Ba (spectral type T1) is the brightest known T-type brown dwarf, and is expected to dominate the photometric signal. We typically find no strong variability associated with the target during each individual night of observing, but see significant changes in mean brightness - by as much as 0.10 magnitudes - over the 2 months of the campaign. This strong variation is apparent on a timescale of at least 2 days. We detect no clear periodic signature, which suggests we may be observing the T1 brown dwarf almost pole-on, and the days-long variability in mean brightness is caused by changes in the large-scale structure of the cloud coverage. Dynamic clouds will very likely produce lightning, and complementary high cadence V-band and Hα images were acquired to search for the emission signatures associated with stochastic ‘strikes’. We report no positive detections for the target in either of these passbands

Transit timing variations in the WASP-4 planetary system*

Abstract Transits in the planetary system WASP-4 were recently found to occur 80 s earlier than expected in observations from the TESS satellite. We present 22 new times of mid-transit that confirm the existence of transit timing variations, and are well fitted by a quadratic ephemeris with period decay dP/dt = −9.2 ± 1.1 ms yr−1. We rule out instrumental issues, stellar activity and the Applegate mechanism as possible causes. The light-time effect is also not favoured due to the non-detection of changes in the systemic velocity. Orbital decay and apsidal precession are plausible but unproven. WASP-4 b is only the third hot Jupiter known to show transit timing variations to high confidence. We discuss a variety of observations of this and other planetary systems that would be useful in improving our understanding of WASP-4 in particular and orbital decay in general