Experimental scheme for unambiguous discrimination of linearly independent symmetric states

We propose an optimal discrimination scheme for a case of four linearly independent nonorthogonal symmetric quantum states, based on linear optics only. The probability of discrimination is in agreement with the optimal probability for unambiguous discrimination among N symmetric states [Phys. Lett. A \textbf{250}, 223 (1998)]. The experimental setup can be extended for the case of discrimination among $2^M$ nonorthogonal symmetric quantum states

Experimental observation of fractional topological phases with photonic qudits

Geometrical and topological phases play a fundamental role in quantum theory. Geometric phases have been proposed as a tool for implementing unitary gates for quantum computation. A fractional topological phase has been recently discovered for bipartite systems. The dimension of the Hilbert space determines the topological phase of entangled qudits under local unitary operations. Here we investigate fractional topological phases acquired by photonic entangled qudits. Photon pairs prepared as spatial qudits are operated inside a Sagnac interferometer and the two-photon interference pattern reveals the topological phase as fringes shifts when local operations are performed. Dimensions $d = 2, 3$ and $4$ were tested, showing the expected theoretical values.Comment: 6 pages, 4 figure

Anomalous lifetime distributions and topological traps in ordering dynamics

We address the role of community structure of an interaction network in ordering dynamics, as well as associated forms of metastability. We consider the voter and AB model dynamics in a network model which mimics social interactions. The AB model includes an intermediate state between the two excluding options of the voter model. For the voter model we find dynamical metastable disordered states with a characteristic mean lifetime. However, for the AB dynamics we find a power law distribution of the lifetime of metastable states, so that the mean lifetime is not representative of the dynamics. These trapped metastable states, which can order at all time scales, originate in the mesoscopic network structure.Comment: 7 pages; 6 figure

Derecho a la comunicación en América Latina

El libro presenta una discusión teórica haciendo una puesta a punto respecto a la comunicación como derecho humano, mostrando casos concretos que exhiben avances y retrocesos en la implementación y medición de los efectos del derecho en algunos países de la región a nivel de gobierno tanto nacional como local. De esta manera, esta propuesta constituye una referencia ineludible para docentes, investigadores y estudiantes del campo de la comunicación, el derecho y las ciencias sociales en general, debido a que el derecho a la comunicación incide en el alcance de otros derechos como la libertad de expresión, el acceso a la información pública y la libertad de prensa, vitales a la hora de fortalecer la participación política, la toma de decisiones informada, el periodismo de investigación y la calidad de la democracia como régimen político.ITESO, A.C

Towards a target label-free suboptimum oligonucleotide displacement-based detection system

A novel method for the future development of label-free DNA sensors is proposed here. The approach is based on the displacement of a labelled suboptimum mutated oligonucleotide hybridised with the immobilised biotin-capture probe. The target fully complementary to the biotin-capture probe can displace the labelled oligonucleotide causing a subsequent decrease of the signal that verifies the presence of the target. The decrease of signal was demonstrated to be proportional to the target concentration. A study of the hybridisation of mutated and complementary labelled oligonucleotides with an immobilised biotin-capture probe was carried out. Different kinetic and thermodynamic behaviour was observed for heterogeneous hybridisation of biotin-capture probe with complementary or suboptimum oligonucleotides. The displacement method evaluated colourimetrically achieved the objective of decreasing the response time from 1 h for direct hybridisation of 19-mer oligonucleotides in the direct enzyme-linked oligonucleotide assay (ELONA) to 5 min in the case of displacement detection in the micromolar concentration range

Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population

Behçet's disease (BD) is a multifactorial disorder associated with the HLA region. Recently, the ERAP1 gene has been proposed as a susceptibility locus with a recessive model and with epistatic interaction with HLA-B51. ERAP1 trims peptides in the endoplasmic reticulum to optimize their length for MHC-I binding. Polymorphisms in this gene have been related with the susceptibility to other immune-mediated diseases associated to HLA class I. Our aim was, the replication in the Spanish population of the association described in the Turkish population between ERAP1 (rs17482078) and BD. Additionally, in order to improve the understanding of this association we analyzed four additional SNPs (rs27044, rs10050860, rs30187 and rs2287987) associated with other diseases related to HLA class I and the haplotype blocks in this gene region. According to our results, frequencies of the homozygous genotypes for the minor alleles of all the SNPs were increased among patients and the OR values were higher in the subgroup of patients with the HLA-B risk factors, although differences were not statistically significant. Moreover, the presence of the same mutation in both chromosomes increased the OR values from 4.51 to 10.72 in individuals carrying the HLA-B risk factors. Therefore, although they were not statistically significant, our data were consistent with an association between ERAP1 and BD as well as with an epistatic interaction between ERAP1 and HLA-B in the Spanish population