Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion

B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells

The Diversity of Aphidlion-like Larvae over the Last 130 Million Years

Aphidlions are larvae of certain lacewings (Neuroptera), and more precisely larvae of the groups Chrysopidae, green lacewings, and Hemerobiidae, brown lacewings. The name ‘aphidlion’ originates from their ecological function as specialised predators of aphids. Accordingly, they also play an economic role as biological pest control. Aphidlions have, mostly, elongated spindle-shaped bodies, and similarly to most lacewing larvae they are equipped with a pair of venom-injecting stylets. Fossils interpreted as aphidlions are known to be preserved in amber from the Cretaceous (130 and 100 million years ago), the Eocene (about 35 million years ago) and the Miocene (about 15 million years ago) ages. In this study, new aphidlion-like larvae are reported from Cretaceous amber from Myanmar (about 100 million years old) and Eocene Baltic amber. The shapes of head and stylets were compared between the different time slices. With the newly described fossils and specimens from the literature, a total of 361 specimens could be included in the analysis: 70 specimens from the Cretaceous, 5 from the Eocene, 3 from the Miocene, 188 extant larvae of Chrysopidae, and 95 extant larvae of Hemerobiidae. The results indicate that the diversity of head shapes remains largely unchanged over time, yet there is a certain increase in the diversity of head shapes in the larvae of Hemerobiidae. In certain other groups of Neuroptera, a distinct decrease in the diversity of head shapes in larval stages was observed

Impact of Public Reporting on Quality of Postacute Care

Evidence supporting the use of public reporting of quality information to improve health care quality is mixed. While public reporting may improve reported quality, its effect on quality of care more broadly is uncertain. This study tests whether public reporting in the setting of nursing homes resulted in improvement of reported and broader but unreported quality of postacute care. Data Sources/Study Setting . 1999–2005 nursing home Minimum Data Set and inpatient Medicare claims. Study Design . We examined changes in postacute care quality in U.S. nursing homes in response to the initiation of public reporting on the Centers for Medicare and Medicaid Services website, Nursing Home Compare. We used small nursing homes that were not subject to public reporting as a contemporaneous control and also controlled for patient selection into nursing homes. Postacute care quality was measured using three publicly reported clinical quality measures and 30-day potentially preventable rehospitalization rates, an unreported measure of quality. Principal Findings . Reported quality of postacute care improved after the initiation of public reporting for two of the three reported quality measures used in Nursing Home Compare. However, rates of potentially preventable rehospitalization did not significantly improve and, in some cases, worsened. Conclusions . Public reporting of nursing home quality was associated with an improvement in most postacute care performance measures but not in the broader measure of rehospitalization.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74796/1/j.1475-6773.2009.00967.x.pd

Thermal and non-thermal components of the interstellar medium at sub-kiloparsec scales in galaxies

Aims: We present new radio continuum observations of ten BIMA SONG galaxies, taken at 1.4 GHz with the Very Large Array. These observations allow us to extend the study of the relationships between the radio continuum (RC) and CO emission to 22 CO luminous galaxies for which single dish CO images have been added to interferometric data. New Spitzer infrared (IR) images of six of these galaxies have been released. The analysis of these high resolution images allowed us to probe the RC-IR-CO correlations down to linear scales of a few hundred pc. Results: for the 22 galaxies analysed, the RC-CO correlation on scales from $\sim10$ kpc down to $\sim100$ pc is nearly linear and has a scatter of a factor of two, i.e. comparable to that of the global correlations. There is no evidence for any severe degradation of the scatter below the kpc scale. This also applies to the six galaxies for which high-resolution mid-IR data are available. In the case of NGC 5194, we find that the non-thermal radio spectral index is correlated with the RC/FIR ratio. Conclusions: The scatter of the point-by-point correlations does not increase significantly with spatial resolution. We thus conclude that we have not yet probed the physical scales at which the correlations break down. However, we observe local deviations from the correlations in regions with a high star formation rate, such as the spiral arms, where we observe a flat radio spectrum and a low RC/FIR ratio. In the intra-arm regions and in the peripheral regions of the disk, the RC/FIR is generally higher and it is characterized by a steepening of the radio spectrum.Comment: 27 pages, 9 figures (low resolution), accepted for publication in A&A. High resolution version of the paper is available at: http://lucipher.ca.astro.it/~rpaladin/PAPER/RC-C