4.5 years multi-wavelength observations of Mrk 421 during the ARGO-YBJ and Fermi common operation time

We report on the extensive multi-wavelength observations of the blazar Markarian 421 (Mrk 421) covering radio to gamma-rays, during the 4.5 year period of ARGO-YBJ and Fermi common operation time, from August 2008 to February 2013. In particular, thanks to the ARGO-YBJ and Fermi data, the whole energy range from 100 MeV to 10 TeV is covered without any gap. In the observation period, Mrk 421 showed both low and high activity states at all wavebands. The correlations among flux variations in different wavebands were analyzed. Seven large flares, including five X-ray flares and two GeV gamma-ray flares with variable durations (3-58 days), and one X-ray outburst phase were identified and used to investigate the variation of the spectral energy distribution with respect to a relative quiescent phase. During the outburst phase and the seven flaring episodes, the peak energy in X-rays is observed to increase from sub-keV to few keV. The TeV gamma-ray flux increases up to 0.9-7.2 times the flux of the Crab Nebula. The behavior of GeV gamma-rays is found to vary depending on the flare, a feature that leads us to classify flares into three groups according to the GeV flux variation. Finally, the one-zone synchrotron self-Compton model was adopted to describe the emission spectra. Two out of three groups can be satisfactorily described using injected electrons with a power-law spectral index around 2.2, as expected from relativistic diffuse shock acceleration, whereas the remaining group requires a harder injected spectrum. The underlying physical mechanisms responsible for different groups may be related to the acceleration process or to the environment properties.Comment: 17 pages, 9 figures, 5 tables, Accepted for publication in ApJ

Study of the diffuse gamma-ray emission from the Galactic plane with ARGO-YBJ

The events recorded by ARGO-YBJ in more than five years of data collection have been analyzed to determine the diffuse gamma-ray emission in the Galactic plane at Galactic longitudes 25{\deg} < l < 100{\deg} and Galactic latitudes . The energy range covered by this analysis, from ~350 GeV to ~2 TeV, allows the connection of the region explored by Fermi with the multi-TeV measurements carried out by Milagro. Our analysis has been focused on two selected regions of the Galactic plane, i.e., 40{\deg} < l < 100{\deg} and 65{\deg} < l < 85{\deg} (the Cygnus region), where Milagro observed an excess with respect to the predictions of current models. Great care has been taken in order to mask the most intense gamma-ray sources, including the TeV counterpart of the Cygnus cocoon recently identified by ARGO-YBJ, and to remove residual contributions. The ARGO-YBJ results do not show any excess at sub-TeV energies corresponding to the excess found by Milagro, and are consistent with the predictions of the Fermi model for the diffuse Galactic emission. From the measured energy distribution we derive spectral indices and the differential flux at 1 TeV of the diffuse gamma-ray emission in the sky regions investigated.Comment: 11 pages, 6 figures, published in AP

Search for Gamma-Ray Emission from the Sun during Solar Minimum with the ARGO-YBJ Experiment

The hadronic interaction of cosmic rays with solar atmosphere can produce high energy gamma-rays. The gamma-ray luminosity is correlated both with the flux of primary cosmic rays and the intensity of the solar magnetic field. The gamma-rays below 200 GeV have been observed by Fermi without any evident energy cutoff. The bright gamma-ray flux above 100 GeV has been detected only during solar minimum. The only available data in the TeV range come from the HAWC observations, however, outside the solar minimum. The ARGO-YBJ data set has been used to search for sub-TeV/TeV gamma-rays from the Sun during the solar minimum from 2008 to 2010, the same time period covered by the Fermi data. A suitable model containing the Sun shadow, solar disk emission, and inverse-Compton emission has been developed, and the chi-square minimization method was used to quantitatively estimate the disk gamma-ray signal. The result shows that no significant gamma-ray signal is detected and upper limits to the gamma-ray flux at 0.3-7 TeV are set at the 95% confidence level. In the low energy range these limits are consistent with the extrapolation of the Fermi-LAT measurements taken during solar minimum and are compatible with a softening of the gamma-ray spectrum below 1 TeV. They also provide an experimental upper bound to any solar disk emission at TeV energies. Models of dark matter annihilation via long-lived mediators predicting gamma-ray fluxes >10 -7 GeV cm -2 s -1 below 1 TeV are ruled out by the ARGO-YBJ limits

Search for Gamma-Ray Emission from the Sun during Solar Minimum with the ARGO-YBJ Experiment

The hadronic interaction of cosmic rays with solar atmosphere can produce high energy gamma rays. The gamma-ray luminosity is correlated both with the flux of primary cosmic rays and the intensity of the solar magnetic field. The gamma rays below 200 GeV have been observed by $Fermi$ without any evident energy cutoff. The bright gamma-ray flux above 100 GeV has been detected only during solar minimum. The only available data in TeV range come from the HAWC observations, however outside the solar minimum. The ARGO-YBJ dataset has been used to search for sub-TeV/TeV gamma rays from the Sun during the solar minimum from 2008 to 2010, the same time period covered by the Fermi data. A suitable model containing the Sun shadow, solar disk emission and inverse-Compton emission has been developed, and the chi-square minimization method was used to quantitatively estimate the disk gamma-ray signal. The result shows that no significant gamma-ray signal is detected and upper limits to the gamma-ray flux at 0.3$-$7 TeV are set at 95\% confidence level. In the low energy range these limits are consistent with the extrapolation of the Fermi-LAT measurements taken during solar minimum and are compatible with a softening of the gamma-ray spectrum below 1 TeV. They provide also an experimental upper bound to any solar disk emission at TeV energies. Models of dark matter annihilation via long-lived mediators predicting gamma-ray fluxes > $10^{-7}$ GeV $cm^{-2}$ $s^{-1}$ below 1 TeV are ruled out by the ARGO-YBJ limits

Search for Gamma Ray Bursts with the ARGO-YBJ Detector in Shower Mode

The ARGO-YBJ detector, located at the Yangbajing Cosmic Ray Laboratory (4300 m a. s. l., Tibet, China), was a full coverage air shower array dedicated to gamma ray astronomy and cosmic ray studies. The wide field of view (~ 2 sr) and high duty cycle (> 86%), made ARGO-YBJ suitable to search for short and unexpected gamma ray emissions like gamma ray bursts (GRBs). Between 2007 November 6 and 2013 February 7, 156 satellite-triggered GRBs (24 of them with known redshift) occurred within the ARGO-YBJ field of view. A search for possible emission associated to these GRBs has been made in the two energy ranges 10-100 GeV and 10-1000 GeV. No significant excess has been found in time coincidence with the satellite detections nor in a time window of one hour after the bursts. Taking into account the EBL absorption, upper limits to the energy fluence at 99% of confidence level have been evaluated,with values ranging from ~ 10-5 erg cm-2 to ~10-1 erg cm-2.Comment: 24pages and 12 figure

CRAB NEBULA: FIVE-YEAR OBSERVATION WITH ARGO-YBJ

The ARGO-YBJ air shower detector monitored the Crab Nebula gamma-ray emission from 2007 November to 2013 February. The integrated signal, consisting of similar to 3.3 x 10(5) events, reached the statistical significance of 21.1 standard deviations. The obtained energy spectrum in the energy range 0.3-20 TeV can be described by a power law function dN/dE = I-0 (E/2TeV)(-alpha), with a flux normalization I-0 = (5.2 +/- 0.2) x 10(-12) photons cm(-2) s(-1) TeV (1) and alpha = 2.63 +/- 0.05, corresponding to an integrated flux above 1 TeV of 1.97 x 10(-11) photons cm(-2) s(-1). The systematic error is estimated to be less than 30% for the flux normalization and 0.06 for the spectral index. Assuming a power law spectrum with an exponential cutoff dN/dE = I-0 (E/2 TeV)(-alpha) exp (-E/E-cut), the lower limit of the cutoff energy E-cut is 12 TeV, at 90% confidence level. Our extended data set allows the study of the TeV emission over long timescales. Over five years, the light curve of the Crab Nebula in 200-day bins is compatible with a steady emission with a probability of 7.3 x 10(-2). A correlated analysis with Fermi-LAT data over similar to 4.5 yr using the light curves of the two experiments gives a Pearson correlation coefficient r = 0.56 +/- 0.22. Concerning flux variations on timescales of days, a "blind" search for flares with a duration of 1-15 days gives no excess with a significance higher than four standard deviations. The average rate measured by ARGO-YBJ during the three most powerful flares detected by Fermi-LAT is 205 +/- 91 photons day(-1), consistent with the average value of 137 +/- 10 day(-1)

Spintronics: Fundamentals and applications

Spintronics, or spin electronics, involves the study of active control and manipulation of spin degrees of freedom in solid-state systems. This article reviews the current status of this subject, including both recent advances and well-established results. The primary focus is on the basic physical principles underlying the generation of carrier spin polarization, spin dynamics, and spin-polarized transport in semiconductors and metals. Spin transport differs from charge transport in that spin is a nonconserved quantity in solids due to spin-orbit and hyperfine coupling. The authors discuss in detail spin decoherence mechanisms in metals and semiconductors. Various theories of spin injection and spin-polarized transport are applied to hybrid structures relevant to spin-based devices and fundamental studies of materials properties. Experimental work is reviewed with the emphasis on projected applications, in which external electric and magnetic fields and illumination by light will be used to control spin and charge dynamics to create new functionalities not feasible or ineffective with conventional electronics.Comment: invited review, 36 figures, 900+ references; minor stylistic changes from the published versio

Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment

<p>Abstract</p> <p>Background</p> <p>A widely-used approach for discovering functional and physical interactions among proteins involves phylogenetic profile comparisons (PPCs). Here, proteins with similar profiles are inferred to be functionally related under the assumption that proteins involved in the same metabolic pathway or cellular system are likely to have been co-inherited during evolution.</p> <p>Results</p> <p>Our experimentation with <it>E. coli </it>and yeast proteins with 16 different carefully composed reference sets of genomes revealed that the phyletic patterns of proteins in prokaryotes alone could be adequate enough to make reasonably accurate functional linkage predictions. A slight improvement in performance is observed on adding few eukaryotes into the reference set, but a noticeable drop-off in performance is observed with increased number of eukaryotes. Inclusion of most parasitic, pathogenic or vertebrate genomes and multiple strains of the same species into the reference set do not necessarily contribute to an improved sensitivity or accuracy. Interestingly, we also found that evolutionary histories of individual pathways have a significant affect on the performance of the PPC approach with respect to a particular reference set. For example, to accurately predict functional links in carbohydrate or lipid metabolism, a reference set solely composed of prokaryotic (or bacterial) genomes performed among the best compared to one composed of genomes from all three super-kingdoms; this is in contrast to predicting functional links in translation for which a reference set composed of prokaryotic (or bacterial) genomes performed the worst. We also demonstrate that the widely used random null model to quantify the statistical significance of profile similarity is incomplete, which could result in an increased number of false-positives.</p> <p>Conclusion</p> <p>Contrary to previous proposals, it is not merely the number of genomes but a careful selection of informative genomes in the reference set that influences the prediction accuracy of the PPC approach. We note that the predictive power of the PPC approach, especially in eukaryotes, is heavily influenced by the primary endosymbiosis and subsequent bacterial contributions. The over-representation of parasitic unicellular eukaryotes and vertebrates additionally make eukaryotes less useful in the reference sets. Reference sets composed of highly non-redundant set of genomes from all three super-kingdoms fare better with pathways showing considerable vertical inheritance and strong conservation (e.g. translation apparatus), while reference sets solely composed of prokaryotic genomes fare better for more variable pathways like carbohydrate metabolism. Differential performance of the PPC approach on various pathways, and a weak positive correlation between functional and profile similarities suggest that caution should be exercised while interpreting functional linkages inferred from genome-wide large-scale profile comparisons using a single reference set.</p

Magnetic Hydroxyapatite Bone Substitutes to Enhance Tissue Regeneration: Evaluation In Vitro Using Osteoblast-Like Cells and In Vivo in a Bone Defect

In case of degenerative disease or lesion, bone tissue replacement and regeneration is an important clinical goal. In particular, nowadays, critical size defects rely on the engineering of scaffolds that are 3D structural supports, allowing cellular infiltration and subsequent integration with the native tissue. Several ceramic hydroxyapatite (HA) scaffolds with high porosity and good osteointegration have been developed in the past few decades but they have not solved completely the problems related to bone defects. In the present study we have developed a novel porous ceramic composite made of HA that incorporates magnetite at three different ratios: HA/Mgn 95/5, HA/Mgn 90/10 and HA/Mgn 50/50. The scaffolds, consolidated by sintering at high temperature in a controlled atmosphere, have been analysed in vitro using human osteoblast-like cells. Results indicate high biocompatibility, similar to a commercially available HA bone graft, with no negative effects arising from the presence of magnetite or by the use of a static magnetic field. HA/Mgn 90/10 was shown to enhance cell proliferation at the early stage. Moreover, it has been implanted in vivo in a critical size lesion of the rabbit condyle and a good level of histocompatibility was observed. Such results identify this scaffold as particularly relevant for bone tissue regeneration and open new perspectives for the application of a magnetic field in a clinical setting of bone replacement, either for magnetic scaffold fixation or magnetic drug delivery

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis