An Adaptive Gaze Tracking System in the Diverse Environment

oai:ojs.ijiis.org:article/124For understanding the learning effect, the gaze tracking is a more objective method to collect the data on eye movement and used to analyze the learning behaviors. In order to provide an analysis tool to apply in diverse environments, an adaptive gaze tracking system is proposed in this paper. This system can offer helpful suggestions for educators when improving the instruction. Additionally, the experimental results show that the estimation of gaze points was successful even when the distance and head rotation alter

Employability Skill Development of Mechanical Engineering Students Through Project Based Learning in Vocational High School in South Sulawesi

Abstract: Embedding employability skills in learning requires a learning model that allows effective in improving employability skills of students Learning model that if able to meet these expectations is project based learning. This study aims to determine the contribution of project based learning to employability skills of students of SMK Package Engineering Skills Engineering in South Sulawesi. This research uses quantitative approach with non experimental design with sample size 325 students. Data collection uses questionnaires to obtain data on project-based learning implementation and employability skills. The data of the research were analyzed by using descriptive analysis and regression analysis which previously conducted normality and linearity test. Based on the results of the research is known that the implementation of project based learning model contributes to the development of employability skill students of machining engineering SMK 59.8%

Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes

Type 1 diabetes (T1D) is caused by the destruction of β cells in pancreatic islets by autoimmune T cells. Islet transplantation has been established as an effective treatment for T1D. However, the survival of islet grafts is often disrupted by recurrent autoimmunity. Alpha-lipoic acid (ALA) has been reported to have immunomodulatory effects and, therefore, may have therapeutic potential in the treatment of T1D. In this study, we investigated the therapeutic potential of ALA in autoimmunity inhibition. We treated non-obese diabetic (NOD) mice with spontaneous diabetes and islet-transplantation mice with ALA. The onset of diabetes was decreased and survival of the islet grafts was extended. The populations of Th1 cells decreased, and regulatory T cells (Tregs) increased in ALA-treated mice. The in vitro Treg differentiation was significantly increased by treatment with ALA. The adoptive transfer of ALA-differentiated Tregs into NOD recipients improved the outcome of the islet grafts. Our results showed that in vivo ALA treatment suppressed spontaneous diabetes and autoimmune recurrence in NOD mice by inhibiting the Th1 immune response and inducing the differentiation of Tregs. Our study also demonstrated the therapeutic potential of ALA in Treg-based cell therapies and islet transplantation used in the treatment of T1D

Subchronic Immunotoxicity Assessment of Genetically Modified Virus-Resistant Papaya in Rats

Papaya is an important fruit that provides a variety of vitamins with nutritional value and also holds some pharmacological properties, including immunomodulation. Genetically modified (GM) papaya plants resistant to Papaya ringspot virus (PRSV) infection have been generated by cloning the coat protein gene of the PRSV which can be used as a valuable strategy to fight PRSV infection and to increase papaya production. In order to assess the safety of GM papaya as a food, this subchronic study was conducted to assess the immunomodulatory responses of the GM papaya line 823-2210, when compared with its parent plant of non-GM papaya, Tainung-2 (TN-2), in Sprague-Dawley (SD) rats. Both non-GM and GM 823-2210 papaya fruits at low (1 g/kg bw) and high (2 g/kg bw) dosages were administered via daily oral gavage to male and female rats consecutively for 90 days. Immunophenotyping, mitogen-induced splenic cell proliferation, antigen-specific antibody response, and histopathology of the spleen and thymus were evaluated at the end of the experiment. Results of immunotoxicity assays revealed no consistent difference between rats fed for 90 days with GM 823-2210 papaya fruits, as opposed to those fed non-GM TN-2 papaya fruits, suggesting that with regard to immunomodulatory responses, GM 823-2210 papaya fruits maintain substantial equivalence to fruits of their non-GM TN-2 parent