379 research outputs found

    #improveresourcesharing: Indiana Resource Sharing White Paper

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    This white paper calls for a series of changes to improve resource sharing in the state of Indiana. These changes include; making rare and scarcely held resources such as local history discoverable; making Indiana Evergreen’s collections discoverable and requestable by other libraries; implementing recommendations on membership in Indiana Share; adherence to best practices for resource sharing; and, recognizing that the population is mobile and that users of public libraries may also be users of academic libraries that a common brand for resource sharing be created to help users find the service at all their libraries

    Proto-Urban Establishments in Inner Asia : Surveys of an Iron Age Walled Site in Eastern Mongolia

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    Funding Information: The field expedition in 2015 was funded by National Geographic Society (#W321-14). Geomagnetic and DGPS survey equipment was graciously loaned to us from the Graduate School of Human Development in Landscapes at Christian-Albrechts-UniversitĂ€t zu Kiel, and members of the Institut fĂŒr Ur-und FrĂŒhgeschichte at CAU-Kiel gave assistance in the field. Radiocarbon dating of bone and charcoal samples were conducted at PoznaƄ Radiocarbon Laboratory through funding from the ERC Consolidator Grant (#615040) for the “Nomadic Empires” Project at University of Oxford. Pedestrian surveys were conducted primarily by J. Wright, faunal analyses by T. TĂŒvshinjargal, and magnetic modelling by T. Wunderlich. We wish to thank D. Schultz for assistance in the field, as well as the National Museum of Mongolia and Tsagaan-Ovoo sum for helping facilitate many of the in-field project logistics. Lastly, our thanks to the extremely thorough comments from the editors and anonymous reviewers which greatly improved the clarity of the content. All remaining mistakes are of course ours. Publisher Copyright: © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Peer reviewe

    Molecular simulations studies of gas adsorption in metal–organic frameworks

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    Using computational tools ranging from molecular simulations – including both Monte Carlo and molecular dynamics methods – to quantum mechanical (QM) calculations (primarily at density functional theory (DFT) level), this work focuses on addressing some of the challenges faced in molecular simulations of gas adsorption in metal–organic frameworks (MOFs). This work consists of two themes: one concerns gas adsorption in MOFs with coordinatively unsaturated metal sites (cus’s), and the other one deals with predicting and understanding the breathing behaviour of the flexible MOF MIL-53(Sc). It has been shown experimentally that incorporation of cus’s – also known as “open” metal sites or unsaturated metal centres – into MOFs significantly enhances the uptake of certain gases such as CO2 and CH4. As a result of the considerably enhanced, localized guest-molecule interactions with the cus’s, it, however, remains a challenge to predict correctly adsorption isotherms and/or mechanisms in MOFs with cus’s using grand-canonical Monte Carlo (GCMC) simulations based on generic classical force fields. To address this problem, two multi-scale modelling approaches – which combine GCMC simulations with QM calculations – have been proposed in this work. The first approach is based on the direct implementation of a fluid–framework potential energy surface, calculated by a hybrid DFT/ab initio method, in the GCMC simulations. The second approach involves parameterization of ab initio force fields for GCMC simulations of gas adsorption in MOFs with cus’s. This approach focuses on the generation of accurate ab initio reference data, selection of semiempirical model potentials, and force-field fitting through a multi-objective genetic algorithm approach. The multi-scale simulation strategy not only yields adsorption isotherms in very good agreement with experimental data but also correctly captures adsorption mechanisms, including the adsorption on the cus’s, observed experimentally but absent from GCMC simulations based on generic force fields. The second challenge that this work aims to address concerns the “breathing” phenomenon of MOFs, in which the framework structure adapts its pore opening to accommodate guest molecules, for example. The breathing effect gives rise to some exceptional properties of these MOFs and hence promising applications. However, framework flexibility often poses a challenge for computational studies of such MOFs, because suitable flexible force fields for frameworks are lacking and the effort involved in developing a new one is no less a challenge. Here, an alternative to the force-field-based approach is adopted. Ab initio molecular dynamics (AIMD) simulations – which combine classical molecular dynamics simulations with electronic-structure calculations “on the fly” – have been deployed to study structural changes of the breathing MOF MIL-53(Sc) in response to changes in temperature over the range 100–623 K and adsorption of CO2 at 0–0.9 bar at 196 K. AIMD simulations employing dispersion-corrected DFT accurately simulated the experimentally observed closure of MIL-53(Sc) upon solvent removal and the transition of the empty MOF from the closed-pore phase to the very-narrow-pore phase with increasing temperature. AIMD simulations were also used to mimic the CO2 adsorption of MIL-53(Sc) in silico by allowing the MIL-53(Sc) framework to evolve freely in response to CO2 loadings corresponding to the two steps in the experimental adsorption isotherm. The resulting structures enabled the structure determination of the two CO2-containing intermediate and large-pore phases observed by experimental synchrotron X-ray diffraction studies with increasing CO2 pressure; this would not have been possible for the intermediate structure via conventional methods because of diffraction peak broadening. Furthermore, the strong and anisotropic peak broadening observed for the intermediate structure could be explained in terms of fluctuations of the framework predicted by the AIMD simulations. Fundamental insights from the molecular-level interactions further revealed the origin of the breathing of MIL-53(Sc) upon temperature variation and CO2 adsorption. Both the multi-scale simulation strategy for gas adsorption in MOFs with cus’s and the AIMD study of the stimuli-responsive breathing behaviour of MIL-53(Sc) illustrate the power and promise of combining molecular simulations with quantum mechanical calculations for the prediction and understanding of MOFs

    Antarctic climate, Southern Ocean circulation patterns, and deep water formation during the Eocene

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    We assess early-to-middle Eocene seawater neodymium (Nd) isotope records from seven Southern Ocean deep-sea drill sites to evaluate the role of Southern Ocean circulation in long-term Cenozoic climate change. Our study sites are strategically located on either side of the Tasman Gateway and are positioned at a range of shallow (Nd(t) = −9.3 ± 1.5). IODP Site U1356 off the coast of AdĂ©lie Land, a locus of modern-day Antarctic Bottom Water production, is identified as a site of persistent deep water formation from the early Eocene to the Oligocene. East of the Tasman Gateway an additional local source of intermediate/deep water formation is inferred at ODP Site 277 in the SW Pacific Ocean (ΔNd(t) = −8.7 ± 1.5). Antarctic-proximal shelf sites (ODP Site 1171 and Site U1356) reveal a pronounced erosional event between 49 and 48 Ma, manifested by ~2 ΔNd unit negative excursions in seawater chemistry toward the composition of bulk sediments at these sites. This erosional event coincides with the termination of peak global warmth following the Early Eocene Climatic Optimum and is associated with documented cooling across the study region and increased export of Antarctic deep waters, highlighting the complexity and importance of Southern Ocean circulation in the greenhouse climate of the Eocene

    The Pediatric Asthma Risk Score: A New Gold Standard for Asthma Prediction

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    Rationale: Early prediction of asthma is critical to identify potential primary prevention strategies. The Pediatric Asthma Risk Score (PARS) is a continuous score to predict early-life asthma but was developed and validated in relatively homogenous populations. We compared PARS directly to the Asthma Predictive Index (API) and validated in 10 cohorts with varying race, ethnicity, sex, cohort type, missing data and birth decades, and perform a meta-analysis across all 10 cohorts. Methods: We utilized data from 5674 children participating in the Children’s Respiratory and Environmental Workgroup. We applied both PARS and the API in each cohort, as well as harmonized across all cohorts, and directly compared the ability of each tool to predict asthma development at ages 5-10. Results: The PARS area under the curve (AUC) was significantly higher than the AUC of the API in 9 cohorts (p-value range 0.01 - \u3c0.001). The PARS AUC did not differ by cohort type (high risk or general population), decade of enrollment, race, sex, ethnicity, missing PARS factors or polysensitization definition (skin prick test vs. specific IgE). The weights of the 6 PARS factors in the meta-analysis were very similar to the original weights, validating the original PARS scoring. Conclusions: This multi-cohort study makes the PARS the most validated model of asthma prediction in children to date, not only with respect to the number of cohorts used but also with regards to capturing the diversity of asthma in the United States. Future studies may consider PARS the new gold standard in pediatric asthma risk prediction

    The Vehicle, Fall 1986

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    Table of Contents Selling Poetry: Honesty with the InvestorPatrick Peterspage 2 Father\u27s Book, Jan. 1984 (A Fictional Autobiography)James T. Finneganpage 3 Pet Day in Afternoon KindergartenDan Von Holtenpage 7 Dental Dreams in the Bathroom MirrorDan Von Holtenpage 7 PhotographStephanie Eihlpage 8 SilenceJoe Hortonpage 8 SkullMichael Salempage 9 The TunnelJim Harrispage 10 Lindenwood CemeteryJean Chandlerpage 12 Into the SeaDan Seltzerpage 13 PhotographStephanie Eihlpage 13 WindowsJim Harrispage 14 Little Pieces of YouStuart Albertpage 18 Slicing the AppleAmy Callpage 19 Winter WalkLarry Mitchellpage 19 Komical KellyJohn Fehrmannpage 20 Thermal SueJohn Fehrmannpage 20 Death PoemBob Zordanipage 21 Venice, ItalySherry L. Clinepage 22 RoadkillPhil Simpsonpage 24 I Hate CowsLori Delzer, Joe Crites, Becky Michaelpage 32 Telephone Operators: 1942Jim Harrispage 33 Expiration Date 3/8/65Edward Schellpage 34 Desert FloorPatrick Peterspage 35 PhotographLawrence McGownpage 36 PhotographStephanie Eihlpage 37 Coping with NightStuart Albertpage 38 PhotographDan Mountpage 38 One On OnePatrick Peterspage 39 An Acquired TasteTina Wrightpage 40 PhotographStephanie Eihlpage 40 PhotographStephanie Eihlpage 41 When Children Are Alone, The Devil SpeaksTom Greenpage 41 BobChristy Denphypage 42 Gut & ScissorsDane Buczkowskipage 42 This Old HouseAmy Callpage 43 MortgageTina Wrightpage 43https://thekeep.eiu.edu/vehicle/1048/thumbnail.jp

    A randomized trial of mail vs. telephone invitation to a community-based cardiovascular health awareness program for older family practice patients [ISRCTN61739603]

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    BACKGROUND: Family physicians can play an important role in encouraging patients to participate in community-based health promotion initiatives designed to supplement and enhance their in-office care. Our objectives were to determine effective approaches to invite older family practice patients to attend cardiovascular health awareness sessions in community pharmacies, and to assess the feasibility and acceptability of a program incorporating invitation by physicians and feedback to physicians. METHODS: We conducted a prospective randomized trial with 1 family physician practice and 5 community pharmacies in Dundas, Ontario. Regular patients 65 years or older (n = 235) were randomly allocated to invitation by mail or telephone to attend pharmacy cardiovascular health awareness sessions led by volunteer peer health educators. A health record review captured blood pressure status, monitoring and control. At the sessions, volunteers helped patients to measure blood pressure using in-store machines and a validated portable device (BPM-100), and recorded blood pressure readings and self-reported cardiovascular risk factors. We compared attendance rates in the mail and telephone invitation groups and explored factors potentially associated with attendance. RESULTS: The 119 patients invited by mail and 116 patients contacted by telephone had a mean age of 75.7 (SD, 6.4) years and 46.8% were male. Overall, 58.3% (137/235) of invitees attended a pharmacy cardiovascular health awareness session. Patients invited by telephone were more likely to attend than those invited by mail (72.3% vs. 44.0%, OR 3.3; 95%CI 1.9–5.7; p < 0.001). CONCLUSION: While the attendance in response to a telephone invitation was higher, response to a single letter was substantial. Attendance rates indicated considerable interest in community-based cardiovascular health promotion activities. A large-scale trial of a pharmacy cardiovascular health awareness program for older primary care patients is feasible

    The Vehicle, Fall 1986

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    Table of Contents Selling Poetry: Honesty with the InvestorPatrick Peterspage 2 Father\u27s Book, Jan. 1984 (A Fictional Autobiography)James T. Finneganpage 3 Pet Day in Afternoon KindergartenDan Von Holtenpage 7 Dental Dreams in the Bathroom MirrorDan Von Holtenpage 7 PhotographStephanie Eihlpage 8 SilenceJoe Hortonpage 8 SkullMichael Salempage 9 The TunnelJim Harrispage 10 Lindenwood CemeteryJean Chandlerpage 12 Into the SeaDan Seltzerpage 13 PhotographStephanie Eihlpage 13 WindowsJim Harrispage 14 Little Pieces of YouStuart Albertpage 18 Slicing the AppleAmy Callpage 19 Winter WalkLarry Mitchellpage 19 Komical KellyJohn Fehrmannpage 20 Thermal SueJohn Fehrmannpage 20 Death PoemBob Zordanipage 21 Venice, ItalySherry L. Clinepage 22 RoadkillPhil Simpsonpage 24 I Hate CowsLori Delzer, Joe Crites, Becky Michaelpage 32 Telephone Operators: 1942Jim Harrispage 33 Expiration Date 3/8/65Edward Schellpage 34 Desert FloorPatrick Peterspage 35 PhotographLawrence McGownpage 36 PhotographStephanie Eihlpage 37 Coping with NightStuart Albertpage 38 PhotographDan Mountpage 38 One On OnePatrick Peterspage 39 An Acquired TasteTina Wrightpage 40 PhotographStephanie Eihlpage 40 PhotographStephanie Eihlpage 41 When Children Are Alone, The Devil SpeaksTom Greenpage 41 BobChristy Denphypage 42 Gut & ScissorsDane Buczkowskipage 42 This Old HouseAmy Callpage 43 MortgageTina Wrightpage 43https://thekeep.eiu.edu/vehicle/1048/thumbnail.jp
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