644 research outputs found
On Ptolemaic metric simplicial complexes
We show that under certain mild conditions, a metric simplicial complex which
satisfies the Ptolemy inequality is a CAT(0) space. Ptolemy's inequality is
closely related to inversions of metric spaces. For a large class of metric
simplicial complexes, we characterize those which are isometric to Euclidean
space in terms of metric inversions.Comment: 13 page
Slip statistics of dislocation avalanches under different loading modes
Slowly compressed microcrystals deform via intermittent slip events, observed as displacement jumps or stress drops. Experiments often use one of two loading modes: an increasing applied stress (stress driven, soft), or a constant strain rate (strain driven, hard). In this work we experimentally test the influence of the deformation loading conditions on the scaling behavior of slip events. It is found that these common deformation modes strongly affect time series properties, but not the scaling behavior of the slip statistics when analyzed with a mean-field model. With increasing plastic strain, the slip events are found to be smaller and more frequent when strain driven, and the slip-size distributions obtained for both drives collapse onto the same scaling function with the same exponents. The experimental results agree with the predictions of the used mean-field model, linking the slip behavior under different loading modes
Dark energy constraints and correlations with systematics from CFHTLS weak lensing, SNLS supernovae Ia and WMAP5
We combine measurements of weak gravitational lensing from the CFHTLS-Wide
survey, supernovae Ia from CFHT SNLS and CMB anisotropies from WMAP5 to obtain
joint constraints on cosmological parameters, in particular, the dark energy
equation of state parameter w. We assess the influence of systematics in the
data on the results and look for possible correlations with cosmological
parameters.
We implement an MCMC algorithm to sample the parameter space of a flat CDM
model with a dark-energy component of constant w. Systematics in the data are
parametrised and included in the analysis. We determine the influence of
photometric calibration of SNIa data on cosmological results by calculating the
response of the distance modulus to photometric zero-point variations. The weak
lensing data set is tested for anomalous field-to-field variations and a
systematic shape measurement bias for high-z galaxies.
Ignoring photometric uncertainties for SNLS biases cosmological parameters by
at most 20% of the statistical errors, using supernovae only; the parameter
uncertainties are underestimated by 10%. The weak lensing field-to-field
variance pointings is 5%-15% higher than that predicted from N-body
simulations. We find no bias of the lensing signal at high redshift, within the
framework of a simple model. Assuming a systematic underestimation of the
lensing signal at high redshift, the normalisation sigma_8 increases by up to
8%. Combining all three probes we obtain -0.10<1+w<0.06 at 68% confidence
(-0.18<1+w<0.12 at 95%), including systematic errors. Systematics in the data
increase the error bars by up to 35%; the best-fit values change by less than
0.15sigma. [Abridged]Comment: 14 pages, 10 figures. Revised version, matches the one to be
published in A&A. Modifications have been made corresponding to the referee's
suggestions, including reordering of some section
Niemann-Pick type C Suspicion Index tool: analyses by age and association of manifestations
Clinical manifestations and treatment of mucopolysaccharidosis type I patients in Latin America as compared with the rest of the world
Background Mucopolysaccharidosis I (MPS I) comprises a spectrum of clinical manifestations and is divided into three phenotypes reflecting clinical severity: Hurler, Hurler-Scheie, and Scheie syndromes. There may be important variations in clinical manifestations of this genetic disease in patients residing in different regions of the world.Methods Using data from the MPS I Registry (as of September 2009), we evaluated patients from Latin America (n=118) compared with patients from the rest of the world [ROW (n=727)].Results Phenotype distribution differed among patients in Latin America compared to ROW(Hurler 31 vs. 62%, Hurler-Scheie 36 vs. 21%, Scheie 10 vs. 11%, and unknown 22 vs. 6%). the frequency of certain symptoms, such as cardiac valve abnormalities, sleep impairment, and joint contractures, also differed between Latin America and ROW for some phenotypes. Median age at MPS I diagnosis was earlier in the ROW than Latin America for all phenotypes, and age at first treatment for Hurler and Hurler-Scheie patients was also earlier in the ROW. Hurler patients in Latin America showed a gap of 3.1 years between median ages of diagnosis and first treatment compared to only 0.5 years in the ROW. Treatment allocation in Latin America compared to ROW was as follows: enzyme replacement therapy (ERT) only, 80 vs. 45%; hematopoietic stem cell transplantation (HSCT) only, 0.9 vs. 27%; both ERT and HSCT, 0 vs. 16%; and neither treatment, 19 vs. 13%.Conclusion These data highlight important differences in MPS I patients between Latin America and ROW in terms of phenotypic distribution, clinical manifestations, and treatment practices.MPS I Registry team at Genzyme CorporationHosp Nacl Pediat JP Garrahan, Unidad Errores Congenitos Metab, Buenos Aires, DF, ArgentinaHosp Especialidades UMAE 25, Monterrey, MexicoGenzyme Corp, Latin Amer Grp, Registry Program, Rio de Janeiro, BrazilUniv Rosario, Fdn Univ Ciencias Salud, Bogota, ColombiaUniv Valparaiso, Fac Med, Neurol Infantil Programa Formac Neuropediat, Valparaiso, ChileUniv Chile, INTA, Lab Genet & Enfermedades Metab, Santiago, ChileUniversidade Federal de São Paulo, Ctr Referencia Erros Inatos Metab, São Paulo, BrazilGenzyme Corp, Latin Amer Grp, Compassionate Use Program, Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Ctr Referencia Erros Inatos Metab, São Paulo, BrazilWeb of Scienc
Isomer shift and magnetic moment of the long-lived 1/2 isomer in Zn: signature of shape coexistence near Ni
Collinear laser spectroscopy has been performed on the Zn
isotope at ISOLDE-CERN. The existence of a long-lived isomer with a few hundred
milliseconds half-life was confirmed, and the nuclear spins and moments of the
ground and isomeric states in Zn as well as the isomer shift were
measured. From the observed hyperfine structures, spins and
are firmly assigned to the ground and isomeric states. The magnetic moment
(Zn) = 1.1866(10) , confirms the spin-parity
with a shell-model configuration, in excellent
agreement with the prediction from large scale shell-model theories. The
magnetic moment (Zn) = 1.0180(12) supports a
positive parity for the isomer, with a wave function dominated by a 2h-1p
neutron excitation across the shell gap. The large isomer shift
reveals an increase of the intruder isomer mean square charge radius with
respect to that of the ground state:
= +0.204(6) fm, providing first evidence of shape coexistence.Comment: 5 pages, 4 figures, 1 table, Accepeted by Phys. Rev. Lett. (2016
Developmental biographies of Olympic super-elite and elite athletes – a multidisciplinary pattern recognition analysis
This multidisciplinary study used pattern recognition analyses to examine the developmental biographies of 16 Great British Olympic and World Champions (‘Super-Elite’) and 16 matched international athletes who had not won major medals (‘Elite’). Athlete, coach and parent interviews (260 total interview hours) combined in-depth qualitative and quantitative methods. A combination of demographics, psychosocial characteristics, coach and family relationships, practice, competition, and performance development discriminated Super-Elite from Elite athletes with > 90% accuracy. Compared to Elite athletes, Super-Elite athletes were characterized by: (1) An early critical negative life experience in close proximity to significant positive sport-related events; (2) higher relative importance of sport over other aspects of life, stronger obsessiveness/perfectionism, and sport-related ruthlessness/selfishness; (3) conjoint outcome and mastery focus, and use of counterphobic and/or ‘total preparation’ strategies to maintain/enhance performance under pressure; (4) coaches who better met their physical and psychosocial needs; (5) coming back after severe performance setbacks during adulthood, and career ‘turning points’ leading to enhanced determination to excel; (6) more pronounced diversified youth sport engagement, and prolonged extensive sport-specific practice and competitions; and (7) continued performance improvement over more years during adulthood, eventually attaining their (first) gold medal after 21 ± 6 practice years. The findings are discussed relative to potential causal interactions and theoretical implications
Estimation of cosmological parameters using adaptive importance sampling
We present a Bayesian sampling algorithm called adaptive importance sampling
or Population Monte Carlo (PMC), whose computational workload is easily
parallelizable and thus has the potential to considerably reduce the wall-clock
time required for sampling, along with providing other benefits. To assess the
performance of the approach for cosmological problems, we use simulated and
actual data consisting of CMB anisotropies, supernovae of type Ia, and weak
cosmological lensing, and provide a comparison of results to those obtained
using state-of-the-art Markov Chain Monte Carlo (MCMC). For both types of data
sets, we find comparable parameter estimates for PMC and MCMC, with the
advantage of a significantly lower computational time for PMC. In the case of
WMAP5 data, for example, the wall-clock time reduces from several days for MCMC
to a few hours using PMC on a cluster of processors. Other benefits of the PMC
approach, along with potential difficulties in using the approach, are analysed
and discussed.Comment: 17 pages, 11 figure
- …