263 research outputs found

    COORDINATION CHEMISTRY OF PIPERAZINE AND PIPERAZINE DERIVATIVES

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    Reference to index of poetry and photographs of Rev. Frederick A Woods

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    Rev. Frederick A Woods (1861-1944) was a Congregational Church minister, who served at Bellerive and other places, and was Chairman of the Congregational Union of Tasmania. These papers include many sacred poems and other miscellaneous poetry and notes and photographs of himself and family

    Towards a long-term record of solar total and spectral irradiance

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    The variation of total solar irradiance (TSI) has been measured since 1978 and that of the spectral irradiance for an even shorter amount of time. Semi-empirical models are now available that reproduce over 80% of the measured irradiance variations. An extension of these models into the more distant past is needed in order to serve as input to climate simulations. Here we review our most recent efforts to model solar total and spectral irradiance on time scales from days to centuries and even longer. Solar spectral irradiance has been reconstructed since 1947. Reconstruction of solar total irradiance goes back to 1610 and suggests a value of about 1-1.5 Wm2^{-2} for the increase in the cycle-averaged TSI since the end of the Maunder minimum, which is significantly lower than previously assumed but agrees with other modern models. First steps have also been made towards reconstructions of solar total and spectral irradiance on time scales of millennia

    Dependence as a Unifying Construct in Defining Alzheimer's Disease Severity

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    This article reviews measures of Alzheimer's disease (AD) progression in relation to patient dependence and offers a unifying conceptual framework for dependence in AD. Clinicians typically characterize AD by symptomatic impairments in three domains: cognition, function, and behavior. From a patient's perspective, changes in these domains, individually and in concert, ultimately lead to increased dependence and loss of autonomy. Examples of dependence in AD range from a need for reminders (early AD) to requiring safety supervision and assistance with basic functions (late AD). Published literature has focused on the clinical domains as somewhat separate constructs and has given limited attention to the concept of patient dependence as a descriptor of AD progression. This article presents the concept of dependence on others for care needs as a potential method for translating the effect of changes in cognition, function, and behavior into a more holistic, transparent description of AD progression

    Small Platforms, High Return: The Need to Enhance Investment in Small Satellites for Focused Science, Career Development, and Improved Equity

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    In the next decade, there is an opportunity for very high return on investment of relatively small budgets by elevating the priority of smallsat funding in heliophysics. We've learned in the past decade that these missions perform exceptionally well by traditional metrics, e.g., papers/year/\$M (Spence et al. 2022 -- arXiv:2206.02968). It is also well established that there is a "leaky pipeline" resulting in too little diversity in leadership positions (see the National Academies Report at https://www.nationalacademies.org/our-work/increasing-diversity-in-the-leadership-of-competed-space-missions). Prioritizing smallsat funding would significantly increase the number of opportunities for new leaders to learn -- a crucial patch for the pipeline and an essential phase of career development. At present, however, there are far more proposers than the available funding can support, leading to selection ratios that can be as low as 6% -- in the bottom 0.5th percentile of selection ratios across the history of ROSES. Prioritizing SmallSat funding and substantially increasing that selection ratio are the fundamental recommendations being made by this white paper.Comment: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 6 pages, 1 figur
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