Neurobiological Correlates Of Personality And Emotional Expression In Traumatic Brain Injury

Many individuals with traumatic brain injury (TBI) experience cognitive, emotional, and functional deficits, all of which can contribute to chronic stress. Unfortunately, individuals with TBI often engage in less effective coping than non-brain-injured individuals, which has negative implications for rehabilitation. Differences in personality traits have been linked to individual differences in coping styles, physiological stress reactivity, and emotional disclosure. Research on personality and coping after TBI has been sparse. Thus, the present study examined the influence of TBI on the pattern of the relationships between personality, emotional expression, and stress reactivity. Eighty-one adults who sustained moderate to severe TBI and 76 significant others of individuals with TBI participated. Personality was assessed using the Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scale, and self-report of affectivity was measured with the Positive and Negative Affect Schedule (PANAS). Verbal and nonverbal emotional expression were gleaned from a 3-minute videotaped speech task for which participants were asked to talk about stressful aspects of recovery from brain injury. Physiological measures of stress were also collected during the speech task. Results indicate that the pattern of relations between personality, emotional expression, and stress reactivity are affected by TBI; however, consistencies between the groups were also found. Both groups showed similar patterns for BIS in terms of propensity toward negative affectivity, as well as concomitant verbal output of negative emotion. Significant others showed a distinctive pattern for BAS sensitivity, which was associated with positive affectivity and low nonverbal expressions of sadness relative to a propensity to express anxiety and anger during the emotional challenge. By comparison, people with TBI showed a global pattern for BAS sensitivity of heightened affectivity (positive and negative affectivity), as well as explicit verbal output reflecting negative emotionality. Like significant others, BAS was associated with the propensity toward nonverbal expression of anxiety during the emotional challenge; however, people with TBI expressed more happiness, and less anxiety and helplessness than did significant others. Impairments in awareness of deficits and impaired cognitive appraisal of stress following TBI are likely to have contributed to the finding that adults with TBI exhibited more happiness and less anxiety than significant others. In general, TBI appears to enhance BAS but not BIS, which is supported by higher BAS sensitivity as a function of TBI severity and relative to individuals without TBI. For both groups, BAS sensitivity was favorably related to acute stress reactivity. In fact, among people with TBI BAS was uniquely related to stress coping, beyond that explained by demographic and injury characteristics. Taken together, the findings generally depict a pattern in which BAS facilitates expression of emotion and may also buffer or relieve experience of stress during emotional challenge. The BIS/BAS theory of personality and scale appear to be promising avenues for future research in these regards. The present study provides insight into how brain injury affects the relations between personality, stress reactivity, and emotional expression. Findings also highlight the importance of considering personality traits when studying emotional expression. Future research investigating the utility of these associations to predict rehabilitation and quality of life outcomes among brain-injured individuals has the potential to inform recovery prognosis and treatment recommendations

Hearing Loss And Verbal Memory Assessment In Older Adults

Prior research has found that adults with hearing loss perform worse on cognitive testing than adults without hearing loss, and some studies have suggested that hearing loss is associated with dementia. Heavy emphasis on tests involving auditory stimuli for memory assessment may result in overdiagnosis of cognitive impairment in individuals with hearing loss. The present study compared visual and auditory versions of a verbal memory test among older adults with and without hearing loss. Forty-one adults with moderate-to-severe, sensorineural hearing loss (HL) and 41 age-matched adults with normal hearing (NH) participated. Age ranged from 55 – 80 years. They completed a neuropsychological battery that included auditory and visual versions of the Hopkins Verbal Learning Testing-Revised (HVLT-R). The auditory conditions included a Natural Auditory condition for which stimuli was presented at a normal speaking volume and a Crossed Auditory condition for which individuals with hearing loss completed the test with amplified volume and individuals with normal hearing completed the test under a hearing loss simulation. Mixed-model ANOVA indicated significant group (HL vs. NH) by condition (Visual vs. Natural Auditory vs. Crossed Auditory HVLT-R) interactions with large effect sizes. Post hoc contrasts showed that the HL group performed significantly worse than the NH group on the Natural Auditory version. The opposite pattern was found for the Crossed Auditory condition: The NH group performed significantly worse than the HL group. The groups were equivalent on the Visual condition and showed small effect sizes. Auditory and visual versions were highly correlated for the NH group but not for the HL group. Groups did not significantly differ on other neuropsychological tests and showed small effect sizes. Moreover, for the HL group, the visual version of the verbal memory test was strongly correlated with other neuropsychological tests whereas the standard auditory version was not. Cognitively intact older adults with hearing loss appeared impaired on an auditory-verbal word list memory test under typical administration conditions. Visual assessment of verbal memory shows evidence of superior validity and is a viable alternative method to assess memory function especially in older populations

Mentalizing and motivation neural function during social interactions in autism spectrum disorders

AbstractAutism Spectrum Disorders (ASDs) are characterized by core deficits in social functions. Two theories have been suggested to explain these deficits: mind-blindness theory posits impaired mentalizing processes (i.e. decreased ability for establishing a representation of others' state of mind), while social motivation theory proposes that diminished reward value for social information leads to reduced social attention, social interactions, and social learning. Mentalizing and motivation are integral to typical social interactions, and neuroimaging evidence points to independent brain networks that support these processes in healthy individuals. However, the simultaneous function of these networks has not been explored in individuals with ASDs. We used a social, interactive fMRI task, the Domino game, to explore mentalizing- and motivation-related brain activation during a well-defined interval where participants respond to rewards or punishments (i.e. motivation) and concurrently process information about their opponent's potential next actions (i.e. mentalizing). Thirteen individuals with high-functioning ASDs, ages 12–24, and 14 healthy controls played fMRI Domino games against a computer-opponent and separately, what they were led to believe was a human-opponent. Results showed that while individuals with ASDs understood the game rules and played similarly to controls, they showed diminished neural activity during the human-opponent runs only (i.e. in a social context) in bilateral middle temporal gyrus (MTG) during mentalizing and right Nucleus Accumbens (NAcc) during reward-related motivation (Pcluster<0.05 FWE). Importantly, deficits were not observed in these areas when playing against a computer-opponent or in areas related to motor and visual processes. These results demonstrate that while MTG and NAcc, which are critical structures in the mentalizing and motivation networks, respectively, activate normally in a non-social context, they fail to respond in an otherwise identical social context in ASD compared to controls. We discuss implications to both the mind-blindness and social motivation theories of ASD and the importance of social context in research and treatment protocols

Gender perspectives on views and preferences of older people on exercise to prevent falls: a systematic mixed studies review

Background: To offer fall prevention exercise programs that attract older people of both sexes there is a need to understand both womens and mens views and preferences regarding these programs. This paper aims to systematically review the literature to explore any underlying gender perspectives or gender interpretations on older peoples views or preferences regarding uptake and adherence to exercise to prevent falls. Methods: A review of the literature was carried out using a convergent qualitative design based on systematic searches of seven electronic databases (PubMed, CINAHL, Amed, PsycINFO, Scopus, PEDro, and OTseeker). Two investigators identified eligible studies. Each included article was read by at least two authors independently to extract data into tables. Views and preferences reported were coded and summarized in themes of facilitators and barriers using a thematic analysis approach. Results: Nine hundred and nine unique studies were identified. Twenty five studies met the criteria for inclusion. Only five of these contained a gender analysis of mens and womens views on fall prevention exercises. The results suggests that both women and men see women as more receptive to and in more need of fall prevention messages. The synthesis from all 25 studies identified six themes illustrating facilitators and six themes describing barriers for older people either starting or adhering to fall prevention exercise. The facilitators were: support from professionals or family; social interaction; perceived benefits; a supportive exercise context; feelings of commitment; and having fun. Barriers were: practical issues; concerns about exercise; unawareness; reduced health status; lack of support; and lack of interest. Considerably more women than men were included in the studies. Conclusion: Although there is plenty of information on the facilitators and barriers to falls prevention exercise in older people, there is a distinct lack of studies investigating differences or similarities in older womens and mens views regarding fall prevention exercise. In order to ensure that fall prevention exercise is appealing to both sexes and that the inclusion of both men and women are encouraged, more research is needed to find out whether gender differences exists and whether practitioners need to offer a range of opportunities and support strategies to attract both women and men to falls prevention exercise.Funding Agencies|Swedish Research Council [2015-03481]; Strategic Research Programme in Care Sciences, Umea University; Karolinska Institute, Sweden; Umea University</p

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

Background: Novel therapeutic agents that selectively induce tumor cell death are urgently needed in the clinical management of cancers. Such agents would constitute effective adjuvant approaches to traditional chemotherapy regimens. Organosulfur compounds (OSCs), such as diallyl disulfide, have demonstrated anti-proliferative effects on cancer cells. We have previously shown that synthesized relatives of dysoxysulfone, a natural OSC derived from the Fijian medicinal plant, Dysoxylum richi, possess tumor-specific antiproliferative effects and are thus promising lead candidates. Methods: Because our structure-activity analyses showed that regions flanking the disulfide bond mediated specificity, we synthesized 18 novel OSCs by structural modification of the most promising dysoxysulfone derivatives. These compounds were tested for anti-proliferative and apoptotic activity in both normal and leukemic cells. Results: Six OSCs exhibited tumor-specific killing, having no effect on normal bone marrow, and are thus candidates for future toxicity studies. We then employed mRNA expression profiling to characterize the mechanisms by which different OSCs induce apoptosis. Using Gene Ontology analysis we show that each OSC altered a unique set of pathways, and that these differences could be partially rationalized from a transcription factor binding site analysis. For example, five compounds altered genes with a large enrichment of p53 binding sites in their promoter regions (p < 0.0001). Conclusions: Taken together, these data establish OSCs derivatized from dysoxysulfone as a novel group of compounds for development as anti-cancer agents

The Optimal Study: Describing the Key Components of Optimal Health Care Delivery to UK Care Home Residents: A Research Protocol

Long-term institutional care in the United Kingdom is provided by care homes. Residents have prevalent cognitive impairment and disability, have multiple diagnoses, and are subject to polypharmacy. Prevailing models of health care provision (ad hoc, reactive, and coordinated by general practitioners) result in unacceptable variability of care. A number of innovative responses to improve health care for care homes have been commissioned. The organization of health and social care in the United Kingdom is such that it is unlikely that a single solution to the problem of providing quality health care for care homes will be identified that can be used nationwide. Realist evaluation is a methodology that uses both qualitative and quantitative data to establish an in-depth understanding of what works, for whom, and in what settings. In this article we describe a protocol for using realist evaluation to understand the context, mechanisms, and outcomes that shape effective health care delivery to care home residents in the United Kingdom. By describing this novel approach, we hope to inform international discourse about research methodologies in long-term care settings internationally

Assessment of chemical species of lead accumulated in tidemarks of human articular cartilage by X-ray absorption near-edge structure analysis

Lead is a toxic trace element that shows a highly specific accumulation in the transition zone between calcified and non-calcified articular cartilage, the so-called ‘tidemark’. Excellent agreement has been found between XANES spectra of synthetic Pb-doped carbonated hydroxyapatite and spectra obtained in the tidemark region and trabecular bone of normal human samples, confirming that in both tissues Pb is incorporated into the hydroxyapatite crystal structure of bone. During this study the µ-XANES set-up at the SUL-X beamline at ANKA was tested and has proven to be well suited for speciation of lead in human mineralized tissue samples

State Control and the Effects of Foreign Relations on Bilateral Trade

Do states use trade to reward and punish partners? WTO rules and the pressures of globalization restrict states’ capacity to manipulate trade policies, but we argue that governments can link political goals with economic outcomes using less direct avenues of influence over firm behavior. Where governments intervene in markets, politicization of trade is likely to occur. In this paper, we examine one important form of government control: state ownership of firms. Taking China and India as examples, we use bilateral trade data by firm ownership type, as well as measures of bilateral political relations based on diplomatic events and UN voting to estimate the effect of political relations on import and export flows. Our results support the hypothesis that imports controlled by state-owned enterprises (SOEs) exhibit stronger responsiveness to political relations than imports controlled by private enterprises. A more nuanced picture emerges for exports; while India’s exports through SOEs are more responsive to political tensions than its flows through private entities, the opposite is true for China. This research holds broader implications for how we should think about the relationship between political and economic relations going forward, especially as a number of countries with partially state-controlled economies gain strength in the global economy

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed that brain metastases evade phosphatidylinositide 3-kinase (PI3K) inhibition despite drug accumulation in the brain lesions. In comparison to extracranial disease, we observed increased HER3 expression and phosphorylation in brain lesions. HER3 blockade overcame the resistance of HER2-amplified and/or PIK3CA-mutant breast cancer brain metastases to PI3K inhibitors, resulting in marked tumor growth delay and improvement in mouse survival. These data provide a mechanistic basis for therapeutic resistance in the brain microenvironment and identify translatable treatment strategies for HER2-amplified and/or PIK3CA-mutant breast cancer brain metastases

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin