Low-temperature redetermination of benzofurazan 1-oxide

In the six-membered ring of the low-temperature crystal structure of benzofurazan 1-oxide, C6H4N2O2, the two C atoms adjacent to the N atoms are linked by a delocalized aromatic bond [1.402 (2) Å]; each is connected to its neighbour by a longer, more localized, bond [1.420 (2), 1.430 (2) Å]. However, the next two bonds in the ring approximate double bonds [1.357 (2), 1.366 (2) Å]. As such, the six-membered ring is better described as a cyclo­hexa­diene system, in contrast to the description in the room-temperature structure reported by Britton & Olson (1979 ▶) [Acta Cryst. B35, 3076–3078]

Effects of an ACTH 4-9 related peptide upon intracranial self stimulation and general activity in the rat

Adult male Sprague-Dawley rats were stereotactically implanted with electrodes within the anterior medial forebrain bundle: The rats were trained to respond for intracranial self-stimulation (ICS) and treated with control solution or varying doses of an ACTH 4-9 related synthetic peptide (Org 2766; H-Met(O 2 )-Glu-His-Phe- d -Lys-Phe-OH). The drug affected ICS as measured in overnight response records, with the highest dose reliably increasing the amount of responding. In a second experiment rats were similarly treated and general activity was assessed. No remarkable changes in activity were present at any tested dose. The findings corroborate previous reports suggesting ACTH-related peptides may be active in a variety of motivated tasks, but less active with respect to general activity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46417/1/213_2004_Article_BF00433254.pd