Caracterización y calibración automática de bobinas de Heltmoltz en DC

La caracterización y calibración de un electroimán es de suma importancia para las posibles aplicaciones futuras que se pretendan con el equipo. En este trabajo, se informan y justifican teóricamente los procesos seguidos para la caracterización y calibración automática de un electroimán Phylatex. Además se presentan las curvas experimentales de campo magnético producido por las bobinas en función de la corriente aplicada, obteniéndose el comportamiento esperado de acuerdo a la teoría de materiales ferromagnéticos. Finalmente se presenta este procedimiento como alternativa para la caracterización de nuevos materiales.Characterization and calibration of electromagnets is a very important issue if the objective is to develop any further application with the equipment. In this work it is informed and theoretically justify the automatic characterization and calibration of a Phylatex electromagnet. Besides, the experimental curves produced by a magnetic field as function of the feeder current in the windinos are also provided, resulting in an expected behaviour according to the theory of ferromagnetic materials. Finally an alternative procedure for the characterization of materials is presented

Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion

Producción CientíficaMetronomic chemotherapy using the 5-FU prodrug uracil-tegafur (UFT) and cyclophosphamide (CTX) was previously shown to only modestly delay primary tumor growth, but nevertheless markedly suppressed the development of micro-metastasis in an orthotopic breast cancer xenograft model, using the metastatic variant of the MDA-MB-231 cell line, 231/LM2-4. Furthermore, a remarkable prolongation of survival, with no toxicity, was observed in a model of postsurgical advanced metastatic disease. A question that has remained unanswered is the seemingly selective anti-metastatic mechanisms of action responsible for this treatment. We assessed the in vivo effect of metronomic UFT, CTX or their combination, on vascular density, collagen deposition and c-Met (cell mediators or modulators of tumor cell invasion or dissemination) via histochemistry/immunohistochemistry of primary tumor sections. We also assessed the effect of continuous exposure to low and non-toxic doses of active drug metabolites 5-fluorouracil (5-FU), 4-hydroperoxycyclophosphamide (4-HC) or their combination, on 231/LM2-4 cell invasiveness in vitro. In the in vivo studies, a significant reduction in vascular density and p-Met[Y1003] levels was associated with UFT+CTX treatment. All treatments reduced intratumoral collagen deposition. In the in vitro studies, a significant reduction of collagen IV invasion by all treatments was observed. The 3D structures formed by 231/LM2-4 on Matrigel showed a predominantly Mass phenotype under treated conditions and Stellate phenotype in untreated cultures. Taken together, the results suggest the low-dose metronomic chemotherapy regimens tested can suppress several mediators of tumor invasiveness highlighting a new perspective for the anti-metastatic efficacy of metronomic chemotherapy.Canadian Institutes of Health Research (grant 364411

Caracterización y calibración automática de bobinas de heltmoltz en dc

La caracterización y calibración de un electroimán es de suma importancia para las posibles aplicaciones futuras que se pretendan con el equipo. En este trabajo, se informan y justifican teóricamente los procesos seguidos para la caracterización y calibración automática de un electroimán Phylatex. Además se presentan las curvas experimentales de campo magnético producido por las bobinas en función de la corriente aplicada, obteniéndose el comportamiento esperado de acuerdo a la teoría de materiales ferromagnéticos. Finalmente se presenta este procedimiento como alternativa para la caracterización de nuevos materiales

Características clínicas e histopatológicas asociadas a pacientes con Cáncer de Mama Triple Negativo en un Hospital de Referencia peruano, 2012- 2018: Clinical and histopathological characteristics associated with patients with triple-negative Breast cancer at a national reference hospital, 2012 - 2018

Objective: To determine the clinical and histopathological characteristics associated to patients with triple negative breast cancer of the Hipolito Unanue National Hospital between June 2012 to June 2018. Methods: Cross-sectional analytical study. Results: 134 patients were included, out of which 36 (26.9%) were TN and 98 No TN. Of the histopathological characteristics, the most frequent CD was III and II for the two groups. The histological type that predominated was the infiltrating ductal type in both groups. The high histological grade was characteristic in NT (58%) unlike non TN. The NTs were larger 5.75 cm in contrast to the TNs with 3 cm, and the Ki 67 was higher in the TN 35% in contrast to the NON TN with 15%. In the bivariate analysis the size (RP: 1.4, CI: 1.17-1.68, p = 0.0001), Ki 67 (RP: 1.05, CI: 1.03-1.07, p = 0.001), BMI ≥25 kg/m2 ( RP: 1.14, CI: 1.23-6.22, p = 0.014), Histological Grade 3 (RP: 3.87, CI: 1.74-8.63, p = 0.001), size ≥5 cm (RP: 2.94, CI: 1.33-6.48, p = 0.008) were significant. In the multivariate analysis it was found that grade 3 (PR: 1.74, CI: 1.01-3, p = 0.0046) and Ki 67 (RP: 1.02, CI: 1.01-1.03, p = 0.0001) were histopathological characteristics associated with CMTN. Conclusion: There are histopathological characteristics associated with triple negative breast cancer particularly high histological grade and Ki67 value.Objetivo:Determinar las características clínicas e histopatológicas asociadas a las pacientes con cáncer de mama triple negativo (CMTN) en un Hospital peruano de referencia. Métodos: Estudio transversal, analítico. Se revisaron las historias clínicas de todas las pacientes atendidas en el Hospital Nacional Hipóito Unanue durante el periodo de junio del 2012 a junio del 2018. Resultados: Se incluyeron 134 pacientes de los cuales 36 (26.9%) correspondieron a CMTN. el estadío clínico más frecuente fue el III y II para los dos grupos. El tipo histológico que más predomino fue el tipo ductal infiltrante en ambos grupos. El grado histológico elevado fue característico en los casos de CMTN (58%) a diferencia de los No TN. Los CMTN fueron de mayor tamaño (5.75 cm vs 3cm en no TN), y el Ki 67 fue más elevado en el TN (35% en comparación con el No TN con 15%). Se determinó en el análisis bivariado que el tamaño (RP: 1.4, IC: 1.17-1.68, p= 0.0001), Ki 67 (RP: 1.05, IC: 1.03-1.07, p= 0.001), IMC ≥25 kg/m2 (RP: 1.14, IC: 1.23-6.22, p= 0.014) y el Grado Histológico 3 (RP:3.87, IC: 1.74-8.63, p= 0.001) se asociaron significativamente a la presencia de CMTN. En el análisis multivariado se encontró que el grado 3 (RP: 1.74, IC: 1.01-3. p= 0.0046) y el Ki 67 (RP: 1.02, IC: 1.01-1.03, p= 0.0001) fueron las características histopatológicas asociados al CMTN. Conclusión: Las características más consistentemente asociadas al cáncer de mama triple negativo en fueron el elevado grado histológico y mayor valor de Ki67

El modelaje webcam frente al derecho laboral Colombiano

Nuestra investigación es una fuente referente de consulta para quienes estén interesados en las fuerzas de trabajo que están emergiendo con las tecnologías, nociones jurídicas actualmente poco estudiadas en el ámbito laboral. En nuestra tesis analizamos cómo se configuran las relaciones laborales que están surgiendo en este nuevo mercado, sus problemáticas y las consecuencias de un fenómeno que requiere estudios más profundos; por lo que esperamos contribuir a la formulación de medios para atender potenciales crisis laborales provocadas por el uso de la tecnología, puesto que no se trata solo de necesidades económicas individuales, sino de un amplio desconocimiento de garantías sociales en el modelaje webcam y actividades afines.Universidad Libre de Colombia - Facultad de Derecho y Ciencias Políticas - Maestría en Derecho Laboral y Seguridad SocialOur research is a reference source of consultation for those who are interested in the work forces that are emerging with technologies, legal notions that are currently little studied in the workplace. In our thesis we analyze how the labor relations that are emerging in this new market are configured, their problems and the consequences of a phenomenon that requires more in-depth studies; For this reason, we hope to contribute to the formulation of means to address potential labor crises caused by the use of technology, since it is not only about individual economic needs, but also a wide ignorance of social guarantees in webcam modeling and related activities

Vitamin D deficiency and non-infectious uveitis:A systematic review and Meta-analysis

Background: Vitamin D plays a critical role in immunomodulation, and its deficiency is implicated in the pathogenesis of several autoimmune diseases. Nevertheless, its relationship with non-infectious uveitis (NIU), an inflammatory ocular disorder, remains inconclusive. Methods:A systematic search was conducted in three databases from database inception until May 8, 2023, to investigate the potential relationship between vitamin D deficiency and NIU. We included observational studies reporting the measurement of vitamin D levels in patients with NIU and healthy controls without restriction of language or date of publication. Three pairs of authors independently screened the title and abstracts for potential eligibility and then in full text. A third author resolved disagreements. Three pairs of independent reviewers abstracted the data from the fully reviewed records and evaluated the risk of bias. We followed The MOOSE and PRISMA guidelines. Random effects meta-analyses were used for primary analysis. Studies not included in the meta-analysis were summarized descriptively. This review was registered in PROSPERO: CRD42022308105. Findings: Of 933 records screened, 11 studies were included, and five were meta-analyzed, encompassing 354 cases and 5728 controls (mean participant age ranging from 7.1 to 58.9 years). Patients with vitamin D deficiency exhibited an Odds Ratio of 2.04 (95% CI = 1.55–2.68, P &lt; 0.00001) for developing NIU compared to controls. Overall, potential sources of bias were low across most studies. Interpretation: Our findings suggest that vitamin D may play an essential role in the pathophysiology of NIU. While the included studies demonstrated generally low potential bias, additional rigorous prospective studies are necessary to confirm these findings and further elucidate the underlying mechanisms involved. Vitamin D supplementation could represent a possible therapeutic strategy for preventing or managing NIU if substantiated. Clinicians should consider screening for and addressing vitamin D deficiency in patients with or at risk for NIU.</p

The mediating role of the entrepreneurial ecosystem in the entrepreneurial personality and green entrepreneurship : the case of Peruvian's university students.

Nowadays, the value of innovation, green behavior, and entrepreneurship have grown, which is essential for a country's sustainable development. However, there has been no in-depth study of what the ecosystem should be to promote entrepreneurship and, thus, care for the environment. For this reason, this study aims to explore the entrepreneurial ecosystem's effect on Peruvian university students' entrepreneurial personality and green entrepreneurship. This study uses a duly validated instrument that includes the three variables divided by dimensions and was applied to a population of university students in Peru. Using a simple random sampling technique, the data were collected from 384 students of Peruvian universities. This study used the Smart-PLS to examine the reliability of the data and the correlation of the dimensions and items of the variables. In conclusion, providing entrepreneurship tools can help students develop desirable personality traits to generate sustainable businesses. The job of universities is to improve education for sustainable development. This means that students should learn the skills and knowledge they need to use environmental practices in their businesses.Edwerson William Pacori Paricahua (Universidad nacional de Juliaca), Jorge Martín Cruz Padilla (Universidad Norbert Wiener), Soraya del Pilar Carranco (Madrid Universidad Central del Ecuador), Jose Omar García Tarazona (Universidad Nacional de educación), Sonia Alejandrina Sotelo Muñoz (Universidad científica del Sur), Jesus Enrique Reyes Acevedo (Universidad Nacional Autónoma de Alto Amazonas), Jose Daniel Sanchez Fernandez (Universidad Católica de Santa María), Isaac Merino Quispe (Universidad Nacional Jose Maria Arguedas), José Luis Arias-Gonzáles (Pontificia Universidad Católica del Perú), Roxana Yolanda Castillo-Acobo (Universidad Nacional de San Agustín), Milagros del Rosario Cáceres-Chávez (Camosun College)Includes bibliographical references

Nanocolumnar coatings on implants exhibiting antibacterial properties

Trabajo presentado en la 2nd International Conference on Nanomaterials Applied to Life Sciences 2020 (NALS 2020), celebrada en Madrid (España), del 29 al 31 de enero de 2020Addressing the problem of infection from the very first stage, i.e. inhibiting the formation of the bacterial biofilm, is a crucial step to prevent implant rejection. Nanocolumnar coatings exhibiting antibacterial properties have been fabricated by oblique deposition with magnetron sputtering [1]. The formation of nanocolumns (Fig.1) is the result of the effects of atomic shadowing when the atoms reach the surface along an inclined direction [2]. This technique is environmentally friendly: it is carried out at RT and does not involve chemical products (no recycling problems). Such methodology have been tested in a semiindustrial scale reactor, successfully coating in a single step the two sides of fixation plates for bone fractures [3]. Several in vitro experiments have been performed: analysis of bacterial adhesion and biofilm formation, analysis of osteoblast proliferation and mitochondrial activity, and osteoblasts–bacteria competitive growth scenarios, the latter also named “Race for the Surface” competition. In all these cases, the coatings show an opposite behavior toward osteoblast and bacterial proliferation [1,3]. Moreover, they are effective against Gram positive (S. aureus) and Gram negative (E. coli) bacteria [4]. Finally, when a synergic route is followed and the coatings are functionalized with Te nanorods, the antibacterial properties are enhanced, since Te adds contact-killing (Fig. 2), i.e. bactericidal effect, whilst the biocompatibility is preserved [4].MINECO and Fundación Domingo Martínez for funding. J.M.G.-M. thanks the Fulbright Commissio

Knowledge to Serve the City: Insights from an Emerging Knowledge-Action Network to Address Vulnerability and Sustainability in San Juan, Puerto Rico

This paper presents initial efforts to establish the San Juan Urban Long-Term Research Area Exploratory (ULTRA-Ex), a long-term program aimed at developing transdisciplinary social-ecological system (SES) research to address vulnerability and sustainability for the municipality of San Juan. Transdisciplinary approaches involve the collaborations between researchers, stakeholders, and citizens to produce socially-relevant knowledge and support decision-making. We characterize the transdisciplinary arrangement emerging in San Juan ULTRA-Ex as a knowledge-action network composed of multiple formal and informal actors (e.g., scientists, policymakers, civic organizations and other stakeholders) where knowledge, ideas, and strategies for sustainability are being produced, evaluated, and validated. We describe in this paper the on-the-ground social practices and dynamics that emerged from developing a knowledge-action network in our local context. Specifically, we present six social practices that were crucial to the development of our knowledge-action network: 1) understanding local framings; 2) analyzing existing knowledge-action systems in the city; 3) framing the social-ecological research agenda; 4) collaborative knowledge production and integration; 5) boundary objects and practices; and 6) synthesis, application, and adaptation. We discuss key challenges and ways to move forward in building knowledge-action networks for sustainability. Our hope is that the insights learned from this process will stimulate broader discussions on how to develop knowledge for urban sustainability, especially in tropical cities where these issues are under-explored