Flood magnitude-frequency and lithologic control on bedrock river incision in post-orogenic terrain

Mixed bedrock-alluvial rivers - bedrock channels lined with a discontinuous alluvial cover - are key agents in the shaping of mountain belt topography by bedrock fluvial incision. Whereas much research focuses upon the erosional dynamics of such rivers in the context of rapidly uplifting orogenic landscapes, the present study investigates river incision processes in a post-orogenic (cratonic) landscape undergoing extremely low rates of incision (> 5 m/Ma). River incision processes are examined as a function of substrate lithology and the magnitude and frequency of formative flows along Sandy Creek gorge, a mixed bedrock-alluvial stream in arid SE-central Australia. Incision is focused along a bedrock channel with a partial alluvial cover arranged into riffle-pool macrobedforms that reflect interactions between rock structure and large-flood hydraulics. Variations in channel width and gradient determine longitudinal trends in mean shear stress (τb) and therefore also patterns of sediment transport and deposition. A steep and narrow, non-propagating knickzone (with 5% alluvial cover) coincides with a resistant quartzite unit that subdivides the gorge into three reaches according to different rock erodibility and channel morphology. The three reaches also separate distinct erosional styles: bedrock plucking (i.e. detachment-limited erosion) prevails along the knickzone, whereas along the upper and lower gorge rock incision is dependent upon large formative floods exceeding critical erosion thresholds (τc) for coarse boulder deposits that line 70% of the channel thalweg (i.e. transport-limited erosion). The mobility of coarse bed materials (up to 2 m diameter) during late Holocene palaeofloods of known magnitude and age is evaluated using step-backwater flow modelling in conjunction with two selective entrainment equations. A new approach for quantifying the formative flood magnitude in mixed bedrock-alluvial rivers is described here based on the mobility of a key coarse fraction of the bed materials; in this case the d84 size fraction. A 350 m3/s formative flood fully mobilises the coarse alluvial cover with τb200-300 N/m2 across the upper and lower gorge riffles, peaking over 500 N/m2 in the knickzone. Such floods have an annual exceedance probability much less than 10- 2 and possibly as low as 10- 3. The role of coarse alluvial cover in the gorge is discussed at two scales: (1) modulation of bedrock exposure at the reach-scale, coupled with adjustment to channel width and gradient, accommodates uniform incision across rocks of different erodibility in steady-state fashion; and (2) at the sub-reach scale where coarse boulder deposits (corresponding to <i>τ</i><sub>b</sub> minima) cap topographic convexities in the rock floor, thereby restricting bedrock incision to rare large floods. While recent studies postulate that decreasing uplift rates during post-orogenic topographic decay might drive a shift to transport-limited conditions in river networks, observations here and elsewhere in post-orogenic settings suggest, to the contrary, that extremely low erosion rates are maintained with substantial bedrock channel exposure. Although bed material mobility is known to be rate-limiting for bedrock river incision under low sediment flux conditions, exactly how a partial alluvial cover might be spatially distributed to either optimise or impede the rate of bedrock incision is open to speculation. Observations here suggest that the small volume of very stable bed materials lining Sandy Creek gorge is distributed so as to minimise the rate of bedrock fluvial incision over time

Ending the reign of short-acting β2-agonists in Australia?

Acknowledgements We would like to acknowledge and thank Steph James, Kiran Dhillon, Sophie Jones, Rob Campbell, Ying Liu, Marion Magee, Ondrej Rejda, Lisa Sugg, and Nicole O'Sullivan for their valuable contributions.Peer reviewe

The association between short-acting β2-agonist over-prescription, and patient-reported acquisition and use on asthma control and exacerbations : data from Australia

Acknowledgements Author Contribution The authors meet criteria for authorship as recommended by the International Committee of Medical Journal Editors. All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis, and interpretation, or in all these areas. The first draft of the manuscript was written by Dr. Rebecca Vella and all authors took part in drafting, revising or critically reviewing the article. All authors gave final approval of the version to be published. All authors have agreed on the journal to which the article has been submitted and agree to be accountable for all aspects of the work. All authors have given approval for the submission of this article. The authors received no direct compensation related to the development of the manuscript. Funding This study was conducted by Optimum Patient Care Australia (OPCA) and was partially funded by AstraZeneca and Optimum Patient Care Australia (OPCA). The cost of the Open Access Fees were provided by AstraZeneca. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribution.Peer reviewedPostprin

IL-1α Mediated Chorioamnionitis Induces Depletion of FoxP3+ Cells and Ileal Inflammation in the Ovine Fetal Gut

Endotoxin induced chorioamnionitis increases IL-1 and provokes an inflammatory response in the fetal ileum that interferes with intestinal maturation. In the present study, we tested in an ovine chorioamnionitis model whether IL-1 is a major cytokine driving the inflammatory response in the fetal ileum.Sheep bearing singleton fetuses received a single intraamniotic injection of recombinant ovine IL-1α at 7, 3 or 1 d before caesarian delivery at 125 days gestational age (term = 150 days).3 and 7 d after IL-1α administration, intestinal mRNA levels for IL-4, IL-10, IFN-γ and TNF-α were strongly elevated. Numbers of CD3+ and CD4+ T-lymphocytes and myeloidperoxidase+ cells were increased whereas FoxP3+ T-cells were detected at low frequency. This increased proinflammatory state was associated with ileal mucosal barrier loss as demonstrated by decreased levels of the intestinal fatty acid binding protein and disruption of the tight junctional protein ZO-1.Intraamniotic IL-1α causes an acute detrimental inflammatory response in the ileum, suggesting that induction of IL-1 is a critical element in the pathophysiological effects of endotoxin induced chorioamnionitis. A disturbed balance between T-effector and FoxP3+ cells may contribute to this process

A Biodiverse Rich Environment Does Not Contribute to a Better Diet: A Case Study from DR Congo

The potential of biodiversity to increase and sustain nutrition security is increasingly recognized by the international research community. To date however, dietary assessment studies that have assessed how biodiversity actually contributes to human diets are virtually absent. This study measured the contribution of wild edible plants (WEP) to the dietary quality in the high biodiverse context of DR Congo. The habitual dietary intake was estimated from 2 multiple-pass 24 h dietary recalls for 363 urban and 129 rural women. All WEP were collected during previous ethnobotanical investigations and identified and deposited in the National Botanical Garden of Belgium (BR). Results showed that in a high biodiverse region with precarious food security, WEP are insufficiently consumed to increase nutrition security or dietary adequacy. The highest contribution came from Dacryodes edulis in the village sample contributing 4.8% of total energy intake. Considering the nutrient composition of the many WEP available in the region and known by the indigenous populations, the potential to increase nutrition security is vast. Additional research regarding the dietary contribution of agricultural biodiversity and the nutrient composition of WEP would allow to integrate them into appropriate dietary guidelines for the region and pave the way to domesticate the most interesting WEP

Human and mouse essentiality screens as a resource for disease gene discovery

The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the International Mouse Phenotyping Consortium and essentiality screens carried out on human cell lines. We propose a cross-species gene classification across the Full Spectrum of Intolerance to Loss-of-function (FUSIL) and demonstrate that genes in five mutually exclusive FUSIL categories have differing biological properties. Most notably, Mendelian disease genes, particularly those associated with developmental disorders, are highly overrepresented among genes non-essential for cell survival but required for organism development. After screening developmental disorder cases from three independent disease sequencing consortia, we identify potentially pathogenic variants in genes not previously associated with rare diseases. We therefore propose FUSIL as an efficient approach for disease gene discovery. Discovery of causal variants for monogenic disorders has been facilitated by whole exome and genome sequencing, but does not provide a diagnosis for all patients. Here, the authors propose a Full Spectrum of Intolerance to Loss-of-Function (FUSIL) categorization that integrates gene essentiality information to aid disease gene discovery

The Nilgiri Tahr Hemitragus hylocrius

Volume: 65Start Page: 769End Page: 77