4,019 research outputs found

    Closing the Economic Security Equity Gap for Mississippi's BlackMales

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    Creating opportunities for young men and boys of color to reach their full potential helps to advance individual opportunity, family sustainability, community prosperity, and Mississippi's overall economic competitiveness. Early supports, like positive school climates that fulfill students' socio-emotional needs, help build a foundation for young men and boys of color to succeed and establish economic security into adulthood

    Telling time with an intrinsically noisy clock

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    Intracellular transmission of information via chemical and transcriptional networks is thwarted by a physical limitation: the finite copy number of the constituent chemical species introduces unavoidable intrinsic noise. Here we provide a method for solving for the complete probabilistic description of intrinsically noisy oscillatory driving. We derive and numerically verify a number of simple scaling laws. Unlike in the case of measuring a static quantity, response to an oscillatory driving can exhibit a resonant frequency which maximizes information transmission. Further, we show that the optimal regulatory design is dependent on the biophysical constraints (i.e., the allowed copy number and response time). The resulting phase diagram illustrates under what conditions threshold regulation outperforms linear regulation.Comment: 10 pages, 5 figure

    Kinetic Accessibility of Buried DNA Sites in Nucleosomes

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    Using a theoretical model for spontaneous partial DNA unwrapping from histones, we study the transient exposure of protein-binding DNA sites within nucleosomes. We focus on the functional dependence of the rates for site exposure and reburial on the site position, which is measurable experimentally and pertinent to gene regulation. We find the dependence to be roughly described by a random walker model. Close inspection reveals a surprising physical effect of flexibility-assisted barrier crossing, which we characterize within a toy model, the "semiflexible Brownian rotor."Comment: final version as published in Phys. Rev. Let

    Hydrodynamic induced deformation and orientation of a microscopic elastic filament

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    We describe simulations of a microscopic elastic filament immersed in a fluid and subject to a uniform external force. Our method accounts for the hydrodynamic coupling between the flow generated by the filament and the friction force it experiences. While models that neglect this coupling predict a drift in a straight configuration, our findings are very different. Notably, a force with a component perpendicular to the filament axis induces bending and perpendicular alignment. Moreover, with increasing force we observe four shape regimes, ranging from slight distortion to a state of tumbling motion that lacks a steady state. We also identify the appearance of marginally stable structures. Both the instability of these shapes and the observed alignment can be explained by the combined action of induced bending and non-local hydrodynamic interactions. Most of these effects should be experimentally relevant for stiff micro-filaments, such as microtubules.Comment: three figures. To appear in Phys Rev Let

    Preface "Nonlinear processes in oceanic and atmospheric flows"

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    Nonlinear phenomena are essential ingredients in many oceanic and atmospheric processes, and successful understanding of them benefits from multidisciplinary collaboration between oceanographers, meteorologists, physicists and mathematicians. The present Special Issue on ``Nonlinear Processes in Oceanic and Atmospheric Flows'' contains selected contributions from attendants to the workshop which, in the above spirit, was held in Castro Urdiales, Spain, in July 2008. Here we summarize the Special Issue contributions, which include papers on the characterization of ocean transport in the Lagrangian and in the Eulerian frameworks, generation and variability of jets and waves, interactions of fluid flow with plankton dynamics or heavy drops, scaling in meteorological fields, and statistical properties of El Ni\~no Southern Oscillation.Comment: This is the introductory article to a Special Issue on "Nonlinear Processes in Oceanic and Atmospheric Flows'', published in the journal Nonlinear Processes in Geophysics, where the different contributions are summarized. The Special Issue itself is freely available from http://www.nonlin-processes-geophys.net/special_issue103.htm

    Lagrangian descriptors and the assessment of the predictive capacity of oceanic data sets

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    We use a recently developed Lagrangian transport tool, <i>Lagrangian descriptors</i>, to compare the transport properties of data distributed by AVISO and numerical simulations obtained from the HYCOM model in the Yucatán–Florida current system. Our data correspond to the months from June through August 2010. Structures obtained from HYCOM are noisier than those from AVISO; however, both AVISO and HYCOM succeed in identifying Lagrangian structures that influence the paths of drifters, such as eddies, currents, lobes, etc. We find evidence in which AVISO gives the positions of important hyperbolic trajectories in a manner that is inconsistent with the trajectories of the drifters, while for the same examples HYCOM succeeds to this end

    Designing Computationally Creative Musical Performance Systems

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    This is work in progress where we outline a design process for a computationally creative musical performance system using the Creative Systems Framework (CSF). The proposed system is intended to produce virtuosic interpretations, and subsequent synthesized renderings of these interpretations with a physical model of a bass guitar, using case-based reasoning and reflection. We introduce our interpretations of virtuosity and musical performance, outline the suitability of case-based reasoning in computationally creative systems and introduce notions of computational creativity and the CSF. We design our system by formalising the components of the CSF and briefly outline a potential implementation. In doing so, we demonstrate how the CSF can be used as a tool to aid in designing computationally creative musical performance systems

    Targeted mixing in an array of alternating vortices

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    Transport and mixing properties of passive particles advected by an array of vortices are investigated. Starting from the integrable case, it is shown that a special class of perturbations allows one to preserve separatrices which act as effective transport barriers, while triggering chaotic advection. In this setting, mixing within the two dynamical barriers is enhanced while long range transport is prevented. A numerical analysis of mixing properties depending on parameter values is performed; regions for which optimal mixing is achieved are proposed. Robustness of the targeted mixing properties regarding errors in the applied perturbation are considered, as well as slip/no-slip boundary conditions for the flow
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