93 research outputs found

    A Study Of Fifty Industrial Technology Programs For A Comparative Evaluation Of Prairie View\u27s Industrial Technology Program

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    Even though a considerable expansion of technician training has taken place during the past five years, it is doubtful whether the nation will be able to meet the projected need unless the rate of increase in training facilities are accelerated. With the fast changing world of today, there is a need for a large number of well-trained technicians. This has created a need for well-developed technology programs. These programs should keep abreast of the rapid changes in industry. In order to keep abreast, periodical evaluations of industrial technology programs are advisable. To understand our culture in America we must understand technology because it is our culture. To understand what has made America great, we must search technology. To understand what will keep America great, we must study technology. In the past few years, the enrollment in Industrial Technology at Prairie View A. and M. College has increased tremendously. To provide these students with the best available experiences and training, a study of Industrial Technology curriculums was needed. The purpose of the study was to compare the Industrial Technology program at Prairie View A. and M. College with other similar programs. This study may prove helpful to the Industrial Technology Division at Prairie View A. & M. College. This study has shown small differences and basic similarities between the fifty selected programs and Prairie View\u27s program which could be considered as a competitive Industrial Technology Program

    Ideas from Kansas

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    Wood Ashes

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    Identification of chemical inducers of metastasis-related cell differentiation events using peptide microarrays

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    The epithelial-mesenchymal transition (EMT) is a key indicator of cancer progression and metastasis in vivo. The most important inducer of EMT is activation of the transforming growth factor beta (TGF-β) pathway. In addition to initiating EMT, TGF-β is able to cause cancer cells to switch cell states from the non-stem cancer cell (NSCC) to the more invasive and tumorigenic cancer stem cell (CSC) state. Investigation into factors that can activate the TGF-β pathway, and thereby initiate EMT or the NSCC-to-CSC conversion, is therefore of critical importance. It is well known that the chemical environment immediately surrounding the cell determines cell differentiation events. Small molecules such as peptides, then, can induce such events in cells that are bound to the peptides. In this project, we aimed to identify peptide ligands that were able to induce EMT in cells adhered to the peptide surface. Five peptides previously discovered through phage display (panning against MDA-MB-231 cells) along with three control peptides, were printed onto gold-coated glass slides in a patterned array using a DNA microarray printer and tested against NMuMG cells. The arrays of cells were then fixed and stained for eCadherin (an epithelial marker). We found that after four days of culture on the peptide-modified surfaces, eCadherin levels were decreased on two of the five test peptide surfaces, as well as in both of the positive control peptide surfaces, suggesting that those cell populations underwent EMT. Future studies will indicate whether these peptides can additionally induce the NSCC-to-CSC conversion. *Indicates faculty mentor

    CFGP: a web-based, comparative fungal genomics platform

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    Since the completion of the Saccharomyces cerevisiae genome sequencing project in 1996, the genomes of over 80 fungal species have been sequenced or are currently being sequenced. Resulting data provide opportunities for studying and comparing fungal biology and evolution at the genome level. To support such studies, the Comparative Fungal Genomics Platform (CFGP; http://cfgp.snu.ac.kr), a web-based multifunctional informatics workbench, was developed. The CFGP comprises three layers, including the basal layer, middleware and the user interface. The data warehouse in the basal layer contains standardized genome sequences of 65 fungal species. The middleware processes queries via six analysis tools, including BLAST, ClustalW, InterProScan, SignalP 3.0, PSORT II and a newly developed tool named BLASTMatrix. The BLASTMatrix permits the identification and visualization of genes homologous to a query across multiple species. The Data-driven User Interface (DUI) of the CFGP was built on a new concept of pre-collecting data and post-executing analysis instead of the ‘fill-in-the-form-and-press-SUBMIT’ user interfaces utilized by most bioinformatics sites. A tool termed Favorite, which supports the management of encapsulated sequence data and provides a personalized data repository to users, is another novel feature in the DUI

    Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

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    New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria. Enzymes in polyamine biosynthesis and thiol metabolism, as well as polyamine transporters, are potential drug targets within these organisms. In the present review, the current knowledge of unique properties of polyamine metabolism in these parasites is outlined. These properties include prozyme regulation of AdoMetDC (S-adenosylmethionine decarboxylase) activity in trypanosomatids, co-expression of ODC (ornithine decarboxylase) and AdoMetDC activities in a single protein in plasmodia, and formation of trypanothione, a unique compound linking polyamine and thiol metabolism in trypanosomatids. Particularly interesting features within polyamine metabolism in these parasites are highlighted for their potential in selective therapeutic strategies
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