Risking Attachments in Teaching Child and Youth Care in Twenty-First-Century Settler Colonial, Environmental and Biotechnological Worlds

As a way to implicate ourselves in the politics of teaching child and youth care, we write as witnesses of the world and, in so doing, we make risky attachments by exploring a politically engaged child and youth care education that does not promote insurance, control or detachment. Rather, in this paper we critically locate child and youth care education within the political and economic realities of today’s world. We grapple with the complexities of educating child and youth care practitioners deeply embedded in neoliberal capitalism and settler colonialism, and explore the conceptual shifts that we are experimenting with in our own teaching practices to engage in human service work that responds with care to individual and family need and suffering by engaging with the very structures that perpetuate harm and violence in our society

Portraits of Teachers: The Professional and Personal Characteristics of Twelve Primary Teachers.

The purpose of this study was to determine the personal and professional characteristics of six teachers who reported high developmentally appropriate beliefs and practices and six teachers who reported low developmentally appropriate beliefs and practices. The sample was identified using teachers\u27 scores on a self-reported survey measure of developmentally appropriate practice based on the 1987 guidelines by NAEYC. Qualitative data were collected through interviews with open-ended questions. By providing an in-depth description as a literary portrait of each teacher, this study provides insight into the beliefs and practical knowledge that inform the teaching practices of 12 primary grade teachers. A cross-case analysis within each group revealed common themes of teacher autonomy, teacher efficacy, and teaching strategies. Personal and professional characteristics are differentiated between the groups and are considered to influence teacher beliefs and practice

The STAR-MELT Python package for emission line analysis of YSOs

We introduce the STAR-MELT Python package that we developed to facilitate the analysis of time-resolved emission line spectroscopy of young stellar objects. STAR-MELT automatically extracts, identifies and fits emission lines. We summarise our analysis methods that utilises the time domain of high-resolution stellar spectra to investigate variability in the line profiles and corresponding emitting regions. This allows us to probe the innermost disc and accretion structures of YSOs. Local temperatures and densities can be determined using Boltzmann statistics, the Saha equation, and the Sobolev large velocity gradient approximation. STAR-MELT allows for new results to be obtained from archival data, as well as facilitating timely analysis of new data as it is obtained. We present the results of applying STAR-MELT to three YSOs, using spectra from UVES, XSHOOTER, FEROS, HARPS, and ESPaDOnS. We demonstrate what can be achieved for data with disparate time sampling, for stars with different inclinations and variability types. For EX Lupi, we confirm the presence of a localised and stable stellar-surface hotspot associated with the footprint of the accretion column. For GQ Lupi A, we find that the maximum infall rate from an accretion column is correlated with lines produced in the lowest temperatures. For CVSO109 we investigate the rapid temporal variability of a redshifted emission wing, indicative of rotating and infalling material in the inner disc. Our results show that STAR-MELT is a useful tool for such analysis, as well as other applications for emission lines.<br/

Protostars and stars in the Coronet cluster: Age, evolution, and cluster structure

We present new optical spectroscopy with FLAMES/VLT, near-IR imaging with HAWK-I/VLT, and 870 micron mapping with APEX/LABOCA of the Coronet cluster. The optical data allow to estimate spectral types, extinction and the presence of accretion in 6 more M-type members, in addition to the 12 that we had previously studied. The submillimeter maps and near-IR data reveal the presence of nebular structures and high extinction regions, which are in some cases associated to known IR, optical, and X-ray sources. Most star formation is associated to two elongated structures crossing in the central part of the cluster. Placing all the 18 objects with known spectral types and extinction in the HR diagram suggests that the cluster is younger than previously thought (<2 Myr, and probably ~0.5-1 Myr). The new age estimate is in agreement with the evolutionary status of the various protostars in the region and with its compactness (<1.3 pc across), but results in a conflict with the low disk and accretion fraction (only 50-65% of low-mass stars appear to have protoplanetary disks, and most transitional and homologously depleted disks are consistent with no accretion) and with the evolutionary features observed in the mid-IR spectra and spectral energy distributions of the disks.Comment: 30 pages, 9 figures, 6 tables, ApJ in pres

ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition

Joubert syndrome (JBTS) is a genetically heterogeneous autosomal recessive neurodevelopmental ciliopathy. We investigated further the underlying genetic etiology of Joubert syndrome by studying two unrelated families in whom JBTS was not associated with pathogenic variants in known JBTSrelated genes. Combined autozygosity mapping of both families highlighted a candidate locus on chromosome 10 (chr10: 101569997-109106128 (hg 19)), and exome sequencing revealed two missense variants in ARL3 within the candidate locus. The encoded protein, ADP Ribosylation Factor-Like GTPase 3, ARL3, is a small GTP-binding protein that is involved in directing lipid-modified proteins into the cilium in a GTP-dependent manner. Both missense variants replace the highly conserved Arg149 residue, which we show to be necessary for the interaction with its guanine nucleotide exchange factor ARL13B, such that the mutant protein is associated with reduced INPP5E and NPHP3 localisation in cilia. We propose that ARL3 provides a potential hub in the network of encoded ciliopathy genes, whereby perturbation of ARL3 results in the mislocalisation of multiple ciliary proteins due to abnormal displacement of lipidated protein cargo

TeraHz tuning of whispering gallery modes in a PDMS, stand-alone, stretchable microsphere

We report on tuning the optical whispering gallery modes in a poly dimethyl siloxane-based (PDMS) microsphere resonator by more than a THz. The PDMS microsphere system consists of a solid spherical resonator directly formed with double stems on either side. The stems act like tie-rods for simple mechanical stretching of the microresonator over tens of microns, resulting in tuning of the whispering gallery modes by one free spectral range. Further investigations demonstrate that the whispering gallery mode shift has a higher sensitivity (0.13 nm/{\mu}N) to an applied force when the resonator is in its maximally stretched state compared to its relaxed state.Comment: 3 pages, 4 figures, submitted to Optics Letter

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible strategy to ameliorate metabolic syndrome. In particular, an increase in cellular NAD+ levels has beneficial effects, likely because of the activation of sirtuins. Previously, we reported that CD38 is the primary NAD+ase in mammals. Moreover, CD38 knockout mice have higher NAD+ levels and are protected against obesity and metabolic syndrome. Here, we show that CD38 regulates global protein acetylation through changes in NAD+ levels and sirtuin activity. In addition, we characterize two CD38 inhibitors: quercetin and apigenin. We show that pharmacological inhibition of CD38 results in higher intracellular NAD+ levels and that treatment of cell cultures with apigenin decreases global acetylation as well as the acetylation of p53 and RelA-p65. Finally, apigenin administration to obese mice increases NAD+ levels, decreases global protein acetylation, and improves several aspects of glucose and lipid homeostasis. Our results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD+-dependent pathways

Patient experiences of anxiety, depression and acute pain after surgery: a longitudinal perspective

This study sought to explore the impact of the psychological variables anxiety and depression, on pain experience over time following surgery. Eighty-five women having major gynaecological surgery were assessed for anxiety, depression and pain after surgery. To gain further understanding, 37 patients participated in a semi-structured taped telephone interview 4–6 weeks post-operatively. Pre-operative anxiety was found to be predictive of post-operative anxiety on Day 2, with patients who experienced high levels of anxiety before surgery continuing to feel anxious afterwards. By Day 4 both anxiety and depression scores increased as pain increased and one-third of the sample experienced levels of anxiety in psychiatric proportions whilst under one-third experienced similar levels of depression. These findings have significant implications for the provision of acute pain management after surgery. Future research and those managing acute pain services need to consider the multidimensional effect of acute pain and the interface between primary and secondary care