6 research outputs found

    Die Rolle der Lehrenden in intergenerationellen Lehrveranstaltungen: Eine multimethodale Untersuchung an der Universität Leipzig

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    Seit über 20 Jahren nehmen Regelstudierende und Seniorenstudierendegemeinsam an Lehrveranstaltungen der UniversitätLeipzig teil. Sie lernen miteinander. Doch lernensie auch voneinander? Lernen sie intergenerationell? Undwelche Rolle nehmen die Lehrenden in diesen intergenerationellenLehr-Lernarrangements ein? Wie können sie einenintergenerationellen Austausch fördern? Im Rahmen eineskooperativen Forschungsprojekts wurden mittels Fragebögen,teilnehmenden Beobachtungen und Interviews die Studierendenmeinungenerhoben. Die Ergebnisse präsentieren einenIst-Stand und zeigen Perspektiven auf

    Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study.

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    BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. METHODS: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. RESULTS: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. CONCLUSIONS: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake

    Die Rolle der Lehrenden in intergenerationellen Lehrveranstaltungen. Eine multimethodale Untersuchung an der Universität Leipzig

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    Seit über 20 Jahren nehmen Regelstudierende und Seniorenstudierende gemeinsam an Lehrveranstaltungen der Universität Leipzig teil. Sie lernen miteinander. Doch lernen sie auch voneinander? Lernen sie intergenerationell? Und welche Rolle nehmen die Lehrenden in diesen intergenerationellen Lehr-Lernarrangements ein? Wie können sie einen intergenerationellen Austausch fördern? Im Rahmen eines kooperativen Forschungsprojekts wurden mittels Fragebögen, teilnehmenden Beobachtungen und Interviews die Studierendenmeinungen erhoben. Die Ergebnisse präsentieren einen Ist-Stand und zeigen Perspektiven auf. (DIPF/Orig.
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