131 research outputs found
Intramolecular Imino Diels-Alder Reaction: Progress toward the Synthesis of Uncialamycin
We herein described an intramolecular imino Diels-Alder reaction promoted with BF3.OEt2/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quitioline moiety of the uncialamycin, a new enediyne natural product
Algebraic Properties of Qualitative Spatio-Temporal Calculi
Qualitative spatial and temporal reasoning is based on so-called qualitative
calculi. Algebraic properties of these calculi have several implications on
reasoning algorithms. But what exactly is a qualitative calculus? And to which
extent do the qualitative calculi proposed meet these demands? The literature
provides various answers to the first question but only few facts about the
second. In this paper we identify the minimal requirements to binary
spatio-temporal calculi and we discuss the relevance of the according axioms
for representation and reasoning. We also analyze existing qualitative calculi
and provide a classification involving different notions of a relation algebra.Comment: COSIT 2013 paper including supplementary materia
Quantifying resistance and resilience to local extinction for conservation prioritization
This is the final version. Available on open access from Ecological Society of America via the DOI in this recordSpecies-focused conservation planning is often based on reducing local extinction risk at key sites. However, with increasing levels of habitat fragmentation and pressures from climate change and overexploitation, surrounding landscapes also influence the persistence of species populations, and their effects are increasingly incorporated in conservation planning and management for both species and communities. Here, we present a framework based on metapopulation dynamics in fragmented landscapes, for quantifying the survival (resistance) and reestablishment of species populations following localized extinction events (resilience). We explore the application of this framework to guide the conservation of a group of threatened bird species endemic to papyrus (Cyperus papyrus) swamps in East and Central Africa. Using occupancy data for five species collected over two years from a network of wetlands in Uganda, we determine the local and landscape factors that influence local extinction and colonization, and map expected rates of population turnover across the network to draw inferences about the locations which contribute most to regional resistance and resilience for all species combined. Slight variation in the factors driving extinction and colonization between individual papyrus birds led to species-specific differences in the spatial patterns of site-level resistance and resilience. However, despite this, locations with the highest resistance and/or resilience overlapped for most species and reveal where resources could be invested for multi-species persistence. This novel simplified framework can aid decision making associated with conservation planning and prioritization for multiple species residing in overlapping, fragmented habitats; helping to identify key sites that warrant urgent conservation protection, with consideration of the need to adapt and respond to future change. This article is protected by copyright. All rights reserved.Natural Environment Research Council (NERC)The Explorers ClubBritish Ornithologists’ UnionRoyal Geographic SocietyJohn Muir TrustGilchrist Educational Trus
A framework for models of movement in geographic space
This article concerns the theoretical foundations of movement informatics. We discuss general frameworks in which models of spatial movement may be developed. In particular, the article considers the object–field and Lagrangian–Eulerian dichotomies, and the SNAP/SPAN ontologies of the dynamic world, and classifies the variety of informatic structures according to these frameworks. A major challenge is transitioning between paradigms. Usually data is captured with respect to one paradigm but can usefully be represented in another. We discuss this process in formal terms and then describe experiments that we performed to show feasibility. It emerges that observational granularity plays a crucial role in these transitions
Synthesis of new simplified hemiasterlin derivatives with α,β-unsaturated carbonyl moiety.
International audienceIn this Letter, we report a convenient and efficient method for the synthesis of new simplified derivatives of hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groups as Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumor cell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB and Hep-G2 cancer cell lines comparable to paclitaxel and ellipticine
A Fuzzy Spatio-Temporal-based Approach for Activity Recognition
International audienceOver the last decade, there has been a significant deployment of systems dedicated to surveillance. These systems make use of real-time sensors that generate continuous streams of data. Despite their success in many cases, the increased number of sensors leads to a cognitive overload for the operator in charge of their analysis. However, the context and the application requires an ability to react in real-time. The research presented in this paper introduces a spatio-temporal-based approach the objective of which is to provide a qualitative interpretation of the behavior of an entity (e.g., a human or vehicle). The process is formally supported by a fuzzy logic-based approach, and designed in order to be as generic as possible
Day versus night use of forest by red and roe deer as determined by Corine Land Cover and Copernicus Tree Cover Density: assessing use of geographic layers in movement ecology
Diel use of forest and open habitats by large herbivores is linked to species-specific needs of multiple and heterogeneous resources. However, forest cover layers might deviate considerably for a given landscape, potentially affecting evaluations of animals’ habitat use. We assessed inconsistency in the estimates of diel forest use by red and roe deer at GPS location and home range (HR) levels, using two geographic layers: Tree Cover Density (TCD) and Corine Land Cover (CLC). We first measured the classification mismatch of red and roe deer GPS locations between TCD and CLC, also with respect to habitat units’ size. Then, we used generalized Least Squares models to assess the proportional use of forest at day and night at the GPS location and HR levels, both with TCD and CLC. About 20% of the GPS locations were inconsistently classified as forest or open habitat by the two layers, particularly within smaller habitat units. Overall proportion of forest and open habitat, though, was very similar for both layers. In all populations, both deer species used forest more at day than at night and this pattern was more evident with TCD than with CLC. However, at the HR level, forest use estimates were only marginally different between the two layers. When estimating animal habitat use, geographic layer choice requires careful evaluation with respect to ecological questions and target species. Habitat use analyses based on GPS locations are more sensitive to layer choice than those based on home ranges.publishedVersio
Modelling potential movement in constrained travel environments using rough space–time prisms
A GIS toolkit for measuring and mapping space–time accessibility from a place-based perspective
Tractable Fragments of Temporal Sequences of Topological Information
In this paper, we focus on qualitative temporal sequences of topological
information. We firstly consider the context of topological temporal sequences
of length greater than 3 describing the evolution of regions at consecutive
time points. We show that there is no Cartesian subclass containing all the
basic relations and the universal relation for which the algebraic closure
decides satisfiability. However, we identify some tractable subclasses, by
giving up the relations containing the non-tangential proper part relation and
not containing the tangential proper part relation. We then formalize an
alternative semantics for temporal sequences. We place ourselves in the context
of the topological temporal sequences describing the evolution of regions on a
partition of time (i.e. an alternation of instants and intervals). In this
context, we identify large tractable fragments
- …