464 research outputs found
The factor VII activating protease G511E (Marburg) variant and cardiovascular risk
A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a prothrombotic state. The current study has addressed risk for coronary heart disease in a prospective study of cardio vascular disorders (Northwick Park Heart Study II). An interactive effect upon risk was found between the 511E allele and elevated levels of cholesterol and triglyceride. Fibrinogen could substitute for triglyceride levels in this risk-interaction analysis. The findings support the proposal that the FSAP 511E allele exacerbates atherosclerosis or its clinical sequelae
Electron transport through interacting quantum dots
We present a detailed theoretical investigation of the effect of Coulomb
interactions on electron transport through quantum dots and double barrier
structures connected to a voltage source via an arbitrary linear impedance.
Combining real time path integral techniques with the scattering matrix
approach we derive the effective action and evaluate the current-voltage
characteristics of quantum dots at sufficiently large conductances. Our
analysis reveals a reach variety of different regimes which we specify in
details for the case of chaotic quantum dots. At sufficiently low energies the
interaction correction to the current depends logarithmically on temperature
and voltage. We identify two different logarithmic regimes with the crossover
between them occurring at energies of order of the inverse dwell time of
electrons in the dot. We also analyze the frequency-dependent shot noise in
chaotic quantum dots and elucidate its direct relation to interaction effects
in mesoscopic electron transport.Comment: 21 pages, 4 figures. References added, discussion slightly extende
Funding for preventative Children’s Services and rates of children becoming looked after : a natural experiment using longitudinal area-level data in England
Background
Children in care face adverse health outcomes, throughout the life-course, relative to the general population. In England, over the last decade, the rate of children entering care has increased. The rate of change differs markedly for older and younger children, who may also experience different preventative services. These services have been subject to inequitable spending reductions due to fiscal policies trailing the 2008 recession.
Objective
To assess the impact of cuts to prevention on rates of preschool children and adolescents entering care between 2012 and 2019.
Participants and Setting
Children aged 1–4 and 16–17 years, across 150 English upper-tier local authorities.
Methods
Our outcomes were annual rates of children entering care, aged 1–4 and 16–17. Our exposures were Children’s Services prevention spend per child under 5, and per child over 12. Regression models were used to quantify, within areas, associations between trends in prevention spend and trends in rates of children entering care, controlling for employment and child poverty rates.
Results
We found no association between changes in prevention spend per child under 5 and changes in care entry for 1–4-year-olds. However, spending reductions per child over 12 were associated with rising rates of 16–17-year-olds entering care. Every £10 per child decrease in prevention spend was associated with an estimated additional 1.9 per 100,000 children aged 16–17 entering care the following year (95% CI 0.7 to 2.9), equivalent to 1 in 25 care entries in this age group between 2012 and 2019.
Conclusion
This study offers evidence that rising rates of older children entering care has partly been driven by cuts to prevention services catering to their needs. Policies to tackle adverse trends should promote reinvestment in youth services, placing ordinary help on a robust statutory footing
Using the past to constrain the future: how the palaeorecord can improve estimates of global warming
Climate sensitivity is defined as the change in global mean equilibrium
temperature after a doubling of atmospheric CO2 concentration and provides a
simple measure of global warming. An early estimate of climate sensitivity,
1.5-4.5{\deg}C, has changed little subsequently, including the latest
assessment by the Intergovernmental Panel on Climate Change.
The persistence of such large uncertainties in this simple measure casts
doubt on our understanding of the mechanisms of climate change and our ability
to predict the response of the climate system to future perturbations. This has
motivated continued attempts to constrain the range with climate data, alone or
in conjunction with models. The majority of studies use data from the
instrumental period (post-1850) but recent work has made use of information
about the large climate changes experienced in the geological past.
In this review, we first outline approaches that estimate climate sensitivity
using instrumental climate observations and then summarise attempts to use the
record of climate change on geological timescales. We examine the limitations
of these studies and suggest ways in which the power of the palaeoclimate
record could be better used to reduce uncertainties in our predictions of
climate sensitivity.Comment: The final, definitive version of this paper has been published in
Progress in Physical Geography, 31(5), 2007 by SAGE Publications Ltd, All
rights reserved. \c{opyright} 2007 Edwards, Crucifix and Harriso
Low-field MRI: a report on the 2022 ISMRM workshop
In March 2022, the first ISMRM Workshop on Low-Field MRI was held virtually. The goals of this workshop were to discuss recent low field MRI technology including hardware and software developments, novel methodology, new contrast mechanisms, as well as the clinical translation and dissemination of these systems. The virtual Workshop was attended by 368 registrants from 24 countries, and included 34 invited talks, 100 abstract presentations, 2 panel discussions, and 2 live scanner demonstrations. Here, we report on the scientific content of the Workshop and identify the key themes that emerged. The subject matter of the Workshop reflected the ongoing developments of low-field MRI as an accessible imaging modality that may expand the usage of MRI through cost reduction, portability, and ease of installation. Many talks in this Workshop addressed the use of computational power, efficient acquisitions, and contemporary hardware to overcome the SNR limitations associated with low field strength. Participants discussed the selection of appropriate clinical applications that leverage the unique capabilities of low-field MRI within traditional radiology practices, other point-of-care settings, and the broader community. The notion of "image quality" versus "information content" was also discussed, as images from low-field portable systems that are purpose-built for clinical decision-making may not replicate the current standard of clinical imaging. Speakers also described technical challenges and infrastructure challenges related to portability and widespread dissemination, and speculated about future directions for the field to improve the technology and establish clinical value.Radiolog
Rudeness and Rapport: Insults and Learning Gains in Peer Tutoring
Abstract. For 20 years, researchers have envisioned artificially intelligent learning companions that evolve with their students as they grow and learn. However, while communication theory suggests that positivity decreases over time in relationships, most tutoring systems designed to build rapport with a student remain adamantly polite, and may therefore inadvertently distance the learner from the agent over time. We present an analysis of high school friends interacting in a peer tutoring environment as a step towards designing agents that sustain long-term pedagogical relationships with learners. We find that tu-tees and tutors use different language behaviors: tutees express more playful-ness and face-threat, while tutors attend more to the task. This face-threat by the tutee is associated with increased learning gains for their tutor. Additionally, a small sample of partners who were strangers learned less than friends, and in these dyads increased face-threat was negatively correlated with learning. Our findings support the idea that learning companions should gradually move to-wards playful face-threat as they build relationships with their students
Longitudinal double-spin asymmetry and cross section for inclusive neutral pion production at midrapidity in polarized proton collisions at sqrt(s) = 200 GeV
We report a measurement of the longitudinal double-spin asymmetry A_LL and
the differential cross section for inclusive Pi0 production at midrapidity in
polarized proton collisions at sqrt(s) = 200 GeV. The cross section was
measured over a transverse momentum range of 1 < p_T < 17 GeV/c and found to be
in good agreement with a next-to-leading order perturbative QCD calculation.
The longitudinal double-spin asymmetry was measured in the range of 3.7 < p_T <
11 GeV/c and excludes a maximal positive gluon polarization in the proton. The
mean transverse momentum fraction of Pi0's in their parent jets was found to be
around 0.7 for electromagnetically triggered events.Comment: 6 pages, 3 figures, submitted to Phys. Rev. D (RC
High non-photonic electron production in + collisions at = 200 GeV
We present the measurement of non-photonic electron production at high
transverse momentum ( 2.5 GeV/) in + collisions at
= 200 GeV using data recorded during 2005 and 2008 by the STAR
experiment at the Relativistic Heavy Ion Collider (RHIC). The measured
cross-sections from the two runs are consistent with each other despite a large
difference in photonic background levels due to different detector
configurations. We compare the measured non-photonic electron cross-sections
with previously published RHIC data and pQCD calculations. Using the relative
contributions of B and D mesons to non-photonic electrons, we determine the
integrated cross sections of electrons () at 3 GeV/10 GeV/ from bottom and charm meson decays to be = 4.0({\rm
stat.})({\rm syst.}) nb and =
6.2({\rm stat.})({\rm syst.}) nb, respectively.Comment: 17 pages, 17 figure
Evolution of the differential transverse momentum correlation function with centrality in Au+Au collisions at GeV
We present first measurements of the evolution of the differential transverse
momentum correlation function, {\it C}, with collision centrality in Au+Au
interactions at GeV. {\it C} exhibits a strong dependence
on collision centrality that is qualitatively similar to that of number
correlations previously reported. We use the observed longitudinal broadening
of the near-side peak of {\it C} with increasing centrality to estimate the
ratio of the shear viscosity to entropy density, , of the matter formed
in central Au+Au interactions. We obtain an upper limit estimate of
that suggests that the produced medium has a small viscosity per unit entropy.Comment: 7 pages, 4 figures, STAR paper published in Phys. Lett.
Longitudinal scaling property of the charge balance function in Au + Au collisions at 200 GeV
We present measurements of the charge balance function, from the charged
particles, for diverse pseudorapidity and transverse momentum ranges in Au + Au
collisions at 200 GeV using the STAR detector at RHIC. We observe that the
balance function is boost-invariant within the pseudorapidity coverage [-1.3,
1.3]. The balance function properly scaled by the width of the observed
pseudorapidity window does not depend on the position or size of the
pseudorapidity window. This scaling property also holds for particles in
different transverse momentum ranges. In addition, we find that the width of
the balance function decreases monotonically with increasing transverse
momentum for all centrality classes.Comment: 6 pages, 3 figure
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