Use of a Brief Screening Tool to Assess Intellectual Functioning in a Forensic Population

Individuals with intellectual disability are over-represented in forensic settings, including jails, prisons and forensic psychiatric treatment units. Identification of intellectual disability is important in such settings, especially in light of the implications of intellectual disability in legal issues including competency to stand trial, criminal responsibility and capital sentencing. We examined the utility of a brief test of intelligence (PROFOKS), assessing knowledge of proverbs, fund of knowledge and similarities in a series of 29 inpatients residing in a forensic psychiatric unit. PROFOKS correlated strongly with performance on the Wechsler Abbreviated Scale of Intelligence (WASI), including the full scale, verbal and performance IQs and WASI subscales. The PROFOKS appears to be a useful screening tool in identifying intellectual disability in a forensic psychiatric population

Data Warehousing Failures: Case Studies and Findings

Eight studies of data warehousing failures are presented. They were written based on interviews with people who were associated with the projects. The extent of the failure varies with the organization, but in all cases, the project was at least a disappointment. Read the cases and prepare a one or two page discussion of the following: 1. What’s the scope of what can be considered a data warehousing failure? Discuss. 2. What generalizations apply across the cases? 3. What do you find most interesting in the failure stories? 4. Do they provide any insights about how a failure might be avoided

Quantum-state selection, alignment, and orientation of large molecules using static electric and laser fields

Supersonic beams of polar molecules are deflected using inhomogeneous electric fields. The quantum-state selectivity of the deflection is used to spatially separate molecules according to their quantum state. A detailed analysis of the deflection and the obtained quantum-state selection is presented. The rotational temperatures of the molecular beams are determined from the spatial beam profiles and are all approximately 1 K. Unprecedented degrees of laser-induced alignment $(=0.972)$ and orientation of iodobenzene molecules are demonstrated when the state-selected samples are used. Such state-selected and oriented molecules provide unique possibilities for many novel experiments in chemistry and physics.Comment: minor changes, references update

Acceptability and use of a patient-held communication tool for people living with dementia: a longitudinal qualitative study

Brendan McCormack - ORCID 0000-0001-8525-8905 https://orcid.org/0000-0001-8525-8905Replaced AM with VoR on 2020-05-19Objectives: To assess the acceptability and use of a low-cost patient-held communication tool.Design: Longitudinal Qualitative interviews at three time points over 18 months and document content analysisSetting: Primary and community servicesParticipants: Twenty-eight dyads - People living with dementia in Northern Ireland and their informal carers.Interventions: a patient-held healthcare “passport” for people living with dementia.Primary and secondary outcomes: acceptability and use of the passport – barriers and facilitators to successful engagement.Results: There was a qualified appreciation of the healthcare passport and a much more nuanced, individualistic or personalised approach to its desirability and use. How people perceive it and what they actually do with it, are strongly determined by individual contexts, dementia stage and other health problems, social and family needs and capacities. We noted concerns about privacy and ambivalence about engaging with health professionals.Conclusion: Such tools may be of use but there is a need for demanding, thoughtful, and nuanced programme delivery for future implementation in dementia care. The incentivisation and commitment of General Practitioners is crucial. Altering the asymmetrical relationship between professionals and patients requires more extensive attention.This study was supported by a grant from the R&D Division of the Northern Ireland Public Health Agency & Atlantic Philanthropies COM/5017/14https://doi.org/10.1136/bmjopen-2019-036249pubpu

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells:Roles of platelets and podoplanin

Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a blood-lymphatic mixing phenotype. We investigated the roles of podoplanin and its interaction with platelets in migration and tube formation by LEC. Addition of platelets or antibody-mediated crosslinking of podoplanin inhibited LEC migration induced by vascular endothelial growth factors (VEGF-A or VEGF-C), but did not modify basal migration or the response to basic fibroblast growth factor or epidermal growth factor. In addition, platelets and podoplanin crosslinking disrupted networks of LEC formed in co-culture with fibroblasts. Depletion of podoplanin in LEC using siRNA negated the pro-migratory effect of VEGF-A and VEGF-C. Inhibition of RhoA or Rho-kinase reduced LEC migration induced by VEGF-C, but had no further effect after crosslinking of podoplanin, suggesting that podoplanin is required for signaling downstream of VEGF-receptors but upstream of RhoA. Together, these data reveal for the first time that podoplanin is an intrinsic specific regulator of VEGF-mediated migration and network formation in LEC and identify crosslinking of podoplanin by platelets or antibodies as mechanisms to modulate this pathway

Final State Rescattering and Color-suppressed \bar B^0-> D^{(*)0} h^0 Decays

The color-suppressed \bar B^0-> D^{(*)0}\pi^0, D^{(*)0}\eta, D^0\omega decay modes have just been observed for the first time. The rates are all larger than expected, hinting at the presence of final state interactions. Considering \bar B^0-> D^{(*)0}\pi^0 mode alone, an elastic D^{(*)}\pi -> D^{(*)}\pi rescattering phase difference \delta \equiv \delta_{1/2} - \delta_{3/2} \sim 30^\circ would suffice, but the \bar B^0-> D^{(*)0}\eta, D^0\omega modes compel one to extend the elastic formalism to SU(3) symmetry. We find that a universal a_2/a_1=0.25 and two strong phase differences 20^\circ \sim \theta < \delta < \delta^\prime \sim 50^\circ can describe both DP and D^*P modes rather well; the large phase of order 50^\circ is needed to account for the strength of {\it both} the D^{(*)0}\pi^0 and D^{(*)0}\eta modes. For DV modes, the nonet symmetry reduces the number of physical phases to just one, giving better predictive power. Two solutions are found. We predict the rates of the \bar B^0-> D^{+}_s K^-, D^{*+}_s K^-, D^0\rho^0, D^+_s K^{*-} and D^0\phi modes, as well as \bar B^0-> D^{0}\bar K^0, D^{*0}\bar K^0, D^{0}\bar K^{*0} modes. The formalism may have implications for rates and CP asymmetries of charmless modes.Comment: REVTeX4, 18 pages, 5 figures, to appear in Phys. Rev.

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and perinatal lethality. Furthermore, we find that conditional deletion of Syk in the haematopoietic lineage, or conditional deletion of CLEC-2 or Syk in the megakaryocyte/platelet lineage, also causes defects in brain vascular and lymphatic development, although the mice are viable. In contrast, conditional deletion of Syk in other haematopoietic lineages had no effect on viability or brain vasculature and lymphatic development. We show that platelets, but not platelet releasate, modulate the migration and intercellular adhesion of lymphatic endothelial cells through a pathway that is dependent on CLEC-2 and Syk. These studies demonstrate that megakaryocyte/platelet expression of CLEC-2 and Syk is required for normal brain vasculature and lymphatic development and that platelet CLEC-2 and Syk directly modulate lymphatic endothelial cell behaviour in vitro