29 research outputs found
Ariel - Volume 10 Number 3
Executive Editors
Madalyn Schaefgen
David Reich
Business Manager
David Reich
News Editors
Medical College
Edward Zurad
CAHS
John Guardiani
World
Mark Zwanger
Features Editors
Meg Trexler
Jim O\u27Brien
Editorials Editor
Jeffrey Banyas
Photography and Sports Editor
Stuart Singer
Commons Editor
Brenda Peterso
A facile synthesis and evaluation of new biomolecule-based coumarin-thiazoline hybrids as potent anti-tubercular agents with cytotoxicity, DNA cleavage and X-ray studies
An efficient and rapid synthesis of coumarin-thiazoline hybrids (1a-1j) under microwave irradiation is described with high yields. The synthesized compounds were characterized using elemental and spectroscopic analysis; in addition, the structures of compounds 1a, 1b, 1e and 1h have been elucidated using single crystal X-ray diffraction techniques. All the newly synthesized compounds were screened for their in vitro anti-tubercular activity and in a DNA cleavage study, while the most active compounds were subjected to a cytotoxicity assay on Vero cell lines. Among those tested, compound 1b exhibited excellent anti-tubercular activity (MIC 0.09 mg ml(-1)) with a low level of cytotoxicity, suggesting that compound 1b is a promising lead for subsequent investigations in search of new anti-tubercular agents. Furthermore, a DNA cleavage study using an agarose gel electrophoresis method revealed that compounds 1b, 1d, 1f and 1i cleaved DNA more efficiently and thereby exhibit nuclease activity