CXCR1 Expression to Improve Anti-Cancer Efficacy of Intravenously Injected CAR-NK Cells in Mice with Peritoneal Xenografts

10.1016/j.omto.2019.12.006Molecular Therapy - Oncolytics1675-8

A Meta-Analysis of Perceived Locus of Causality in Exercise, Sport, and Physical Education Contexts

The present article conducts a meta-analytic review of the research adopting the perceived locus of causality in the contexts of sport, exercise, and physical education. A literature search of published articles identified three main research foci: (a) the development of instruments that assess perceived locus of causality; (b) examination of the construct validity of perceived locus of causality by investigating the relevance of the self-determination continuum as well as by using antecedents (e.g., perceived competence) and outcomes (e.g., intentions); and (c) integration of Nicholls’ (1984) concepts of task and ego orientation with perceived locus of causality. A meta-analysis using 21 published articles supported the existence of a self-determination continuum from external regulation to introjection and identification. In addition, path analysis of corrected effect sizes supported the mediating effects of perceived locus of causality on the relationship between perceived competence and intentions. Results are discussed with reference to the assumptions of self-determination theory, Vallerand’s (1997) hierarchical model of intrinsic/extrinsic motivation, and theories of behavioral intentions

Trait self-control and self-discipline: Structure, validity, and invariance across national groups

The aim of the present study was to test the validity of the Brief Self-Control Scale (BSCS; Tangney, Baumeister and Boone 2004) including its dimensional structure based on competing one- and two-factor models, discriminant validity from the conceptually-related self-discipline construct, invariance across multiple samples from different national groups, and predictive validity with respect to health-related behaviors. Samples of undergraduate students (total N = 1282) from four national groups completed the brief self-control scale, the self-discipline scale from the NEO-PI-R, and self-report measures of binge drinking, exercise, and healthy eating. Confirmatory factor analytic models supported a two-factor structure of self-control encompassing restraint and non-impulsivity components. The model exhibited good fit in all samples and invariance of factor loadings in multi-sample analysis. The restraint and non-impulsivity components exhibited discriminant validity and were also distinct from self-discipline. Structural equation models revealed that non-impulsivity predicted binge drinking in three of the samples, and restraint predicted exercise in two samples, with no role for self-discipline. Results point to a multi-dimensional structure for trait self-control consistent with previous theory separating impulsive- and control-related components

Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis

10.18632/oncotarget.14592Oncotarget8813545-1355

Development of a quality-of-life instrument for autoimmune bullous disease: The autoimmune bullous disease quality of life questionnaire

IMPORTANCE Quality-of-life (QOL) evaluation is an increasingly important outcome measure in dermatology, with disease-specific QOL instruments being the most sensitive to changes in disease status. OBJECTIVE To develop a QOL instrument specific to autoimmune bullous disease (AIBD). DESIGN A comprehensive item generation process was used to build a 45-item pilot Autoimmune Bullous Disease Quality of Life (ABQOL) questionnaire, distributed to 70 patients with AIBD. Experts in bullous disease refined the pilot ABQOL before factor analysis was performed to yield the final ABQOL questionnaire of 17 questions.We evaluated validity and reliability across a range of indices. SETTING Australian dermatology outpatient clinics and private dermatology practices. PATIENTS AND EXPOSURE Patients with a histological diagnosis of AIBD. MAIN OUTCOMES AND MEASURES The development of an AIBD-specific QOL instrument. RESULTS Face and content validity were established through the comprehensive patient interview process and expert review. In terms of convergent validity, the ABQOL was found to have a moderate correlation with scores on the Dermatology Life Quality Index (R = 0.63) and the General Health subscale of the 36-Item Short Form Health Survey (R = 0.69; P = .009) and low correlation with the Pemphigus Disease Area Index (R = 0.42) and Autoimmune Bullous Disease Skin Disorder Intensity Score (R = 0.48). In terms of discriminant validity, the ABQOL was found to be more sensitive than the Dermatology Life Quality Index (P = .02). The ABQOL was also found to be a reliable instrument evaluated by internal consistency (Cronbach α coefficient, 0.84) and test-retest reliability (mean percentage variation, 0.92). CONCLUSIONS AND RELEVANCE The ABQOL has been shown to be a valid and reliable instrument that may serve as an end point in clinical trials. Future work should include incorporating patient weighting on questions to further increase content validity and translation of the measure to other languages