Mid-infrared guided optics: a perspective for astronomical instruments

Research activities during the last decade have shown the strong potential of photonic devices to greatly simplify ground based and space borne astronomical instruments and to improve their performance. We focus specifically on the mid-infrared wavelength regime (about 5-20 microns), a spectral range offering access to warm objects (about 300 K) and to spectral features that can be interpreted as signatures for biological activity (e.g. water, ozone, carbon dioxide). We review the relevant research activities aiming at the development of single-mode guided optics and the corresponding manufacturing technologies. We evaluate the experimentally achieved performance and compare it with the performance requirements for applications in various fields of astronomy. Our goal is to show a perspective for future astronomical instruments based on mid-infrared photonic devices.Comment: 16 pages, published in OSA Optics Express (see http://www.opticsinfobase.org/oe/abstract.cfm?uri=oe-17-3-1947

Continence and micturition : an anatomical basis

Urinary incontinence remains an important clinical problem worldwide, having a significant socio-economic, psychological, and medical burden. Maintaining urinary continence and coordinating micturition are complex processes relying on interaction between somatic and visceral elements, moderated by learned behavior. Urinary viscera and pelvic floor must interact with higher centers to ensure a functionally competent system. This article aims to describe the relevant anatomy and neuronal pathways involved in the maintenance of urinary continence and micturition. Review of relevant literature focusing on pelvic floor and urinary sphincters anatomy, and neuroanatomy of urinary continence and micturition. Data obtained from both live and cadaveric human studies are included. The stretch during bladder filling is believed to cause release of urothelial chemical mediators, which in turn activates afferent nerves and myofibroblasts in the muscosal and submucosal layers respectively, thereby relaying sensation of bladder fullness. The internal urethral sphincter is continuous with detrusor muscle, but its arrangement is variable. The external urethral sphincter blends with fibers of levator ani muscle. Executive decisions about micturition in humans rely on a complex mechanism involving communication between several cerebral centers and primitive sacral spinal reflexes. The pudendal nerve is most commonly damaged in females at the level of sacrospinous ligament. We describe the pelvic anatomy and relevant neuroanatomy involved in maintaining urinary continence and during micturition, subsequently highlighting the anatomical basis of urinary incontinence. Comprehensive anatomical understanding is vital for appropriate medical and surgical management of affected patients, and helps guide development of future therapies. Clin. Anat., 2014. © 2014 Wiley Periodicals, Inc

Application of Single-Mode Fiber-Coupled Receivers in Optical Satellite to High-Altitude Platform Communications

In a free-space optical communication system employing fiber-optic components, the phasefront distortions induced by atmospheric turbulence limit the efficiency with which the laser beam is coupled into a single-mode fiber. We analyze different link scenarios including a geostationary (GEO) satellite, a high-altitude platform (HAP), and an optical ground station (OGS). Single-mode coupled optically preamplified receivers allow for efficient suppression of background noise and highly sensitive detection. While GEO-to-OGS communication suffers from atmospheric turbulence, we demonstrate that GEO-to-HAP communication allows for close to diffraction-limited performance when applying tip-tilt correction

Three telescope nuller based on multibeam injection into single-mode waveguide

International audienc

Three telescope nuller based on multibeam injection into single-mode waveguide

International audienc

Three telescope nuller based on multibeam injection into single-mode waveguide

International audienc

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert’s syndrome. Clin Sci (Lond) 125: 257–264

Abstract Recent epidemiological and clinical data show protection from CVD (cardiovascular disease), all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age-and gender-matched healthy subjects (n = 59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n = 40) was investigated to further support the presented human data. GS subjects had significantly (P < 0.05) improved lipid profile with reduced total cholesterol, LDL-C (LDL-cholesterol), TAG, low-and pro-atherogenic LDL subfractions (LDL-1 + LDL-2), Apo-B, Apo-B/Apo-A1 ratio and lower IL-6 (interleukin 6) and SAA (serum amyloid A) concentrations (P = 0.094). When the control and GS groups were subdivided into younger and older cohorts, older GS subjects demonstrated reduced lipid variables (total cholesterol and LDL-C, TAG and LDL-C subfractions, Apo-B/Apo-A1 ratio; P < 0.05; Apo-B: P < 0.1) compared with controls. These data were supported by lipid analyses in the rodent model showing that Gunn rat serum had lower total cholesterol (2.29 + − 0.38 compared with 1.27 + − 0.72 mM; P < 0.001) and TAG (1.66 + − 0.67 compared with 0.99 + − 0.52 mM; P < 0.001) concentrations compared with controls. These findings indicate that the altered lipid profile and the reduced pro-inflammatory status in hyperbilirubinaemic subjects, particularly in the older individuals, probably contribute additionally to the commonly accepted beneficial antioxidant effects of bilirubin in humans